|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4722848A
(en)
|
1982-12-08 |
1988-02-02 |
Health Research, Incorporated |
Method for immunizing animals with synthetically modified vaccinia virus
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US5019369A
(en)
|
1984-10-22 |
1991-05-28 |
Vestar, Inc. |
Method of targeting tumors in humans
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
EP0452457B1
(en)
|
1989-11-03 |
1997-08-20 |
Vanderbilt University |
Method of in vivo delivery of functioning foreign genes
|
|
US5279833A
(en)
|
1990-04-04 |
1994-01-18 |
Yale University |
Liposomal transfection of nucleic acids into animal cells
|
|
US5204253A
(en)
|
1990-05-29 |
1993-04-20 |
E. I. Du Pont De Nemours And Company |
Method and apparatus for introducing biological substances into living cells
|
|
IL105554A
(en)
*
|
1992-05-05 |
1999-08-17 |
Univ Leiden |
Peptides of human papillomavirus for use in preparations elicit a human T cell response
|
|
EP0646178A1
(en)
|
1992-06-04 |
1995-04-05 |
The Regents Of The University Of California |
expression cassette with regularoty regions functional in the mammmlian host
|
|
WO2003040165A2
(en)
*
|
2000-10-19 |
2003-05-15 |
Epimmune Inc. |
Hla class i and ii binding peptides and their uses
|
|
IL106610A0
(en)
|
1992-08-07 |
1993-12-08 |
Cytel Corp |
Hla binding peptides and their uses
|
|
US9340577B2
(en)
|
1992-08-07 |
2016-05-17 |
Epimmune Inc. |
HLA binding motifs and peptides and their uses
|
|
SG49008A1
(en)
|
1993-03-05 |
1998-05-18 |
Cytel Corp |
Hla-a2.1 binding peptides and their uses
|
|
CN1135181A
(zh)
|
1993-09-14 |
1996-11-06 |
Cytel有限公司 |
使用泛dr结合肽改变免疫应答
|
|
US6071890A
(en)
|
1994-12-09 |
2000-06-06 |
Genzyme Corporation |
Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
|
|
US5849589A
(en)
|
1996-03-11 |
1998-12-15 |
Duke University |
Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
|
|
FR2753627B1
(fr)
|
1996-09-20 |
2003-02-21 |
Galderma Rech Dermatologique |
Utilisation des inhibiteurs de l'activite de l'acide retinoique pour favoriser la cicatrisation
|
|
US6406705B1
(en)
|
1997-03-10 |
2002-06-18 |
University Of Iowa Research Foundation |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
NO309798B1
(no)
|
1999-04-30 |
2001-04-02 |
Targovax As |
Peptidblanding, samt farmasoytisk sammensetning og kreftvaksine som innbefatter peptidblandingen
|
|
EP1189624A4
(en)
|
1999-06-29 |
2005-02-23 |
Epimmune Inc |
Hla binding peptides and their uses
|
|
EP2100620A1
(en)
|
1999-09-16 |
2009-09-16 |
Eisai Corporation of North America |
Nucleic acids encoding polyepitope polypeptides
|
|
US7026443B1
(en)
*
|
1999-12-10 |
2006-04-11 |
Epimmune Inc. |
Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
|
|
JP2003523365A
(ja)
|
2000-01-28 |
2003-08-05 |
スタテンズ セーラム インスティテュート |
Hiv感染の診断及びコントロールのためのhivペプチド及びそれをエンコードする核酸
|
|
CA2343602A1
(en)
|
2000-04-18 |
2001-10-18 |
Genset |
Est's and encoded human proteins
|
|
KR100919266B1
(ko)
*
|
2000-06-26 |
2009-09-30 |
엔벤타 바이오파마슈티컬스 코포레이션 |
인간 파필로마 바이러스 치료법
|
|
DE10037759A1
(de)
|
2000-08-03 |
2002-07-04 |
Gruenenthal Gmbh |
Screeningverfahren
|
|
US20040029114A1
(en)
|
2001-01-24 |
2004-02-12 |
Eos Technology, Inc. |
Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
|
|
AU2002322280A1
(en)
|
2001-06-21 |
2003-01-21 |
Millennium Pharmaceuticals, Inc. |
Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
|
|
US20040076955A1
(en)
|
2001-07-03 |
2004-04-22 |
Eos Biotechnology, Inc. |
Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer
|
|
EP1338606A1
(en)
|
2002-02-22 |
2003-08-27 |
Magnus Von Knebel Doeberitz |
Nucleic Acid encoding an HERV-H polypeptide for diagnosing colorectal cancer
|
|
JPWO2003090788A1
(ja)
|
2002-04-24 |
2005-08-25 |
株式会社ギンコバイオメディカル研究所 |
Th2サイトカイン関連アレルギー疾患を治療および/または予防するためのデコイ、GATA3変異体蛋白質、ならびにこれらを含む医薬組成物
|
|
JP2005533855A
(ja)
*
|
2002-07-24 |
2005-11-10 |
インターツェル・アクチェンゲゼルシャフト |
病原性ウイルスからの別のリーディングフレームによりコードされる抗原
|
|
AU2003284239B2
(en)
*
|
2002-10-21 |
2008-08-21 |
Eisai Inc. |
Compositions and methods for treating human papillomavirus-mediated disease
|
|
ATE557099T1
(de)
*
|
2003-09-05 |
2012-05-15 |
Genencor Int |
Hpv cd8+ t-zell-epitope
|
|
US8673634B2
(en)
|
2003-11-13 |
2014-03-18 |
Massachusetts Eye & Ear Infirmary |
Method for the treatment of hearing loss
|
|
GB0413688D0
(en)
|
2004-06-18 |
2004-07-21 |
Novartis Forschungsstiftung |
Analysis of methylated nucleic acid
|
|
AU2005309601A1
(en)
|
2004-11-23 |
2006-06-01 |
Neuromolecular Pharmaceuticals, Inc. |
Composition comprising a sustained release coating or matrix and an NMDA receptor antagonist, method for administration such NMDA antagonist to a subject
|
|
CN1299769C
(zh)
|
2005-01-31 |
2007-02-14 |
中国医学科学院肿瘤医院肿瘤研究所 |
人乳头瘤病毒和热休克蛋白重组蛋白疫苗及其用途
|
|
US8252893B2
(en)
|
2005-01-31 |
2012-08-28 |
Board Of Trustees Of The University Of Arkansas |
CD8 T cell epitopes in HPV 16 E6 and E7 proteins and uses thereof
|
|
EP3530736A3
(en)
|
2005-05-09 |
2019-11-06 |
ONO Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
|
|
JP4824389B2
(ja)
|
2005-10-28 |
2011-11-30 |
株式会社医学生物学研究所 |
エプスタイン−バールウイルス感染細胞を特異的に攻撃する細胞傷害性t細胞エピトープペプチド及びその用途
|
|
ES2539042T3
(es)
|
2006-06-02 |
2015-06-25 |
Glaxosmithkline Biologicals S.A. |
Procedimiento de identificación de si un paciente será respondedor o no a inmunoterapia
|
|
CA2658393A1
(en)
|
2006-07-21 |
2008-01-24 |
The Regents Of The University Of California |
Human endogenous retrovirus polypeptide compositions and methods of use thereof
|
|
CN105664147A
(zh)
|
2007-02-07 |
2016-06-15 |
日本电气株式会社 |
用于癌症的治疗剂
|
|
WO2008115610A1
(en)
|
2007-03-19 |
2008-09-25 |
Globeimmune, Inc. |
Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer
|
|
PT2175884T
(pt)
|
2007-07-12 |
2016-09-21 |
Gitr Inc |
Terapias de combinação empregando moléculas de ligação a gitr
|
|
EP2071334A1
(en)
|
2007-12-14 |
2009-06-17 |
Transmedi SA |
Compositions and methods of detecting TIABS
|
|
DE102008010954A1
(de)
|
2008-02-25 |
2009-08-27 |
Cichon, Günter, Prof.Dr. |
DNA-Vakzine zur Therapie und Prophylaxe von Gebärmutterhalskrebs und seinen prämalignen Vorstufen
|
|
EP2105511A1
(en)
|
2008-03-28 |
2009-09-30 |
Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. |
Medicament compositions and substances for treatment and identifying adenocarcinoma of the lung
|
|
AU2009292996B2
(en)
|
2008-09-22 |
2015-04-23 |
Baylor College Of Medicine |
Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters
|
|
CN101885778B
(zh)
|
2009-05-13 |
2013-10-16 |
中国疾病预防控制中心病毒病预防控制所 |
Hpv16型l2n120e7e6融合蛋白、基因、制备方法及用途
|
|
EP2509583B1
(en)
|
2009-12-10 |
2019-05-15 |
Merck Patent GmbH |
Pharmaceutical composition comprising oligopeptides, preferably cilengitide
|
|
US9023802B2
(en)
|
2009-12-14 |
2015-05-05 |
Immatics Biotechnologies Gmbh |
HLA-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof
|
|
WO2011091319A2
(en)
|
2010-01-22 |
2011-07-28 |
Baylor Research Institute |
Dendritic cell vaccines
|
|
GB201006360D0
(en)
|
2010-04-16 |
2010-06-02 |
Immatics Biotechnologies Gmbh |
Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
|
|
US9115402B2
(en)
|
2010-05-14 |
2015-08-25 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods of identifying tumor specific neoantigens
|
|
US9089520B2
(en)
|
2010-05-21 |
2015-07-28 |
Baylor College Of Medicine |
Methods for inducing selective apoptosis
|
|
CN103221042B
(zh)
|
2010-06-02 |
2016-02-10 |
阿布拉科斯生物科学有限公司 |
治疗膀胱癌的方法
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
WO2012095639A2
(en)
|
2011-01-14 |
2012-07-19 |
Genefirst Limited |
Methods, compositions, and kits for determing the presence/absence of a varian nucleic acid sequence
|
|
EP2478915A1
(en)
|
2011-01-24 |
2012-07-25 |
Genticel |
CyaA-carried polypeptide(s) and use to induce both therapeutic and prophylactic immune responses
|
|
US8999937B2
(en)
|
2011-02-28 |
2015-04-07 |
Indiana University Research And Technology Corporation |
Glucocorticoid induced leucine zipper mimetics as therapeutic agents in multiple sclerosis
|
|
LT2714071T
(lt)
|
2011-05-24 |
2019-10-10 |
Biontech Rna Pharmaceuticals Gmbh |
Individualizuotos vakcinos nuo vėžio
|
|
WO2012159643A1
(en)
|
2011-05-24 |
2012-11-29 |
Biontech Ag |
Individualized vaccines for cancer
|
|
EP2744912B1
(en)
|
2011-08-18 |
2016-11-02 |
Nestec S.A. |
Compositions and methods for detecting allelic variants
|
|
SI2755997T1
(sl)
|
2011-09-15 |
2018-11-30 |
The United States of America, as represented by Secretary, Department of Health and Human Services, Office of Technology Transfer, National Institutes of Health |
T-celični receptorji, ki prepoznajo HLA-A1- ali HLA-CW7-omejeni mage
|
|
WO2013086464A1
(en)
|
2011-12-07 |
2013-06-13 |
The Broad Institute, Inc. |
Markers associated with chronic lymphocytic leukemia prognosis and progression
|
|
US20130210014A1
(en)
|
2012-02-10 |
2013-08-15 |
Jeff Sharman |
Method for determining the prognosis and therapeutic response in chronic lymphocytic leukemia (cll) patients
|
|
AU2013221642A1
(en)
|
2012-02-15 |
2014-09-25 |
Janssen Diagnostics, Llc |
Highly sensitive method for detecting low frequency mutations
|
|
WO2013151664A1
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins
|
|
NZ702108A
(en)
|
2012-05-03 |
2016-09-30 |
Hutchinson Fred Cancer Res |
Enhanced affinity t cell receptors and methods for making the same
|
|
US9856320B2
(en)
|
2012-05-15 |
2018-01-02 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
|
|
SG10201806573TA
(en)
|
2012-05-25 |
2018-09-27 |
Cellectis |
Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
|
|
MX364370B
(es)
|
2012-07-12 |
2019-04-24 |
Persimmune Inc |
Vacunas contra el cancer personalizadas y terapias de celulas inmunes adoptivas.
|
|
IN2014DN10889A
(enExample)
|
2012-07-13 |
2015-09-11 |
Univ Pennsylvania |
|
|
NZ741124A
(en)
|
2012-07-27 |
2019-11-29 |
Univ Illinois |
Engineering t-cell receptors
|
|
WO2014056986A1
(en)
|
2012-10-11 |
2014-04-17 |
Universitat De Barcelona |
Method to predict the clinical evolution of a patient suffering of chronic lymphocytic leukemia (cll)
|
|
IL298125A
(en)
|
2013-02-26 |
2023-01-01 |
Memorial Sloan Kettering Cancer Center |
Preparations and methods for immunotherapy
|
|
US10176294B2
(en)
|
2013-03-15 |
2019-01-08 |
The Broad Institute, Inc. |
Accurate typing of HLA through exome sequencing
|
|
WO2014172606A1
(en)
|
2013-04-19 |
2014-10-23 |
The Brigham And Women's Hospital, Inc. |
Methods for modulating immune responses during chronic immune conditions by targeting metallothioneins
|
|
CA2912375C
(en)
|
2013-05-13 |
2023-03-14 |
Cellectis |
Methods for engineering highly active t cell for immunotherapy
|
|
JP6608807B2
(ja)
|
2013-05-29 |
2019-11-20 |
セレクティス |
Rnaガイドcasヌクレアーゼ系を用いることによって免疫療法のためにt細胞を操作するための方法
|
|
AU2014275166B2
(en)
|
2013-06-06 |
2020-09-10 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment prevention, and treatment of cancer using PD-L1 isoforms
|
|
JP6740127B2
(ja)
|
2013-12-06 |
2020-08-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新生物ワクチン用製剤
|
|
JP7060324B2
(ja)
|
2013-12-20 |
2022-04-26 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
ネオ抗原ワクチンによる併用療法
|
|
MX2016009306A
(es)
|
2014-01-17 |
2017-04-10 |
Dbv Tech |
Reequilibrado inmunologico epicutaneo.
|
|
EP3110971B1
(en)
|
2014-02-27 |
2019-05-08 |
The Broad Institute Inc. |
T cell balance gene expression and methods of use thereof
|
|
US20170261508A1
(en)
|
2014-03-14 |
2017-09-14 |
The Trustees Of The University Of Pennsylvania |
Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration
|
|
US20160252511A1
(en)
|
2014-03-14 |
2016-09-01 |
Brian J. Czemiecki |
Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration
|
|
US10690658B2
(en)
|
2014-06-05 |
2020-06-23 |
Aimm Therapeutics B.V. |
Means and methods for determining T cell recognition
|
|
WO2016011487A1
(en)
|
2014-07-23 |
2016-01-28 |
Deakin University |
Antagonistic peptides
|
|
SI3198026T1
(sl)
|
2014-08-07 |
2020-02-28 |
Pharmassist Ltd |
Metoda za analiziranje DNA PIK3CA mutantnega statusa v vzorcu
|
|
CN107073070A
(zh)
*
|
2014-08-15 |
2017-08-18 |
格纳西尼有限公司 |
治疗宫颈癌的方法
|
|
EP3421046A1
(en)
|
2014-11-04 |
2019-01-02 |
Janssen Vaccines & Prevention B.V. |
Therapeutic hpv16 vaccines
|
|
US10975442B2
(en)
|
2014-12-19 |
2021-04-13 |
Massachusetts Institute Of Technology |
Molecular biomarkers for cancer immunotherapy
|
|
KR102698184B1
(ko)
*
|
2015-01-29 |
2024-08-23 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
관문 억제제 및 백신 조합 및 면역요법을 위한 이들의 사용
|
|
EP3265562A4
(en)
|
2015-03-05 |
2018-12-19 |
TrovaGene, Inc. |
Early assessment of mechanism of action and efficacy of anti-cancer therapies using molecular markers in bodily fluids
|
|
WO2016144976A1
(en)
|
2015-03-09 |
2016-09-15 |
Kings College London |
Combination therapy with rar alpha agonists for enhancing th1 response
|
|
EP3075389A1
(en)
|
2015-03-31 |
2016-10-05 |
Technische Universität München |
T cell receptors and peptides derived by mutations for the treatment of cancer
|
|
US20190099475A1
(en)
|
2015-04-08 |
2019-04-04 |
Nantomics, Llc |
Cancer neoepitopes
|
|
JP6913032B2
(ja)
|
2015-05-20 |
2021-08-04 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
共通ネオ抗原
|
|
WO2016203577A1
(ja)
|
2015-06-17 |
2016-12-22 |
株式会社医学生物学研究所 |
細胞傷害性t細胞エピトープペプチド及びその用途
|
|
WO2017004153A1
(en)
|
2015-06-29 |
2017-01-05 |
The Broad Institute Inc. |
Tumor and microenvironment gene expression, compositions of matter and methods of use thereof
|
|
WO2017011710A2
(en)
|
2015-07-14 |
2017-01-19 |
Whitehead Institute For Biomedical Research |
Chromosome neighborhood structures and methods relating thereto
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
US11492670B2
(en)
|
2015-10-27 |
2022-11-08 |
The Broad Institute Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
JP6976960B2
(ja)
|
2015-11-27 |
2021-12-08 |
カーサリクス プロプライエタリー リミテッド |
遺伝子改変された細胞およびその使用
|
|
CN108701172A
(zh)
|
2016-02-12 |
2018-10-23 |
南托米克斯有限责任公司 |
高通量识别患者特异性新表位作为癌症免疫疗法的治疗靶点
|
|
CN105693828A
(zh)
|
2016-02-17 |
2016-06-22 |
深圳市中美康士生物科技有限公司 |
一种新的eb病毒ebna1表位肽及其在ebv相关疾病的诊断、治疗和预防中的用途
|
|
GB201603568D0
(en)
|
2016-03-01 |
2016-04-13 |
Immatics Biotechnologies Gmbh |
Efficient treatment options including peptides and combination of peptide and cell based medicaments for use in immunotherapy against urinary bladder cancer
|
|
SG11201808196UA
(en)
|
2016-03-31 |
2018-10-30 |
Neon Therapeutics Inc |
Neoantigens and methods of their use
|
|
KR102614675B1
(ko)
|
2016-04-15 |
2023-12-19 |
메모리얼 슬로안 케터링 캔서 센터 |
유전자이식 t 세포 및 키메라 항원 수용체 t 세포 조성물 및 관련 방법
|
|
AU2017254477A1
(en)
|
2016-04-18 |
2018-11-01 |
Jennifer G. ABELIN |
Improved HLA epitope prediction
|
|
WO2018037416A1
(en)
|
2016-08-25 |
2018-03-01 |
Yeda Research And Development Co. Ltd. |
Methods and compositions for treating autoimmune diseases
|
|
KR20190093816A
(ko)
*
|
2016-10-26 |
2019-08-26 |
큐어백 아게 |
지질 나노입자 mRNA 백신
|
|
EP3574116A1
(en)
|
2017-01-24 |
2019-12-04 |
The Broad Institute, Inc. |
Compositions and methods for detecting a mutant variant of a polynucleotide
|
|
WO2020000587A1
(zh)
|
2018-06-26 |
2020-01-02 |
龚浩 |
一种方便清洁的灭虫灯
|