JP2023127454A - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
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- JP2023127454A JP2023127454A JP2022031258A JP2022031258A JP2023127454A JP 2023127454 A JP2023127454 A JP 2023127454A JP 2022031258 A JP2022031258 A JP 2022031258A JP 2022031258 A JP2022031258 A JP 2022031258A JP 2023127454 A JP2023127454 A JP 2023127454A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
Description
[2] 前記口腔用組成物中の前記油相の含有割合は、5.00×10-3質量%以上80.00質量%以下である、上記[1]に記載の口腔用組成物。
[3] 前記口腔用組成物中の前記油性抗菌成分の含有割合は、5.00×10-3質量%以上10.00質量%以下である、上記[1]または[2]に記載の口腔用組成物。
[4] 前記油性抗菌成分は、炭素数6以上16以下のアルキル脂肪酸、低級脂肪酸モノグリセリド、分子量600以下のモノテルペン炭化水素類、セスキテルペン炭化水素類、ジテルペン炭化水素類、モノテルペンアルコール類、セスキテルペンアルコール類、ジテルペンアルコール類、フェノール類、ケトン類、テルペンアルデヒド類、脂肪族アルデヒド類、芳香族アルデヒド類、フェノールエーテル類、ラクトン類、エステル類、エーテル類、オキサイド類、カルボン酸類および有機酸類からなる群より選択される1種以上の抗菌成分である、上記[1]~[3]のいずれか1つに記載の口腔用組成物。
油相として、油性抗菌成分のシンナムアルデヒド(長岡香料株式会社製)および他の油性成分の中鎖脂肪酸トリグリセリド(花王株式会社製、ココナードMT)、水相として水、水酸基を有する重縮合ポリマーの粒子としてステアロキシヒドロキシプロピルメチルセルロース(大同化成工業株式会社製、サンジュロース90L)の粒子を用いて、表1に示す組成比(質量%)の口腔用組成物を製造した。具体的には、水を撹拌しながら、ステアロキシヒドロキシプロピルメチルセルロースの粒子を水に添加することによって、複数のステアロキシヒドロキシプロピルメチルセルロースの粒子が水中に分散している混合溶液を得た。続いて、混合溶液を撹拌しながら、融点以上のシンナムアルデヒドを混合溶液に添加することによって、実施例1-1の口腔用組成物を得た。また、混合溶液を撹拌しながら、融点以上のシンナムアルデヒドおよび中鎖脂肪酸トリグリセリドを混合溶液に添加することによって、実施例1-2の口腔用組成物を得た。
油相として、抗菌性を有するカプリン酸(花王株式会社製、ルナック10-98)および他の油性成分の中鎖脂肪酸トリグリセリド(花王株式会社製、ココナードMT)、水相として水、水酸基を有する重縮合ポリマーの粒子としてステアロキシヒドロキシプロピルメチルセルロース(大同化成工業株式会社製、サンジュロース90L)の粒子を用いて、表2に示す組成比(質量%)の口腔用組成物を製造した。具体的には、水を撹拌しながら、ステアロキシヒドロキシプロピルメチルセルロースの粒子を水に添加することによって、複数のステアロキシヒドロキシプロピルメチルセルロースの粒子が水中に分散している混合溶液を得た。続いて、混合溶液を撹拌しながら、融点以上のカプリン酸を混合溶液に添加することによって、実施例2-1の口腔用組成物を得た。また、混合溶液を撹拌しながら、融点以上のカプリン酸および中鎖脂肪酸トリグリセリドを混合溶液に添加することによって、実施例2-2の口腔用組成物を得た。
油相として、抗菌性を有するカプリン酸(花王株式会社製、ルナック10-98)および他の油性成分の中鎖脂肪酸トリグリセリド(花王株式会社製、ココナードMT)、水相として水、自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体としてモノミリスチン酸デカグリセリル(太陽化学株式会社製、サンソフトQ-14S-C)の閉鎖小胞体を用いて、表3に示す組成比(質量%)の口腔用組成物を製造した。具体的には、水を撹拌しながら、モノミリスチン酸デカグリセリルを水に添加することによって、複数のモノミリスチン酸デカグリセリルの閉鎖小胞体が水中に分散している混合溶液を得た。続いて、混合溶液を撹拌しながら、融点以上のカプリン酸を混合溶液に添加することによって、実施例3-1の口腔用組成物を得た。また、混合溶液を撹拌しながら、融点以上のカプリン酸および中鎖脂肪酸トリグリセリドを混合溶液に添加することによって、実施例3-2の口腔用組成物を得た。
油相として、油性抗菌成分のチモール(大阪化成株式会社製、日本薬局方品チモール)および他の油性成分の中鎖脂肪酸トリグリセリド(花王株式会社製、ココナードMT)、水相として水、水酸基を有する重縮合ポリマーの粒子としてステアロキシヒドロキシプロピルメチルセルロース(大同化成工業株式会社製、サンジュロース90L)の粒子を用いて、表4に示す組成比(質量%)の口腔用組成物を製造した。具体的には、水を撹拌しながら、ステアロキシヒドロキシプロピルメチルセルロースの粒子を水に添加することによって、複数のステアロキシヒドロキシプロピルメチルセルロースの粒子が水中に分散している混合溶液を得た。続いて、混合溶液を撹拌しながら、融点以上のチモールを混合溶液に添加することによって、実施例4-1の口腔用組成物を得た。また、混合溶液を撹拌しながら、融点以上のチモールおよび中鎖脂肪酸トリグリセリドを混合溶液に添加することによって、実施例4-2の口腔用組成物を得た。
油相として、油性抗菌成分のチモール(大阪化成株式会社製、日本薬局方品チモール)および他の油性成分の中鎖脂肪酸トリグリセリド(花王株式会社製、ココナードMT)、水相として水、重縮合ポリマーの粒子としてステアロキシヒドロキシプロピルメチルセルロース(大同化成工業株式会社製、サンジュロース90L)の粒子を用いて、表5に示す組成比(質量%)の口腔用組成物を製造した。具体的には、水を撹拌しながら、ステアロキシヒドロキシプロピルメチルセルロースの粒子を水に添加することによって、複数のステアロキシヒドロキシプロピルメチルセルロースの粒子が水中に分散している混合溶液を得た。続いて、混合溶液を撹拌しながら、融点以上のチモールおよび中鎖脂肪酸トリグリセリドを混合溶液に添加することによって、実施例5-1の口腔用組成物を得た。
油相として、抗菌性を有するカプリル酸(花王株式会社製、ルナック8-98)またはカプリン酸(花王株式会社製、ルナック10-98)、水相として水、自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体としてモノミリスチン酸ペンタグリセリル(太陽化学株式会社製、サンソフトA-141E-C)またはモノミリスチン酸デカグリセリル(太陽化学株式会社製、サンソフトQ-14S-C、)の閉鎖小胞体を用いて、表6に示す組成比(質量%)の口腔用組成物を製造した。具体的には、水を撹拌しながら、モノミリスチン酸ペンタグリセリルまたはモノミリスチン酸デカグリセリルを水に添加することによって、複数のモノミリスチン酸ペンタグリセリルの閉鎖小胞体または複数のモノミリスチン酸デカグリセリルの閉鎖小胞体が水中に分散している混合溶液を得た。続いて、混合溶液を撹拌しながら、融点以上のカプリル酸またはカプリン酸を混合溶液に添加することによって、実施例6-1~6-6の口腔用組成物を得た。実施例6-1~6-6で得られた口腔用組成物について、カンジダ菌(C .albicans NBRC1594株)に対する抗菌作用を以下のようにして評価した。
油相として、抗菌性を有するカプリン酸(花王株式会社製、ルナック10-98)および他の油性成分の中鎖脂肪酸トリグリセリド(花王株式会社製、ココナードMT)、水相として水、重縮合ポリマーの粒子としてステアロキシヒドロキシプロピルメチルセルロース(大同化成工業株式会社製、サンジュロース90L)の粒子を用いて、表7に示す組成比(質量%)の口腔用組成物を製造した。具体的には、水を撹拌しながら、ステアロキシヒドロキシプロピルメチルセルロースの粒子を水に添加することによって、複数のステアロキシヒドロキシプロピルメチルセルロースの粒子が水中に分散している混合溶液を得た。続いて、混合溶液を撹拌しながら、融点以上のカプリン酸および中鎖脂肪酸トリグリセリドを混合溶液に添加することによって、実施例7-1の口腔用組成物を得た。
Claims (4)
- 油性抗菌成分を含む油相と、
水相と、
自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体および水酸基を有する重縮合ポリマーの粒子の少なくとも一方と
を含み、O/W型エマルションであることを特徴とする口腔用組成物。 - 前記口腔用組成物中の前記油相の含有割合は、5.00×10-3質量%以上80.00質量%以下である、請求項1に記載の口腔用組成物。
- 前記口腔用組成物中の前記油性抗菌成分の含有割合は、5.00×10-3質量%以上10.00質量%以下である、請求項1または2に記載の口腔用組成物。
- 前記油性抗菌成分は、炭素数6以上16以下のアルキル脂肪酸、低級脂肪酸モノグリセリド、分子量600以下のモノテルペン炭化水素類、セスキテルペン炭化水素類、ジテルペン炭化水素類、モノテルペンアルコール類、セスキテルペンアルコール類、ジテルペンアルコール類、フェノール類、ケトン類、テルペンアルデヒド類、脂肪族アルデヒド類、芳香族アルデヒド類、フェノールエーテル類、ラクトン類、エステル類、エーテル類、オキサイド類、カルボン酸類および有機酸類からなる群より選択される1種以上の抗菌成分である、請求項1~3のいずれか1項に記載の口腔用組成物。
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WO2010064678A1 (ja) * | 2008-12-03 | 2010-06-10 | 株式会社 資生堂 | 水中油型化粧料 |
JP2010235512A (ja) * | 2009-03-31 | 2010-10-21 | Kanagawa Univ | 防腐防黴剤エマルション |
JP2013087096A (ja) * | 2011-10-19 | 2013-05-13 | Taiyo Kagaku Co Ltd | 抗菌組成物 |
JP2016074656A (ja) * | 2014-10-02 | 2016-05-12 | 学校法人神奈川大学 | 皮膚外用剤および抗シワ剤 |
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WO2010064678A1 (ja) * | 2008-12-03 | 2010-06-10 | 株式会社 資生堂 | 水中油型化粧料 |
JP2010235512A (ja) * | 2009-03-31 | 2010-10-21 | Kanagawa Univ | 防腐防黴剤エマルション |
JP2013087096A (ja) * | 2011-10-19 | 2013-05-13 | Taiyo Kagaku Co Ltd | 抗菌組成物 |
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