CN114930151A - 溶液中颗粒的特征化 - Google Patents

溶液中颗粒的特征化 Download PDF

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Publication number
CN114930151A
CN114930151A CN202080092388.6A CN202080092388A CN114930151A CN 114930151 A CN114930151 A CN 114930151A CN 202080092388 A CN202080092388 A CN 202080092388A CN 114930151 A CN114930151 A CN 114930151A
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CN
China
Prior art keywords
container
particles
light
sample
measurement
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Pending
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CN202080092388.6A
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English (en)
Chinese (zh)
Inventor
菲利普·巴斯克
乔纳森·德里克斯
罗伯特·哈斯林格
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Nortemp Technology Co ltd
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Nortemp Technology Co ltd
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Publication of CN114930151A publication Critical patent/CN114930151A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/019—Biological contaminants; Fouling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
CN202080092388.6A 2019-11-08 2020-11-06 溶液中颗粒的特征化 Pending CN114930151A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19208187 2019-11-08
EP19208187.5 2019-11-08
EP20197910 2020-09-23
EP20197910.1 2020-09-23
PCT/EP2020/081378 WO2021089841A1 (en) 2019-11-08 2020-11-06 Characterization of particles in solution

Publications (1)

Publication Number Publication Date
CN114930151A true CN114930151A (zh) 2022-08-19

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CN202080092388.6A Pending CN114930151A (zh) 2019-11-08 2020-11-06 溶液中颗粒的特征化
CN202080092390.3A Active CN114930152B (zh) 2019-11-08 2020-11-06 溶液中颗粒的特征化

Family Applications After (1)

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Country Status (8)

Country Link
US (1) US20220404284A1 (https=)
EP (2) EP4055366B1 (https=)
JP (2) JP2023501942A (https=)
KR (2) KR102891303B1 (https=)
CN (2) CN114930151A (https=)
AU (2) AU2020379227B2 (https=)
CA (1) CA3153480A1 (https=)
WO (2) WO2021089834A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116735436A (zh) * 2023-06-27 2023-09-12 沈阳农业大学 一种zeta电位快速测定土壤胶体临界聚沉浓度的方法
EP4328569A1 (en) * 2022-08-23 2024-02-28 NanoTemper Technologies GmbH Measuring high protein concentrations

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7658575B2 (ja) 2021-09-09 2025-04-08 国立大学法人東京農工大学 生体試料中のミスフォールディングタンパク質検出方法
EP4654117A1 (en) * 2024-05-20 2025-11-26 Malvern Panalytical Limited Material characterisation trend analysis

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EP3159674A1 (en) * 2015-10-19 2017-04-26 European Molecular Biology Laboratory Measurement cell for saxs measurements and for dls measurements
CN107782643A (zh) * 2017-09-27 2018-03-09 华中科技大学 一种高浓度颗粒群的光纤动态光散射检测方法
CN108139309A (zh) * 2015-10-01 2018-06-08 微量热技术有限公司 用于光学地测量颗粒的稳定性和聚集的系统和方法
CN108983252A (zh) * 2018-07-30 2018-12-11 武汉舒博光电技术有限公司 双光束超分辨定位系统及方法

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CN108139309A (zh) * 2015-10-01 2018-06-08 微量热技术有限公司 用于光学地测量颗粒的稳定性和聚集的系统和方法
EP3159674A1 (en) * 2015-10-19 2017-04-26 European Molecular Biology Laboratory Measurement cell for saxs measurements and for dls measurements
CN107782643A (zh) * 2017-09-27 2018-03-09 华中科技大学 一种高浓度颗粒群的光纤动态光散射检测方法
CN108983252A (zh) * 2018-07-30 2018-12-11 武汉舒博光电技术有限公司 双光束超分辨定位系统及方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4328569A1 (en) * 2022-08-23 2024-02-28 NanoTemper Technologies GmbH Measuring high protein concentrations
CN116735436A (zh) * 2023-06-27 2023-09-12 沈阳农业大学 一种zeta电位快速测定土壤胶体临界聚沉浓度的方法

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Publication number Publication date
CN114930152B (zh) 2026-04-03
EP4055365A1 (en) 2022-09-14
AU2020378640A1 (en) 2022-04-28
AU2020379227A1 (en) 2022-04-21
KR20220092620A (ko) 2022-07-01
JP2023500642A (ja) 2023-01-10
EP4055365B1 (en) 2026-01-21
WO2021089834A1 (en) 2021-05-14
WO2021089841A1 (en) 2021-05-14
EP4055366C0 (en) 2026-02-18
JP7461078B2 (ja) 2024-04-03
KR102891303B1 (ko) 2025-11-26
EP4055366A1 (en) 2022-09-14
WO2021089841A9 (en) 2022-06-30
CA3153480A1 (en) 2021-05-14
KR20220093215A (ko) 2022-07-05
EP4055366B1 (en) 2026-02-18
US20220373557A1 (en) 2022-11-24
JP2023501942A (ja) 2023-01-20
US20220404284A1 (en) 2022-12-22
EP4055365C0 (en) 2026-01-21
CN114930152A (zh) 2022-08-19
AU2020379227B2 (en) 2025-11-06

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Application publication date: 20220819