ECSP18081582A - Constructos de alfavirus vivo atenuado y métodos y usos de los mismos - Google Patents
Constructos de alfavirus vivo atenuado y métodos y usos de los mismosInfo
- Publication number
- ECSP18081582A ECSP18081582A ECSENADI201881582A ECDI201881582A ECSP18081582A EC SP18081582 A ECSP18081582 A EC SP18081582A EC SENADI201881582 A ECSENADI201881582 A EC SENADI201881582A EC DI201881582 A ECDI201881582 A EC DI201881582A EC SP18081582 A ECSP18081582 A EC SP18081582A
- Authority
- EC
- Ecuador
- Prior art keywords
- live attenuated
- methods
- constructs
- alfavirus
- embodiments relate
- Prior art date
Links
- 230000002238 attenuated effect Effects 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 241000710929 Alphavirus Species 0.000 abstract 4
- 241000255925 Diptera Species 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000007887 Alphavirus Infections Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36161—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36161—Methods of inactivation or attenuation
- C12N2770/36162—Methods of inactivation or attenuation by genetic engineering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662316264P | 2016-03-31 | 2016-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP18081582A true ECSP18081582A (es) | 2019-02-28 |
Family
ID=58501809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI201881582A ECSP18081582A (es) | 2016-03-31 | 2018-10-30 | Constructos de alfavirus vivo atenuado y métodos y usos de los mismos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20190106682A1 (enExample) |
| EP (1) | EP3436062A1 (enExample) |
| JP (1) | JP2019509750A (enExample) |
| KR (1) | KR20180135913A (enExample) |
| CN (1) | CN109195625A (enExample) |
| AU (1) | AU2017241669A1 (enExample) |
| BR (1) | BR112018069079A2 (enExample) |
| CA (1) | CA3019536A1 (enExample) |
| CO (1) | CO2018010359A2 (enExample) |
| CR (1) | CR20180457A (enExample) |
| DO (1) | DOP2018000209A (enExample) |
| EC (1) | ECSP18081582A (enExample) |
| MX (1) | MX2018011839A (enExample) |
| PE (1) | PE20190178A1 (enExample) |
| PH (1) | PH12018502120A1 (enExample) |
| SG (1) | SG11201808479VA (enExample) |
| WO (1) | WO2017172698A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112399860B (zh) | 2018-06-06 | 2024-08-16 | 麻省理工学院 | 用于在真核细胞中翻译的环状rna |
| CN110213711B (zh) * | 2019-04-22 | 2021-06-18 | 腾讯科技（深圳）有限公司 | 一种常驻点的估计方法、装置、设备和介质 |
| CN114561366B (zh) * | 2022-03-30 | 2023-06-20 | 西南民族大学 | 一种山羊库布病毒分离株及其应用 |
| US12297285B2 (en) | 2022-06-24 | 2025-05-13 | Orna Therapeutics, Inc. | Circular RNA encoding chimeric antigen receptors targeting BCMA |
| CN117925540B (zh) * | 2024-03-22 | 2024-06-18 | 北京昭衍新药研究中心股份有限公司 | 一种cv2117-hav-htlv-2多基因假病毒及其制备方法和应用 |
| CN118127077B (zh) * | 2024-05-08 | 2024-07-16 | 南京农业大学三亚研究院 | 基于盖塔病毒骨架的嵌合甲病毒制备方法和应用 |
| KR102864666B1 (ko) * | 2025-04-21 | 2025-09-29 | 대한민국 | 치쿤구니아 바이러스 외피 재조합 dna를 포함하는 백신 조성물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050112095A1 (en) * | 2002-07-09 | 2005-05-26 | Tsu-An Hsu | Internal ribosome entry sites for recombinant protein expression |
| JP5758632B2 (ja) | 2008-01-24 | 2015-08-05 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システムＴｈｅ Ｂｏａｒｄ Ｏｆ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｔｅｘａｓ Ｓｙｓｔｅｍ | 蚊において複製不可能な弱毒化組み換えアルファウイルス属及びそれらの使用 |
-
2017
- 2017-03-28 EP EP17716083.5A patent/EP3436062A1/en not_active Withdrawn
- 2017-03-28 AU AU2017241669A patent/AU2017241669A1/en not_active Abandoned
- 2017-03-28 US US16/088,815 patent/US20190106682A1/en not_active Abandoned
- 2017-03-28 JP JP2018551252A patent/JP2019509750A/ja not_active Withdrawn
- 2017-03-28 WO PCT/US2017/024450 patent/WO2017172698A1/en not_active Ceased
- 2017-03-28 PE PE2018001927A patent/PE20190178A1/es unknown
- 2017-03-28 MX MX2018011839A patent/MX2018011839A/es unknown
- 2017-03-28 CA CA3019536A patent/CA3019536A1/en not_active Abandoned
- 2017-03-28 BR BR112018069079A patent/BR112018069079A2/pt not_active IP Right Cessation
- 2017-03-28 SG SG11201808479VA patent/SG11201808479VA/en unknown
- 2017-03-28 CR CR20180457A patent/CR20180457A/es unknown
- 2017-03-28 CN CN201780032818.3A patent/CN109195625A/zh active Pending
- 2017-03-28 KR KR1020187031480A patent/KR20180135913A/ko not_active Ceased
-
2018
- 2018-09-27 CO CONC2018/0010359A patent/CO2018010359A2/es unknown
- 2018-09-28 DO DO2018000209A patent/DOP2018000209A/es unknown
- 2018-10-01 PH PH12018502120A patent/PH12018502120A1/en unknown
- 2018-10-30 EC ECSENADI201881582A patent/ECSP18081582A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3436062A1 (en) | 2019-02-06 |
| MX2018011839A (es) | 2019-05-23 |
| BR112018069079A2 (pt) | 2019-01-29 |
| PE20190178A1 (es) | 2019-02-01 |
| CR20180457A (es) | 2019-04-09 |
| US20190106682A1 (en) | 2019-04-11 |
| DOP2018000209A (es) | 2019-01-31 |
| JP2019509750A (ja) | 2019-04-11 |
| SG11201808479VA (en) | 2018-10-30 |
| PH12018502120A1 (en) | 2019-07-15 |
| KR20180135913A (ko) | 2018-12-21 |
| CO2018010359A2 (es) | 2018-12-14 |
| WO2017172698A1 (en) | 2017-10-05 |
| CA3019536A1 (en) | 2017-10-05 |
| AU2017241669A1 (en) | 2018-11-22 |
| CN109195625A (zh) | 2019-01-11 |
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