JP2023501528A - Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成 - Google Patents

Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成 Download PDF

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JP2023501528A
JP2023501528A JP2022527130A JP2022527130A JP2023501528A JP 2023501528 A JP2023501528 A JP 2023501528A JP 2022527130 A JP2022527130 A JP 2022527130A JP 2022527130 A JP2022527130 A JP 2022527130A JP 2023501528 A JP2023501528 A JP 2023501528A
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compound
cancer
usa
acid
compounds
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JP2023501528A5 (https=
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パーソンズ，アンドリュー・ティー
ビーバー，マシュー
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022527130A 2019-11-14 2020-11-13 Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成 Pending JP2023501528A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962935502P 2019-11-14 2019-11-14
US62/935,502 2019-11-14
PCT/US2020/060421 WO2021097212A1 (en) 2019-11-14 2020-11-13 Improved synthesis of kras g12c inhibitor compound

Publications (2)

Publication Number Publication Date
JP2023501528A true JP2023501528A (ja) 2023-01-18
JP2023501528A5 JP2023501528A5 (https=) 2023-11-17

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JP2022527130A Pending JP2023501528A (ja) 2019-11-14 2020-11-13 Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成

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US (3) US12466825B2 (https=)
EP (2) EP4058453B1 (https=)
JP (1) JP2023501528A (https=)
CN (2) CN120463705A (https=)
AR (1) AR120457A1 (https=)
AU (1) AU2020381492B2 (https=)
BR (1) BR112022009390A2 (https=)
CA (1) CA3158188A1 (https=)
CL (1) CL2022001258A1 (https=)
DK (1) DK4058453T3 (https=)
ES (1) ES3063064T3 (https=)
FI (1) FI4058453T3 (https=)
IL (1) IL292315A (https=)
LT (1) LT4058453T (https=)
MX (2) MX2022005708A (https=)
PL (1) PL4058453T3 (https=)
PT (1) PT4058453T (https=)
SI (1) SI4058453T1 (https=)
TW (2) TWI882037B (https=)
WO (1) WO2021097212A1 (https=)

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US11285156B2 (en) 2018-06-12 2022-03-29 Amgen Inc. Substituted piperazines as KRAS G12C inhibitors
JP7516029B2 (ja) 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
EP3738593A1 (en) 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers
WO2020236947A1 (en) 2019-05-21 2020-11-26 Amgen Inc. Solid state forms
AU2020277398B2 (en) 2019-05-21 2026-01-29 Amgen Inc. Solid state forms
JP7837865B2 (ja) * 2019-11-14 2026-03-31 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改良合成法
JP2023501528A (ja) 2019-11-14 2023-01-18 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成
CN114585624A (zh) * 2020-06-02 2022-06-03 上海喆邺生物科技有限公司 一种手性中间体及其制备方法
JP2023544450A (ja) 2020-09-23 2023-10-23 エラスカ・インコーポレイテッド 三環式ピリドン及びピリミドン
CA3201663A1 (en) 2020-11-20 2022-05-27 Amgen Inc. Process for preparing 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione
WO2022133345A1 (en) 2020-12-18 2022-06-23 Erasca, Inc. Tricyclic pyridones and pyrimidones
KR20240156373A (ko) 2022-03-07 2024-10-29 암젠 인크 4-메틸-2-프로판-2-일-피리딘-3-카르보니트릴의 제조 방법
CN115466259B (zh) * 2022-08-16 2023-12-05 山东大学 一种kras g12c抑制剂索托拉西布的制备方法

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JP2002047292A (ja) * 2000-07-27 2002-02-12 Hokko Chem Ind Co Ltd フェニルボロン酸類およびトリフェニルボロキシン類の製造方法
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JP2019031476A (ja) * 2017-05-22 2019-02-28 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤及びその使用方法
WO2019051291A1 (en) * 2017-09-08 2019-03-14 Amgen Inc. Inhibitors of kras g12c and methods of using the same
WO2019213516A1 (en) * 2018-05-04 2019-11-07 Amgen Inc. Kras g12c inhibitors and methods of using the same

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