AU2013240248B2 - Delivery of packaged RNA to mammalian cells - Google Patents

Delivery of packaged RNA to mammalian cells Download PDF

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Publication number
AU2013240248B2
AU2013240248B2 AU2013240248A AU2013240248A AU2013240248B2 AU 2013240248 B2 AU2013240248 B2 AU 2013240248B2 AU 2013240248 A AU2013240248 A AU 2013240248A AU 2013240248 A AU2013240248 A AU 2013240248A AU 2013240248 B2 AU2013240248 B2 AU 2013240248B2
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virus
vlp
protein
polynucleotide
rna
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AU2013240248A1 (en
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Deb K. Chatterjee
Stanislaw J. Kaczmarczyk
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US Department of Health and Human Services
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Government of the United States of America
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Priority to AU2019201911A priority Critical patent/AU2019201911A1/en
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/11011—Alpharetrovirus, e.g. avian leucosis virus
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    • C12N2740/10011—Retroviridae
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    • C12N2740/10011—Retroviridae
    • C12N2740/11011—Alpharetrovirus, e.g. avian leucosis virus
    • C12N2740/11041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
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    • C12N2770/00011—Details
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    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
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    • C12N2810/00—Vectors comprising a targeting moiety
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    • C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
    • C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV

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AU2013240248A 2012-03-26 2013-03-15 Delivery of packaged RNA to mammalian cells Active AU2013240248B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2019201911A AU2019201911A1 (en) 2012-03-26 2019-03-19 Delivery of packaged RNA to mammalian cells
AU2021240286A AU2021240286B2 (en) 2012-03-26 2021-10-01 Delivery of packaged RNA to mammalian cells

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261615687P 2012-03-26 2012-03-26
US61/615,687 2012-03-26
PCT/US2013/031876 WO2013148302A1 (en) 2012-03-26 2013-03-15 Delivery of packaged rna to mammalian cells

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AU2019201911A Division AU2019201911A1 (en) 2012-03-26 2019-03-19 Delivery of packaged RNA to mammalian cells

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AU2013240248A1 AU2013240248A1 (en) 2014-11-06
AU2013240248B2 true AU2013240248B2 (en) 2018-12-20

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AU2013240248A Active AU2013240248B2 (en) 2012-03-26 2013-03-15 Delivery of packaged RNA to mammalian cells
AU2019201911A Abandoned AU2019201911A1 (en) 2012-03-26 2019-03-19 Delivery of packaged RNA to mammalian cells
AU2021240286A Active AU2021240286B2 (en) 2012-03-26 2021-10-01 Delivery of packaged RNA to mammalian cells

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AU2019201911A Abandoned AU2019201911A1 (en) 2012-03-26 2019-03-19 Delivery of packaged RNA to mammalian cells
AU2021240286A Active AU2021240286B2 (en) 2012-03-26 2021-10-01 Delivery of packaged RNA to mammalian cells

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US (3) US9506041B2 (enExample)
EP (2) EP3663395B1 (enExample)
JP (2) JP2015527296A (enExample)
AU (3) AU2013240248B2 (enExample)
WO (1) WO2013148302A1 (enExample)

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