JP2023501942A - 溶液中の粒子の特徴付け - Google Patents

溶液中の粒子の特徴付け Download PDF

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JP2023501942A
JP2023501942A JP2022525257A JP2022525257A JP2023501942A JP 2023501942 A JP2023501942 A JP 2023501942A JP 2022525257 A JP2022525257 A JP 2022525257A JP 2022525257 A JP2022525257 A JP 2022525257A JP 2023501942 A JP2023501942 A JP 2023501942A
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container
particles
sample
dls
measurements
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JP2023501942A5 (https=
Inventor
バースケ，フィリップ
デリクス，ヨナタン
ハスリンガー，ロベルト
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ナノテンパー・テクノロジーズ・ゲーエムベーハー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/019—Biological contaminants; Fouling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
JP2022525257A 2019-11-08 2020-11-06 溶液中の粒子の特徴付け Pending JP2023501942A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19208187 2019-11-08
EP19208187.5 2019-11-08
EP20197910 2020-09-23
EP20197910.1 2020-09-23
PCT/EP2020/081378 WO2021089841A1 (en) 2019-11-08 2020-11-06 Characterization of particles in solution

Publications (2)

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JP2023501942A true JP2023501942A (ja) 2023-01-20
JP2023501942A5 JP2023501942A5 (https=) 2023-11-06

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JP2022525257A Pending JP2023501942A (ja) 2019-11-08 2020-11-06 溶液中の粒子の特徴付け
JP2022525259A Active JP7461078B2 (ja) 2019-11-08 2020-11-06 溶液中の粒子の特徴付け

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US (1) US20220404284A1 (https=)
EP (2) EP4055366B1 (https=)
JP (2) JP2023501942A (https=)
KR (2) KR102891303B1 (https=)
CN (2) CN114930151A (https=)
AU (2) AU2020379227B2 (https=)
CA (1) CA3153480A1 (https=)
WO (2) WO2021089834A1 (https=)

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* Cited by examiner, † Cited by third party
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JP7658575B2 (ja) 2021-09-09 2025-04-08 国立大学法人東京農工大学 生体試料中のミスフォールディングタンパク質検出方法
EP4328569A1 (en) * 2022-08-23 2024-02-28 NanoTemper Technologies GmbH Measuring high protein concentrations
CN116735436A (zh) * 2023-06-27 2023-09-12 沈阳农业大学 一种zeta电位快速测定土壤胶体临界聚沉浓度的方法
EP4654117A1 (en) * 2024-05-20 2025-11-26 Malvern Panalytical Limited Material characterisation trend analysis

Citations (6)

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JPH05506928A (ja) * 1990-04-23 1993-10-07 ソリッド　ステイト　ファームズ　インコーポレイテッド 沈降式血液分析装置および方法
JP2005221503A (ja) * 2004-02-05 2005-08-18 Rina Netzwerk Rna-Technologien Gmbh 生体分子結晶の生成を監視するための方法
JP2007516411A (ja) * 2003-06-27 2007-06-21 コミツサリア タ レネルジー アトミーク 生物学的試料または化学的試料を定量分析するための方法
JP2013104876A (ja) * 2011-11-14 2013-05-30 Leica Microsystems Cms Gmbh 試料における励起状態の寿命を測定するための方法
JP2018507387A (ja) * 2014-12-12 2018-03-15 ナノテンパー・テクノロジーズ・ゲーエムベーハー 無封止でキャピラリをテンパリングする方法およびシステム
US20180313758A1 (en) * 2017-05-01 2018-11-01 Wyatt Technology Corporation High throughput method and apparatus for measuring multiple optical properties of a liquid sample

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US5973779A (en) * 1996-03-29 1999-10-26 Ansari; Rafat R. Fiber-optic imaging probe
WO2003071269A2 (en) * 2002-02-20 2003-08-28 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing stability of biological molecules
EP1704402B1 (en) * 2004-01-14 2016-05-11 Luminex Corporation Methods and systems for dynamic range expansion
EP2115424B1 (en) * 2007-02-02 2018-10-24 Canadian Blood Services Method of detecting bacterial contamination using dynamic light scattering
US8817244B2 (en) * 2010-01-15 2014-08-26 Mitsui Engineering & Shipbuilding Co., Ltd. Fluorescence measurement device and fluorescence measurement method
DE102010005962B4 (de) * 2010-01-21 2012-01-26 Alv-Laser Vertriebsgesellschaft Mbh Verfahren zur Bestimmung der statischen und/oder dynamischen Lichtstreuung
GB201415783D0 (en) * 2014-09-05 2014-10-22 Malvern Instr Ltd Particle characterisation
KR20170013768A (ko) * 2015-07-28 2017-02-07 울산과학기술원 라만 센서 및 라만 분석 방법
EP4242304A3 (en) * 2015-10-01 2024-02-07 Revolution Medicines, Inc. Methods and reagents for analyzing protein-protein interfaces
LT3150988T (lt) * 2015-10-01 2021-06-25 Nanotemper Technologies Gmbh Dalelių stabilumo ir agregacijos optinio matavimo sistema bei būdas
EP3159674A1 (en) * 2015-10-19 2017-04-26 European Molecular Biology Laboratory Measurement cell for saxs measurements and for dls measurements
US9554738B1 (en) * 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
KR101934926B1 (ko) * 2017-01-10 2019-01-03 충남대학교산학협력단 유동 유체 내의 나노입자 거동 예측 방법 및 장치
CN107782643A (zh) * 2017-09-27 2018-03-09 华中科技大学 一种高浓度颗粒群的光纤动态光散射检测方法
CA3089230A1 (en) * 2018-03-02 2019-09-06 Cdr-Life Ag Trispecific antigen binding proteins
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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05506928A (ja) * 1990-04-23 1993-10-07 ソリッド　ステイト　ファームズ　インコーポレイテッド 沈降式血液分析装置および方法
JP2007516411A (ja) * 2003-06-27 2007-06-21 コミツサリア タ レネルジー アトミーク 生物学的試料または化学的試料を定量分析するための方法
JP2005221503A (ja) * 2004-02-05 2005-08-18 Rina Netzwerk Rna-Technologien Gmbh 生体分子結晶の生成を監視するための方法
JP2013104876A (ja) * 2011-11-14 2013-05-30 Leica Microsystems Cms Gmbh 試料における励起状態の寿命を測定するための方法
JP2018507387A (ja) * 2014-12-12 2018-03-15 ナノテンパー・テクノロジーズ・ゲーエムベーハー 無封止でキャピラリをテンパリングする方法およびシステム
US20180313758A1 (en) * 2017-05-01 2018-11-01 Wyatt Technology Corporation High throughput method and apparatus for measuring multiple optical properties of a liquid sample

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CN114930152B (zh) 2026-04-03
EP4055365A1 (en) 2022-09-14
AU2020378640A1 (en) 2022-04-28
AU2020379227A1 (en) 2022-04-21
KR20220092620A (ko) 2022-07-01
JP2023500642A (ja) 2023-01-10
EP4055365B1 (en) 2026-01-21
WO2021089834A1 (en) 2021-05-14
WO2021089841A1 (en) 2021-05-14
EP4055366C0 (en) 2026-02-18
JP7461078B2 (ja) 2024-04-03
KR102891303B1 (ko) 2025-11-26
EP4055366A1 (en) 2022-09-14
CN114930151A (zh) 2022-08-19
WO2021089841A9 (en) 2022-06-30
CA3153480A1 (en) 2021-05-14
KR20220093215A (ko) 2022-07-05
EP4055366B1 (en) 2026-02-18
US20220373557A1 (en) 2022-11-24
US20220404284A1 (en) 2022-12-22
EP4055365C0 (en) 2026-01-21
CN114930152A (zh) 2022-08-19
AU2020379227B2 (en) 2025-11-06

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