JP2023509966A - 腫瘍溶解性ウイルス様小胞の組成物および使用方法 - Google Patents

腫瘍溶解性ウイルス様小胞の組成物および使用方法 Download PDF

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JP2023509966A
JP2023509966A JP2022542209A JP2022542209A JP2023509966A JP 2023509966 A JP2023509966 A JP 2023509966A JP 2022542209 A JP2022542209 A JP 2022542209A JP 2022542209 A JP2022542209 A JP 2022542209A JP 2023509966 A JP2023509966 A JP 2023509966A
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vlv
encoding
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ビジャン アルマシアン，
ヴァレリアン ナカール，
シャンヨン マ，
バースカラ レディ マディナ，
ケペン ワン，
ティムール ヤロヴィンスキー，
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カロジェン コーポレイション
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JP2022542209A 2020-01-10 2021-01-08 腫瘍溶解性ウイルス様小胞の組成物および使用方法 Pending JP2023509966A (ja)

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PCT/US2021/012834 WO2021142366A1 (en) 2020-01-10 2021-01-08 Compositions and methods of use of oncolytic virus like vesicles

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EP4460564A4 (en) * 2022-01-08 2026-02-11 Carogen Corp MULTI-ANTIGEN THERAPEUTIC VACCINES TO TREAT OR PREVENT CHRONIC HEPATITIS B VIRUS INFECTION
JP2025508866A (ja) * 2022-02-22 2025-04-10 ヴァイロ バイオ インク． 腫瘍溶解性ウイルスおよび使用方法
CN119110727A (zh) * 2022-02-22 2024-12-10 卡罗根公司 用于感染性疾病和癌症免疫疗法应用的多功能病毒样囊泡(vlv)平台
US20260034208A1 (en) * 2022-07-26 2026-02-05 Yale University Virus-like vesicles (vlvs) based vaccines and methods of preventing, ameliorating, and/or treating covid-19 and/or hepatocellular carcinoma (hcc)
IL320318A (en) * 2022-10-19 2025-06-01 Kalivir Immunotherapeutics Inc Nucleic acids encoding tgf-beta inhibitor and il-12 and uses thereof
WO2024119388A1 (zh) * 2022-12-07 2024-06-13 上海鑫湾生物科技有限公司 一种用于共表达多种目的基因的构建体及其用途
CN118831091A (zh) * 2023-04-11 2024-10-25 浙江自贸区红岸基地生物科技有限公司 一种saRNA递送系统及其制备方法和应用
WO2025208054A1 (en) * 2024-03-28 2025-10-02 Regeneron Pharmaceuticals, Inc. Recombinant rhabdovirus encoding interleukin-12 (il-12)
CN120733012A (zh) * 2024-08-20 2025-10-03 浙江大学 基于mRNA及蛋白编码的肿瘤药物、制备方法及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500325A (ja) * 1999-05-17 2004-01-08 シェーリング　コーポレイション 細胞増殖障害を処置するための組成物および方法
JP2017515509A (ja) * 2014-05-16 2017-06-15 イエール ユニバーシティ ワクチン用途のための高力価ウイルス様ベシクルの進化の方法
JP2017515508A (ja) * 2014-05-16 2017-06-15 イエール ユニバーシティ 慢性ｂ型肝炎ウイルス（ｈｂｖ）感染症を予防または処置するためのウイルス様ベシクル（ｖｌｖ）ベースのワクチン
JP2019527737A (ja) * 2016-08-09 2019-10-03 アルケヤール， アルモハナッドＡＬＫＡＹＹＡＬ， Ａｌｍｏｈａｎａｄ Ｉｌ１２を発現する腫瘍溶解性ラブドウイルス

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2862982B1 (fr) * 2003-12-02 2006-04-28 Genethon Particules virales contenant un vecteur derive d'alpha-virus et procede de preparation de ladite particule virale.
ES2746960T3 (es) * 2006-09-12 2020-03-09 Alphavax Inc Partículas de replicón de alfavirus que codifican IL-12 como adyuvantes inmunológicos
WO2008119827A1 (en) 2007-04-02 2008-10-09 Fit Biotech Oy Transreplicase constructs
GB2460265A (en) * 2008-05-23 2009-11-25 Univ Dublin City Detection assembly
WO2017167317A1 (es) 2016-03-31 2017-10-05 Centro De Ingenieria Genetica Y Biotecnologia Composición farmacéutica que comprende los antígenos de la superficie y de la nucleocápsida del virus de la hepatitis b
JP7799945B2 (ja) * 2017-09-22 2026-01-16 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック 変異型ウイルスタンパク質

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500325A (ja) * 1999-05-17 2004-01-08 シェーリング　コーポレイション 細胞増殖障害を処置するための組成物および方法
JP2017515509A (ja) * 2014-05-16 2017-06-15 イエール ユニバーシティ ワクチン用途のための高力価ウイルス様ベシクルの進化の方法
JP2017515508A (ja) * 2014-05-16 2017-06-15 イエール ユニバーシティ 慢性ｂ型肝炎ウイルス（ｈｂｖ）感染症を予防または処置するためのウイルス様ベシクル（ｖｌｖ）ベースのワクチン
JP2019527737A (ja) * 2016-08-09 2019-10-03 アルケヤール， アルモハナッドＡＬＫＡＹＹＡＬ， Ａｌｍｏｈａｎａｄ Ｉｌ１２を発現する腫瘍溶解性ラブドウイルス

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J VIROL, vol. 89, no. 20, JPN6025003197, 5 August 2015 (2015-08-05), pages 10407 - 10415, ISSN: 0005674075 *
外科と代謝・栄養, vol. 53, no. 5, JPN6025003198, 2019, pages 267 - 270, ISSN: 0005784434 *
日薬理誌, vol. 142, JPN6025003196, 2013, pages 85 - 88, ISSN: 0005674076 *

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