JP2019509750A5 - - Google Patents
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- JP2019509750A5 JP2019509750A5 JP2018551252A JP2018551252A JP2019509750A5 JP 2019509750 A5 JP2019509750 A5 JP 2019509750A5 JP 2018551252 A JP2018551252 A JP 2018551252A JP 2018551252 A JP2018551252 A JP 2018551252A JP 2019509750 A5 JP2019509750 A5 JP 2019509750A5
- Authority
- JP
- Japan
- Prior art keywords
- ires
- virus
- alphavirus
- attenuated
- subtype
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 108091033319 polynucleotide Proteins 0.000 claims description 28
- 102000040430 polynucleotide Human genes 0.000 claims description 28
- 239000002157 polynucleotide Substances 0.000 claims description 28
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims description 10
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims description 8
- 241001529459 Enterovirus A71 Species 0.000 claims description 7
- 241000710209 Theiler's encephalomyelitis virus Species 0.000 claims description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 69
- 241000710929 Alphavirus Species 0.000 claims 49
- 230000002238 attenuated effect Effects 0.000 claims 36
- 241000700605 Viruses Species 0.000 claims 23
- 241001502567 Chikungunya virus Species 0.000 claims 9
- 108091027544 Subgenomic mRNA Proteins 0.000 claims 9
- 241000709661 Enterovirus Species 0.000 claims 7
- 230000035772 mutation Effects 0.000 claims 7
- 108091026890 Coding region Proteins 0.000 claims 6
- 241000710961 Semliki Forest virus Species 0.000 claims 6
- 241000710189 Aphthovirus Species 0.000 claims 5
- 101710159910 Movement protein Proteins 0.000 claims 5
- 101710144117 Non-structural protein 4 Proteins 0.000 claims 5
- 241000710945 Eastern equine encephalitis virus Species 0.000 claims 4
- 101710121417 Envelope glycoprotein Proteins 0.000 claims 4
- 241000710831 Flavivirus Species 0.000 claims 4
- 210000000234 capsid Anatomy 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 241000711573 Coronaviridae Species 0.000 claims 3
- 241000255925 Diptera Species 0.000 claims 3
- 241000711557 Hepacivirus Species 0.000 claims 3
- 241000430519 Human rhinovirus sp. Species 0.000 claims 3
- 241000608292 Mayaro virus Species 0.000 claims 3
- 241000763097 Me Tri virus Species 0.000 claims 3
- 101800001758 RNA-directed RNA polymerase nsP4 Proteins 0.000 claims 3
- 241000710924 Togaviridae Species 0.000 claims 3
- 241000608278 Una virus Species 0.000 claims 3
- 241000710951 Western equine encephalitis virus Species 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 2
- 241000709664 Picornaviridae Species 0.000 claims 2
- 230000003044 adaptive effect Effects 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 1
- 206010066919 Epidemic polyarthritis Diseases 0.000 claims 1
- 208000000832 Equine Encephalomyelitis Diseases 0.000 claims 1
- 241000283073 Equus caballus Species 0.000 claims 1
- 241001328112 Igbo Ora virus Species 0.000 claims 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241000710942 Ross River virus Species 0.000 claims 1
- 101710172711 Structural protein Proteins 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000003705 ribosome Anatomy 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 description 15
- 229920001184 polypeptide Polymers 0.000 description 7
- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- 241000710188 Encephalomyocarditis virus Species 0.000 description 1
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 description 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662316264P | 2016-03-31 | 2016-03-31 | |
| US62/316,264 | 2016-03-31 | ||
| PCT/US2017/024450 WO2017172698A1 (en) | 2016-03-31 | 2017-03-28 | Live, attenuated alphavirus constructs and methods and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019509750A JP2019509750A (ja) | 2019-04-11 |
| JP2019509750A5 true JP2019509750A5 (enExample) | 2020-05-07 |
Family
ID=58501809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018551252A Withdrawn JP2019509750A (ja) | 2016-03-31 | 2017-03-28 | 生弱毒化アルファウイルス構築物及び方法、ならびにそれらの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20190106682A1 (enExample) |
| EP (1) | EP3436062A1 (enExample) |
| JP (1) | JP2019509750A (enExample) |
| KR (1) | KR20180135913A (enExample) |
| CN (1) | CN109195625A (enExample) |
| AU (1) | AU2017241669A1 (enExample) |
| BR (1) | BR112018069079A2 (enExample) |
| CA (1) | CA3019536A1 (enExample) |
| CO (1) | CO2018010359A2 (enExample) |
| CR (1) | CR20180457A (enExample) |
| DO (1) | DOP2018000209A (enExample) |
| EC (1) | ECSP18081582A (enExample) |
| MX (1) | MX2018011839A (enExample) |
| PE (1) | PE20190178A1 (enExample) |
| PH (1) | PH12018502120A1 (enExample) |
| SG (1) | SG11201808479VA (enExample) |
| WO (1) | WO2017172698A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020024292A2 (pt) * | 2018-06-06 | 2021-03-02 | Massachusetts Institute Of Technology | rna circular para translação em células eucarióticas |
| CN110213711B (zh) * | 2019-04-22 | 2021-06-18 | 腾讯科技（深圳）有限公司 | 一种常驻点的估计方法、装置、设备和介质 |
| CN114561366B (zh) * | 2022-03-30 | 2023-06-20 | 西南民族大学 | 一种山羊库布病毒分离株及其应用 |
| US12297285B2 (en) | 2022-06-24 | 2025-05-13 | Orna Therapeutics, Inc. | Circular RNA encoding chimeric antigen receptors targeting BCMA |
| CN117925540B (zh) * | 2024-03-22 | 2024-06-18 | 北京昭衍新药研究中心股份有限公司 | 一种cv2117-hav-htlv-2多基因假病毒及其制备方法和应用 |
| CN118127077B (zh) * | 2024-05-08 | 2024-07-16 | 南京农业大学三亚研究院 | 基于盖塔病毒骨架的嵌合甲病毒制备方法和应用 |
| KR102864666B1 (ko) * | 2025-04-21 | 2025-09-29 | 대한민국 | 치쿤구니아 바이러스 외피 재조합 dna를 포함하는 백신 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050112095A1 (en) * | 2002-07-09 | 2005-05-26 | Tsu-An Hsu | Internal ribosome entry sites for recombinant protein expression |
| KR101668849B1 (ko) * | 2008-01-24 | 2016-10-24 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 모기에서 복제 불가능한 약독화된 재조합 알파바이러스 및 그의 용도 |
-
2017
- 2017-03-28 CA CA3019536A patent/CA3019536A1/en not_active Abandoned
- 2017-03-28 EP EP17716083.5A patent/EP3436062A1/en not_active Withdrawn
- 2017-03-28 CR CR20180457A patent/CR20180457A/es unknown
- 2017-03-28 WO PCT/US2017/024450 patent/WO2017172698A1/en not_active Ceased
- 2017-03-28 CN CN201780032818.3A patent/CN109195625A/zh active Pending
- 2017-03-28 AU AU2017241669A patent/AU2017241669A1/en not_active Abandoned
- 2017-03-28 KR KR1020187031480A patent/KR20180135913A/ko not_active Ceased
- 2017-03-28 BR BR112018069079A patent/BR112018069079A2/pt not_active IP Right Cessation
- 2017-03-28 US US16/088,815 patent/US20190106682A1/en not_active Abandoned
- 2017-03-28 MX MX2018011839A patent/MX2018011839A/es unknown
- 2017-03-28 PE PE2018001927A patent/PE20190178A1/es unknown
- 2017-03-28 SG SG11201808479VA patent/SG11201808479VA/en unknown
- 2017-03-28 JP JP2018551252A patent/JP2019509750A/ja not_active Withdrawn
-
2018
- 2018-09-27 CO CONC2018/0010359A patent/CO2018010359A2/es unknown
- 2018-09-28 DO DO2018000209A patent/DOP2018000209A/es unknown
- 2018-10-01 PH PH12018502120A patent/PH12018502120A1/en unknown
- 2018-10-30 EC ECSENADI201881582A patent/ECSP18081582A/es unknown
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