SI4058453T1 - Izboljšana sinteza spojine zaviralca KRAS G12C - Google Patents

Izboljšana sinteza spojine zaviralca KRAS G12C

Info

Publication number
SI4058453T1
SI4058453T1 SI202030733T SI202030733T SI4058453T1 SI 4058453 T1 SI4058453 T1 SI 4058453T1 SI 202030733 T SI202030733 T SI 202030733T SI 202030733 T SI202030733 T SI 202030733T SI 4058453 T1 SI4058453 T1 SI 4058453T1
Authority
SI
Slovenia
Prior art keywords
kras
inhibitor compound
improved synthesis
synthesis
improved
Prior art date
Application number
SI202030733T
Other languages
English (en)
Slovenian (sl)
Inventor
Andrew T. Parsons
Matthew Beaver
Original Assignee
Amgen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen, Inc. filed Critical Amgen, Inc.
Publication of SI4058453T1 publication Critical patent/SI4058453T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI202030733T 2019-11-14 2020-11-13 Izboljšana sinteza spojine zaviralca KRAS G12C SI4058453T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962935502P 2019-11-14 2019-11-14
PCT/US2020/060421 WO2021097212A1 (en) 2019-11-14 2020-11-13 Improved synthesis of kras g12c inhibitor compound
EP20821492.4A EP4058453B1 (en) 2019-11-14 2020-11-13 Improved synthesis of kras g12c inhibitor compound

Publications (1)

Publication Number Publication Date
SI4058453T1 true SI4058453T1 (sl) 2026-04-30

Family

ID=73790234

Family Applications (1)

Application Number Title Priority Date Filing Date
SI202030733T SI4058453T1 (sl) 2019-11-14 2020-11-13 Izboljšana sinteza spojine zaviralca KRAS G12C

Country Status (20)

Country Link
US (3) US12466825B2 (https=)
EP (2) EP4058453B1 (https=)
JP (1) JP2023501528A (https=)
CN (2) CN120463705A (https=)
AR (1) AR120457A1 (https=)
AU (1) AU2020381492B2 (https=)
BR (1) BR112022009390A2 (https=)
CA (1) CA3158188A1 (https=)
CL (1) CL2022001258A1 (https=)
DK (1) DK4058453T3 (https=)
ES (1) ES3063064T3 (https=)
FI (1) FI4058453T3 (https=)
IL (1) IL292315A (https=)
LT (1) LT4058453T (https=)
MX (2) MX2022005708A (https=)
PL (1) PL4058453T3 (https=)
PT (1) PT4058453T (https=)
SI (1) SI4058453T1 (https=)
TW (2) TWI882037B (https=)
WO (1) WO2021097212A1 (https=)

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AU2018273356B2 (en) 2017-05-22 2021-09-16 Amgen Inc. KRAS G12C inhibitors and methods of using the same
US11285156B2 (en) 2018-06-12 2022-03-29 Amgen Inc. Substituted piperazines as KRAS G12C inhibitors
JP7516029B2 (ja) 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
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WO2020236947A1 (en) 2019-05-21 2020-11-26 Amgen Inc. Solid state forms
AU2020277398B2 (en) 2019-05-21 2026-01-29 Amgen Inc. Solid state forms
JP7837865B2 (ja) * 2019-11-14 2026-03-31 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改良合成法
JP2023501528A (ja) 2019-11-14 2023-01-18 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の改善された合成
CN114585624A (zh) * 2020-06-02 2022-06-03 上海喆邺生物科技有限公司 一种手性中间体及其制备方法
JP2023544450A (ja) 2020-09-23 2023-10-23 エラスカ・インコーポレイテッド 三環式ピリドン及びピリミドン
CA3201663A1 (en) 2020-11-20 2022-05-27 Amgen Inc. Process for preparing 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione
WO2022133345A1 (en) 2020-12-18 2022-06-23 Erasca, Inc. Tricyclic pyridones and pyrimidones
KR20240156373A (ko) 2022-03-07 2024-10-29 암젠 인크 4-메틸-2-프로판-2-일-피리딘-3-카르보니트릴의 제조 방법
CN115466259B (zh) * 2022-08-16 2023-12-05 山东大学 一种kras g12c抑制剂索托拉西布的制备方法

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