JP2023510349A5 - - Google Patents

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Publication number
JP2023510349A5
JP2023510349A5 JP2022542333A JP2022542333A JP2023510349A5 JP 2023510349 A5 JP2023510349 A5 JP 2023510349A5 JP 2022542333 A JP2022542333 A JP 2022542333A JP 2022542333 A JP2022542333 A JP 2022542333A JP 2023510349 A5 JP2023510349 A5 JP 2023510349A5
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JP
Japan
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JP2022542333A
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Japanese (ja)
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JP2023510349A (ja
JP7846624B2 (ja
JPWO2021142199A5 (https=
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JP2022542333A 2020-01-09 2021-01-08 ペプチド含有リンカーとの部位特異的抗体-薬物コンジュゲート Active JP7846624B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202062958916P 2020-01-09 2020-01-09
US62/958,916 2020-01-09
US202063040735P 2020-06-18 2020-06-18
US63/040,735 2020-06-18
PCT/US2021/012611 WO2021142199A1 (en) 2020-01-09 2021-01-08 Site specific antibody-drug conjugates with peptide-containing linkers

Publications (4)

Publication Number Publication Date
JP2023510349A JP2023510349A (ja) 2023-03-13
JPWO2021142199A5 JPWO2021142199A5 (https=) 2024-01-19
JP2023510349A5 true JP2023510349A5 (https=) 2024-01-19
JP7846624B2 JP7846624B2 (ja) 2026-04-15

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ID=74495099

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JP2022542333A Active JP7846624B2 (ja) 2020-01-09 2021-01-08 ペプチド含有リンカーとの部位特異的抗体-薬物コンジュゲート

Country Status (12)

Country Link
US (2) US11786605B2 (https=)
EP (1) EP4087614A1 (https=)
JP (1) JP7846624B2 (https=)
KR (1) KR20220124762A (https=)
CN (1) CN115884793A (https=)
AU (1) AU2021205312A1 (https=)
BR (1) BR112022013255A2 (https=)
CA (1) CA3163833A1 (https=)
IL (1) IL294321B1 (https=)
MX (1) MX2022008437A (https=)
TW (1) TW202140075A (https=)
WO (1) WO2021142199A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL294321B1 (en) 2020-01-09 2026-04-01 Mersana Therapeutics Inc Antibody-drug conjugates are attached at a specific site with linkers that include peptides.
JP2024501894A (ja) 2021-01-04 2024-01-16 メルサナ セラピューティクス インコーポレイテッド B7h4ターゲティング抗体-薬物コンジュゲートおよびその使用方法
CN118574857A (zh) * 2022-01-27 2024-08-30 岩唐生物科技(杭州)有限责任公司 靶向cd3的多特异性抗体及其应用
US20240190958A1 (en) * 2022-10-18 2024-06-13 Tubulis Gmbh Novel antibody drug conjugates with novel napi2b antibodies, therapeutic methods and uses thereof
WO2025248500A1 (en) 2024-05-31 2025-12-04 Janssen Biotech, Inc. Antibody drug conjugates that target enpp3

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
ES2149768T3 (es) 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US20080070981A1 (en) 2000-02-23 2008-03-20 Henryk Borowy-Borowski Water-soluble compositions of bioactive lipophilic compounds
ES2276708T3 (es) 1999-11-24 2007-07-01 Immunogen, Inc. Agentes citotoxicos que comprenden taxanos y su uso terapeutico.
ATE344801T1 (de) 1999-12-29 2006-11-15 Immunogen Inc Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US6756397B2 (en) 2002-04-05 2004-06-29 Immunogen, Inc. Prodrugs of CC-1065 analogs
US6534660B1 (en) 2002-04-05 2003-03-18 Immunogen, Inc. CC-1065 analog synthesis
US6596757B1 (en) 2002-05-14 2003-07-22 Immunogen Inc. Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use
WO2004063344A2 (en) 2003-01-10 2004-07-29 Government Of The United States Of America As Represented By The Sercretary Of The Department Of Health And Human Services National Institutes Of Health CATALYTIC DOMAINS OF β/1,4)-GALACTOSYLTRANSFERASE I HAVING ALTERED DONOR AND ACCEPTOR SPECIFICITIES, DOMAINS THAT PROMOTE IN VITRO PROTEIN FOLDING, AND METHODS FOR THEIR USE
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
DK1812031T3 (en) 2004-11-01 2015-09-14 Univ California Compositions and methods for the modification of biomolecules
US8431558B2 (en) 2004-11-01 2013-04-30 The Regents Of The University Of California Compositions and methods for modification of biomolecules
US8367065B2 (en) 2006-09-15 2013-02-05 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
WO2009097128A1 (en) 2008-01-29 2009-08-06 Ludwig Institute For Cancer Research Ltd. Membrane transporter napi2b (slc34a2) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy
WO2009102820A2 (en) 2008-02-11 2009-08-20 Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services Modified sugar substrates and methods of use
DK2563753T6 (en) 2010-04-27 2016-04-04 Synaffix Bv Fused cyclooctynforbindelser and their use in metal-free click-reactions
GB201115841D0 (en) 2011-09-13 2011-10-26 Genovis Ab Protein and method
US9199237B2 (en) * 2012-09-04 2015-12-01 Michael Baumgartner Automated well plate
EP2908818A4 (en) 2012-10-16 2016-07-13 Endocyte Inc CONJUGATES OF DRUG DELIVERY CONTAINING ARTIFICIAL AMINO ACIDS AND METHODS OF USE
FI2911699T4 (fi) 2012-10-23 2025-12-09 Synaffix Bv Muokattu vasta-aine, vasta-ainekonjugaatti ja menetelmä niiden valmistamiseksi
EP3004062B1 (en) 2013-05-24 2017-07-19 SynAffix B.V. Substituted azadibenzocyclooctyne compounds and their use in metal-free click reactions
EP3057618B1 (en) 2013-10-14 2022-12-14 SynAffix B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
ES2826398T3 (es) 2013-10-15 2021-05-18 Seagen Inc Enlazadores-fármacos pegilados para una mejor farmacocinética de los conjugados ligando-fármaco
US10599164B2 (en) * 2014-06-12 2020-03-24 Halliburton Energy Services, Inc. Determination of substance presence, identity and/or level in vessels
TWI695011B (zh) 2014-06-18 2020-06-01 美商梅爾莎納醫療公司 抗her2表位之單株抗體及其使用之方法
EP3177633B1 (en) 2014-08-04 2022-07-20 SynAffix B.V. Process for the modification of a glycoprotein using a beta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof
CN107810273B (zh) 2015-04-23 2022-09-27 西纳福克斯股份有限公司 用为或衍生自β-(1,4)-N-乙酰半乳糖胺转移酶的糖基转移酶修饰糖蛋白的方法
US10858641B2 (en) 2016-02-08 2020-12-08 Synaffix B.V. Enzymes for trimming of glycoproteins
EP3413916A1 (en) 2016-02-08 2018-12-19 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates
WO2017137457A1 (en) 2016-02-08 2017-08-17 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates
CN109310885B (zh) 2016-03-15 2022-05-31 梅尔莎纳医疗公司 NaPi2b靶向抗体-药物缀合物及其使用方法
WO2017188866A1 (en) * 2016-04-25 2017-11-02 Telefonaktiebolaget Lm Ericsson (Publ) System information configuration update in a wireless communication network
US11135307B2 (en) 2016-11-23 2021-10-05 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates
TW201834697A (zh) 2017-02-28 2018-10-01 美商梅爾莎納醫療公司 Her2標靶抗體-藥物結合物之組合療法
EP3685166A2 (en) 2017-09-20 2020-07-29 Mersana Therapeutics, Inc. Compositions and methods for predicting response to napi2b-targeted therapy
IL294321B1 (en) 2020-01-09 2026-04-01 Mersana Therapeutics Inc Antibody-drug conjugates are attached at a specific site with linkers that include peptides.

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