JP2023175694A5 - - Google Patents
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- Publication number
- JP2023175694A5 JP2023175694A5 JP2023132864A JP2023132864A JP2023175694A5 JP 2023175694 A5 JP2023175694 A5 JP 2023175694A5 JP 2023132864 A JP2023132864 A JP 2023132864A JP 2023132864 A JP2023132864 A JP 2023132864A JP 2023175694 A5 JP2023175694 A5 JP 2023175694A5
- Authority
- JP
- Japan
- Prior art keywords
- ylcarbonyl
- piperidin
- trifluoro
- pyridin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XEDHVZKDSYZQBF-UHFFFAOYSA-N lasmiditan Chemical compound C1CN(C)CCC1C(=O)C1=CC=CC(NC(=O)C=2C(=CC(F)=CC=2F)F)=N1 XEDHVZKDSYZQBF-UHFFFAOYSA-N 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024173307A JP2025020117A (ja) | 2009-04-02 | 2024-10-02 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16609709P | 2009-04-02 | 2009-04-02 | |
| US61/166,097 | 2009-04-02 | ||
| JP2019103591A JP6887462B2 (ja) | 2009-04-02 | 2019-06-03 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2021084001A JP7110446B2 (ja) | 2009-04-02 | 2021-05-18 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
| JP2022115213A JP7335397B2 (ja) | 2009-04-02 | 2022-07-20 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022115213A Division JP7335397B2 (ja) | 2009-04-02 | 2022-07-20 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024173307A Division JP2025020117A (ja) | 2009-04-02 | 2024-10-02 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023175694A JP2023175694A (ja) | 2023-12-12 |
| JP2023175694A5 true JP2023175694A5 (https=) | 2024-05-08 |
| JP7566996B2 JP7566996B2 (ja) | 2024-10-15 |
Family
ID=42826711
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503747A Active JP5727457B2 (ja) | 2009-04-02 | 2010-04-02 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2014214205A Withdrawn JP2015013903A (ja) | 2009-04-02 | 2014-10-21 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2016144048A Withdrawn JP2016188241A (ja) | 2009-04-02 | 2016-07-22 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2018036494A Pending JP2018087247A (ja) | 2009-04-02 | 2018-03-01 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2019103591A Active JP6887462B2 (ja) | 2009-04-02 | 2019-06-03 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2021084001A Active JP7110446B2 (ja) | 2009-04-02 | 2021-05-18 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
| JP2022115213A Active JP7335397B2 (ja) | 2009-04-02 | 2022-07-20 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
| JP2023132864A Active JP7566996B2 (ja) | 2009-04-02 | 2023-08-17 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
| JP2024173307A Pending JP2025020117A (ja) | 2009-04-02 | 2024-10-02 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
Family Applications Before (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503747A Active JP5727457B2 (ja) | 2009-04-02 | 2010-04-02 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2014214205A Withdrawn JP2015013903A (ja) | 2009-04-02 | 2014-10-21 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2016144048A Withdrawn JP2016188241A (ja) | 2009-04-02 | 2016-07-22 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2018036494A Pending JP2018087247A (ja) | 2009-04-02 | 2018-03-01 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2019103591A Active JP6887462B2 (ja) | 2009-04-02 | 2019-06-03 | ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物 |
| JP2021084001A Active JP7110446B2 (ja) | 2009-04-02 | 2021-05-18 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
| JP2022115213A Active JP7335397B2 (ja) | 2009-04-02 | 2022-07-20 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024173307A Pending JP2025020117A (ja) | 2009-04-02 | 2024-10-02 | ２，４，６－トリフルオロ－ｎ－［６－（１－メチル－ピペリジン－４－カルボニル）－ピリジン－２－イル］－ベンズアミドの組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20100256187A1 (https=) |
| EP (1) | EP2413933B2 (https=) |
| JP (9) | JP5727457B2 (https=) |
| KR (1) | KR101697801B1 (https=) |
| CN (2) | CN107412230A (https=) |
| AU (1) | AU2010232497B2 (https=) |
| CA (1) | CA2757019C (https=) |
| CY (2) | CY1119785T1 (https=) |
| DK (1) | DK2413933T4 (https=) |
| ES (1) | ES2655881T5 (https=) |
| FI (1) | FIC20230001I1 (https=) |
| FR (1) | FR23C1002I2 (https=) |
| HK (1) | HK1243923A1 (https=) |
| HR (1) | HRP20171742T4 (https=) |
| HU (2) | HUE037261T2 (https=) |
| IL (1) | IL215483A (https=) |
| LT (2) | LT2413933T (https=) |
| LU (1) | LUC00295I2 (https=) |
| MX (1) | MX2011010359A (https=) |
| NL (1) | NL301214I2 (https=) |
| NO (2) | NO2413933T3 (https=) |
| NZ (1) | NZ596161A (https=) |
| PL (1) | PL2413933T5 (https=) |
| PT (1) | PT2413933T (https=) |
| SI (1) | SI2413933T2 (https=) |
| WO (1) | WO2010115125A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| WO2009145842A2 (en) | 2008-04-04 | 2009-12-03 | Forsight Labs, Llc | Therapeutic device for pain management and vision |
| PL2413933T5 (pl) | 2009-04-02 | 2021-10-18 | Colucid Pharmaceuticals, Inc. | 2,4,6-trifluoro-N-[6-(1-metylopiperydyno-4-karbonylo)pirydyn-2-ylo]benzamid do leczenia migreny drogą doustną lub dożylną |
| US8697876B2 (en) | 2010-04-02 | 2014-04-15 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists |
| US12044905B2 (en) | 2011-04-28 | 2024-07-23 | Journey1 Inc | Contact lenses for refractive correction |
| CA2916885A1 (en) | 2013-06-26 | 2014-12-31 | Nexisvision, Inc. | Contact lenses for refractive correction |
| KR20190075130A (ko) | 2016-12-06 | 2019-06-28 | 코루시드 파마슈티컬즈 인코포레이티드 | 피리디노일피페리딘 5-ht1f 작용제에 관한 조성물 및 방법 |
| TWI826514B (zh) | 2018-09-04 | 2023-12-21 | 美商美國禮來大藥廠 | 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥 |
| TWI776175B (zh) | 2019-07-09 | 2022-09-01 | 美商美國禮來大藥廠 | 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備 |
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| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5011472A (en) * | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| JPH03255426A (ja) | 1990-03-06 | 1991-11-14 | Toshiba Corp | 有機非線形光学材料 |
| US5385912A (en) * | 1991-03-08 | 1995-01-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Multicyclic tertiary amine polyaromatic squalene synthase inhibitors |
| US5360735A (en) | 1992-01-08 | 1994-11-01 | Synaptic Pharmaceutical Corporation | DNA encoding a human 5-HT1F receptor, vectors, and host cells |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| US5698571A (en) * | 1994-10-05 | 1997-12-16 | Eli Lilly And Company | 5-HT1F mediated inhibition of neurogenic meningeal extravasation: a method for the treatment of migraine |
| US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| NZ305166A (en) * | 1995-03-20 | 1998-12-23 | Lilly Co Eli | 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments |
| US5942536A (en) | 1995-10-10 | 1999-08-24 | Eli Lilly And Company | N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists |
| US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
| BR9711273A (pt) | 1996-08-28 | 1999-08-17 | Lilly Co Eli | 1,2,3,4- Tetraidro-2-dibenzofuranaminas substituidas e 2- aminociclohepta b benzofuranos |
| AU4652697A (en) | 1996-10-08 | 1998-05-05 | Eli Lilly And Company | New serotonin 5-ht1f agonists |
| ZA979961B (en) | 1996-11-15 | 1999-05-05 | Lilly Co Eli | 5-HT1F agonists |
| EP0875513A1 (en) | 1997-04-14 | 1998-11-04 | Eli Lilly And Company | Substituted heteroaromatic 5-HT 1F agonists |
| ID23053A (id) | 1997-06-04 | 2000-01-20 | Lilly Co Eli | Karboksamida yang digunakan sebagai agonis 5-ht <if> |
| US5905084A (en) | 1997-11-14 | 1999-05-18 | Eli Lilly And Company | 5-HTIF -agonists effective in treating migraine |
| US6528529B1 (en) * | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| AU4961499A (en) | 1998-06-26 | 2000-01-17 | Eli Lilly And Company | 5-HT1f agonists |
| JP2002519348A (ja) | 1998-06-30 | 2002-07-02 | イーライ・リリー・アンド・カンパニー | ５−ｈｔ１ｆアゴニスト |
| US6608079B1 (en) | 1998-12-11 | 2003-08-19 | Eli Lilly And Company | Indole derivatives and their use as 5-HT1F agonists |
| DE60036924T2 (de) | 1999-02-10 | 2008-08-14 | Eli Lilly And Co., Indianapolis | 5-ht1f agonisten |
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| WO2002006196A1 (en) | 2000-07-13 | 2002-01-24 | Merck Patent Gmbh | Chiral compounds i |
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| TWI263497B (en) * | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
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| AU2005311251A1 (en) | 2004-12-01 | 2006-06-08 | Devgen Nv | 5-carboxamido substituted thiazole derivatives that interact with ion channels, in particular with ion channels from the Kv family |
| KR20060067738A (ko) * | 2004-12-15 | 2006-06-20 | 주식회사 대웅제약 | 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 신규한 ｎ-아릴아마이드 유도체 및 이를함유하는 약제학적 조성물 |
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| PL2413933T5 (pl) † | 2009-04-02 | 2021-10-18 | Colucid Pharmaceuticals, Inc. | 2,4,6-trifluoro-N-[6-(1-metylopiperydyno-4-karbonylo)pirydyn-2-ylo]benzamid do leczenia migreny drogą doustną lub dożylną |
| US8697876B2 (en) | 2010-04-02 | 2014-04-15 | Colucid Pharmaceuticals, Inc. | Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists |
| KR20190075130A (ko) | 2016-12-06 | 2019-06-28 | 코루시드 파마슈티컬즈 인코포레이티드 | 피리디노일피페리딘 5-ht1f 작용제에 관한 조성물 및 방법 |
| TWI754772B (zh) | 2017-09-06 | 2022-02-11 | 美商美國禮來大藥廠 | 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法 |
| TWI826514B (zh) | 2018-09-04 | 2023-12-21 | 美商美國禮來大藥廠 | 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥 |
| TWI776175B (zh) | 2019-07-09 | 2022-09-01 | 美商美國禮來大藥廠 | 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備 |
-
2010
- 2010-04-02 PL PL10759491T patent/PL2413933T5/pl unknown
- 2010-04-02 MX MX2011010359A patent/MX2011010359A/es active IP Right Grant
- 2010-04-02 PT PT107594913T patent/PT2413933T/pt unknown
- 2010-04-02 JP JP2012503747A patent/JP5727457B2/ja active Active
- 2010-04-02 NO NO10759491A patent/NO2413933T3/no unknown
- 2010-04-02 SI SI201031598T patent/SI2413933T2/sl unknown
- 2010-04-02 HR HRP20171742TT patent/HRP20171742T4/hr unknown
- 2010-04-02 DK DK10759491.3T patent/DK2413933T4/da active
- 2010-04-02 NZ NZ596161A patent/NZ596161A/xx unknown
- 2010-04-02 ES ES10759491T patent/ES2655881T5/es active Active
- 2010-04-02 CA CA2757019A patent/CA2757019C/en active Active
- 2010-04-02 WO PCT/US2010/029810 patent/WO2010115125A2/en not_active Ceased
- 2010-04-02 EP EP10759491.3A patent/EP2413933B2/en active Active
- 2010-04-02 AU AU2010232497A patent/AU2010232497B2/en active Active
- 2010-04-02 CN CN201611165874.8A patent/CN107412230A/zh active Pending
- 2010-04-02 US US12/753,489 patent/US20100256187A1/en not_active Abandoned
- 2010-04-02 HU HUE10759491A patent/HUE037261T2/hu unknown
- 2010-04-02 CN CN2010800251419A patent/CN102753171A/zh active Pending
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2014
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2016
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2017
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2018
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