JP7225090B2 - 接触活性化系に関連する疾患の代謝物バイオマーカー - Google Patents

接触活性化系に関連する疾患の代謝物バイオマーカー Download PDF

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JP7225090B2
JP7225090B2 JP2019514825A JP2019514825A JP7225090B2 JP 7225090 B2 JP7225090 B2 JP 7225090B2 JP 2019514825 A JP2019514825 A JP 2019514825A JP 2019514825 A JP2019514825 A JP 2019514825A JP 7225090 B2 JP7225090 B2 JP 7225090B2
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metabolite
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disease
biomarkers
hae
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JP2019534446A (ja
JP2019534446A5 (enExample
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セクストン，ダニエル，ジェー．
ヴィスワナサン，マリーニ
フォーセット，ライアン
ガウル，トゥリプティ
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Takeda Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/942—Serotonin, i.e. 5-hydroxy-tryptamine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7095—Inflammation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
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  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019514825A 2016-09-16 2017-09-15 接触活性化系に関連する疾患の代謝物バイオマーカー Active JP7225090B2 (ja)

Priority Applications (3)

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JP2023017898A JP7451791B2 (ja) 2016-09-16 2023-02-08 接触活性化系に関連する疾患の代謝物バイオマーカー
JP2024034012A JP7692508B2 (ja) 2016-09-16 2024-03-06 接触活性化系に関連する疾患の代謝物バイオマーカー
JP2025092519A JP2025124816A (ja) 2016-09-16 2025-06-03 接触活性化系に関連する疾患の代謝物バイオマーカー

Applications Claiming Priority (5)

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US201662395770P 2016-09-16 2016-09-16
US62/395,770 2016-09-16
US201762518367P 2017-06-12 2017-06-12
US62/518,367 2017-06-12
PCT/US2017/051755 WO2018053247A1 (en) 2016-09-16 2017-09-15 Metabolite biomarkers for diseases associated with the contact activation system

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JP2019534446A JP2019534446A (ja) 2019-11-28
JP2019534446A5 JP2019534446A5 (enExample) 2020-10-22
JP7225090B2 true JP7225090B2 (ja) 2023-02-20

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JP2023017898A Active JP7451791B2 (ja) 2016-09-16 2023-02-08 接触活性化系に関連する疾患の代謝物バイオマーカー
JP2024034012A Active JP7692508B2 (ja) 2016-09-16 2024-03-06 接触活性化系に関連する疾患の代謝物バイオマーカー
JP2025092519A Pending JP2025124816A (ja) 2016-09-16 2025-06-03 接触活性化系に関連する疾患の代謝物バイオマーカー

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JP2024034012A Active JP7692508B2 (ja) 2016-09-16 2024-03-06 接触活性化系に関連する疾患の代謝物バイオマーカー
JP2025092519A Pending JP2025124816A (ja) 2016-09-16 2025-06-03 接触活性化系に関連する疾患の代謝物バイオマーカー

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US (3) US11340237B2 (enExample)
EP (1) EP3513197A1 (enExample)
JP (4) JP7225090B2 (enExample)
KR (3) KR20250030022A (enExample)
CN (2) CN117169508A (enExample)
AU (1) AU2017325986B2 (enExample)
BR (1) BR112019005167A2 (enExample)
CA (1) CA3037157A1 (enExample)
CO (1) CO2019002607A2 (enExample)
IL (2) IL265199B2 (enExample)
MX (2) MX2019002918A (enExample)
WO (1) WO2018053247A1 (enExample)

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CN113495137A (zh) * 2021-06-29 2021-10-12 江苏省中医院 两种代谢标志物单独或联合在制备诊断克罗恩病的试剂盒中的应用
CN117310059B (zh) * 2023-11-30 2024-02-02 中国人民解放军总医院 用于早期诊断或监测克罗恩病的血浆代谢标志物组合及应用

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JP2023058612A (ja) 2023-04-25
JP2025124816A (ja) 2025-08-26
US20190361036A1 (en) 2019-11-28
CN109716137B (zh) 2023-07-21
US20220365101A1 (en) 2022-11-17
AU2017325986B2 (en) 2023-12-14
CA3037157A1 (en) 2018-03-22
KR20190053914A (ko) 2019-05-20
BR112019005167A2 (pt) 2019-07-02
MX2019002918A (es) 2019-07-18
AU2024200561A1 (en) 2024-02-15
JP7692508B2 (ja) 2025-06-13
NZ751481A (en) 2024-02-23
WO2018053247A1 (en) 2018-03-22
IL314752A (en) 2024-10-01
JP2024059990A (ja) 2024-05-01
MX2024004195A (es) 2024-04-23
KR102775437B1 (ko) 2025-03-05
KR20220154245A (ko) 2022-11-21
JP2019534446A (ja) 2019-11-28
KR102464380B1 (ko) 2022-11-07
IL265199B1 (en) 2024-09-01
US11340237B2 (en) 2022-05-24
JP7451791B2 (ja) 2024-03-18
IL265199A (en) 2019-05-30
AU2017325986A1 (en) 2019-04-04
KR20250030022A (ko) 2025-03-05
CO2019002607A2 (es) 2019-03-29
CN109716137A (zh) 2019-05-03
IL265199B2 (en) 2025-01-01
US20250199014A1 (en) 2025-06-19
CN117169508A (zh) 2023-12-05
EP3513197A1 (en) 2019-07-24
US12188948B2 (en) 2025-01-07

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