JP2023033281A5 - - Google Patents
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- JP2023033281A5 JP2023033281A5 JP2022198753A JP2022198753A JP2023033281A5 JP 2023033281 A5 JP2023033281 A5 JP 2023033281A5 JP 2022198753 A JP2022198753 A JP 2022198753A JP 2022198753 A JP2022198753 A JP 2022198753A JP 2023033281 A5 JP2023033281 A5 JP 2023033281A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- composition
- antibody
- light chain
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims description 14
- 108060003951 Immunoglobulin Proteins 0.000 claims description 3
- 102000018358 immunoglobulin Human genes 0.000 claims description 3
- 229940072221 immunoglobulins Drugs 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- XQUPVDVFXZDTLT-UHFFFAOYSA-N 1-[4-[[4-(2,5-dioxopyrrol-1-yl)phenyl]methyl]phenyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C(C=C1)=CC=C1CC1=CC=C(N2C(C=CC2=O)=O)C=C1 XQUPVDVFXZDTLT-UHFFFAOYSA-N 0.000 claims description 2
- 229920003192 poly(bis maleimide) Polymers 0.000 claims description 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims 2
- 238000004132 cross linking Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000003568 thioethers Chemical class 0.000 claims 2
- SOYPUUFPUFRXRI-UHFFFAOYSA-N 1,5-dibromo-2,4-dimethylbenzene Chemical group CC1=CC(C)=C(Br)C=C1Br SOYPUUFPUFRXRI-UHFFFAOYSA-N 0.000 claims 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 125000005179 haloacetyl group Chemical group 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 claims 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 239000012491 analyte Substances 0.000 description 8
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
- RPENMORRBUTCPR-UHFFFAOYSA-M sodium;1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].ON1C(=O)CC(S([O-])(=O)=O)C1=O RPENMORRBUTCPR-UHFFFAOYSA-M 0.000 description 2
- IPJGAEWUPXWFPL-UHFFFAOYSA-N 1-[3-(2,5-dioxopyrrol-1-yl)phenyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C1=CC=CC(N2C(C=CC2=O)=O)=C1 IPJGAEWUPXWFPL-UHFFFAOYSA-N 0.000 description 1
- RQKQQZAZSOOCFT-UHFFFAOYSA-N 1-[5-(2,5-dioxopyrrol-1-yl)naphthalen-1-yl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C1=CC=CC2=C(N3C(C=CC3=O)=O)C=CC=C12 RQKQQZAZSOOCFT-UHFFFAOYSA-N 0.000 description 1
- CXCHEKCRJQRVNG-UHFFFAOYSA-N 2,2,2-trifluoroethanesulfonyl chloride Chemical compound FC(F)(F)CS(Cl)(=O)=O CXCHEKCRJQRVNG-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 150000007942 carboxylates Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1603291.4 | 2016-02-25 | ||
| GBGB1603291.4A GB201603291D0 (en) | 2016-02-25 | 2016-02-25 | Antibodies |
| US201662368606P | 2016-07-29 | 2016-07-29 | |
| US62/368,606 | 2016-07-29 | ||
| PCT/GB2017/050489 WO2017144900A1 (en) | 2016-02-25 | 2017-02-24 | Mass spectrometry kit |
| JP2018544901A JP7246927B2 (ja) | 2016-02-25 | 2017-02-24 | 質量分析キット |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544901A Division JP7246927B2 (ja) | 2016-02-25 | 2017-02-24 | 質量分析キット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023033281A JP2023033281A (ja) | 2023-03-10 |
| JP2023033281A5 true JP2023033281A5 (https=) | 2024-05-09 |
| JP7541070B2 JP7541070B2 (ja) | 2024-08-27 |
Family
ID=55806928
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544901A Active JP7246927B2 (ja) | 2016-02-25 | 2017-02-24 | 質量分析キット |
| JP2022017497A Active JP7541045B2 (ja) | 2016-02-25 | 2022-02-07 | 質量分析キット |
| JP2022198753A Active JP7541070B2 (ja) | 2016-02-25 | 2022-12-13 | 質量分析キット |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544901A Active JP7246927B2 (ja) | 2016-02-25 | 2017-02-24 | 質量分析キット |
| JP2022017497A Active JP7541045B2 (ja) | 2016-02-25 | 2022-02-07 | 質量分析キット |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12461108B2 (https=) |
| EP (2) | EP3420361B1 (https=) |
| JP (3) | JP7246927B2 (https=) |
| KR (1) | KR102851057B1 (https=) |
| CN (2) | CN108885218A (https=) |
| AU (1) | AU2017222399B2 (https=) |
| DK (1) | DK3420361T3 (https=) |
| ES (1) | ES2936783T3 (https=) |
| GB (1) | GB201603291D0 (https=) |
| WO (1) | WO2017144900A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201708262D0 (en) | 2017-05-23 | 2017-07-05 | Binding Site Group Ltd | Assay for plasma cell associated disease |
| JP2022519246A (ja) * | 2019-01-31 | 2022-03-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗体電荷不均一性についてのネイティブマイクロ流体ｃｅ－ｍｓ解析法 |
| CN110009008B (zh) * | 2019-03-18 | 2020-11-06 | 四川大学 | 基于提取的免疫固定电泳图特征对其进行自动分类的方法 |
| CN113811772B (zh) * | 2019-05-10 | 2024-12-06 | 结合点集团有限公司 | 质谱分析校准物 |
| GB201906599D0 (en) | 2019-05-10 | 2019-06-26 | Binding Site Group Ltd | Mass spectrometry calibrator |
| GB201915946D0 (en) | 2019-11-01 | 2019-12-18 | Binding Site Group Ltd | Quantitation of immunoglobulins i n mass spectrometry |
| GB202007047D0 (en) * | 2020-05-13 | 2020-06-24 | Binding Site Group Ltd | Mass spectrometry controls |
| GB202008887D0 (en) * | 2020-06-11 | 2020-07-29 | Binding Site Group Ltd | A method of identifying or characterising an immune response in a subject |
| GB202016822D0 (en) | 2020-10-23 | 2020-12-09 | Binding Site Group Ltd | Quantitation of immunoglobulins in mass spectrometry |
| CN113720900A (zh) * | 2021-09-14 | 2021-11-30 | 首都医科大学附属北京朝阳医院 | 一种基于madli-tof ms技术检测血清中m蛋白的方法 |
| CN114324557B (zh) * | 2021-12-03 | 2024-05-10 | 融智生物科技（青岛）有限公司 | 一种基于MALDI-TOF MS的ζ-珠蛋白的检测方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991003493A1 (en) | 1989-08-29 | 1991-03-21 | The University Of Southampton | Bi-or trispecific (fab)3 or (fab)4 conjugates |
| WO1991006570A1 (en) * | 1989-10-25 | 1991-05-16 | The University Of Melbourne | HYBRID Fc RECEPTOR MOLECULES |
| EP1400536A1 (en) * | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| AU691297B2 (en) * | 1994-05-13 | 1998-05-14 | Miltenyi Biotec Gmbh | Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood |
| JP2826965B2 (ja) * | 1995-01-12 | 1998-11-18 | オリエンタル酵母工業株式会社 | 免疫吸着体とその製造法 |
| ATE285417T1 (de) | 1995-11-03 | 2005-01-15 | Binding Site Ltd | Herstellung von antikörpern |
| US6207370B1 (en) * | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| US6897044B1 (en) | 1999-01-28 | 2005-05-24 | Biogen Idec, Inc. | Production of tetravalent antibodies |
| JP2008500269A (ja) * | 2003-10-08 | 2008-01-10 | イーバイオサイエンス | 天然免疫グロブリン結合試薬とその作製及び使用方法 |
| GB0501741D0 (en) * | 2005-01-27 | 2005-03-02 | Binding Site The Ltd | Antibody |
| US20090030187A1 (en) | 2005-03-14 | 2009-01-29 | Tous Guillermo I | Macromolecules comprising a thioether cross-link |
| JP4950879B2 (ja) | 2005-04-12 | 2012-06-13 | 松森 昭 | 心疾患診断用バイオマーカー及びその利用 |
| US7893616B2 (en) * | 2006-02-27 | 2011-02-22 | Ohio State University | Process to determine enzyme activity |
| JP2010515020A (ja) | 2006-12-21 | 2010-05-06 | ノバルティス アーゲー | 抗体定量法 |
| MX2012003538A (es) | 2009-10-09 | 2012-08-03 | Symphogen As | Cuantificacion multiple de proteinas recombinantes individuales en una mezcla mediante peptidos distintivos y espectrometria de masas. |
| GB201001946D0 (en) | 2010-02-05 | 2010-03-24 | Binding Site Group The Ltd | Cancer prognostic assay |
| GB2478520A (en) | 2010-03-02 | 2011-09-14 | Binding Site Group Ltd | Kidney prognostic assay |
| GB201117172D0 (en) | 2011-10-05 | 2011-11-16 | Binding Site Group The Ltd | Diabetes |
| GB201121265D0 (en) | 2011-12-12 | 2012-01-18 | Binding Site Group The Ltd | Assay |
| CA2866699A1 (en) | 2012-03-09 | 2013-09-12 | Ucl Business Plc | Chemical modification of antibodies |
| WO2014121031A1 (en) * | 2013-01-31 | 2014-08-07 | Excelimmune, Inc. | Characterization of antibody mixtures by mass spectrometry |
| WO2015131169A2 (en) * | 2014-02-28 | 2015-09-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Personalized myeloma detection |
| CA2944767C (en) | 2014-04-04 | 2022-07-12 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
| EP3175242A4 (en) * | 2014-07-29 | 2017-12-27 | Mayo Foundation for Medical Education and Research | Quantifying monoclonal antibody therapeutics by lc-ms/ms |
| PL3209767T3 (pl) * | 2014-10-21 | 2021-01-11 | Gennova Biopharmaceuticals Ltd. | Nowy sposób oczyszczania do izolacji i komercyjnej produkcji zrekombinowanego tnk-tpa (tenekteplazy) |
| EP3353200A4 (en) | 2015-09-24 | 2019-06-26 | Mayo Foundation for Medical Education and Research | IDENTIFICATION OF FREE LIGHT CHAINS FROM IMMOBILIZED LOBULIN BY MASS SPECTROMETRY |
| GB201708262D0 (en) * | 2017-05-23 | 2017-07-05 | Binding Site Group Ltd | Assay for plasma cell associated disease |
-
2016
- 2016-02-25 GB GBGB1603291.4A patent/GB201603291D0/en not_active Ceased
-
2017
- 2017-02-24 US US16/078,986 patent/US12461108B2/en active Active
- 2017-02-24 EP EP17708320.1A patent/EP3420361B1/en active Active
- 2017-02-24 JP JP2018544901A patent/JP7246927B2/ja active Active
- 2017-02-24 DK DK17708320.1T patent/DK3420361T3/da active
- 2017-02-24 KR KR1020187027703A patent/KR102851057B1/ko active Active
- 2017-02-24 AU AU2017222399A patent/AU2017222399B2/en active Active
- 2017-02-24 EP EP22190012.9A patent/EP4123308A1/en active Pending
- 2017-02-24 WO PCT/GB2017/050489 patent/WO2017144900A1/en not_active Ceased
- 2017-02-24 CN CN201780013491.5A patent/CN108885218A/zh active Pending
- 2017-02-24 ES ES17708320T patent/ES2936783T3/es active Active
- 2017-02-24 CN CN202211574983.0A patent/CN116148479A/zh active Pending
-
2022
- 2022-02-07 JP JP2022017497A patent/JP7541045B2/ja active Active
- 2022-12-13 JP JP2022198753A patent/JP7541070B2/ja active Active
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