JP2023518439A5 - - Google Patents
Info
- Publication number
- JP2023518439A5 JP2023518439A5 JP2022556142A JP2022556142A JP2023518439A5 JP 2023518439 A5 JP2023518439 A5 JP 2023518439A5 JP 2022556142 A JP2022556142 A JP 2022556142A JP 2022556142 A JP2022556142 A JP 2022556142A JP 2023518439 A5 JP2023518439 A5 JP 2023518439A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotides
- dsrna
- antisense
- chain
- antisense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062991405P | 2020-03-18 | 2020-03-18 | |
| US62/991,405 | 2020-03-18 | ||
| US202063071106P | 2020-08-27 | 2020-08-27 | |
| US63/071,106 | 2020-08-27 | ||
| PCT/US2021/022688 WO2021188626A1 (en) | 2020-03-18 | 2021-03-17 | Oligonucleotides for mapt modulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023518439A JP2023518439A (ja) | 2023-05-01 |
| JP2023518439A5 true JP2023518439A5 (https=) | 2024-03-28 |
Family
ID=77768304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022556142A Pending JP2023518439A (ja) | 2020-03-18 | 2021-03-17 | Ｍａｐｔ調節のためのオリゴヌクレオチド |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20210363523A1 (https=) |
| EP (1) | EP4121537A4 (https=) |
| JP (1) | JP2023518439A (https=) |
| KR (1) | KR20230004448A (https=) |
| CN (1) | CN115552006A (https=) |
| AU (1) | AU2021238319A1 (https=) |
| CA (1) | CA3171246A1 (https=) |
| MX (1) | MX2022011516A (https=) |
| WO (1) | WO2021188626A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160319278A1 (en) | 2015-04-03 | 2016-11-03 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| WO2017030973A1 (en) | 2015-08-14 | 2017-02-23 | University Of Massachusetts | Bioactive conjugates for oligonucleotide delivery |
| JP7406793B2 (ja) | 2017-06-23 | 2023-12-28 | ユニバーシティー オブ マサチューセッツ | ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法 |
| US11279930B2 (en) | 2018-08-23 | 2022-03-22 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
| CN113614232A (zh) | 2019-01-18 | 2021-11-05 | 马萨诸塞大学 | 动态药代动力学修饰锚 |
| KR20220047989A (ko) | 2019-08-09 | 2022-04-19 | 유니버시티 오브 매사추세츠 | Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드 |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| AU2021246024A1 (en) * | 2020-03-30 | 2022-10-27 | Alnylam Pharmaceuticals, Inc. | Microtubule associated protein Tau (MAPT) iRNA agent compositions and methods of use thereof |
| WO2021242883A1 (en) | 2020-05-26 | 2021-12-02 | University Of Massachusetts | Synthetic oligonucleotides having regions of block and cluster modifications |
| TW202328449A (zh) | 2021-09-24 | 2023-07-16 | 美商艾拉倫製藥公司 | 微管相關蛋白ＴＡＵ（ＭＡＰＴ）ｉＲＮＡ試劑組合物及其使用方法 |
| WO2023064707A1 (en) * | 2021-10-07 | 2023-04-20 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing tau expression |
| US20230212576A1 (en) * | 2021-12-13 | 2023-07-06 | Eli Lilly And Company | Mapt rna interference agents |
| WO2023173061A2 (en) * | 2022-03-11 | 2023-09-14 | University Of Massachusetts | Oligonucleotides for app modulation |
| JP2025511297A (ja) * | 2022-04-01 | 2025-04-15 | タケダ ファーマシューティカルズ ユーエスエー インコーポレイテッド | 神経変性障害の治療方法 |
| CN119173631A (zh) * | 2022-05-12 | 2024-12-20 | 迪克纳制药公司 | 用于抑制mapt表达的组合物和方法 |
| JP2025517123A (ja) * | 2022-05-13 | 2025-06-03 | ユリウス－マクシミリアンズ－ウニヴェルジテート ウュルツブルグ | アルツハイマー病の処置のためのＨＮＲＮＰ Ｒ－媒介Ｍａｐｔ ｍＲＮＡ輸送の遮断を介する軸索タウ（ｔａｕ）タンパク質蓄積を減少させるための方法及び分子 |
| AU2023354157A1 (en) * | 2022-09-29 | 2025-04-10 | Atalanta Therapeutics, Inc. | Sirna compositions and methods targeting microtubule associated protein tau nucleic acids |
| KR20250129743A (ko) * | 2022-12-29 | 2025-08-29 | 보이저 테라퓨틱스, 인크. | Mapt를 조절하기 위한 조성물 및 방법 |
| WO2024201423A2 (en) * | 2023-03-30 | 2024-10-03 | Biorchestra Co., Ltd. | Microtubule-associated protein tau targeting sirnas and uses thereof |
| TW202448484A (zh) * | 2023-04-20 | 2024-12-16 | 美商雅迪克斯製藥公司 | Ｍａｐｔ調節組合物及其使用方法 |
| AU2024315297A1 (en) * | 2023-08-01 | 2026-02-12 | Tuojie Biotech (Shanghai) Co., Ltd. | Dsrna targeting mapt and pharmaceutical use thereof |
| WO2025077806A1 (en) * | 2023-10-11 | 2025-04-17 | Shanghai Argo Biopharmaceutical Co., Ltd. | Compositions and methods for inhibiting expression of microtubule associated protein tau (mapt) |
| US12551569B2 (en) | 2024-03-31 | 2026-02-17 | Arrowhead Pharmaceuticals, Inc. | RNAi agents for inhibiting expression of microtubule associated protein tau (MAPT), compositions thereof, and methods of use |
| WO2025233849A2 (en) * | 2024-05-07 | 2025-11-13 | Janssen Pharmaceutica Nv | MAPT siRNA AND USES THEREOF |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050255086A1 (en) * | 2002-08-05 | 2005-11-17 | Davidson Beverly L | Nucleic acid silencing of Huntington's Disease gene |
| WO2006047673A2 (en) * | 2004-10-27 | 2006-05-04 | Vanderbilt University | Mammalian genes involved in infection |
| GB0605337D0 (en) * | 2006-03-17 | 2006-04-26 | Genomica Sau | Treatment of CNS conditions |
| EP2145014B1 (en) * | 2007-04-05 | 2012-12-12 | The J. David Gladstone Institutes | Agents that reduce neuronal overexcitation |
| WO2010141511A2 (en) * | 2009-06-01 | 2010-12-09 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
| TW202246503A (zh) * | 2013-07-19 | 2022-12-01 | 美商百健Ｍａ公司 | 用於調節τ蛋白表現之組合物 |
| US10513701B2 (en) * | 2015-03-25 | 2019-12-24 | Università Degli Studi Di Trento | RNA interference mediated therapy for neurodegenerative diseases |
| US20160319278A1 (en) * | 2015-04-03 | 2016-11-03 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| US10478503B2 (en) * | 2016-01-31 | 2019-11-19 | University Of Massachusetts | Branched oligonucleotides |
| US11279930B2 (en) * | 2018-08-23 | 2022-03-22 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
| WO2021041247A1 (en) * | 2019-08-23 | 2021-03-04 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
-
2021
- 2021-03-17 US US17/204,480 patent/US20210363523A1/en active Pending
- 2021-03-17 WO PCT/US2021/022688 patent/WO2021188626A1/en not_active Ceased
- 2021-03-17 KR KR1020227031792A patent/KR20230004448A/ko active Pending
- 2021-03-17 MX MX2022011516A patent/MX2022011516A/es unknown
- 2021-03-17 JP JP2022556142A patent/JP2023518439A/ja active Pending
- 2021-03-17 CA CA3171246A patent/CA3171246A1/en active Pending
- 2021-03-17 AU AU2021238319A patent/AU2021238319A1/en active Pending
- 2021-03-17 EP EP21770963.3A patent/EP4121537A4/en active Pending
- 2021-03-17 CN CN202180034587.6A patent/CN115552006A/zh active Pending
-
2025
- 2025-09-24 US US19/338,285 patent/US20260109982A1/en active Pending
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