JP2023082171A5 - - Google Patents
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- JP2023082171A5 JP2023082171A5 JP2023060933A JP2023060933A JP2023082171A5 JP 2023082171 A5 JP2023082171 A5 JP 2023082171A5 JP 2023060933 A JP2023060933 A JP 2023060933A JP 2023060933 A JP2023060933 A JP 2023060933A JP 2023082171 A5 JP2023082171 A5 JP 2023082171A5
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- 239000003814 drug Substances 0.000 claims 54
- 229940079593 drug Drugs 0.000 claims 53
- 150000001875 compounds Chemical class 0.000 claims 51
- 125000000217 alkyl group Chemical group 0.000 claims 38
- 229910052739 hydrogen Inorganic materials 0.000 claims 37
- 239000003446 ligand Substances 0.000 claims 31
- 229910052757 nitrogen Inorganic materials 0.000 claims 31
- 229910052799 carbon Inorganic materials 0.000 claims 30
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 29
- 239000000562 conjugate Substances 0.000 claims 26
- 239000001257 hydrogen Substances 0.000 claims 25
- 150000003839 salts Chemical group 0.000 claims 20
- 125000005842 heteroatom Chemical group 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 17
- 125000002947 alkylene group Chemical group 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 238000007363 ring formation reaction Methods 0.000 claims 14
- 125000006850 spacer group Chemical group 0.000 claims 13
- 101000629400 Homo sapiens Mesoderm-specific transcript homolog protein Proteins 0.000 claims 12
- 102100026821 Mesoderm-specific transcript homolog protein Human genes 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 150000001721 carbon Chemical group 0.000 claims 12
- 150000008134 glucuronides Chemical group 0.000 claims 12
- 150000003335 secondary amines Chemical class 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 150000003512 tertiary amines Chemical group 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 108010016626 Dipeptides Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 238000003776 cleavage reaction Methods 0.000 claims 7
- 230000007017 scission Effects 0.000 claims 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims 6
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000004103 aminoalkyl group Chemical group 0.000 claims 6
- 239000000611 antibody drug conjugate Substances 0.000 claims 6
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 6
- 230000002159 abnormal effect Effects 0.000 claims 5
- 150000001412 amines Chemical class 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 125000004122 cyclic group Chemical group 0.000 claims 5
- 125000000524 functional group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 4
- 239000004365 Protease Substances 0.000 claims 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 4
- 125000002015 acyclic group Chemical group 0.000 claims 4
- 125000000837 carbohydrate group Chemical group 0.000 claims 4
- 239000002131 composite material Substances 0.000 claims 4
- 125000006575 electron-withdrawing group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000004434 sulfur atom Chemical group 0.000 claims 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 3
- 235000008206 alpha-amino acids Nutrition 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 108010044540 auristatin Proteins 0.000 claims 3
- 150000001576 beta-amino acids Chemical class 0.000 claims 3
- SNCZNSNPXMPCGN-UHFFFAOYSA-N butanediamide Chemical compound NC(=O)CCC(N)=O SNCZNSNPXMPCGN-UHFFFAOYSA-N 0.000 claims 3
- -1 compound compound Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 230000003463 hyperproliferative effect Effects 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 206010000830 Acute leukaemia Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 101710160107 Outer membrane protein A Proteins 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010039491 Sarcoma Diseases 0.000 claims 2
- 208000009956 adenocarcinoma Diseases 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 208000024207 chronic leukemia Diseases 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 125000005549 heteroarylene group Chemical group 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 229930184737 tubulysin Natural products 0.000 claims 2
- DLKUYSQUHXBYPB-NSSHGSRYSA-N (2s,4r)-4-[[2-[(1r,3r)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2s,3s)-3-methyl-2-[[(2r)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-2-methyl-5-(4-methylphenyl)pentanoic acid Chemical compound N([C@@H]([C@@H](C)CC)C(=O)N(COC(=O)CC(C)C)[C@H](C[C@@H](OC(C)=O)C=1SC=C(N=1)C(=O)N[C@H](C[C@H](C)C(O)=O)CC=1C=CC(C)=CC=1)C(C)C)C(=O)[C@H]1CCCCN1C DLKUYSQUHXBYPB-NSSHGSRYSA-N 0.000 claims 1
- OMRPLUKQNWNZAV-CONSDPRKSA-N (6as)-3-[3-[[(6as)-2-methoxy-8-(4-methoxyphenyl)-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-8-(4-aminophenyl)-2-methoxy-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one Chemical compound C1=CC(OC)=CC=C1C1=CN2C(=O)C3=CC(OC)=C(OCCCOC=4C(=CC=5C(=O)N6C=C(C[C@H]6C=NC=5C=4)C=4C=CC(N)=CC=4)OC)C=C3N=C[C@@H]2C1 OMRPLUKQNWNZAV-CONSDPRKSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 206010000890 Acute myelomonocytic leukaemia Diseases 0.000 claims 1
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 1
- 201000003076 Angiosarcoma Diseases 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010006417 Bronchial carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000005243 Chondrosarcoma Diseases 0.000 claims 1
- 201000009047 Chordoma Diseases 0.000 claims 1
- 208000006332 Choriocarcinoma Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000009798 Craniopharyngioma Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
- 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 claims 1
- 208000036566 Erythroleukaemia Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 201000008808 Fibrosarcoma Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical group NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025219 Lymphangioma Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims 1
- 208000007054 Medullary Carcinoma Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000035490 Megakaryoblastic Acute Leukemia Diseases 0.000 claims 1
- 206010027406 Mesothelioma Diseases 0.000 claims 1
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 208000033835 Myelomonocytic Acute Leukemia Diseases 0.000 claims 1
- 206010028729 Nasal cavity cancer Diseases 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000005890 Neuroma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000007641 Pinealoma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 206010043515 Throat cancer Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 208000014070 Vestibular schwannoma Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 208000004064 acoustic neuroma Diseases 0.000 claims 1
- 208000017733 acquired polycythemia vera Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 208000021841 acute erythroid leukemia Diseases 0.000 claims 1
- 208000037832 acute lymphoblastic B-cell leukemia Diseases 0.000 claims 1
- 208000037833 acute lymphoblastic T-cell leukemia Diseases 0.000 claims 1
- 208000013593 acute megakaryoblastic leukemia Diseases 0.000 claims 1
- 208000020700 acute megakaryocytic leukemia Diseases 0.000 claims 1
- 208000011912 acute myelomonocytic leukemia M4 Diseases 0.000 claims 1
- 208000036676 acute undifferentiated leukemia Diseases 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 208000003362 bronchogenic carcinoma Diseases 0.000 claims 1
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- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000002445 cystadenocarcinoma Diseases 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 229930182480 glucuronide Natural products 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 208000025750 heavy chain disease Diseases 0.000 claims 1
- 201000002222 hemangioblastoma Diseases 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 206010024627 liposarcoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
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- 208000015534 lymphangioendothelioma Diseases 0.000 claims 1
- 208000012804 lymphangiosarcoma Diseases 0.000 claims 1
- 230000000527 lymphocytic effect Effects 0.000 claims 1
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- 230000002132 lysosomal effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
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- 201000008026 nephroblastoma Diseases 0.000 claims 1
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- 201000002528 pancreatic cancer Diseases 0.000 claims 1
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- 208000004019 papillary adenocarcinoma Diseases 0.000 claims 1
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- 206010035059 pineocytoma Diseases 0.000 claims 1
- 208000037244 polycythemia vera Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 201000008407 sebaceous adenocarcinoma Diseases 0.000 claims 1
- 201000007321 sebaceous carcinoma Diseases 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 201000010965 sweat gland carcinoma Diseases 0.000 claims 1
- 210000001258 synovial membrane Anatomy 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662372455P | 2016-08-09 | 2016-08-09 | |
| US62/372,455 | 2016-08-09 | ||
| JP2019503986A JP7257951B2 (ja) | 2016-08-09 | 2017-08-09 | 改善された生理化学的特性を有する自己安定性リンカーを用いる薬物コンジュゲート |
| PCT/US2017/046157 WO2018031690A1 (en) | 2016-08-09 | 2017-08-09 | Drug conjugates with self-stabilizing linkers having improved physiochemical properties |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503986A Division JP7257951B2 (ja) | 2016-08-09 | 2017-08-09 | 改善された生理化学的特性を有する自己安定性リンカーを用いる薬物コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023082171A JP2023082171A (ja) | 2023-06-13 |
| JP2023082171A5 true JP2023082171A5 (https=) | 2023-07-18 |
| JP7573679B2 JP7573679B2 (ja) | 2024-10-25 |
Family
ID=61162990
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503986A Active JP7257951B2 (ja) | 2016-08-09 | 2017-08-09 | 改善された生理化学的特性を有する自己安定性リンカーを用いる薬物コンジュゲート |
| JP2023060933A Active JP7573679B2 (ja) | 2016-08-09 | 2023-04-04 | 改善された生理化学的特性を有する自己安定性リンカーを用いる薬物コンジュゲート |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503986A Active JP7257951B2 (ja) | 2016-08-09 | 2017-08-09 | 改善された生理化学的特性を有する自己安定性リンカーを用いる薬物コンジュゲート |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11944689B2 (https=) |
| EP (1) | EP3496747A4 (https=) |
| JP (2) | JP7257951B2 (https=) |
| KR (2) | KR20190038579A (https=) |
| CN (1) | CN109562152B (https=) |
| AU (2) | AU2017310436B2 (https=) |
| BR (1) | BR112019001945A2 (https=) |
| EA (1) | EA201990470A1 (https=) |
| IL (1) | IL264453A (https=) |
| MA (1) | MA45945A (https=) |
| MX (2) | MX2019001302A (https=) |
| SG (1) | SG11201900699QA (https=) |
| TW (2) | TWI851531B (https=) |
| WO (1) | WO2018031690A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240156969A1 (en) * | 2015-12-04 | 2024-05-16 | Seagen Inc. | Conjugates of quaternized tubulysin compounds |
| CN109843919A (zh) | 2016-03-25 | 2019-06-04 | 西雅图基因公司 | 用于制备聚乙二醇化的药物-接头及其中间体的方法 |
| TWI851531B (zh) | 2016-08-09 | 2024-08-11 | 美商思進公司 | 具有改善之生理化學性質之具自我穩定連接子之藥物結合物 |
| KR102648564B1 (ko) | 2017-03-24 | 2024-03-19 | 씨젠 인크. | 글루쿠로니드 약물-링커의 제조 공정 및 그 중간물 |
| TWI851577B (zh) | 2018-06-07 | 2024-08-11 | 美商思進公司 | 喜樹鹼結合物 |
| GB201820864D0 (en) * | 2018-12-20 | 2019-02-06 | J A Kemp | Antibody-drug conjugates |
| JP7590328B2 (ja) | 2018-12-21 | 2024-11-26 | レゲネロン ファーマシューティカルス，インコーポレーテッド | ツブリシン及びタンパク質－ツブリシンコンジュゲート |
| KR102501394B1 (ko) * | 2019-05-02 | 2023-02-21 | 주식회사 레고켐 바이오사이언스 | 트리스 구조를 가지는 링커를 포함하는 리간드-약물 접합체 |
| JP2022530482A (ja) * | 2019-05-02 | 2022-06-29 | レゴケム バイオサイエンシズ， インク． | トリス構造を有するリンカーを含むリガンド―薬物複合体 |
| US20220304993A1 (en) * | 2019-06-21 | 2022-09-29 | Ascendis Pharma A/S | Conjugates of an electron-donating nitrogen or tertiary amine comprising compounds |
| CN115867283A (zh) * | 2020-12-23 | 2023-03-28 | 启德医药科技（苏州）有限公司 | 包含开环硫代琥珀酰亚胺基团、寡肽片段和手性部分的新型异构化合物 |
| US20240209080A1 (en) | 2021-04-10 | 2024-06-27 | Profoundbio Us Co. | Folr1 binding agents, conjugates thereof and methods of using the same |
| CA3216459A1 (en) | 2021-04-23 | 2022-10-27 | Profoundbio Us Co. | Anti-cd70 antibodies, conjugates thereof and methods of using the same |
| TW202320857A (zh) | 2021-07-06 | 2023-06-01 | 美商普方生物製藥美國公司 | 連接子、藥物連接子及其結合物及其使用方法 |
| CN118119409A (zh) | 2021-09-03 | 2024-05-31 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
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-
2017
- 2017-08-09 TW TW106126961A patent/TWI851531B/zh active
- 2017-08-09 US US16/324,198 patent/US11944689B2/en active Active
- 2017-08-09 CN CN201780047894.1A patent/CN109562152B/zh active Active
- 2017-08-09 MA MA045945A patent/MA45945A/fr unknown
- 2017-08-09 BR BR112019001945-6A patent/BR112019001945A2/pt unknown
- 2017-08-09 KR KR1020197005530A patent/KR20190038579A/ko not_active Ceased
- 2017-08-09 WO PCT/US2017/046157 patent/WO2018031690A1/en not_active Ceased
- 2017-08-09 EA EA201990470A patent/EA201990470A1/ru unknown
- 2017-08-09 JP JP2019503986A patent/JP7257951B2/ja active Active
- 2017-08-09 AU AU2017310436A patent/AU2017310436B2/en not_active Ceased
- 2017-08-09 MX MX2019001302A patent/MX2019001302A/es unknown
- 2017-08-09 EP EP17840229.3A patent/EP3496747A4/en active Pending
- 2017-08-09 KR KR1020247000631A patent/KR20240010534A/ko not_active Withdrawn
- 2017-08-09 TW TW113107936A patent/TW202500191A/zh unknown
- 2017-08-09 SG SG11201900699QA patent/SG11201900699QA/en unknown
-
2019
- 2019-01-24 IL IL264453A patent/IL264453A/en unknown
-
2022
- 2022-11-24 AU AU2022275478A patent/AU2022275478B2/en not_active Expired - Fee Related
-
2023
- 2023-04-04 JP JP2023060933A patent/JP7573679B2/ja active Active
- 2023-12-13 MX MX2023013592A patent/MX2023013592A/es unknown
-
2024
- 2024-01-11 US US18/410,296 patent/US20240226320A1/en not_active Abandoned
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