JP2023058612A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2023058612A5 JP2023058612A5 JP2023017898A JP2023017898A JP2023058612A5 JP 2023058612 A5 JP2023058612 A5 JP 2023058612A5 JP 2023017898 A JP2023017898 A JP 2023017898A JP 2023017898 A JP2023017898 A JP 2023017898A JP 2023058612 A5 JP2023058612 A5 JP 2023058612A5
- Authority
- JP
- Japan
- Prior art keywords
- metabolite
- acid
- subject
- biomarkers
- acid amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002207 metabolite Substances 0.000 claims 32
- 239000000090 biomarker Substances 0.000 claims 25
- 238000000034 method Methods 0.000 claims 21
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 8
- 206010019860 Hereditary angioedema Diseases 0.000 claims 7
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 6
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims 4
- 239000000523 sample Substances 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 3
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 3
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 3
- HSEMFIZWXHQJAE-UHFFFAOYSA-N hexadecanamide Chemical compound CCCCCCCCCCCCCCCC(N)=O HSEMFIZWXHQJAE-UHFFFAOYSA-N 0.000 claims 3
- SFIHQZFZMWZOJV-HZJYTTRNSA-N linoleamide Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(N)=O SFIHQZFZMWZOJV-HZJYTTRNSA-N 0.000 claims 3
- 238000004949 mass spectrometry Methods 0.000 claims 3
- FATBGEAMYMYZAF-KTKRTIGZSA-N oleamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(N)=O FATBGEAMYMYZAF-KTKRTIGZSA-N 0.000 claims 3
- 229940076279 serotonin Drugs 0.000 claims 3
- UNSRRHDPHVZAHH-YOILPLPUSA-N (5Z,8Z,11Z)-icosatrienoic acid Chemical compound CCCCCCCC\C=C/C\C=C/C\C=C/CCCC(O)=O UNSRRHDPHVZAHH-YOILPLPUSA-N 0.000 claims 2
- CQSLTKIXAJTQGA-FLIBITNWSA-N 12,13-DiHOME Chemical compound CCCCCC(O)C(O)C\C=C/CCCCCCCC(O)=O CQSLTKIXAJTQGA-FLIBITNWSA-N 0.000 claims 2
- HNICUWMFWZBIFP-IRQZEAMPSA-N 13(S)-HODE Chemical compound CCCCC[C@H](O)\C=C\C=C/CCCCCCCC(O)=O HNICUWMFWZBIFP-IRQZEAMPSA-N 0.000 claims 2
- FFXKPSNQCPNORO-MBYQGORISA-N 19,20-DiHDPA Chemical compound CCC(O)C(O)C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O FFXKPSNQCPNORO-MBYQGORISA-N 0.000 claims 2
- UNSRRHDPHVZAHH-UHFFFAOYSA-N 6beta,11alpha-Dihydroxy-3alpha,5alpha-cyclopregnan-20-on Natural products CCCCCCCCC=CCC=CCC=CCCCC(O)=O UNSRRHDPHVZAHH-UHFFFAOYSA-N 0.000 claims 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims 2
- 102100029111 Fatty-acid amide hydrolase 1 Human genes 0.000 claims 2
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical group NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- CZWCKYRVOZZJNM-USOAJAOKSA-N dehydroepiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 CZWCKYRVOZZJNM-USOAJAOKSA-N 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 108010046094 fatty-acid amide hydrolase Proteins 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000004060 metabolic process Effects 0.000 claims 2
- 229940055726 pantothenic acid Drugs 0.000 claims 2
- 235000019161 pantothenic acid Nutrition 0.000 claims 2
- 239000011713 pantothenic acid Substances 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 claims 2
- 230000037359 steroid metabolism Effects 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- YWYQTGBBEZQBGO-ZVPCKFNKSA-N (3s,5s,8r,9s,10s,13s,14s,17s)-17-[(1s)-1-hydroxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-ZVPCKFNKSA-N 0.000 claims 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims 1
- ALBNSVAJDFJRKQ-DNKQKWOHSA-N 16alpha-hydroxydehydroepiandrosterone 3-sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C([C@H](O)C4)=O)[C@@H]4[C@@H]3CC=C21 ALBNSVAJDFJRKQ-DNKQKWOHSA-N 0.000 claims 1
- GOLXRNDWAUTYKT-UHFFFAOYSA-M 3-(1H-indol-3-yl)propanoate Chemical compound C1=CC=C2C(CCC(=O)[O-])=CNC2=C1 GOLXRNDWAUTYKT-UHFFFAOYSA-M 0.000 claims 1
- XGILAAMKEQUXLS-UHFFFAOYSA-N 3-(indol-3-yl)lactic acid Chemical compound C1=CC=C2C(CC(O)C(O)=O)=CNC2=C1 XGILAAMKEQUXLS-UHFFFAOYSA-N 0.000 claims 1
- ADVPTQAUNPRNPO-REOHCLBHSA-N 3-sulfino-L-alanine Chemical compound OC(=O)[C@@H](N)C[S@@](O)=O ADVPTQAUNPRNPO-REOHCLBHSA-N 0.000 claims 1
- AURFZBICLPNKBZ-YZRLXODZSA-N 3alpha-hydroxy-5beta-pregnan-20-one Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-YZRLXODZSA-N 0.000 claims 1
- BTTWKVFKBPAFDK-LOVVWNRFSA-N 4-Androstenediol Chemical compound O[C@H]1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 BTTWKVFKBPAFDK-LOVVWNRFSA-N 0.000 claims 1
- UWPTUYJASNIIJM-LOVVWNRFSA-N 4-androstene-3beta,17beta-diol disulfate Chemical compound OS(=O)(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)OS(O)(=O)=O)[C@@H]4[C@@H]3CCC2=C1 UWPTUYJASNIIJM-LOVVWNRFSA-N 0.000 claims 1
- CBMYJHIOYJEBSB-CUZKMJQKSA-N 5a-androstane-3a,17a-diol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 CBMYJHIOYJEBSB-CUZKMJQKSA-N 0.000 claims 1
- JHFAETDERBWUOO-YSZCXEEOSA-N 5alpha-androstane-3beta,17beta-diol disulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)OS(O)(=O)=O)[C@@H]4[C@@H]3CC[C@H]21 JHFAETDERBWUOO-YSZCXEEOSA-N 0.000 claims 1
- XEBKSQSGNGRGDW-YFHOEESVSA-N 9,10-DiHOME Chemical compound CCCCC\C=C/CC(O)C(O)CCCCCCCC(O)=O XEBKSQSGNGRGDW-YFHOEESVSA-N 0.000 claims 1
- CUHJQOVOXFVMSQ-UHFFFAOYSA-N 9-hydroxyoctadeca-2,4-dienoic acid Chemical compound CCCCCCCCCC(O)CCCC=CC=CC(O)=O CUHJQOVOXFVMSQ-UHFFFAOYSA-N 0.000 claims 1
- ZMITXKRGXGRMKS-UHFFFAOYSA-N Androsteronsulfat-pyridiniumsalz Natural products C1C(OS(O)(=O)=O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC21 ZMITXKRGXGRMKS-UHFFFAOYSA-N 0.000 claims 1
- OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 claims 1
- UCUNFLYVYCGDHP-BYPYZUCNSA-N L-methionine sulfone Chemical compound CS(=O)(=O)CC[C@H](N)C(O)=O UCUNFLYVYCGDHP-BYPYZUCNSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- XUYPXLNMDZIRQH-LURJTMIESA-N N-acetyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC(C)=O XUYPXLNMDZIRQH-LURJTMIESA-N 0.000 claims 1
- QAAQQTDJEXMIMF-YZXCLFAISA-N Pregn-5-ene-3beta,20alpha-diol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@@H](O)C)[C@@]1(C)CC2 QAAQQTDJEXMIMF-YZXCLFAISA-N 0.000 claims 1
- ZFFFJLDTCLJDHL-JQYCEVDMSA-N Pregnanediol-3-glucuronide Chemical compound O([C@H]1C[C@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H](O)C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ZFFFJLDTCLJDHL-JQYCEVDMSA-N 0.000 claims 1
- AURFZBICLPNKBZ-UHFFFAOYSA-N Pregnanolone Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 AURFZBICLPNKBZ-UHFFFAOYSA-N 0.000 claims 1
- ZJUKTBDSGOFHSH-WFMPWKQPSA-N S-Adenosylhomocysteine Chemical compound O[C@@H]1[C@H](O)[C@@H](CSCC[C@H](N)C(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZJUKTBDSGOFHSH-WFMPWKQPSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- YWYQTGBBEZQBGO-UHFFFAOYSA-N UC1011 Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(O)C)C1(C)CC2 YWYQTGBBEZQBGO-UHFFFAOYSA-N 0.000 claims 1
- MENQCIVHHONJLU-FZCSVUEKSA-N [(3s,5s,8r,9s,10s,13s,14s,17s)-17-acetyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate Chemical compound C([C@@H]1CC2)[C@@H](OS(O)(=O)=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 MENQCIVHHONJLU-FZCSVUEKSA-N 0.000 claims 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims 1
- ADVPTQAUNPRNPO-UHFFFAOYSA-N alpha-amino-beta-sulfino-propionic acid Natural products OC(=O)C(N)CS(O)=O ADVPTQAUNPRNPO-UHFFFAOYSA-N 0.000 claims 1
- ZMITXKRGXGRMKS-HLUDHZFRSA-N androsterone sulfate Chemical compound C1[C@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@H]21 ZMITXKRGXGRMKS-HLUDHZFRSA-N 0.000 claims 1
- 238000005251 capillar electrophoresis Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 claims 1
- 229960004544 cortisone Drugs 0.000 claims 1
- 229960003067 cystine Drugs 0.000 claims 1
- VFNGKCDDZUSWLR-UHFFFAOYSA-L disulfate(2-) Chemical compound [O-]S(=O)(=O)OS([O-])(=O)=O VFNGKCDDZUSWLR-UHFFFAOYSA-L 0.000 claims 1
- 229950007402 eltanolone Drugs 0.000 claims 1
- ZMITXKRGXGRMKS-LUJOEAJASA-N epiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@H]21 ZMITXKRGXGRMKS-LUJOEAJASA-N 0.000 claims 1
- 238000004817 gas chromatography Methods 0.000 claims 1
- 229930182480 glucuronide Natural products 0.000 claims 1
- 150000008134 glucuronides Chemical class 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 238000003018 immunoassay Methods 0.000 claims 1
- -1 lipid peroxide Chemical class 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 229940099459 n-acetylmethionine Drugs 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 229950009829 prasterone sulfate Drugs 0.000 claims 1
- DIJBBUIOWGGQOP-QGVNFLHTSA-N pregnenolone sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 DIJBBUIOWGGQOP-QGVNFLHTSA-N 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- CBXWGGFGZDVPNV-UHFFFAOYSA-N so4-so4 Chemical compound OS(O)(=O)=O.OS(O)(=O)=O CBXWGGFGZDVPNV-UHFFFAOYSA-N 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024034012A JP7692508B2 (ja) | 2016-09-16 | 2024-03-06 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
| JP2025092519A JP2025124816A (ja) | 2016-09-16 | 2025-06-03 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662395770P | 2016-09-16 | 2016-09-16 | |
| US62/395,770 | 2016-09-16 | ||
| US201762518367P | 2017-06-12 | 2017-06-12 | |
| US62/518,367 | 2017-06-12 | ||
| JP2019514825A JP7225090B2 (ja) | 2016-09-16 | 2017-09-15 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
| PCT/US2017/051755 WO2018053247A1 (en) | 2016-09-16 | 2017-09-15 | Metabolite biomarkers for diseases associated with the contact activation system |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514825A Division JP7225090B2 (ja) | 2016-09-16 | 2017-09-15 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024034012A Division JP7692508B2 (ja) | 2016-09-16 | 2024-03-06 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023058612A JP2023058612A (ja) | 2023-04-25 |
| JP2023058612A5 true JP2023058612A5 (enExample) | 2023-10-10 |
| JP7451791B2 JP7451791B2 (ja) | 2024-03-18 |
Family
ID=59974882
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514825A Active JP7225090B2 (ja) | 2016-09-16 | 2017-09-15 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
| JP2023017898A Active JP7451791B2 (ja) | 2016-09-16 | 2023-02-08 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
| JP2024034012A Active JP7692508B2 (ja) | 2016-09-16 | 2024-03-06 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
| JP2025092519A Pending JP2025124816A (ja) | 2016-09-16 | 2025-06-03 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019514825A Active JP7225090B2 (ja) | 2016-09-16 | 2017-09-15 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024034012A Active JP7692508B2 (ja) | 2016-09-16 | 2024-03-06 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
| JP2025092519A Pending JP2025124816A (ja) | 2016-09-16 | 2025-06-03 | 接触活性化系に関連する疾患の代謝物バイオマーカー |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11340237B2 (enExample) |
| EP (1) | EP3513197A1 (enExample) |
| JP (4) | JP7225090B2 (enExample) |
| KR (3) | KR20250030022A (enExample) |
| CN (2) | CN117169508A (enExample) |
| AU (2) | AU2017325986B2 (enExample) |
| BR (1) | BR112019005167A2 (enExample) |
| CA (1) | CA3037157A1 (enExample) |
| CO (1) | CO2019002607A2 (enExample) |
| IL (2) | IL314752A (enExample) |
| MX (2) | MX2019002918A (enExample) |
| WO (1) | WO2018053247A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20181419T1 (hr) | 2010-01-06 | 2018-11-16 | Dyax Corp. | Plazma kalikrein vezni proteini |
| CN106132442B (zh) * | 2014-01-21 | 2023-07-14 | 武田药品工业株式会社 | 血浆激肽释放酶结合蛋白和其在治疗遗传性血管性水肿中的用途 |
| KR102555955B1 (ko) | 2014-03-27 | 2023-07-18 | 다케다 파머수티컬 컴패니 리미티드 | 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법 |
| AU2017325983B2 (en) | 2016-09-16 | 2023-12-07 | Takeda Pharmaceutical Company Limited | Protein biomarkers for diseases associated with the contact activation system |
| KR20250030022A (ko) | 2016-09-16 | 2025-03-05 | 다케다 파머수티컬 컴패니 리미티드 | 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커 |
| EP3521828A1 (en) * | 2018-01-31 | 2019-08-07 | Centogene AG | Method for the diagnosis of hereditary angioedema |
| EP3999846A4 (en) | 2019-07-25 | 2023-08-09 | Overture Life, Inc | IDENTIFICATION OF VIABLE HUMAN EMBRYO |
| CN110514772A (zh) * | 2019-08-09 | 2019-11-29 | 中国医学科学院基础医学研究所 | 透明肾细胞癌代谢标志物在肾细胞癌早期筛查和诊断产品中的应用 |
| CN113495137A (zh) * | 2021-06-29 | 2021-10-12 | 江苏省中医院 | 两种代谢标志物单独或联合在制备诊断克罗恩病的试剂盒中的应用 |
| CN117310059B (zh) * | 2023-11-30 | 2024-02-02 | 中国人民解放军总医院 | 用于早期诊断或监测克罗恩病的血浆代谢标志物组合及应用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| DE69533472T2 (de) | 1994-01-11 | 2006-01-12 | Dyax Corp., Cambridge | Kallikreinhemmende "kunitz-domäne"-proteine und derivaten davon |
| US20040152633A1 (en) | 2001-05-31 | 2004-08-05 | Jorgensen Marianne Ulrich | Kunitz-type sequences and polypeptides |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| PT1941867E (pt) | 2002-06-07 | 2012-02-16 | Dyax Corp | Polipeptídeo contendo um domínio kunitz modificado |
| WO2005075662A2 (en) * | 2004-01-28 | 2005-08-18 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with kallikrein 2 (klk2) |
| EP1598428A1 (en) | 2004-05-18 | 2005-11-23 | Georg Dewald | Methods and kits to detect Hereditary angioedema type III |
| ITMI20041963A1 (it) * | 2004-10-15 | 2005-01-15 | Luso Farmaco Inst | "antagonisti non-peptidici della bradichinina e loro composizioni farmaceutiche" |
| CA2625744A1 (en) | 2005-10-11 | 2007-04-19 | Tethys Bioscience, Inc. | Diabetes-associated markers and methods of use thereof |
| US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
| CA2658523C (en) * | 2006-07-31 | 2012-06-12 | Activesite Pharmaceuticals, Inc. | Inhibitors of plasma kallikrein |
| EP2069778A2 (en) | 2006-08-03 | 2009-06-17 | Numira Biosciences, Inc. | Methods and compositions for identifying biomarkers |
| WO2008046528A1 (en) | 2006-10-16 | 2008-04-24 | Bayer Healthcare Ag | Npr3 as a biomarker, therapeutic and diagnostic target |
| WO2008046510A1 (en) | 2006-10-16 | 2008-04-24 | Bayer Healthcare Ag | Fn1 as a biomarker, therapeutic and diagnostic target |
| WO2008046512A1 (en) | 2006-10-16 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | Prss23 as a biomarker, therapeutic and diagnostic target |
| ES2383235T3 (es) | 2006-10-16 | 2012-06-19 | Bayer Pharma Aktiengesellschaft | CTGF como biomarcador , diana terapéutica y diagnóstica |
| WO2008046509A1 (en) | 2006-10-16 | 2008-04-24 | Bayer Schering Pharma Aktiengesellschaft | Ltbp2 as a biomarker, therapeutic and diagnostic target |
| US20100081136A1 (en) | 2006-10-16 | 2010-04-01 | Stefan Golz | Crtac as a biomarker, therapeutic and diagnostic target |
| WO2008046508A1 (en) | 2006-10-16 | 2008-04-24 | Bayer Healthcare Ag | Tgfb2 as a biomarker, therapeutic and diagnostic target |
| FR2914066B1 (fr) | 2007-03-20 | 2009-05-22 | Polyintell Sarl | Kit d'analyse comprenant au moins deux polymeres a empreintes moleculaires et au moins un marqueur, ainsi que le procede d'analyse l'utilisant |
| EP2281204B1 (en) * | 2008-04-29 | 2014-01-08 | Psychemedics Corporation | Solid phase multi-analyte assay for drugs of abuse and their metabolites |
| WO2010045180A1 (en) * | 2008-10-13 | 2010-04-22 | Metabolon, Inc. | Biomarkers for inflammatory bowel disease and methods using the same |
| CN102667485B (zh) * | 2009-08-12 | 2015-04-22 | 福满代谢组技术有限公司 | 抑郁症的生物标记物、抑郁症的生物标记物的测定方法、计算机程序及记录介质 |
| WO2011051805A1 (en) | 2009-10-27 | 2011-05-05 | Anaxomics Biotech Sl | Methods and systems for identifying molecules or processes of biological interest by using knowledge discovery in biological data |
| PH12012500850A1 (en) * | 2009-10-30 | 2013-01-07 | Prometheus Laboratories Inc | Methods for diagnosing irritable bowel syndrome |
| EP2502079B1 (en) * | 2009-11-20 | 2015-01-28 | Pharnext | New diagnostic tools for charcot-marie-tooth disease |
| HRP20181419T1 (hr) | 2010-01-06 | 2018-11-16 | Dyax Corp. | Plazma kalikrein vezni proteini |
| WO2011119772A1 (en) | 2010-03-23 | 2011-09-29 | Purdue Research Foundation | Early detection of recurrent breast cancer using metabolite profiling |
| US20120040383A1 (en) | 2010-08-12 | 2012-02-16 | Wei Jia | Methods and Kits Relating To Metabolite Biomarkers For Colorectal Cancer |
| IL269565B2 (en) | 2011-01-06 | 2024-06-01 | Dyax Corp | Plasma kallikrein binding proteins |
| JP5986440B2 (ja) * | 2012-07-05 | 2016-09-06 | 国立医薬品食品衛生研究所長 | アルツハイマー病の発症を予測する方法 |
| CN114949001A (zh) * | 2012-08-29 | 2022-08-30 | 加州理工学院 | 孤独症谱系障碍的诊断和治疗 |
| US20140086825A1 (en) * | 2012-09-24 | 2014-03-27 | William J. McFaul | Methods and kits for assessing, modulating and treating substances affecting bodily processes |
| JP6444315B2 (ja) | 2013-01-20 | 2018-12-26 | ダイアックス コーポレーション | ブラジキニン媒介障害の評価および治療 |
| KR102209796B1 (ko) | 2013-01-20 | 2021-01-29 | 다이액스 코포레이션 | pKal 매개 장애의 평가, 검정 및 치료 |
| MX2015012650A (es) * | 2013-03-14 | 2016-06-21 | Shire Human Genetic Therapies | Metodos para el tratamiento de angioedema mediado receptores debradicinina b2. |
| WO2014144380A1 (en) * | 2013-03-15 | 2014-09-18 | Intrexon Corporation | Boron-containing diacylhydrazines |
| KR20250066486A (ko) * | 2013-10-21 | 2025-05-13 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법 |
| EP2884282A1 (en) * | 2013-12-13 | 2015-06-17 | CONARIS research institute AG | Use of tryptophan as a biomarker for patient selection, dosing and therapy monitoring for pharmaceutical compositions targeting the intestinal microbiota in diseases featuring tryptophan deficiency |
| WO2015157407A1 (en) * | 2014-04-08 | 2015-10-15 | Metabolon, Inc. | Small molecule biochemical profiling of individual subjects for disease diagnosis and health assessment |
| US20170343557A1 (en) | 2014-09-22 | 2017-11-30 | Kenneth Kun-Yu WU | Use of 5-methoxytryptophan as diagnostic agent of inflammatory diseases |
| AU2016243160B2 (en) * | 2015-03-30 | 2022-02-24 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for preventing hereditary angioedema attack |
| JP6907188B2 (ja) | 2015-08-13 | 2021-07-21 | ダイアックス コーポレーション | 接触系活性化の評価のためのプロテアーゼ阻害剤を含む真空採血管 |
| JP6570472B2 (ja) | 2016-03-30 | 2019-09-04 | 株式会社マンダム | 毛髪の損傷の評価方法 |
| WO2018053260A1 (en) | 2016-09-16 | 2018-03-22 | Dyax Corp. | Rna biomarkers for hereditary angioedema |
| KR20250030022A (ko) | 2016-09-16 | 2025-03-05 | 다케다 파머수티컬 컴패니 리미티드 | 접촉 활성화 시스템과 연관된 질환을 위한 대사물질 바이오마커 |
| AU2017325983B2 (en) | 2016-09-16 | 2023-12-07 | Takeda Pharmaceutical Company Limited | Protein biomarkers for diseases associated with the contact activation system |
-
2017
- 2017-09-15 KR KR1020257006143A patent/KR20250030022A/ko active Pending
- 2017-09-15 KR KR1020227038426A patent/KR102775437B1/ko active Active
- 2017-09-15 AU AU2017325986A patent/AU2017325986B2/en active Active
- 2017-09-15 WO PCT/US2017/051755 patent/WO2018053247A1/en not_active Ceased
- 2017-09-15 MX MX2019002918A patent/MX2019002918A/es unknown
- 2017-09-15 BR BR112019005167-8A patent/BR112019005167A2/pt active Search and Examination
- 2017-09-15 CA CA3037157A patent/CA3037157A1/en active Pending
- 2017-09-15 EP EP17777137.5A patent/EP3513197A1/en active Pending
- 2017-09-15 IL IL314752A patent/IL314752A/en unknown
- 2017-09-15 JP JP2019514825A patent/JP7225090B2/ja active Active
- 2017-09-15 US US16/333,101 patent/US11340237B2/en active Active
- 2017-09-15 IL IL265199A patent/IL265199B2/en unknown
- 2017-09-15 KR KR1020197010802A patent/KR102464380B1/ko active Active
- 2017-09-15 CN CN202310782203.XA patent/CN117169508A/zh active Pending
- 2017-09-15 CN CN201780057052.4A patent/CN109716137B/zh active Active
-
2019
- 2019-03-13 MX MX2024004195A patent/MX2024004195A/es unknown
- 2019-03-21 CO CONC2019/0002607A patent/CO2019002607A2/es unknown
-
2022
- 2022-04-25 US US17/728,285 patent/US12188948B2/en active Active
-
2023
- 2023-02-08 JP JP2023017898A patent/JP7451791B2/ja active Active
-
2024
- 2024-01-30 AU AU2024200561A patent/AU2024200561A1/en active Pending
- 2024-03-06 JP JP2024034012A patent/JP7692508B2/ja active Active
- 2024-11-26 US US18/960,119 patent/US20250199014A1/en active Pending
-
2025
- 2025-06-03 JP JP2025092519A patent/JP2025124816A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023058612A5 (enExample) | ||
| JP2019534446A5 (enExample) | ||
| Rajska et al. | Metabolomic insight into polycystic ovary syndrome—An overview | |
| JP2023175853A (ja) | 疾患診断および健康評価のための個々の対象の低分子生化学プロファイリングの方法 | |
| Tai et al. | Development and evaluation of a reference measurement procedure for the determination of estradiol-17β in human serum using isotope-dilution liquid Chromatography− Tandem mass spectrometry | |
| EP2502079B1 (en) | New diagnostic tools for charcot-marie-tooth disease | |
| Li et al. | Discovery of novel lipid profiles in PCOS: do insulin and androgen oppositely regulate bioactive lipid production? | |
| US20200116743A1 (en) | Method of Assessing Liver Triglyceride Levels Using a Body Fluid Sample | |
| Feng et al. | Activated NF-κB/Nrf2 and Wnt/β-catenin pathways are associated with lipid metabolism in CKD patients with microalbuminuria and macroalbuminuria | |
| US8470602B2 (en) | Methods and systems for determining the presence or amount of delta 5 steroid compounds in a sample | |
| JP2018502286A (ja) | 脂肪肝疾患のバイオマーカーおよびその使用方法 | |
| Jiewen et al. | Metabolomics in gestational diabetes mellitus: a review | |
| JP2023169161A (ja) | インスリン及びｃ－ペプチドの定量の方法 | |
| Nakatani et al. | Wide-scope targeted analysis of bioactive lipids in human plasma by LC/MS/MS | |
| Dong et al. | A UHPLC-MS/MS method for profiling multifunctional steroids in human hair | |
| Guo et al. | Research progress of metabolomics in psoriasis | |
| Shibata et al. | Methodological approach to the intracrine study and estimation of DHEA and DHEA-S using liquid chromatography–tandem mass spectrometry (LC–MS/MS) | |
| US20240168029A1 (en) | Application of composition in preparation of drug for diagnosing infantile hemangioma and/or monitoring progress and prognosis thereof, and kit and drug | |
| ES2686542T3 (es) | Medios y procedimientos para determinar una cantidad normalizada de aclaramiento de un biomarcador de enfermedad metabólica en una muestra | |
| Tagawa et al. | Strain differences of neurosteroid levels in mouse brain | |
| Galazis et al. | Metabolomic biomarkers of impaired glucose tolerance and type 2 diabetes mellitus with a potential for risk stratification in women with polycystic ovary syndrome | |
| WO2022049726A1 (ja) | 胆汁酸類、ステロール類、及びホルモン類の分析方法及び分析システム | |
| JP6806948B1 (ja) | 胆汁酸類、ステロール類、及びホルモン類の分析方法及び分析システム | |
| NZ751481B2 (en) | Metabolite biomarkers for diseases associated with the contact activation system | |
| Jansakova et al. | Steroidogenic pathway in girls diagnosed with autism spectrum disorders |