CN115135317A - 减少nmda拮抗剂的副作用 - Google Patents

减少nmda拮抗剂的副作用 Download PDF

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Publication number
CN115135317A
CN115135317A CN202180010285.5A CN202180010285A CN115135317A CN 115135317 A CN115135317 A CN 115135317A CN 202180010285 A CN202180010285 A CN 202180010285A CN 115135317 A CN115135317 A CN 115135317A
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China
Prior art keywords
hours
racemic ketamine
pharmaceutically acceptable
acceptable salt
score
Prior art date
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Pending
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CN202180010285.5A
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English (en)
Chinese (zh)
Inventor
拉吉·梅赫拉
蒂莫西·惠特克
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Silos Therapeutics Ltd
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Silos Therapeutics Ltd
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Priority to CN202511379764.0A priority Critical patent/CN121489916A/zh
Publication of CN115135317A publication Critical patent/CN115135317A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180010285.5A 2020-01-22 2021-01-22 减少nmda拮抗剂的副作用 Pending CN115135317A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511379764.0A CN121489916A (zh) 2020-01-22 2021-01-22 减少nmda拮抗剂的副作用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062964598P 2020-01-22 2020-01-22
US62/964,598 2020-01-22
US202063079791P 2020-09-17 2020-09-17
US63/079,791 2020-09-17
PCT/US2021/014748 WO2021150985A1 (en) 2020-01-22 2021-01-22 Reducing side effects of nmda antagonists

Related Child Applications (1)

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CN202511379764.0A Division CN121489916A (zh) 2020-01-22 2021-01-22 减少nmda拮抗剂的副作用

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CN115135317A true CN115135317A (zh) 2022-09-30

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CN202511379764.0A Pending CN121489916A (zh) 2020-01-22 2021-01-22 减少nmda拮抗剂的副作用

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US (5) US20230064327A1 (https=)
EP (1) EP4093388A1 (https=)
JP (2) JP2023511370A (https=)
KR (1) KR20220137033A (https=)
CN (2) CN115135317A (https=)
AU (1) AU2021210405A1 (https=)
BR (1) BR112022014382A2 (https=)
CA (1) CA3164022A1 (https=)
CL (1) CL2022001958A1 (https=)
IL (1) IL294485A (https=)
MX (1) MX2022009050A (https=)
PH (1) PH12022551856A1 (https=)
TW (1) TW202139981A (https=)
WO (1) WO2021150985A1 (https=)

Cited By (1)

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CN120919139A (zh) * 2025-09-09 2025-11-11 徐州百瑞麻醉科技研究院有限公司 一种抗抑郁药物组合物及其应用

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US11980595B2 (en) 2018-02-15 2024-05-14 National University Corporation Chiba University Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases
WO2019213551A1 (en) 2018-05-04 2019-11-07 Perception Neuroscience, Inc. Methods of treating substance abuse
JP2023511370A (ja) 2020-01-22 2023-03-17 シーロス セラピューティクス， インコーポレイテッド Ｎｍｄａ拮抗薬の副作用の低減
US20240261236A1 (en) * 2021-05-14 2024-08-08 Seelos Therapeutics, Inc. Methods of using nmda receptor antagonists
TW202310825A (zh) * 2021-05-14 2023-03-16 美商西羅斯醫療公司 減少ｎｍｄａ受體拮抗劑之副作用
WO2025240537A1 (en) * 2024-05-13 2025-11-20 Gilgamesh Pharmaceuticals, Inc. Methods of treating psychiatric disorders or pain using (r)-2-(4-fluorophenyl)-2-(methylamino)cyclohexan-1-one or pharmaceutically acceptable salts thereof

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN101466364A (zh) * 2006-03-22 2009-06-24 纽约大学西奈山医学院 鼻内施用氯胺酮治疗抑郁症
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TW202139981A (zh) 2021-11-01
US20240342113A1 (en) 2024-10-17
BR112022014382A2 (pt) 2022-09-13
AU2021210405A1 (en) 2022-08-25
EP4093388A1 (en) 2022-11-30
CN121489916A (zh) 2026-02-10
JP2023511370A (ja) 2023-03-17
US20230270694A1 (en) 2023-08-31
PH12022551856A1 (en) 2024-01-03
KR20220137033A (ko) 2022-10-11
US12440457B2 (en) 2025-10-14
JP2026050474A (ja) 2026-03-19
IL294485A (en) 2022-09-01
US20230241008A1 (en) 2023-08-03
US20230064327A1 (en) 2023-03-02
CA3164022A1 (en) 2021-07-29
MX2022009050A (es) 2022-10-27
WO2021150985A1 (en) 2021-07-29
CL2022001958A1 (es) 2023-05-26
US20230321007A1 (en) 2023-10-12

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