KR20230005194A - 미세소관 관련된 단백질 TAU (MAPT) iRNA 제제 조성물 및 이의 사용 방법 - Google Patents

미세소관 관련된 단백질 TAU (MAPT) iRNA 제제 조성물 및 이의 사용 방법 Download PDF

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KR20230005194A
KR20230005194A KR1020227037984A KR20227037984A KR20230005194A KR 20230005194 A KR20230005194 A KR 20230005194A KR 1020227037984 A KR1020227037984 A KR 1020227037984A KR 20227037984 A KR20227037984 A KR 20227037984A KR 20230005194 A KR20230005194 A KR 20230005194A
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만갈라 미나크시 사운다라판디안
제임스 디. 맥키닌치
엘란 피쉴레비흐
아담 카스토레노
카랄람보스 카이타니스
마크 케이. 슈레겔
조나단 에드워드 파레이
제프리 주버
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알닐람 파마슈티칼스 인코포레이티드
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KR1020227037984A 2020-03-30 2021-03-30 미세소관 관련된 단백질 TAU (MAPT) iRNA 제제 조성물 및 이의 사용 방법 Pending KR20230005194A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063002030P 2020-03-30 2020-03-30
US63/002,030 2020-03-30
US202163164467P 2021-03-22 2021-03-22
US63/164,467 2021-03-22
PCT/US2021/024858 WO2021202511A2 (en) 2020-03-30 2021-03-30 MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF

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KR20230005194A true KR20230005194A (ko) 2023-01-09

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US (1) US20230203486A1 (https=)
EP (1) EP4126230A4 (https=)
JP (1) JP2023521604A (https=)
KR (1) KR20230005194A (https=)
CN (1) CN116234585A (https=)
AU (1) AU2021246024A1 (https=)
BR (1) BR112022019606A2 (https=)
CA (1) CA3178304A1 (https=)
IL (1) IL296851A (https=)
MX (1) MX2022012293A (https=)
TW (1) TW202143984A (https=)
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WO2023064707A1 (en) * 2021-10-07 2023-04-20 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing tau expression
US20230212576A1 (en) 2021-12-13 2023-07-06 Eli Lilly And Company Mapt rna interference agents
JP2025507372A (ja) 2022-02-11 2025-03-18 アルナイラム ファーマシューティカルズ， インコーポレイテッド 微小管関連タンパク質タウ（ＭＡＰＴ）ｉＲＮＡ剤組成物およびその使用方法
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KR20250129743A (ko) * 2022-12-29 2025-08-29 보이저 테라퓨틱스, 인크. Mapt를 조절하기 위한 조성물 및 방법
WO2024201423A2 (en) * 2023-03-30 2024-10-03 Biorchestra Co., Ltd. Microtubule-associated protein tau targeting sirnas and uses thereof
TW202448484A (zh) * 2023-04-20 2024-12-16 美商雅迪克斯製藥公司 Ｍａｐｔ調節組合物及其使用方法
AU2024315297A1 (en) * 2023-08-01 2026-02-12 Tuojie Biotech (Shanghai) Co., Ltd. Dsrna targeting mapt and pharmaceutical use thereof
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WO2026010722A1 (en) * 2024-07-03 2026-01-08 Voyager Therapeutics, Inc. Compositions and methods for regulating mapt
WO2026017176A1 (zh) * 2024-07-19 2026-01-22 北京安龙生物医药有限公司 靶向微管相关蛋白Tau基因的寡核苷酸及其用途
CN121780524A (zh) * 2024-08-02 2026-04-03 北京尧景基因技术有限公司 抑制MAPT基因表达的siRNA及其缀合物和应用
WO2026067655A1 (zh) * 2024-09-26 2026-04-02 大睿生物医药科技(上海)有限公司 调控TAU表达的dsRNA分子

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US20230203486A1 (en) 2023-06-29
TW202143984A (zh) 2021-12-01
CA3178304A1 (en) 2021-10-07
MX2022012293A (es) 2022-10-27
WO2021202511A3 (en) 2021-11-25
AU2021246024A1 (en) 2022-10-27
IL296851A (en) 2022-11-01
CN116234585A (zh) 2023-06-06
EP4126230A4 (en) 2025-07-30
JP2023521604A (ja) 2023-05-25
WO2021202511A2 (en) 2021-10-07
BR112022019606A2 (pt) 2022-11-16
EP4126230A2 (en) 2023-02-08

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