JP2023511370A - Ｎｍｄａ拮抗薬の副作用の低減 - Google Patents

Ｎｍｄａ拮抗薬の副作用の低減 Download PDF

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Publication number
JP2023511370A
JP2023511370A JP2022544288A JP2022544288A JP2023511370A JP 2023511370 A JP2023511370 A JP 2023511370A JP 2022544288 A JP2022544288 A JP 2022544288A JP 2022544288 A JP2022544288 A JP 2022544288A JP 2023511370 A JP2023511370 A JP 2023511370A
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racemic ketamine
pharmaceutically acceptable
acceptable salt
intranasal administration
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JP2023511370A5 (https=
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ラジ メーラ，
ティモシー ウィタカー，
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シーロス セラピューティクス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022544288A 2020-01-22 2021-01-22 Ｎｍｄａ拮抗薬の副作用の低減 Withdrawn JP2023511370A (ja)

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JP2026003608A JP2026050474A (ja) 2020-01-22 2026-01-13 Ｎｍｄａ拮抗薬の副作用の低減

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US202062964598P 2020-01-22 2020-01-22
US62/964,598 2020-01-22
US202063079791P 2020-09-17 2020-09-17
US63/079,791 2020-09-17
PCT/US2021/014748 WO2021150985A1 (en) 2020-01-22 2021-01-22 Reducing side effects of nmda antagonists

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JP2023511370A5 JP2023511370A5 (https=) 2024-01-29

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US (5) US20230064327A1 (https=)
EP (1) EP4093388A1 (https=)
JP (2) JP2023511370A (https=)
KR (1) KR20220137033A (https=)
CN (2) CN115135317A (https=)
AU (1) AU2021210405A1 (https=)
BR (1) BR112022014382A2 (https=)
CA (1) CA3164022A1 (https=)
CL (1) CL2022001958A1 (https=)
IL (1) IL294485A (https=)
MX (1) MX2022009050A (https=)
PH (1) PH12022551856A1 (https=)
TW (1) TW202139981A (https=)
WO (1) WO2021150985A1 (https=)

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US11980595B2 (en) 2018-02-15 2024-05-14 National University Corporation Chiba University Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases
WO2019213551A1 (en) 2018-05-04 2019-11-07 Perception Neuroscience, Inc. Methods of treating substance abuse
JP2023511370A (ja) 2020-01-22 2023-03-17 シーロス セラピューティクス， インコーポレイテッド Ｎｍｄａ拮抗薬の副作用の低減
US20240261236A1 (en) * 2021-05-14 2024-08-08 Seelos Therapeutics, Inc. Methods of using nmda receptor antagonists
TW202310825A (zh) * 2021-05-14 2023-03-16 美商西羅斯醫療公司 減少ｎｍｄａ受體拮抗劑之副作用
WO2025240537A1 (en) * 2024-05-13 2025-11-20 Gilgamesh Pharmaceuticals, Inc. Methods of treating psychiatric disorders or pain using (r)-2-(4-fluorophenyl)-2-(methylamino)cyclohexan-1-one or pharmaceutically acceptable salts thereof
CN120919139A (zh) * 2025-09-09 2025-11-11 徐州百瑞麻醉科技研究院有限公司 一种抗抑郁药物组合物及其应用

Citations (2)

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JP2009530385A (ja) * 2006-03-22 2009-08-27 マウント シナイ スクール オブ メディシン うつ病の治療のためのケタミンの鼻内投与
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TW202139981A (zh) 2021-11-01
US20240342113A1 (en) 2024-10-17
BR112022014382A2 (pt) 2022-09-13
AU2021210405A1 (en) 2022-08-25
EP4093388A1 (en) 2022-11-30
CN121489916A (zh) 2026-02-10
US20230270694A1 (en) 2023-08-31
PH12022551856A1 (en) 2024-01-03
KR20220137033A (ko) 2022-10-11
US12440457B2 (en) 2025-10-14
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