JP2016505050A5 - - Google Patents
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- Publication number
- JP2016505050A5 JP2016505050A5 JP2015553921A JP2015553921A JP2016505050A5 JP 2016505050 A5 JP2016505050 A5 JP 2016505050A5 JP 2015553921 A JP2015553921 A JP 2015553921A JP 2015553921 A JP2015553921 A JP 2015553921A JP 2016505050 A5 JP2016505050 A5 JP 2016505050A5
- Authority
- JP
- Japan
- Prior art keywords
- chlorokynurenine
- pharmaceutical composition
- unit dose
- amount
- consisting essentially
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- HQLHZNDJQSRKDT-QMMMGPOBSA-N (2s)-2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid Chemical compound OC(=O)[C@@H](N)CC(=O)C1=CC=C(Cl)C=C1N HQLHZNDJQSRKDT-QMMMGPOBSA-N 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 239000004615 ingredient Substances 0.000 claims 5
- UAWVRVFHMOSAPU-UHFFFAOYSA-N 7-chlorokynurenic acid Chemical compound C1=CC(Cl)=CC2=NC(C(=O)O)=CC(O)=C21 UAWVRVFHMOSAPU-UHFFFAOYSA-N 0.000 claims 2
- 208000004454 Hyperalgesia Diseases 0.000 claims 2
- 208000035154 Hyperesthesia Diseases 0.000 claims 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 230000036470 plasma concentration Effects 0.000 claims 2
- 230000036642 wellbeing Effects 0.000 claims 2
- 208000012661 Dyskinesia Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000009251 neurologic dysfunction Effects 0.000 claims 1
- 208000015015 neurological dysfunction Diseases 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361849191P | 2013-01-22 | 2013-01-22 | |
| US61/849,191 | 2013-01-22 | ||
| PCT/US2014/012598 WO2014116739A1 (en) | 2013-01-22 | 2014-01-22 | Dosage forms and therapeutic uses l-4-chlorokynurenine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018171786A Division JP6804497B2 (ja) | 2013-01-22 | 2018-09-13 | Ｌ−４−クロロキヌレニンの剤形及び治療的使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505050A JP2016505050A (ja) | 2016-02-18 |
| JP2016505050A5 true JP2016505050A5 (https=) | 2017-02-23 |
| JP6436913B2 JP6436913B2 (ja) | 2018-12-12 |
Family
ID=51228003
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015553921A Active JP6436913B2 (ja) | 2013-01-22 | 2014-01-22 | Ｌ−４−クロロキヌレニンの剤形及び治療的使用 |
| JP2018171786A Active JP6804497B2 (ja) | 2013-01-22 | 2018-09-13 | Ｌ−４−クロロキヌレニンの剤形及び治療的使用 |
| JP2020115273A Active JP7021298B2 (ja) | 2013-01-22 | 2020-07-03 | Ｌ－４－クロロキヌレニンの剤形及び治療的使用 |
| JP2022015622A Pending JP2022070894A (ja) | 2013-01-22 | 2022-02-03 | Ｌ－４－クロロキヌレニンの剤形及び治療的使用 |
| JP2024027330A Pending JP2024069257A (ja) | 2013-01-22 | 2024-02-27 | Ｌ－４－クロロキヌレニンの剤形及び治療的使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018171786A Active JP6804497B2 (ja) | 2013-01-22 | 2018-09-13 | Ｌ−４−クロロキヌレニンの剤形及び治療的使用 |
| JP2020115273A Active JP7021298B2 (ja) | 2013-01-22 | 2020-07-03 | Ｌ－４－クロロキヌレニンの剤形及び治療的使用 |
| JP2022015622A Pending JP2022070894A (ja) | 2013-01-22 | 2022-02-03 | Ｌ－４－クロロキヌレニンの剤形及び治療的使用 |
| JP2024027330A Pending JP2024069257A (ja) | 2013-01-22 | 2024-02-27 | Ｌ－４－クロロキヌレニンの剤形及び治療的使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (8) | US9993450B2 (https=) |
| EP (4) | EP4385563A3 (https=) |
| JP (5) | JP6436913B2 (https=) |
| KR (5) | KR20230003410A (https=) |
| CN (4) | CN105073108A (https=) |
| AU (5) | AU2014209466B2 (https=) |
| BR (1) | BR112015017535A2 (https=) |
| CA (3) | CA3216579A1 (https=) |
| CY (1) | CY1122403T1 (https=) |
| DK (3) | DK3228313T3 (https=) |
| ES (3) | ES2751138T3 (https=) |
| HK (1) | HK1217170A1 (https=) |
| HR (2) | HRP20240812T1 (https=) |
| HU (1) | HUE067381T2 (https=) |
| IL (3) | IL291831B1 (https=) |
| MX (2) | MX375318B (https=) |
| PL (2) | PL3598971T3 (https=) |
| PT (3) | PT3228313T (https=) |
| RS (1) | RS59687B1 (https=) |
| SI (2) | SI3228313T1 (https=) |
| WO (1) | WO2014116739A1 (https=) |
| ZA (2) | ZA201505569B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4385563A3 (en) | 2013-01-22 | 2024-08-21 | Vistagen Therapeutics, Inc. | Dosage forms and therapeutic uses l-4-chlorokynurenine |
| KR20240068766A (ko) * | 2015-05-22 | 2024-05-17 | 비스타젠 쎄라퓨틱스, 인크. | L-４-클로로키누레닌의 치료적 용도 |
| WO2017044516A1 (en) * | 2015-09-08 | 2017-03-16 | Cephalon, Inc. | Prodrugs of chlorokynurenines |
| CN112236412B (zh) | 2018-02-09 | 2024-01-30 | 维斯塔津治疗公司 | 4-氯代犬尿氨酸及中间体的合成 |
| CN109223785A (zh) * | 2018-10-29 | 2019-01-18 | 中国药科大学 | 犬尿喹啉酸或其衍生物在制备改善慢性精神应激相关病理损伤药物中的应用 |
| WO2022082100A1 (en) * | 2020-10-16 | 2022-04-21 | Vistagen Therapeutics, Inc. | Cocrystals of l-4-chlorokynurenine, compositions and therapeutic uses thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5086072A (en) * | 1990-06-18 | 1992-02-04 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex |
| US5360814A (en) | 1991-02-28 | 1994-11-01 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
| US5484814A (en) | 1991-02-28 | 1996-01-16 | Merrell Dow Pharmaceuticals Inc. | NMDA antagonists |
| US5763393A (en) | 1996-05-17 | 1998-06-09 | Neurotherapeutics L.P. | Neuroactive peptides |
| TW518218B (en) | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
| WO2003015713A2 (en) | 2001-08-20 | 2003-02-27 | Maiken Nedergaard | Treatment of glial tumors with glutamate antagonists |
| JP2006502158A (ja) | 2002-09-06 | 2006-01-19 | デュレクト コーポレーション | グルタメート媒介神経伝達のモジュレーターの内耳への送達 |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| AU2007235876A1 (en) | 2006-04-12 | 2007-10-18 | Probiodrug Ag | Enzyme inhibitors |
| EP1903028A1 (en) * | 2006-09-22 | 2008-03-26 | Werner Tschollar | Conjugates of glutamate and NMDA receptor channel blockers without excito-toxic effects |
| CA2606658A1 (en) | 2006-10-13 | 2008-04-13 | Mike Tyers | Compositions and methods for treating neurological disorders or damage |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| WO2009135091A1 (en) * | 2008-04-30 | 2009-11-05 | Medivation Technologies, Inc. | Use of asenapine and related compounds for the treatment of neuronal or non-neuronal diseases or conditions |
| US20110190347A1 (en) * | 2008-08-21 | 2011-08-04 | Richter Gedeon Nyrt. | Methods for treating neuropathic pain |
| DK2421519T3 (en) | 2009-04-23 | 2017-02-06 | Univ Zuerich | NMDA RECEPTOR BLOCKERS FOR THE TREATMENT OF SEAL CELL ANAEMS |
| CN102802630A (zh) * | 2009-06-17 | 2012-11-28 | 塔加西普特公司 | 通过神经元烟碱受体配体逆转左旋多巴诱导的运动障碍 |
| EP2466312B1 (en) | 2009-08-12 | 2019-10-16 | Human Metabolome Technologies, Inc. | Phosphoethanolamine as biomarker of depression |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| EP2338873A1 (en) * | 2009-12-22 | 2011-06-29 | Gmeiner, Peter | New aminotetraline derivatives |
| SI2582366T1 (sl) * | 2010-06-15 | 2016-02-29 | Gruenenthal Gmbh | Farmacevtska kombinacija za zdravljenje bolečine |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| EP4385563A3 (en) | 2013-01-22 | 2024-08-21 | Vistagen Therapeutics, Inc. | Dosage forms and therapeutic uses l-4-chlorokynurenine |
| US20160031800A1 (en) | 2013-03-14 | 2016-02-04 | Vistagen Therapeutics, Inc. | Synthesis of chiral kynurenine compounds and intermediates |
| AU2014342624A1 (en) | 2013-10-28 | 2016-06-02 | Naurex, Inc. | NMDA receptor modulators and prodrugs, salts, and uses thereof |
| KR20240068766A (ko) | 2015-05-22 | 2024-05-17 | 비스타젠 쎄라퓨틱스, 인크. | L-４-클로로키누레닌의 치료적 용도 |
-
2014
- 2014-01-22 EP EP24164414.5A patent/EP4385563A3/en not_active Withdrawn
- 2014-01-22 CN CN201480010060.XA patent/CN105073108A/zh active Pending
- 2014-01-22 MX MX2015009277A patent/MX375318B/es active IP Right Grant
- 2014-01-22 EP EP19196366.9A patent/EP3598971B1/en active Active
- 2014-01-22 CN CN202110387953.8A patent/CN113209068A/zh active Pending
- 2014-01-22 US US14/762,015 patent/US9993450B2/en active Active
- 2014-01-22 PT PT171700792T patent/PT3228313T/pt unknown
- 2014-01-22 ES ES17170079T patent/ES2751138T3/es active Active
- 2014-01-22 SI SI201431410T patent/SI3228313T1/sl unknown
- 2014-01-22 CN CN202110384159.8A patent/CN113116877A/zh active Pending
- 2014-01-22 EP EP17170079.2A patent/EP3228313B1/en active Active
- 2014-01-22 KR KR1020227044517A patent/KR20230003410A/ko not_active Ceased
- 2014-01-22 ES ES19196366T patent/ES2980120T3/es active Active
- 2014-01-22 IL IL291831A patent/IL291831B1/en unknown
- 2014-01-22 KR KR1020237021428A patent/KR20230098711A/ko not_active Ceased
- 2014-01-22 PL PL19196366.9T patent/PL3598971T3/pl unknown
- 2014-01-22 RS RS20191519A patent/RS59687B1/sr unknown
- 2014-01-22 DK DK17170079T patent/DK3228313T3/da active
- 2014-01-22 PL PL17170079T patent/PL3228313T3/pl unknown
- 2014-01-22 DK DK19196366.9T patent/DK3598971T3/da active
- 2014-01-22 HK HK16105132.0A patent/HK1217170A1/zh unknown
- 2014-01-22 HR HRP20240812TT patent/HRP20240812T1/hr unknown
- 2014-01-22 CN CN202110387961.2A patent/CN112933073A/zh active Pending
- 2014-01-22 KR KR1020217015432A patent/KR102335919B1/ko active Active
- 2014-01-22 ES ES14743570.5T patent/ES2635353T3/es active Active
- 2014-01-22 PT PT147435705T patent/PT2948140T/pt unknown
- 2014-01-22 CA CA3216579A patent/CA3216579A1/en active Pending
- 2014-01-22 SI SI201432078T patent/SI3598971T1/sl unknown
- 2014-01-22 KR KR1020157022405A patent/KR102257284B1/ko active Active
- 2014-01-22 AU AU2014209466A patent/AU2014209466B2/en active Active
- 2014-01-22 HU HUE19196366A patent/HUE067381T2/hu unknown
- 2014-01-22 CA CA3128321A patent/CA3128321C/en active Active
- 2014-01-22 EP EP14743570.5A patent/EP2948140B1/en active Active
- 2014-01-22 DK DK14743570.5T patent/DK2948140T3/en active
- 2014-01-22 WO PCT/US2014/012598 patent/WO2014116739A1/en not_active Ceased
- 2014-01-22 BR BR112015017535-0A patent/BR112015017535A2/pt not_active IP Right Cessation
- 2014-01-22 KR KR1020217039478A patent/KR20210149905A/ko not_active Ceased
- 2014-01-22 JP JP2015553921A patent/JP6436913B2/ja active Active
- 2014-01-22 CA CA2898619A patent/CA2898619C/en active Active
- 2014-01-22 PT PT191963669T patent/PT3598971T/pt unknown
-
2015
- 2015-07-17 MX MX2020009966A patent/MX2020009966A/es unknown
- 2015-07-22 IL IL240090A patent/IL240090B/en active IP Right Grant
- 2015-08-03 ZA ZA2015/05569A patent/ZA201505569B/en unknown
-
2016
- 2016-02-08 US US15/018,219 patent/US9993453B2/en active Active
- 2016-11-02 ZA ZA2016/07581A patent/ZA201607581B/en unknown
-
2018
- 2018-05-14 US US15/978,855 patent/US10632091B2/en active Active
- 2018-06-08 US US16/003,793 patent/US10617663B2/en active Active
- 2018-06-08 US US16/003,816 patent/US10980758B2/en active Active
- 2018-06-08 US US16/003,804 patent/US20180369180A1/en not_active Abandoned
- 2018-09-13 JP JP2018171786A patent/JP6804497B2/ja active Active
- 2018-10-26 AU AU2018253600A patent/AU2018253600B2/en active Active
-
2019
- 2019-11-27 CY CY20191101244T patent/CY1122403T1/el unknown
- 2019-12-04 HR HRP20192189TT patent/HRP20192189T1/hr unknown
-
2020
- 2020-07-01 AU AU2020204420A patent/AU2020204420A1/en not_active Abandoned
- 2020-07-03 JP JP2020115273A patent/JP7021298B2/ja active Active
- 2020-07-16 IL IL276126A patent/IL276126B/en unknown
-
2022
- 2022-02-03 JP JP2022015622A patent/JP2022070894A/ja active Pending
- 2022-06-21 US US17/845,105 patent/US12036198B2/en active Active
- 2022-08-22 AU AU2022221382A patent/AU2022221382B2/en active Active
-
2024
- 2024-02-27 JP JP2024027330A patent/JP2024069257A/ja active Pending
- 2024-03-21 US US18/611,908 patent/US20250161251A1/en active Pending
- 2024-12-18 AU AU2024278564A patent/AU2024278564A1/en active Pending
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