CN115777021A - 用于snca调节的寡核苷酸 - Google Patents

用于snca调节的寡核苷酸 Download PDF

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Publication number
CN115777021A
CN115777021A CN202180035697.4A CN202180035697A CN115777021A CN 115777021 A CN115777021 A CN 115777021A CN 202180035697 A CN202180035697 A CN 202180035697A CN 115777021 A CN115777021 A CN 115777021A
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nucleotides
antisense strand
dsrna
sense strand
strand
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CN202180035697.4A
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Chinese (zh)
Inventor
阿纳斯塔西娅·赫沃罗娃
尚塔尔·弗格森
萨拉·戴维斯
凯瑟琳·莫诺波利
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University of Massachusetts Amherst
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University of Massachusetts Amherst
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN202180035697.4A 2020-03-18 2021-03-17 用于snca调节的寡核苷酸 Pending CN115777021A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062991406P 2020-03-18 2020-03-18
US62/991,406 2020-03-18
US202063071115P 2020-08-27 2020-08-27
US63/071,115 2020-08-27
PCT/US2021/022748 WO2021188661A1 (en) 2020-03-18 2021-03-17 Oligonucleotides for snca modulation

Publications (1)

Publication Number Publication Date
CN115777021A true CN115777021A (zh) 2023-03-10

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CN202180035697.4A Pending CN115777021A (zh) 2020-03-18 2021-03-17 用于snca调节的寡核苷酸

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US (2) US20210363524A1 (https=)
EP (1) EP4121538A4 (https=)
JP (1) JP2023518268A (https=)
KR (1) KR20230002327A (https=)
CN (1) CN115777021A (https=)
AU (1) AU2021238326A1 (https=)
BR (1) BR112022018475A2 (https=)
CA (1) CA3171757A1 (https=)
MX (1) MX2022011536A (https=)
WO (1) WO2021188661A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023201281A2 (en) * 2022-04-14 2023-10-19 University Of Massachusetts Oligonucleotides for atn1 modulation
US20240052344A1 (en) * 2022-05-04 2024-02-15 University Of Massachusetts Oligonucleotides for pms1 modulation
US20260103703A1 (en) * 2022-09-29 2026-04-16 Atalanta Therapeutics, Inc. siRNA COMPOSITIONS AND METHODS TARGETING ALPHA-SYNUCLEIN NUCLEIC ACIDS
WO2024166019A1 (en) * 2023-02-08 2024-08-15 Biorchestra Co., Ltd. Sirna targeting alpha-synuclein and uses thereof
WO2025085713A1 (en) * 2023-10-20 2025-04-24 Spark Therapeutics, Inc. Inhibitory nucleic acid targeting alpha synuclein expression
TW202523678A (zh) * 2023-12-14 2025-06-16 國立臺灣大學 ＣＲＩＳＰＲＩ標靶α－突觸核蛋白
WO2025162214A1 (en) * 2024-01-30 2025-08-07 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of synuclein alpha (snca) gene

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005045034A2 (en) * 2003-10-23 2005-05-19 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA)
US20090176729A1 (en) * 2007-12-14 2009-07-09 Alnylam Pharmaceuticals, Inc. Method of treating neurodegenerative disease
WO2010141511A2 (en) * 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
WO2012027713A2 (en) * 2010-08-26 2012-03-01 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibition of snca
CA2817960C (en) * 2010-11-17 2020-06-09 Ionis Pharmaceuticals, Inc. Modulation of alpha synuclein expression
PL3277814T3 (pl) * 2015-04-03 2020-11-30 University Of Massachusetts Związki oligonukleotydowe ukierunkowane na mrna huntingtyny
US20160319278A1 (en) * 2015-04-03 2016-11-03 University Of Massachusetts Fully stabilized asymmetric sirna
US10478503B2 (en) * 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
KR102931619B1 (ko) * 2018-08-03 2026-02-26 젠자임 코포레이션 알파-시뉴클레인에 대한 변이형 RNAi
WO2020033899A1 (en) * 2018-08-10 2020-02-13 University Of Massachusetts Modified oligonucleotides targeting snps

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EP4121538A4 (en) 2024-07-31
CA3171757A1 (en) 2021-09-23
MX2022011536A (es) 2023-01-04
KR20230002327A (ko) 2023-01-05
US20250043284A1 (en) 2025-02-06
WO2021188661A1 (en) 2021-09-23
BR112022018475A2 (pt) 2022-11-29
US20210363524A1 (en) 2021-11-25
AU2021238326A1 (en) 2022-10-13
EP4121538A1 (en) 2023-01-25
JP2023518268A (ja) 2023-04-28

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