JP2023134488A5 - - Google Patents
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- JP2023134488A5 JP2023134488A5 JP2023101803A JP2023101803A JP2023134488A5 JP 2023134488 A5 JP2023134488 A5 JP 2023134488A5 JP 2023101803 A JP2023101803 A JP 2023101803A JP 2023101803 A JP2023101803 A JP 2023101803A JP 2023134488 A5 JP2023134488 A5 JP 2023134488A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- modified
- molecule according
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000007523 nucleic acids Chemical class 0.000 claims 30
- 108020004707 nucleic acids Proteins 0.000 claims 19
- 102000039446 nucleic acids Human genes 0.000 claims 19
- 241000710929 Alphavirus Species 0.000 claims 16
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 14
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 11
- 101800001603 Capsid protein C Proteins 0.000 claims 5
- 101800001847 Core protein precursor Proteins 0.000 claims 5
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 3
- 108010087302 Viral Structural Proteins Proteins 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 2
- 101800001643 6K protein Proteins 0.000 claims 1
- 101710201734 E3 protein Proteins 0.000 claims 1
- 101710125507 Integrase/recombinase Proteins 0.000 claims 1
- 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 claims 1
- 108091027544 Subgenomic mRNA Proteins 0.000 claims 1
- 241000710924 Togaviridae Species 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000008488 polyadenylation Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662409228P | 2016-10-17 | 2016-10-17 | |
| US62/409,228 | 2016-10-17 | ||
| PCT/US2017/054928 WO2018075235A1 (en) | 2016-10-17 | 2017-10-03 | Recombinant virus replicon systems and uses thereof |
| JP2019520535A JP7382230B2 (ja) | 2016-10-17 | 2017-10-03 | 組み換えウイルスレプリコン系及びその使用 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520535A Division JP7382230B2 (ja) | 2016-10-17 | 2017-10-03 | 組み換えウイルスレプリコン系及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023134488A JP2023134488A (ja) | 2023-09-27 |
| JP2023134488A5 true JP2023134488A5 (enExample) | 2024-03-07 |
Family
ID=60153459
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520535A Active JP7382230B2 (ja) | 2016-10-17 | 2017-10-03 | 組み換えウイルスレプリコン系及びその使用 |
| JP2023101803A Withdrawn JP2023134488A (ja) | 2016-10-17 | 2023-06-21 | 組み換えウイルスレプリコン系及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520535A Active JP7382230B2 (ja) | 2016-10-17 | 2017-10-03 | 組み換えウイルスレプリコン系及びその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11364310B2 (enExample) |
| EP (1) | EP3526332B1 (enExample) |
| JP (2) | JP7382230B2 (enExample) |
| KR (1) | KR102718353B1 (enExample) |
| CN (1) | CN110073002B (enExample) |
| AU (1) | AU2017347725B2 (enExample) |
| BR (1) | BR112019007433A2 (enExample) |
| ES (1) | ES2993107T3 (enExample) |
| MX (1) | MX2019004499A (enExample) |
| WO (1) | WO2018075235A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10538786B2 (en) | 2016-04-13 | 2020-01-21 | Janssen Pharmaceuticals, Inc. | Recombinant arterivirus replicon systems and uses thereof |
| EP3526332B1 (en) * | 2016-10-17 | 2024-06-26 | Janssen Pharmaceuticals, Inc. | Recombinant virus replicon systems and uses thereof |
| CA3045650A1 (en) | 2016-12-05 | 2018-06-14 | Janssen Pharmaceuticals, Inc. | Compositions and methods for enhancing gene expression |
| US11020476B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV) |
| EA202091517A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и устройство для доставки вакцин против вируса гепатита b (hbv) |
| US11021692B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Hepatitis B virus (HBV) vaccines and uses thereof |
| BR112020014525A2 (pt) | 2018-01-19 | 2020-12-08 | Janssen Pharmaceuticals, Inc. | Induzir e intensificar respostas imunes utilizando sistemas de replicon recombinantes |
| WO2019161281A1 (en) | 2018-02-17 | 2019-08-22 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for membrane protein delivery |
| US12331076B2 (en) * | 2018-10-08 | 2025-06-17 | Janssen Pharmaceuticals, Inc. | Alphavirus-based replicons for administration of biotherapeutics |
| JP2022513040A (ja) | 2018-11-14 | 2022-02-07 | フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド | コンパートメント特異的カーゴ送達のための組成物および方法 |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| CA3143632A1 (en) | 2019-06-20 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Self-replicating rna molecules for hepatitis b virus (hbv) vaccines and uses thereof |
| US11679163B2 (en) | 2019-09-20 | 2023-06-20 | Hdt Bio Corp. | Compositions and methods for delivery of RNA |
| AU2020385683A1 (en) | 2019-11-18 | 2022-06-30 | Janssen Biotech, Inc. | Vaccines based on mutant CALR and JAK2 and their uses |
| WO2021138447A1 (en) | 2019-12-31 | 2021-07-08 | Elixirgen Therapeutics, Inc. | Temperature-based transient delivery of nucleic acids and proteins to cells and tissues |
| TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
| TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
| JP2023517644A (ja) | 2020-03-09 | 2023-04-26 | アークトゥラス・セラピューティクス・インコーポレイテッド | コロナウイルスワクチン組成物及び方法 |
| EP4119166A4 (en) | 2020-03-12 | 2024-06-05 | Institute for Basic Science | Composition for inducing apoptosis of cells having genomic sequence variation and method for inducing apoptosis of cells by using composition |
| EP4126021A1 (en) | 2020-03-23 | 2023-02-08 | HDT Bio Corp. | Compositions and methods for delivery of rna |
| JP2023521194A (ja) | 2020-04-13 | 2023-05-23 | ヤンセン バイオテツク，インコーポレーテツド | Ｐｓｍａ及びｓｔｅａｐ１ワクチン並びにそれらの使用 |
| MX2022014167A (es) * | 2020-05-11 | 2023-02-14 | Janssen Pharmaceuticals Inc | Replicón de arn que codifica una proteína de espícula del coronavirus estabilizada. |
| EP4149538A1 (en) | 2020-05-11 | 2023-03-22 | Janssen Pharmaceuticals, Inc. | Sars-cov-2 vaccines |
| WO2022009052A2 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| US20230024133A1 (en) | 2020-07-06 | 2023-01-26 | Janssen Biotech, Inc. | Prostate Neoantigens And Their Uses |
| WO2022009051A1 (en) | 2020-07-06 | 2022-01-13 | Janssen Biotech, Inc. | A method for determining responsiveness to prostate cancer treatment |
| IL299571A (en) | 2020-07-08 | 2023-02-01 | Janssen Sciences Ireland Unlimited Co | Rna replicon vaccines against hbv |
| WO2022026885A2 (en) * | 2020-07-31 | 2022-02-03 | Replicate Bioscience, Inc. | Modified chikungunya viruses and sindbis viruses and uses thereof |
| CN116171150A (zh) | 2020-08-14 | 2023-05-26 | 阿克丘勒斯治疗公司 | 冻干脂质纳米颗粒的方法 |
| CN112458064A (zh) * | 2020-11-20 | 2021-03-09 | 广西大学 | 盖他病毒全长感染性克隆、复制子系统及其制备和应用 |
| WO2022133230A1 (en) | 2020-12-18 | 2022-06-23 | Janssen Pharmaceuticals, Inc. | Combination therapy for treating hepatitis b virus infection |
| CN112852841A (zh) * | 2021-02-03 | 2021-05-28 | 郑州大学 | 一种高效表达目的蛋白的顺式复制子rna构建体 |
| IL309889A (en) * | 2021-07-09 | 2024-03-01 | Replicate Bioscience Inc | Modified eastern equine encephalitis viruses, self-replicating rna constructs, and uses thereof |
| CA3232719A1 (en) | 2021-09-22 | 2023-03-30 | Steven Gregory REED | Sars-cov-2 rna vaccine compositions and methods of use |
| KR20240088845A (ko) | 2021-09-22 | 2024-06-20 | 에이치디티 바이오 코포레이션 | 건조된 나노입자 조성물 |
| CA3232658A1 (en) | 2021-09-22 | 2023-03-30 | Steven Gregory REED | Rna vaccines against infectious diseases |
| KR20240111819A (ko) | 2021-09-22 | 2024-07-17 | 에이치디티 바이오 코포레이션 | 암 치료 조성물 및 이들의 용도 |
| CR20240493A (es) | 2022-05-12 | 2025-01-29 | Msd Int Business Gmbh | Proteínas de fusión de hmpv de prefusión estabilizadas |
| CN119563031A (zh) * | 2022-07-08 | 2025-03-04 | 嘉晨西海(杭州)生物技术有限公司 | 经修饰的自复制mRNA |
| US20240009296A1 (en) * | 2022-07-10 | 2024-01-11 | Pfizer Inc. | Self-amplifying rna encoding an influenza virus antigen |
| WO2025088152A1 (en) | 2023-10-27 | 2025-05-01 | Ziphius Nv | MODIFIED 5'UTRs |
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| EP3526332B1 (en) * | 2016-10-17 | 2024-06-26 | Janssen Pharmaceuticals, Inc. | Recombinant virus replicon systems and uses thereof |
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-
2017
- 2017-10-03 EP EP17787724.8A patent/EP3526332B1/en active Active
- 2017-10-03 BR BR112019007433-3A patent/BR112019007433A2/pt unknown
- 2017-10-03 ES ES17787724T patent/ES2993107T3/es active Active
- 2017-10-03 JP JP2019520535A patent/JP7382230B2/ja active Active
- 2017-10-03 WO PCT/US2017/054928 patent/WO2018075235A1/en not_active Ceased
- 2017-10-03 KR KR1020197013847A patent/KR102718353B1/ko active Active
- 2017-10-03 MX MX2019004499A patent/MX2019004499A/es unknown
- 2017-10-03 CN CN201780075817.7A patent/CN110073002B/zh active Active
- 2017-10-03 AU AU2017347725A patent/AU2017347725B2/en active Active
- 2017-10-03 US US15/723,658 patent/US11364310B2/en active Active
-
2022
- 2022-06-13 US US17/806,581 patent/US20230126773A1/en active Pending
-
2023
- 2023-06-21 JP JP2023101803A patent/JP2023134488A/ja not_active Withdrawn
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