JP2023521604A5 - - Google Patents
Info
- Publication number
- JP2023521604A5 JP2023521604A5 JP2022559557A JP2022559557A JP2023521604A5 JP 2023521604 A5 JP2023521604 A5 JP 2023521604A5 JP 2022559557 A JP2022559557 A JP 2022559557A JP 2022559557 A JP2022559557 A JP 2022559557A JP 2023521604 A5 JP2023521604 A5 JP 2023521604A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- nucleotides
- mapt
- dsrna agent
- antisense
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063002030P | 2020-03-30 | 2020-03-30 | |
| US63/002,030 | 2020-03-30 | ||
| US202163164467P | 2021-03-22 | 2021-03-22 | |
| US63/164,467 | 2021-03-22 | ||
| PCT/US2021/024858 WO2021202511A2 (en) | 2020-03-30 | 2021-03-30 | MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023521604A JP2023521604A (ja) | 2023-05-25 |
| JP2023521604A5 true JP2023521604A5 (https=) | 2024-04-10 |
Family
ID=77929772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559557A Pending JP2023521604A (ja) | 2020-03-30 | 2021-03-30 | 微小管関連タンパク質タウ（ＭＡＰＴ）ｉＲＮＡ剤組成物およびその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230203486A1 (https=) |
| EP (1) | EP4126230A4 (https=) |
| JP (1) | JP2023521604A (https=) |
| KR (1) | KR20230005194A (https=) |
| CN (1) | CN116234585A (https=) |
| AU (1) | AU2021246024A1 (https=) |
| BR (1) | BR112022019606A2 (https=) |
| CA (1) | CA3178304A1 (https=) |
| IL (1) | IL296851A (https=) |
| MX (1) | MX2022012293A (https=) |
| TW (1) | TW202143984A (https=) |
| WO (1) | WO2021202511A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202328449A (zh) * | 2021-09-24 | 2023-07-16 | 美商艾拉倫製藥公司 | 微管相關蛋白ＴＡＵ（ＭＡＰＴ）ｉＲＮＡ試劑組合物及其使用方法 |
| WO2023064707A1 (en) * | 2021-10-07 | 2023-04-20 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing tau expression |
| US20230212576A1 (en) | 2021-12-13 | 2023-07-06 | Eli Lilly And Company | Mapt rna interference agents |
| JP2025507372A (ja) | 2022-02-11 | 2025-03-18 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 微小管関連タンパク質タウ（ＭＡＰＴ）ｉＲＮＡ剤組成物およびその使用方法 |
| KR20240154674A (ko) * | 2022-03-16 | 2024-10-25 | 얀센 파마슈티카 엔브이 | MAPT siRNA 및 이의 용도 |
| KR20250129743A (ko) * | 2022-12-29 | 2025-08-29 | 보이저 테라퓨틱스, 인크. | Mapt를 조절하기 위한 조성물 및 방법 |
| WO2024201423A2 (en) * | 2023-03-30 | 2024-10-03 | Biorchestra Co., Ltd. | Microtubule-associated protein tau targeting sirnas and uses thereof |
| TW202448484A (zh) * | 2023-04-20 | 2024-12-16 | 美商雅迪克斯製藥公司 | Ｍａｐｔ調節組合物及其使用方法 |
| AU2024315297A1 (en) * | 2023-08-01 | 2026-02-12 | Tuojie Biotech (Shanghai) Co., Ltd. | Dsrna targeting mapt and pharmaceutical use thereof |
| WO2025027577A1 (en) * | 2023-08-02 | 2025-02-06 | Consejo Nacional De Investigaciones Científicas Y Técnicas (Conicet) | Micrornas designed against the microtubule-associated protein tau for the treatment of tauopathies |
| WO2025077806A1 (en) * | 2023-10-11 | 2025-04-17 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of microtubule associated protein tau (mapt) |
| US12551569B2 (en) * | 2024-03-31 | 2026-02-17 | Arrowhead Pharmaceuticals, Inc. | RNAi agents for inhibiting expression of microtubule associated protein tau (MAPT), compositions thereof, and methods of use |
| WO2025233849A2 (en) * | 2024-05-07 | 2025-11-13 | Janssen Pharmaceutica Nv | MAPT siRNA AND USES THEREOF |
| WO2026010722A1 (en) * | 2024-07-03 | 2026-01-08 | Voyager Therapeutics, Inc. | Compositions and methods for regulating mapt |
| WO2026017176A1 (zh) * | 2024-07-19 | 2026-01-22 | 北京安龙生物医药有限公司 | 靶向微管相关蛋白Tau基因的寡核苷酸及其用途 |
| CN121780524A (zh) * | 2024-08-02 | 2026-04-03 | 北京尧景基因技术有限公司 | 抑制MAPT基因表达的siRNA及其缀合物和应用 |
| WO2026067655A1 (zh) * | 2024-09-26 | 2026-04-02 | 大睿生物医药科技(上海)有限公司 | 调控TAU表达的dsRNA分子 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101346393B (zh) * | 2005-11-02 | 2015-07-22 | 普洛体维生物治疗公司 | 修饰的siRNA分子及其应用 |
| GB0605337D0 (en) * | 2006-03-17 | 2006-04-26 | Genomica Sau | Treatment of CNS conditions |
| EP2831232A4 (en) * | 2012-03-30 | 2015-11-04 | Univ Washington | METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME |
| US9133461B2 (en) * | 2012-04-10 | 2015-09-15 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the ALAS1 gene |
| CN105264091B (zh) * | 2013-03-14 | 2020-02-28 | Ionis制药公司 | 用于调节tau表达的组合物和方法 |
| US9951330B2 (en) * | 2013-07-11 | 2018-04-24 | The Trustees Of Columbia University In The City Of New York | Micrornas that silence tau expression |
| TW202246503A (zh) * | 2013-07-19 | 2022-12-01 | 美商百健Ｍａ公司 | 用於調節τ蛋白表現之組合物 |
| WO2015038892A1 (en) * | 2013-09-13 | 2015-03-19 | Moderna Therapeutics, Inc. | Polynucleotide compositions containing amino acids |
| IL316808A (en) * | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| US11077132B2 (en) * | 2015-02-04 | 2021-08-03 | F. Hoffmann-La Roche Ag | Tau antisense oligomers and uses thereof |
| US10513701B2 (en) * | 2015-03-25 | 2019-12-24 | Università Degli Studi Di Trento | RNA interference mediated therapy for neurodegenerative diseases |
| IL320434A (en) * | 2015-07-22 | 2025-06-01 | Wave Life Sciences Ltd | Oligonucleotide preparations and methods |
| PH12018501207B1 (en) * | 2015-12-21 | 2024-02-23 | Novartis Ag | Compositions and methods for decreasing tau expression |
| EP3728281A1 (en) * | 2017-12-21 | 2020-10-28 | Alnylam Pharmaceuticals Inc. | Chirally-enriched double-stranded rna agents |
| PE20210346A1 (es) * | 2018-07-03 | 2021-02-25 | Hoffmann La Roche | Oligonucleotidos para modular la expresion de tau |
| US20230099372A1 (en) * | 2020-02-07 | 2023-03-30 | Biorchestra Co., Ltd. | Use of mirna-485 inhibitors for treating tauopathy |
| US20210363523A1 (en) * | 2020-03-18 | 2021-11-25 | University Of Massachusetts | Oligonucleotides for mapt modulation |
-
2021
- 2021-03-30 AU AU2021246024A patent/AU2021246024A1/en active Pending
- 2021-03-30 IL IL296851A patent/IL296851A/en unknown
- 2021-03-30 TW TW110111671A patent/TW202143984A/zh unknown
- 2021-03-30 BR BR112022019606A patent/BR112022019606A2/pt unknown
- 2021-03-30 MX MX2022012293A patent/MX2022012293A/es unknown
- 2021-03-30 KR KR1020227037984A patent/KR20230005194A/ko active Pending
- 2021-03-30 CA CA3178304A patent/CA3178304A1/en active Pending
- 2021-03-30 CN CN202180039190.6A patent/CN116234585A/zh active Pending
- 2021-03-30 EP EP21779121.9A patent/EP4126230A4/en active Pending
- 2021-03-30 JP JP2022559557A patent/JP2023521604A/ja active Pending
- 2021-03-30 US US17/995,035 patent/US20230203486A1/en active Pending
- 2021-03-30 WO PCT/US2021/024858 patent/WO2021202511A2/en not_active Ceased
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