JP2011523347A5 - - Google Patents
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- Publication number
- JP2011523347A5 JP2011523347A5 JP2010544350A JP2010544350A JP2011523347A5 JP 2011523347 A5 JP2011523347 A5 JP 2011523347A5 JP 2010544350 A JP2010544350 A JP 2010544350A JP 2010544350 A JP2010544350 A JP 2010544350A JP 2011523347 A5 JP2011523347 A5 JP 2011523347A5
- Authority
- JP
- Japan
- Prior art keywords
- alphavirus
- attenuated
- subgenomic
- virus
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091027544 Subgenomic mRNA Proteins 0.000 claims description 12
- 230000035772 mutation Effects 0.000 claims description 10
- 241000255925 Diptera Species 0.000 claims description 8
- 101710121417 Envelope glycoprotein Proteins 0.000 claims description 7
- 210000000234 capsid Anatomy 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 3
- 238000011144 upstream manufacturing Methods 0.000 claims description 3
- 108090000565 Capsid Proteins Proteins 0.000 claims description 2
- 102100023321 Ceruloplasmin Human genes 0.000 claims description 2
- 241000710929 Alphavirus Species 0.000 claims 33
- 230000002238 attenuated effect Effects 0.000 claims 20
- 108091026890 Coding region Proteins 0.000 claims 4
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 101710159910 Movement protein Proteins 0.000 claims 3
- 101710144117 Non-structural protein 4 Proteins 0.000 claims 3
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 claims 3
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 2
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 2
- 101800000980 Protease nsP2 Proteins 0.000 claims 2
- 101800001758 RNA-directed RNA polymerase nsP4 Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000003044 adaptive effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241001502567 Chikungunya virus Species 0.000 claims 1
- 241000710945 Eastern equine encephalitis virus Species 0.000 claims 1
- 241000710188 Encephalomyocarditis virus Species 0.000 claims 1
- 241000283073 Equus caballus Species 0.000 claims 1
- 101710144128 Non-structural protein 2 Proteins 0.000 claims 1
- 101710199667 Nuclear export protein Proteins 0.000 claims 1
- 102100021696 Syncytin-1 Human genes 0.000 claims 1
- 241000710951 Western equine encephalitis virus Species 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 244000144972 livestock Species 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000017610 release of virus from host Effects 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 230000005540 biological transmission Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 241000256118 Aedes aegypti Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000003501 vero cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6222908P | 2008-01-24 | 2008-01-24 | |
| US61/062,229 | 2008-01-24 | ||
| PCT/US2009/000458 WO2009131604A2 (en) | 2008-01-24 | 2009-01-23 | Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523347A JP2011523347A (ja) | 2011-08-11 |
| JP2011523347A5 true JP2011523347A5 (enExample) | 2014-06-19 |
| JP5758632B2 JP5758632B2 (ja) | 2015-08-05 |
Family
ID=41217313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544350A Expired - Fee Related JP5758632B2 (ja) | 2008-01-24 | 2009-01-23 | 蚊において複製不可能な弱毒化組み換えアルファウイルス属及びそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8426188B2 (enExample) |
| EP (2) | EP3085787B1 (enExample) |
| JP (1) | JP5758632B2 (enExample) |
| KR (2) | KR101668849B1 (enExample) |
| CN (1) | CN102083986B (enExample) |
| AU (1) | AU2009238667A1 (enExample) |
| CA (2) | CA2713165C (enExample) |
| CO (1) | CO6290702A2 (enExample) |
| IL (2) | IL207167A (enExample) |
| MX (3) | MX367792B (enExample) |
| MY (1) | MY178870A (enExample) |
| NZ (2) | NZ587502A (enExample) |
| SG (2) | SG187513A1 (enExample) |
| WO (1) | WO2009131604A2 (enExample) |
| ZA (1) | ZA201005943B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2183368T3 (en) * | 2007-06-21 | 2016-09-05 | Alphavax Inc | PROMOTER-FREE CASES FOR EXPRESSION OF ALPHAVIRUS STRUCTURE PROTEINS |
| CN102083986B (zh) | 2008-01-24 | 2014-06-18 | 德克萨斯大学系统董事会 | 不能在蚊子中复制的减毒重组甲病毒及其用途 |
| US8961995B2 (en) | 2012-09-20 | 2015-02-24 | Uab Research Foundation | Methods and compositions for alphavirus replicons |
| US9701719B2 (en) | 2012-09-27 | 2017-07-11 | Research Development Foundation | Attenuated Chikungunya virus |
| US10137186B2 (en) | 2013-03-14 | 2018-11-27 | Takeda Vaccines, Inc. | Compositions and methods for live, attenuated alphavirus formulations |
| JP2019509750A (ja) * | 2016-03-31 | 2019-04-11 | タケダ ワクチン, インコーポレイテッドTakeda Vaccines, Inc. | 生弱毒化アルファウイルス構築物及び方法、ならびにそれらの使用 |
| US11090384B2 (en) * | 2016-05-27 | 2021-08-17 | Griffith University | Arthrogenic alphavirus vaccine |
| TW201907937A (zh) | 2017-05-08 | 2019-03-01 | 美商葛利史東腫瘤科技公司 | 阿爾法病毒新抗原載體 |
| SG11202005792RA (en) | 2017-12-20 | 2020-07-29 | Vlp Therapeutics Llc | Alphavirus replicon particle |
| WO2020028749A1 (en) * | 2018-08-03 | 2020-02-06 | Uab Research Foundation | Methods and compositions for alphavirus vaccine |
| CN109536464B (zh) * | 2018-12-10 | 2022-06-10 | 中国科学院武汉病毒研究所 | 一种缺失衣壳蛋白基因的基孔肯雅病毒感染性克隆及构建方法和在制备减毒疫苗中的应用 |
| MX2021014525A (es) | 2019-05-30 | 2022-03-17 | Gritstone Bio Inc | Adenovirus modificados. |
| MX2022007905A (es) | 2019-12-31 | 2022-08-25 | Elixirgen Therapeutics Inc | Administracion transitoria basada en temperatura de acidos nucleicos y proteinas a celulas y tejidos. |
| EP4192496A4 (en) | 2020-08-06 | 2025-01-01 | Gritstone bio, Inc. | MULTIEPITOP VACCINE CASSETTES |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6451592B1 (en) * | 1996-04-05 | 2002-09-17 | Chiron Corporation | Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis |
| CA2327189A1 (en) * | 2000-12-21 | 2002-06-21 | The Minister Of National Defence | Novel dna-based vaccine against the encephalitis alphaviruses |
| KR101518309B1 (ko) * | 2003-03-20 | 2015-05-08 | 알파벡스, 인크. | 개선된 알파바이러스 레플리콘 및 헬퍼 구축물 |
| US7603447B2 (en) | 2004-07-30 | 2009-10-13 | Research In Motion Limited | Method and system for coordinating device setting between a communications client and its host device |
| US7332322B2 (en) | 2004-09-14 | 2008-02-19 | Ilya Frolov | Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof |
| CA2579507C (en) | 2006-03-15 | 2017-06-13 | Institut Pasteur | Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof |
| CN102083986B (zh) | 2008-01-24 | 2014-06-18 | 德克萨斯大学系统董事会 | 不能在蚊子中复制的减毒重组甲病毒及其用途 |
-
2009
- 2009-01-23 CN CN200980110510.1A patent/CN102083986B/zh not_active Expired - Fee Related
- 2009-01-23 EP EP16000617.7A patent/EP3085787B1/en not_active Not-in-force
- 2009-01-23 KR KR1020107018777A patent/KR101668849B1/ko not_active Expired - Fee Related
- 2009-01-23 NZ NZ587502A patent/NZ587502A/xx not_active IP Right Cessation
- 2009-01-23 NZ NZ603790A patent/NZ603790A/en not_active IP Right Cessation
- 2009-01-23 MX MX2014010258A patent/MX367792B/es unknown
- 2009-01-23 KR KR1020167029024A patent/KR101913790B1/ko not_active Expired - Fee Related
- 2009-01-23 CA CA2713165A patent/CA2713165C/en not_active Expired - Fee Related
- 2009-01-23 MX MX2019010530A patent/MX378503B/es unknown
- 2009-01-23 SG SG2013005624A patent/SG187513A1/en unknown
- 2009-01-23 JP JP2010544350A patent/JP5758632B2/ja not_active Expired - Fee Related
- 2009-01-23 CA CA2910235A patent/CA2910235C/en not_active Expired - Fee Related
- 2009-01-23 WO PCT/US2009/000458 patent/WO2009131604A2/en not_active Ceased
- 2009-01-23 EP EP09735287.6A patent/EP2250269B1/en not_active Not-in-force
- 2009-01-23 MY MYPI2010003463A patent/MY178870A/en unknown
- 2009-01-23 SG SG10201606111XA patent/SG10201606111XA/en unknown
- 2009-01-23 MX MX2010007989A patent/MX2010007989A/es active IP Right Grant
- 2009-01-23 AU AU2009238667A patent/AU2009238667A1/en not_active Abandoned
-
2010
- 2010-07-22 IL IL207167A patent/IL207167A/en active IP Right Grant
- 2010-07-23 US US12/804,535 patent/US8426188B2/en active Active
- 2010-08-20 CO CO10102866A patent/CO6290702A2/es active IP Right Grant
- 2010-08-20 ZA ZA2010/05943A patent/ZA201005943B/en unknown
-
2013
- 2013-04-03 US US13/855,960 patent/US9580690B2/en active Active
-
2014
- 2014-04-09 IL IL232032A patent/IL232032A0/en unknown
-
2017
- 2017-02-27 US US15/443,364 patent/US10533186B2/en active Active
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