CN115552006A - 用于mapt调节的寡核苷酸 - Google Patents

用于mapt调节的寡核苷酸 Download PDF

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Publication number
CN115552006A
CN115552006A CN202180034587.6A CN202180034587A CN115552006A CN 115552006 A CN115552006 A CN 115552006A CN 202180034587 A CN202180034587 A CN 202180034587A CN 115552006 A CN115552006 A CN 115552006A
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nucleotides
antisense strand
dsrna
sense strand
strand
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Chinese (zh)
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阿纳斯塔西娅·赫沃罗娃
尚塔尔·弗格森
萨拉·戴维斯
凯瑟琳·莫诺波利
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University of Massachusetts Amherst
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University of Massachusetts Amherst
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CN202180034587.6A 2020-03-18 2021-03-17 用于mapt调节的寡核苷酸 Pending CN115552006A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062991405P 2020-03-18 2020-03-18
US62/991,405 2020-03-18
US202063071106P 2020-08-27 2020-08-27
US63/071,106 2020-08-27
PCT/US2021/022688 WO2021188626A1 (en) 2020-03-18 2021-03-17 Oligonucleotides for mapt modulation

Publications (1)

Publication Number Publication Date
CN115552006A true CN115552006A (zh) 2022-12-30

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CN202180034587.6A Pending CN115552006A (zh) 2020-03-18 2021-03-17 用于mapt调节的寡核苷酸

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US (2) US20210363523A1 (https=)
EP (1) EP4121537A4 (https=)
JP (1) JP2023518439A (https=)
KR (1) KR20230004448A (https=)
CN (1) CN115552006A (https=)
AU (1) AU2021238319A1 (https=)
CA (1) CA3171246A1 (https=)
MX (1) MX2022011516A (https=)
WO (1) WO2021188626A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025026390A1 (zh) * 2023-08-01 2025-02-06 上海拓界生物医药科技有限公司 靶向MAPT的dsRNA及其医药用途
WO2025077806A1 (en) * 2023-10-11 2025-04-17 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of microtubule associated protein tau (mapt)

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US20160319278A1 (en) 2015-04-03 2016-11-03 University Of Massachusetts Fully stabilized asymmetric sirna
WO2017030973A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
US11279930B2 (en) 2018-08-23 2022-03-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
CN113614232A (zh) 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
KR20220047989A (ko) 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
AU2021246024A1 (en) * 2020-03-30 2022-10-27 Alnylam Pharmaceuticals, Inc. Microtubule associated protein Tau (MAPT) iRNA agent compositions and methods of use thereof
WO2021242883A1 (en) 2020-05-26 2021-12-02 University Of Massachusetts Synthetic oligonucleotides having regions of block and cluster modifications
TW202328449A (zh) 2021-09-24 2023-07-16 美商艾拉倫製藥公司 微管相關蛋白ＴＡＵ（ＭＡＰＴ）ｉＲＮＡ試劑組合物及其使用方法
WO2023064707A1 (en) * 2021-10-07 2023-04-20 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing tau expression
US20230212576A1 (en) * 2021-12-13 2023-07-06 Eli Lilly And Company Mapt rna interference agents
WO2023173061A2 (en) * 2022-03-11 2023-09-14 University Of Massachusetts Oligonucleotides for app modulation
JP2025511297A (ja) * 2022-04-01 2025-04-15 タケダ ファーマシューティカルズ ユーエスエー インコーポレイテッド 神経変性障害の治療方法
CN119173631A (zh) * 2022-05-12 2024-12-20 迪克纳制药公司 用于抑制mapt表达的组合物和方法
JP2025517123A (ja) * 2022-05-13 2025-06-03 ユリウス－マクシミリアンズ－ウニヴェルジテート ウュルツブルグ アルツハイマー病の処置のためのＨＮＲＮＰ Ｒ－媒介Ｍａｐｔ ｍＲＮＡ輸送の遮断を介する軸索タウ（ｔａｕ）タンパク質蓄積を減少させるための方法及び分子
AU2023354157A1 (en) * 2022-09-29 2025-04-10 Atalanta Therapeutics, Inc. Sirna compositions and methods targeting microtubule associated protein tau nucleic acids
KR20250129743A (ko) * 2022-12-29 2025-08-29 보이저 테라퓨틱스, 인크. Mapt를 조절하기 위한 조성물 및 방법
WO2024201423A2 (en) * 2023-03-30 2024-10-03 Biorchestra Co., Ltd. Microtubule-associated protein tau targeting sirnas and uses thereof
TW202448484A (zh) * 2023-04-20 2024-12-16 美商雅迪克斯製藥公司 Ｍａｐｔ調節組合物及其使用方法
US12551569B2 (en) 2024-03-31 2026-02-17 Arrowhead Pharmaceuticals, Inc. RNAi agents for inhibiting expression of microtubule associated protein tau (MAPT), compositions thereof, and methods of use
WO2025233849A2 (en) * 2024-05-07 2025-11-13 Janssen Pharmaceutica Nv MAPT siRNA AND USES THEREOF

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US20050255086A1 (en) * 2002-08-05 2005-11-17 Davidson Beverly L Nucleic acid silencing of Huntington's Disease gene
WO2006047673A2 (en) * 2004-10-27 2006-05-04 Vanderbilt University Mammalian genes involved in infection
GB0605337D0 (en) * 2006-03-17 2006-04-26 Genomica Sau Treatment of CNS conditions
EP2145014B1 (en) * 2007-04-05 2012-12-12 The J. David Gladstone Institutes Agents that reduce neuronal overexcitation
WO2010141511A2 (en) * 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
TW202246503A (zh) * 2013-07-19 2022-12-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
US10513701B2 (en) * 2015-03-25 2019-12-24 Università Degli Studi Di Trento RNA interference mediated therapy for neurodegenerative diseases
US20160319278A1 (en) * 2015-04-03 2016-11-03 University Of Massachusetts Fully stabilized asymmetric sirna
US10478503B2 (en) * 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
US11279930B2 (en) * 2018-08-23 2022-03-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
WO2021041247A1 (en) * 2019-08-23 2021-03-04 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025026390A1 (zh) * 2023-08-01 2025-02-06 上海拓界生物医药科技有限公司 靶向MAPT的dsRNA及其医药用途
WO2025077806A1 (en) * 2023-10-11 2025-04-17 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of microtubule associated protein tau (mapt)

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MX2022011516A (es) 2023-01-04
WO2021188626A1 (en) 2021-09-23
EP4121537A4 (en) 2024-07-31
US20260109982A1 (en) 2026-04-23
US20210363523A1 (en) 2021-11-25
JP2023518439A (ja) 2023-05-01
AU2021238319A1 (en) 2022-10-06
KR20230004448A (ko) 2023-01-06
EP4121537A1 (en) 2023-01-25
CA3171246A1 (en) 2021-09-23

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