JP2023518268A5 - - Google Patents

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Publication number
JP2023518268A5
JP2023518268A5 JP2022556250A JP2022556250A JP2023518268A5 JP 2023518268 A5 JP2023518268 A5 JP 2023518268A5 JP 2022556250 A JP2022556250 A JP 2022556250A JP 2022556250 A JP2022556250 A JP 2022556250A JP 2023518268 A5 JP2023518268 A5 JP 2023518268A5
Authority
JP
Japan
Prior art keywords
dsrna
nucleotides
chain
antisense
nucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022556250A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023518268A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/022748 external-priority patent/WO2021188661A1/en
Publication of JP2023518268A publication Critical patent/JP2023518268A/ja
Publication of JP2023518268A5 publication Critical patent/JP2023518268A5/ja
Pending legal-status Critical Current

Links

JP2022556250A 2020-03-18 2021-03-17 Ｓｎｃａ調節のためのオリゴヌクレオチド Pending JP2023518268A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062991406P 2020-03-18 2020-03-18
US62/991,406 2020-03-18
US202063071115P 2020-08-27 2020-08-27
US63/071,115 2020-08-27
PCT/US2021/022748 WO2021188661A1 (en) 2020-03-18 2021-03-17 Oligonucleotides for snca modulation

Publications (2)

Publication Number Publication Date
JP2023518268A JP2023518268A (ja) 2023-04-28
JP2023518268A5 true JP2023518268A5 (https=) 2024-03-27

Family

ID=77772170

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022556250A Pending JP2023518268A (ja) 2020-03-18 2021-03-17 Ｓｎｃａ調節のためのオリゴヌクレオチド

Country Status (10)

Country Link
US (2) US20210363524A1 (https=)
EP (1) EP4121538A4 (https=)
JP (1) JP2023518268A (https=)
KR (1) KR20230002327A (https=)
CN (1) CN115777021A (https=)
AU (1) AU2021238326A1 (https=)
BR (1) BR112022018475A2 (https=)
CA (1) CA3171757A1 (https=)
MX (1) MX2022011536A (https=)
WO (1) WO2021188661A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023201281A2 (en) * 2022-04-14 2023-10-19 University Of Massachusetts Oligonucleotides for atn1 modulation
US20240052344A1 (en) * 2022-05-04 2024-02-15 University Of Massachusetts Oligonucleotides for pms1 modulation
US20260103703A1 (en) * 2022-09-29 2026-04-16 Atalanta Therapeutics, Inc. siRNA COMPOSITIONS AND METHODS TARGETING ALPHA-SYNUCLEIN NUCLEIC ACIDS
WO2024166019A1 (en) * 2023-02-08 2024-08-15 Biorchestra Co., Ltd. Sirna targeting alpha-synuclein and uses thereof
WO2025085713A1 (en) * 2023-10-20 2025-04-24 Spark Therapeutics, Inc. Inhibitory nucleic acid targeting alpha synuclein expression
TW202523678A (zh) * 2023-12-14 2025-06-16 國立臺灣大學 ＣＲＩＳＰＲＩ標靶α－突觸核蛋白
WO2025162214A1 (en) * 2024-01-30 2025-08-07 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of synuclein alpha (snca) gene

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005045034A2 (en) * 2003-10-23 2005-05-19 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA)
US20090176729A1 (en) * 2007-12-14 2009-07-09 Alnylam Pharmaceuticals, Inc. Method of treating neurodegenerative disease
WO2010141511A2 (en) * 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
WO2012027713A2 (en) * 2010-08-26 2012-03-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibition of snca
CA2817960C (en) * 2010-11-17 2020-06-09 Ionis Pharmaceuticals, Inc. Modulation of alpha synuclein expression
PL3277814T3 (pl) * 2015-04-03 2020-11-30 University Of Massachusetts Związki oligonukleotydowe ukierunkowane na mrna huntingtyny
US20160319278A1 (en) * 2015-04-03 2016-11-03 University Of Massachusetts Fully stabilized asymmetric sirna
US10478503B2 (en) * 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
KR102931619B1 (ko) * 2018-08-03 2026-02-26 젠자임 코포레이션 알파-시뉴클레인에 대한 변이형 RNAi
WO2020033899A1 (en) * 2018-08-10 2020-02-13 University Of Massachusetts Modified oligonucleotides targeting snps

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