JP2023503470A - ガラクトセレブロシダーゼの活性の変質に関連する状態におけるアリールおよびヘテロアリール化合物、ならびにそれらの治療的使用 - Google Patents
ガラクトセレブロシダーゼの活性の変質に関連する状態におけるアリールおよびヘテロアリール化合物、ならびにそれらの治療的使用 Download PDFInfo
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- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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| PCT/IB2020/061156 WO2021105906A1 (en) | 2019-11-25 | 2020-11-25 | Aryl and heteroaryl compounds, and therapeutic uses thereof in conditions associated with the alteration of the activity of galactocerebrosidase |
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Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070010520A1 (en) * | 2003-04-09 | 2007-01-11 | Dowling James E | Triazolopyrazines and methods of making and using the same |
| JP2009514962A (ja) * | 2005-11-08 | 2009-04-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atp結合カセット輸送体モジュレータ |
| JP2009522277A (ja) * | 2005-12-28 | 2009-06-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症の処置のためのATP結合カセットトランスポーターのモジュレーターとしての、1−(ベンゾ[d][1,3]ジオキソール−5−イル)−N−(フェニル)シクロプロパン−カルボキサミド誘導体および関連化合物 |
| JP2010535734A (ja) * | 2007-08-08 | 2010-11-25 | メルク セローノ ソシエテ アノニム | 多発性硬化症の治療のための、スフィンゴシン1−ホスフェート(s1p)受容体に結合する6−アミノ−ピリミジン−4−カルボキサミド誘導体及び関連化合物 |
| JP2011526925A (ja) * | 2008-07-01 | 2011-10-20 | ザカロン ファーマシューティカルズ,インク. | ヘパラン硫酸阻害剤 |
| JP2013513617A (ja) * | 2009-12-11 | 2013-04-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atp結合カセット輸送体のモジュレーターとしての4−オキソ−1h−キノリン−3−カルボキサミド |
| JP2013544893A (ja) * | 2010-12-08 | 2013-12-19 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | グルコセレブロシダーゼ活性剤としての置換ピラゾロピリミジン類 |
| JP2014511391A (ja) * | 2011-03-07 | 2014-05-15 | フォンダッツィオーネ・テレソン | Tfebリン酸化阻害剤およびその使用 |
| WO2017026516A1 (ja) * | 2015-08-12 | 2017-02-16 | 持田製薬株式会社 | イソチアゾール誘導体 |
| WO2017040971A1 (en) * | 2015-09-03 | 2017-03-09 | Biomarin Pharmaceutical Inc. | Methods of using inhibitors of pikfyve for the treatment of lysosomal storage disorders and neurodegenerative diseases |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4500714A (en) * | 1981-10-15 | 1985-02-19 | Chugai Seiyaku Kabushiki Kaisha | 3-Substituted-ureido-N-pyridyl benzamides |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| EP1644334B1 (en) * | 2003-05-30 | 2008-01-02 | Eli Lilly and Company | Antithrombotic ethers |
| WO2005049604A2 (en) * | 2003-09-30 | 2005-06-02 | Eli Lilly And Company | Antithrombotic aromatic ethers |
| WO2005085188A2 (en) * | 2004-03-02 | 2005-09-15 | Compass Pharmaceuticals Llc | Compounds and methods for anti-tumor therapy |
| SE0401343D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine N oxide as scaffold |
| SE0401345D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine as scaffold |
| US7470787B2 (en) * | 2005-07-11 | 2008-12-30 | Aerie Pharmaceuticals, Inc. | Isoquinoline compounds |
| WO2010111713A2 (en) * | 2009-03-27 | 2010-09-30 | Zacharon Pharmaceuticals, Inc. | N-linked glycan biosynthesis modulators |
| SI2995306T1 (sl) | 2009-10-19 | 2019-04-30 | Amicus Therapeutics, Inc. | Novi sestavki za preprečevanje in/ali zdravljenje motenj lizosomskega shranjevanja |
| KR101987736B1 (ko) | 2011-03-18 | 2019-06-11 | 젠자임 코포레이션 | 글루코실세라마이드 합성효소 억제제 |
| WO2013078413A1 (en) * | 2011-11-22 | 2013-05-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of lipid storage |
| WO2015153410A1 (en) * | 2014-03-31 | 2015-10-08 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and uses thereof |
| MX2018006856A (es) * | 2015-12-07 | 2018-08-01 | Plexxikon Inc | Compuestos y metodos para modulacion de la quinasa, e indicaciones de los mismos. |
| ES2904615T3 (es) * | 2016-03-16 | 2022-04-05 | Plexxikon Inc | Compuestos y métodos para la modulación de quinasas e indicaciones al respecto |
| CA3031365A1 (en) * | 2016-07-20 | 2018-01-25 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and compositions and uses thereof |
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2020
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Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070010520A1 (en) * | 2003-04-09 | 2007-01-11 | Dowling James E | Triazolopyrazines and methods of making and using the same |
| JP2009514962A (ja) * | 2005-11-08 | 2009-04-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atp結合カセット輸送体モジュレータ |
| JP2009522277A (ja) * | 2005-12-28 | 2009-06-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症の処置のためのATP結合カセットトランスポーターのモジュレーターとしての、1−(ベンゾ[d][1,3]ジオキソール−5−イル)−N−(フェニル)シクロプロパン−カルボキサミド誘導体および関連化合物 |
| JP2010535734A (ja) * | 2007-08-08 | 2010-11-25 | メルク セローノ ソシエテ アノニム | 多発性硬化症の治療のための、スフィンゴシン1−ホスフェート(s1p)受容体に結合する6−アミノ−ピリミジン−4−カルボキサミド誘導体及び関連化合物 |
| JP2011526925A (ja) * | 2008-07-01 | 2011-10-20 | ザカロン ファーマシューティカルズ,インク. | ヘパラン硫酸阻害剤 |
| JP2013513617A (ja) * | 2009-12-11 | 2013-04-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atp結合カセット輸送体のモジュレーターとしての4−オキソ−1h−キノリン−3−カルボキサミド |
| JP2013544893A (ja) * | 2010-12-08 | 2013-12-19 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | グルコセレブロシダーゼ活性剤としての置換ピラゾロピリミジン類 |
| JP2014511391A (ja) * | 2011-03-07 | 2014-05-15 | フォンダッツィオーネ・テレソン | Tfebリン酸化阻害剤およびその使用 |
| WO2017026516A1 (ja) * | 2015-08-12 | 2017-02-16 | 持田製薬株式会社 | イソチアゾール誘導体 |
| WO2017040971A1 (en) * | 2015-09-03 | 2017-03-09 | Biomarin Pharmaceutical Inc. | Methods of using inhibitors of pikfyve for the treatment of lysosomal storage disorders and neurodegenerative diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| IL293409A (en) | 2022-07-01 |
| EP4065546A1 (en) | 2022-10-05 |
| WO2021105906A1 (en) | 2021-06-03 |
| KR20220150880A (ko) | 2022-11-11 |
| MX2022006059A (es) | 2022-09-12 |
| CN115397806A (zh) | 2022-11-25 |
| US20230058312A1 (en) | 2023-02-23 |
| CA3158290A1 (en) | 2021-06-03 |
| AU2020393174A1 (en) | 2022-06-30 |
| BR112022010127A2 (pt) | 2022-09-06 |
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