AU2020379227B2 - Characterization of particles in solution - Google Patents

Characterization of particles in solution

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Publication number
AU2020379227B2
AU2020379227B2 AU2020379227A AU2020379227A AU2020379227B2 AU 2020379227 B2 AU2020379227 B2 AU 2020379227B2 AU 2020379227 A AU2020379227 A AU 2020379227A AU 2020379227 A AU2020379227 A AU 2020379227A AU 2020379227 B2 AU2020379227 B2 AU 2020379227B2
Authority
AU
Australia
Prior art keywords
vessel
light
particles
measurement
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2020379227A
Other languages
English (en)
Other versions
AU2020379227A1 (en
Inventor
Philipp Baaske
Jonathan Derix
Robert Haslinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NanoTemper Technologies GmbH
Original Assignee
NanoTemper Technologies GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NanoTemper Technologies GmbH filed Critical NanoTemper Technologies GmbH
Publication of AU2020379227A1 publication Critical patent/AU2020379227A1/en
Application granted granted Critical
Publication of AU2020379227B2 publication Critical patent/AU2020379227B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/019—Biological contaminants; Fouling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
AU2020379227A 2019-11-08 2020-11-06 Characterization of particles in solution Active AU2020379227B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19208187 2019-11-08
EP19208187.5 2019-11-08
EP20197910 2020-09-23
EP20197910.1 2020-09-23
PCT/EP2020/081370 WO2021089834A1 (en) 2019-11-08 2020-11-06 Characterization of particles in solution

Publications (2)

Publication Number Publication Date
AU2020379227A1 AU2020379227A1 (en) 2022-04-21
AU2020379227B2 true AU2020379227B2 (en) 2025-11-06

Family

ID=73040120

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2020379227A Active AU2020379227B2 (en) 2019-11-08 2020-11-06 Characterization of particles in solution
AU2020378640A Abandoned AU2020378640A1 (en) 2019-11-08 2020-11-06 Characterization of particles in solution

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020378640A Abandoned AU2020378640A1 (en) 2019-11-08 2020-11-06 Characterization of particles in solution

Country Status (8)

Country Link
US (1) US20220404284A1 (https=)
EP (2) EP4055366B1 (https=)
JP (2) JP2023501942A (https=)
KR (2) KR102891303B1 (https=)
CN (2) CN114930151A (https=)
AU (2) AU2020379227B2 (https=)
CA (1) CA3153480A1 (https=)
WO (2) WO2021089834A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7658575B2 (ja) 2021-09-09 2025-04-08 国立大学法人東京農工大学 生体試料中のミスフォールディングタンパク質検出方法
EP4328569A1 (en) * 2022-08-23 2024-02-28 NanoTemper Technologies GmbH Measuring high protein concentrations
CN116735436A (zh) * 2023-06-27 2023-09-12 沈阳农业大学 一种zeta电位快速测定土壤胶体临界聚沉浓度的方法
EP4654117A1 (en) * 2024-05-20 2025-11-26 Malvern Panalytical Limited Material characterisation trend analysis

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5575977A (en) * 1990-04-23 1996-11-19 Solid State Farms, Inc. Apparatus for sedimentation based blood analysis
US5973779A (en) * 1996-03-29 1999-10-26 Ansari; Rafat R. Fiber-optic imaging probe
FR2856792A1 (fr) * 2003-06-27 2004-12-31 Commissariat Energie Atomique Procede et dispositif de dosage d'un echantillon biologique ou chimique
US20100136611A1 (en) * 2007-02-02 2010-06-03 Canadian Blood Services Method of detecting bacterial contamination using dynamic light scattering
EP3159674A1 (en) * 2015-10-19 2017-04-26 European Molecular Biology Laboratory Measurement cell for saxs measurements and for dls measurements
US20180313758A1 (en) * 2017-05-01 2018-11-01 Wyatt Technology Corporation High throughput method and apparatus for measuring multiple optical properties of a liquid sample

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05506928A (ja) * 1990-04-23 1993-10-07 ソリッド　ステイト　ファームズ　インコーポレイテッド 沈降式血液分析装置および方法
WO2003071269A2 (en) * 2002-02-20 2003-08-28 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing stability of biological molecules
EP1704402B1 (en) * 2004-01-14 2016-05-11 Luminex Corporation Methods and systems for dynamic range expansion
DE102004005878A1 (de) * 2004-02-05 2005-09-01 Rina-Netzwerk Rna Technologien Gmbh Verfahren zur Überwachung der Herstellung von Biomolekülkristallen
US8817244B2 (en) * 2010-01-15 2014-08-26 Mitsui Engineering & Shipbuilding Co., Ltd. Fluorescence measurement device and fluorescence measurement method
DE102010005962B4 (de) * 2010-01-21 2012-01-26 Alv-Laser Vertriebsgesellschaft Mbh Verfahren zur Bestimmung der statischen und/oder dynamischen Lichtstreuung
DE102011055330B4 (de) * 2011-11-14 2024-10-31 Leica Microsystems Cms Gmbh Verfahren zum Messen der Lebensdauer eines angeregten Zustandes in einer Probe
GB201415783D0 (en) * 2014-09-05 2014-10-22 Malvern Instr Ltd Particle characterisation
DE102014018535A1 (de) * 2014-12-12 2016-06-16 Nanotemper Technologies Gmbh System und Verfahren für ein abdichtungsfreies Temperieren von Kapillaren
KR20170013768A (ko) * 2015-07-28 2017-02-07 울산과학기술원 라만 센서 및 라만 분석 방법
EP4242304A3 (en) * 2015-10-01 2024-02-07 Revolution Medicines, Inc. Methods and reagents for analyzing protein-protein interfaces
LT3150988T (lt) * 2015-10-01 2021-06-25 Nanotemper Technologies Gmbh Dalelių stabilumo ir agregacijos optinio matavimo sistema bei būdas
US9554738B1 (en) * 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
KR101934926B1 (ko) * 2017-01-10 2019-01-03 충남대학교산학협력단 유동 유체 내의 나노입자 거동 예측 방법 및 장치
CN107782643A (zh) * 2017-09-27 2018-03-09 华中科技大学 一种高浓度颗粒群的光纤动态光散射检测方法
CA3089230A1 (en) * 2018-03-02 2019-09-06 Cdr-Life Ag Trispecific antigen binding proteins
US20210379186A1 (en) * 2018-04-16 2021-12-09 Merck Patent Gmbh Additives for protein formulations to improve thermal stability
CN108983252B (zh) * 2018-07-30 2022-08-26 武汉舒博光电技术有限公司 双光束超分辨定位系统及方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5575977A (en) * 1990-04-23 1996-11-19 Solid State Farms, Inc. Apparatus for sedimentation based blood analysis
US5973779A (en) * 1996-03-29 1999-10-26 Ansari; Rafat R. Fiber-optic imaging probe
FR2856792A1 (fr) * 2003-06-27 2004-12-31 Commissariat Energie Atomique Procede et dispositif de dosage d'un echantillon biologique ou chimique
US20100136611A1 (en) * 2007-02-02 2010-06-03 Canadian Blood Services Method of detecting bacterial contamination using dynamic light scattering
EP3159674A1 (en) * 2015-10-19 2017-04-26 European Molecular Biology Laboratory Measurement cell for saxs measurements and for dls measurements
US20180313758A1 (en) * 2017-05-01 2018-11-01 Wyatt Technology Corporation High throughput method and apparatus for measuring multiple optical properties of a liquid sample

Also Published As

Publication number Publication date
CN114930152B (zh) 2026-04-03
EP4055365A1 (en) 2022-09-14
AU2020378640A1 (en) 2022-04-28
AU2020379227A1 (en) 2022-04-21
KR20220092620A (ko) 2022-07-01
JP2023500642A (ja) 2023-01-10
EP4055365B1 (en) 2026-01-21
WO2021089834A1 (en) 2021-05-14
WO2021089841A1 (en) 2021-05-14
EP4055366C0 (en) 2026-02-18
JP7461078B2 (ja) 2024-04-03
KR102891303B1 (ko) 2025-11-26
EP4055366A1 (en) 2022-09-14
CN114930151A (zh) 2022-08-19
WO2021089841A9 (en) 2022-06-30
CA3153480A1 (en) 2021-05-14
KR20220093215A (ko) 2022-07-05
EP4055366B1 (en) 2026-02-18
US20220373557A1 (en) 2022-11-24
JP2023501942A (ja) 2023-01-20
US20220404284A1 (en) 2022-12-22
EP4055365C0 (en) 2026-01-21
CN114930152A (zh) 2022-08-19

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