JP2015527296A5 - - Google Patents
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- JP2015527296A5 JP2015527296A5 JP2015503322A JP2015503322A JP2015527296A5 JP 2015527296 A5 JP2015527296 A5 JP 2015527296A5 JP 2015503322 A JP2015503322 A JP 2015503322A JP 2015503322 A JP2015503322 A JP 2015503322A JP 2015527296 A5 JP2015527296 A5 JP 2015527296A5
- Authority
- JP
- Japan
- Prior art keywords
- vlp
- polynucleotide
- virus
- protein
- sequence encoding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 241000710929 Alphavirus Species 0.000 claims description 16
- 210000004027 cell Anatomy 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 7
- 239000013598 vector Substances 0.000 claims description 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 241000710960 Sindbis virus Species 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 241000710961 Semliki Forest virus Species 0.000 claims description 3
- 241001430294 unidentified retrovirus Species 0.000 claims description 3
- 230000014509 gene expression Effects 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims 16
- 102000040430 polynucleotide Human genes 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 16
- 210000003527 eukaryotic cell Anatomy 0.000 claims 6
- 101710091045 Envelope protein Proteins 0.000 claims 4
- 101710177291 Gag polyprotein Proteins 0.000 claims 4
- 101710125418 Major capsid protein Proteins 0.000 claims 4
- 101710188315 Protein X Proteins 0.000 claims 4
- 102100021696 Syncytin-1 Human genes 0.000 claims 4
- 239000013612 plasmid Substances 0.000 claims 4
- 101710172711 Structural protein Proteins 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 3
- 230000001177 retroviral effect Effects 0.000 claims 3
- 108020005544 Antisense RNA Proteins 0.000 claims 2
- 241000714474 Rous sarcoma virus Species 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 2
- 239000003184 complementary RNA Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091070501 miRNA Proteins 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 102100028253 Breast cancer anti-estrogen resistance protein 3 Human genes 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 101710204837 Envelope small membrane protein Proteins 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101710145006 Lysis protein Proteins 0.000 claims 1
- 101710141347 Major envelope glycoprotein Proteins 0.000 claims 1
- 241000714177 Murine leukemia virus Species 0.000 claims 1
- 101710138767 Non-structural glycoprotein 4 Proteins 0.000 claims 1
- 101710144127 Non-structural protein 1 Proteins 0.000 claims 1
- 101710144128 Non-structural protein 2 Proteins 0.000 claims 1
- 101710144111 Non-structural protein 3 Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 claims 1
- 102100031776 SH2 domain-containing protein 3A Human genes 0.000 claims 1
- 102100021798 SH2 domain-containing protein 3C Human genes 0.000 claims 1
- 102100031056 Serine protease 57 Human genes 0.000 claims 1
- 101710197596 Serine protease 57 Proteins 0.000 claims 1
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims 1
- 108010059722 Viral Fusion Proteins Proteins 0.000 claims 1
- 108020000999 Viral RNA Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000000120 cytopathologic effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 241000700605 Viruses Species 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 241000710912 Kunjin virus Species 0.000 description 1
- 241000713666 Lentivirus Species 0.000 description 1
- 241000713869 Moloney murine leukemia virus Species 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 210000000234 capsid Anatomy 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 230000006882 induction of apoptosis Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615687P | 2012-03-26 | 2012-03-26 | |
| US61/615,687 | 2012-03-26 | ||
| PCT/US2013/031876 WO2013148302A1 (en) | 2012-03-26 | 2013-03-15 | Delivery of packaged rna to mammalian cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018111489A Division JP6585237B2 (ja) | 2012-03-26 | 2018-06-12 | 哺乳動物細胞へのパッケージングされたｒｎａの新規の送達 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015527296A JP2015527296A (ja) | 2015-09-17 |
| JP2015527296A5 true JP2015527296A5 (enExample) | 2016-05-12 |
Family
ID=47998556
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503322A Pending JP2015527296A (ja) | 2012-03-26 | 2013-03-15 | 哺乳動物細胞へのパッケージングされたｒｎａの新規の送達 |
| JP2018111489A Active JP6585237B2 (ja) | 2012-03-26 | 2018-06-12 | 哺乳動物細胞へのパッケージングされたｒｎａの新規の送達 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018111489A Active JP6585237B2 (ja) | 2012-03-26 | 2018-06-12 | 哺乳動物細胞へのパッケージングされたｒｎａの新規の送達 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9506041B2 (enExample) |
| EP (2) | EP3663395B1 (enExample) |
| JP (2) | JP2015527296A (enExample) |
| AU (3) | AU2013240248B2 (enExample) |
| WO (1) | WO2013148302A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010040023A2 (en) | 2008-10-03 | 2010-04-08 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods and compositions for protein delivery |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| AU2013240248B2 (en) | 2012-03-26 | 2018-12-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Delivery of packaged RNA to mammalian cells |
| EP3967325A1 (en) * | 2013-12-16 | 2022-03-16 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| EP3189147A1 (en) | 2014-09-07 | 2017-07-12 | Selecta Biosciences, Inc. | Methods and compositions for attenuating gene expression modulating anti-viral transfer vector immune responses |
| JP6895391B2 (ja) | 2015-05-15 | 2021-06-30 | フラッシュ セラピューティクス | 少なくとも２つのカプシド形成された非ウイルス性ｒｎａを含む、レトロウイルス粒子 |
| FR3036118B1 (fr) * | 2015-05-15 | 2019-07-12 | Flash Therapeutics | Particule retrovirale comportant au moins deux arn non viraux encapsides. |
| DK3310368T3 (da) | 2015-06-19 | 2025-08-18 | Lgc Clinical Diagnostics Inc | Sindbis control virus |
| US10494613B2 (en) * | 2015-08-28 | 2019-12-03 | Wisconsin Alumni Research Foundation (Warf) | Generation of infectious influenza viruses from virus-like particles |
| CA3004132A1 (en) | 2015-11-09 | 2017-05-18 | Immune Design Corp. | A retroviral vector for the administration and expression of replicon rna expressing heterologous nucleic acids |
| US11197925B2 (en) | 2016-02-19 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| WO2018129268A1 (en) | 2017-01-07 | 2018-07-12 | Selecta Biosciences, Inc. | Patterned dosing of immunosuppressants coupled to synthetic nanocarriers |
| PL3601367T3 (pl) | 2017-03-30 | 2025-03-31 | The University Of Queensland | Cząsteczki chimeryczne i ich zastosowania |
| EP4400174A3 (en) | 2017-09-01 | 2024-10-23 | The Francis Crick Institute Limited | Immunoregulatory molecules and uses therefor |
| US20190142974A1 (en) | 2017-10-13 | 2019-05-16 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| IL319982A (en) | 2017-12-19 | 2025-05-01 | Akouos Inc | AAV virus-mediated delivery of therapeutic antibodies to the inner ear |
| EP3758682A4 (en) | 2018-02-26 | 2021-12-15 | Antolrx, Inc. | TOLEROGENIC LIPOSOMES AND THEIR PROCEDURES FOR USE |
| US12084698B2 (en) | 2018-07-13 | 2024-09-10 | Kyoto University | Virus-like particles and use thereof |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| US11389523B2 (en) | 2018-08-20 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein |
| JP7662157B2 (ja) | 2019-02-08 | 2025-04-15 | ウィスコンシン アルムニ リサーチ ファンデイション | ヒト化細胞系 |
| CA3138525A1 (en) | 2019-04-28 | 2020-11-05 | Selecta Biosciences, Inc. | Methods for treatment of subjects with preexisting immunity to viral transfer vectors |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| MX2021014566A (es) | 2019-05-28 | 2022-03-22 | Selecta Biosciences Inc | Métodos y composiciones para la respuesta inmune atenuada anti-vector de transferencia viral. |
| JP2022536364A (ja) | 2019-06-13 | 2022-08-15 | ザ ジェネラル ホスピタル コーポレイション | 操作されたヒト内在性ウイルス様粒子および細胞への送達のためのその使用方法 |
| WO2021021674A1 (en) | 2019-07-26 | 2021-02-04 | Akouos, Inc. | Methods of treating hearing loss using a secreted target protein |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
| US11739303B2 (en) | 2020-01-24 | 2023-08-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized NA |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| MX2022014204A (es) | 2020-05-13 | 2023-04-14 | Akouos Inc | Composiciones y metodos para tratar la perdida auditiva asociada al gen slc26a4. |
| WO2021231538A2 (en) | 2020-05-13 | 2021-11-18 | Akouos, Inc. | Compositions and methods for treating kcnq4-associated hearing loss |
| KR20230043151A (ko) | 2020-07-24 | 2023-03-30 | 더 제너럴 하스피탈 코포레이션 | 증강된 바이러스-유사 입자 및 세포에의 전달을 위한 그의 사용 방법 |
| CA3197936A1 (en) | 2020-12-01 | 2022-06-09 | Akouos, Inc. | Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms |
| MX2023007800A (es) | 2020-12-29 | 2023-07-11 | Akouos Inc | Composiciones y metodos para tratar la perdida de audicion y/o la perdida de vision asociada a clrn1. |
| US20240269265A1 (en) | 2021-06-09 | 2024-08-15 | Chimeron Bio Corporation | Peptide VLP-Based Vaccines |
| WO2022261355A1 (en) | 2021-06-09 | 2022-12-15 | Chimeron Bio Corporation | Self-amplifying rna-based vlp vaccines |
| CA3233097A1 (en) | 2021-09-30 | 2023-04-06 | Katherine Diane GRIBBLE | Compositions and methods for treating kcnq4-associated hearing loss |
| US20230141563A1 (en) | 2021-10-12 | 2023-05-11 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
| TW202342525A (zh) | 2022-02-02 | 2023-11-01 | 美商阿科奧斯公司 | 用於治療前庭神經鞘瘤相關症狀之抗ｖｅｇｆ抗體構築體及相關方法 |
| WO2023172624A1 (en) | 2022-03-09 | 2023-09-14 | Selecta Biosciences, Inc. | Immunosuppressants in combination with anti-igm agents and related dosing |
| TW202408545A (zh) | 2022-07-08 | 2024-03-01 | 美國貝勒醫學院 | 整合的壓力反應抑制劑及其使用方法 |
| AU2024266138A1 (en) | 2023-05-03 | 2025-11-13 | Manifold Biotechnologies, Inc. | Methods and compositions for high-throughput protein delivery, screening, and detection |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US1004083A (en) | 1911-01-09 | 1911-09-26 | Henry Ritter | Method of making sash-bars and die for forming same. |
| US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| WO1992011291A1 (en) | 1990-12-20 | 1992-07-09 | Smithkline Beecham Biologicals (S.A.) | Vaccines based on hepatitis b surface antigen |
| US5631237A (en) | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
| CN1185811A (zh) | 1995-03-31 | 1998-06-24 | H·沃尔夫 | 依赖于逆转录病毒样颗粒的抗原呈递系统 |
| US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| US6099847A (en) | 1997-05-15 | 2000-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric Gag pseudovirions |
| US6555342B1 (en) | 1998-06-03 | 2003-04-29 | Uab Research Foundation | Fusion protein delivery system and uses thereof |
| US6902886B1 (en) | 1998-11-06 | 2005-06-07 | The Research Foundation Of State University Of New York | Genetic assay for protein nuclear transport |
| US20020052040A1 (en) | 1999-06-30 | 2002-05-02 | Nicholas Hunt | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
| US20020177551A1 (en) | 2000-05-31 | 2002-11-28 | Terman David S. | Compositions and methods for treatment of neoplastic disease |
| US6783939B2 (en) | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| WO2003023026A1 (en) | 2001-09-06 | 2003-03-20 | Alphavax, Inc. | Alphavirus replicon vector systems |
| US20030099668A1 (en) | 2001-09-14 | 2003-05-29 | Cytos Biotechnology Ag | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| US20080115199A1 (en) * | 2001-12-06 | 2008-05-15 | Albert Young | Scheme for device and user authentication with key distribution in a wireless network |
| US8574590B2 (en) | 2003-07-30 | 2013-11-05 | Integral Molecular, Inc. | Lipoparticles comprising proteins, methods of making, and using the same |
| FR2862982B1 (fr) * | 2003-12-02 | 2006-04-28 | Genethon | Particules virales contenant un vecteur derive d'alpha-virus et procede de preparation de ladite particule virale. |
| AU2005247298B8 (en) | 2004-04-14 | 2011-03-10 | Avirid, Inc. | Compositions with modified nucleases targeted to viral nucleic acids and methods of use for prevention and treatment of viral diseases |
| GB0426641D0 (en) | 2004-12-03 | 2005-01-05 | Bioactive Protein Delivery The | Protein delivery system |
| US9101578B2 (en) | 2006-05-01 | 2015-08-11 | Technovax, Inc. | Polyvalent influenza virus-like particle (VLP) compositions |
| DE202006010918U1 (de) * | 2006-07-14 | 2006-10-05 | Flexi-Bogdahn Technik Gmbh & Co. Kg | Leineneinrichtung für eine mechanisch auf- und abrollbare Leine zum Führen von Tieren |
| US20120121650A1 (en) * | 2006-08-18 | 2012-05-17 | Johnston Robert E | Chimeric Virus Vaccines |
| WO2009120883A2 (en) * | 2008-03-26 | 2009-10-01 | Life Technologies Corporation | Virus-like particle mediated cellular delivery |
| WO2010040023A2 (en) | 2008-10-03 | 2010-04-08 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Methods and compositions for protein delivery |
| EP2496609A4 (en) * | 2009-11-03 | 2013-05-08 | Ligocyte Pharmaceuticals Inc | CHIMERIC RSV-F POLYPEPTIDE AND VLPS ON LENTIVIREN OR ALPHA RETROVIRUS GAG BASE |
| AU2013240248B2 (en) | 2012-03-26 | 2018-12-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Delivery of packaged RNA to mammalian cells |
| EP3967325A1 (en) | 2013-12-16 | 2022-03-16 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon |
-
2013
- 2013-03-15 AU AU2013240248A patent/AU2013240248B2/en active Active
- 2013-03-15 WO PCT/US2013/031876 patent/WO2013148302A1/en not_active Ceased
- 2013-03-15 EP EP19207297.3A patent/EP3663395B1/en active Active
- 2013-03-15 EP EP13712661.1A patent/EP2831225A1/en not_active Withdrawn
- 2013-03-15 JP JP2015503322A patent/JP2015527296A/ja active Pending
- 2013-03-15 US US14/388,441 patent/US9506041B2/en active Active
-
2016
- 2016-06-23 US US15/190,992 patent/US10538743B2/en active Active
-
2018
- 2018-06-12 JP JP2018111489A patent/JP6585237B2/ja active Active
-
2019
- 2019-03-19 AU AU2019201911A patent/AU2019201911A1/en not_active Abandoned
- 2019-12-10 US US16/709,147 patent/US20200102545A1/en not_active Abandoned
-
2021
- 2021-10-01 AU AU2021240286A patent/AU2021240286B2/en active Active
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