JP7246927B2 - 質量分析キット - Google Patents

質量分析キット Download PDF

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JP7246927B2
JP7246927B2 JP2018544901A JP2018544901A JP7246927B2 JP 7246927 B2 JP7246927 B2 JP 7246927B2 JP 2018544901 A JP2018544901 A JP 2018544901A JP 2018544901 A JP2018544901 A JP 2018544901A JP 7246927 B2 JP7246927 B2 JP 7246927B2
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fragment
immunoglobulin
light chain
antibody
sample
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JP2019509483A5 (https=
JP2019509483A (ja
Inventor
エル．マーレイ デイビッド
ハーディング スティーブン
アール．バーニッジ デイビッド
ウォールズ グレッグ
ミルズ ジョン
アシュビー ジェイミー
Original Assignee
ザ バインディング サイト グループ リミティド
メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ
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Application filed by ザ バインディング サイト グループ リミティド, メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ filed Critical ザ バインディング サイト グループ リミティド
Publication of JP2019509483A publication Critical patent/JP2019509483A/ja
Priority to JP2022017497A priority Critical patent/JP7541045B2/ja
Priority to JP2022198753A priority patent/JP7541070B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
JP2018544901A 2016-02-25 2017-02-24 質量分析キット Active JP7246927B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022017497A JP7541045B2 (ja) 2016-02-25 2022-02-07 質量分析キット
JP2022198753A JP7541070B2 (ja) 2016-02-25 2022-12-13 質量分析キット

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1603291.4 2016-02-25
GBGB1603291.4A GB201603291D0 (en) 2016-02-25 2016-02-25 Antibodies
US201662368606P 2016-07-29 2016-07-29
US62/368,606 2016-07-29
PCT/GB2017/050489 WO2017144900A1 (en) 2016-02-25 2017-02-24 Mass spectrometry kit

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2022017497A Division JP7541045B2 (ja) 2016-02-25 2022-02-07 質量分析キット
JP2022198753A Division JP7541070B2 (ja) 2016-02-25 2022-12-13 質量分析キット

Publications (3)

Publication Number Publication Date
JP2019509483A JP2019509483A (ja) 2019-04-04
JP2019509483A5 JP2019509483A5 (https=) 2022-12-26
JP7246927B2 true JP7246927B2 (ja) 2023-03-28

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ID=55806928

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JP2018544901A Active JP7246927B2 (ja) 2016-02-25 2017-02-24 質量分析キット
JP2022017497A Active JP7541045B2 (ja) 2016-02-25 2022-02-07 質量分析キット
JP2022198753A Active JP7541070B2 (ja) 2016-02-25 2022-12-13 質量分析キット

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JP2022017497A Active JP7541045B2 (ja) 2016-02-25 2022-02-07 質量分析キット
JP2022198753A Active JP7541070B2 (ja) 2016-02-25 2022-12-13 質量分析キット

Country Status (10)

Country Link
US (1) US12461108B2 (https=)
EP (2) EP3420361B1 (https=)
JP (3) JP7246927B2 (https=)
KR (1) KR102851057B1 (https=)
CN (2) CN108885218A (https=)
AU (1) AU2017222399B2 (https=)
DK (1) DK3420361T3 (https=)
ES (1) ES2936783T3 (https=)
GB (1) GB201603291D0 (https=)
WO (1) WO2017144900A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201708262D0 (en) 2017-05-23 2017-07-05 Binding Site Group Ltd Assay for plasma cell associated disease
JP2022519246A (ja) * 2019-01-31 2022-03-22 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 抗体電荷不均一性についてのネイティブマイクロ流体ｃｅ－ｍｓ解析法
CN110009008B (zh) * 2019-03-18 2020-11-06 四川大学 基于提取的免疫固定电泳图特征对其进行自动分类的方法
CN113811772B (zh) * 2019-05-10 2024-12-06 结合点集团有限公司 质谱分析校准物
GB201906599D0 (en) 2019-05-10 2019-06-26 Binding Site Group Ltd Mass spectrometry calibrator
GB201915946D0 (en) 2019-11-01 2019-12-18 Binding Site Group Ltd Quantitation of immunoglobulins i n mass spectrometry
GB202007047D0 (en) * 2020-05-13 2020-06-24 Binding Site Group Ltd Mass spectrometry controls
GB202008887D0 (en) * 2020-06-11 2020-07-29 Binding Site Group Ltd A method of identifying or characterising an immune response in a subject
GB202016822D0 (en) 2020-10-23 2020-12-09 Binding Site Group Ltd Quantitation of immunoglobulins in mass spectrometry
CN113720900A (zh) * 2021-09-14 2021-11-30 首都医科大学附属北京朝阳医院 一种基于madli-tof ms技术检测血清中m蛋白的方法
CN114324557B (zh) * 2021-12-03 2024-05-10 融智生物科技（青岛）有限公司 一种基于MALDI-TOF MS的ζ-珠蛋白的检测方法

Citations (1)

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WO2015154052A1 (en) 2014-04-04 2015-10-08 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass

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WO1991006570A1 (en) * 1989-10-25 1991-05-16 The University Of Melbourne HYBRID Fc RECEPTOR MOLECULES
EP1400536A1 (en) * 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
AU691297B2 (en) * 1994-05-13 1998-05-14 Miltenyi Biotec Gmbh Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood
JP2826965B2 (ja) * 1995-01-12 1998-11-18 オリエンタル酵母工業株式会社 免疫吸着体とその製造法
ATE285417T1 (de) 1995-11-03 2005-01-15 Binding Site Ltd Herstellung von antikörpern
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6897044B1 (en) 1999-01-28 2005-05-24 Biogen Idec, Inc. Production of tetravalent antibodies
JP2008500269A (ja) * 2003-10-08 2008-01-10 イーバイオサイエンス 天然免疫グロブリン結合試薬とその作製及び使用方法
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Ｍｉｃｈｅｌ Ｇｏｌｄｂｅｒｇ ｅｔ ａｌ．，Ｓｐｅｃｉｆｉｃ ｉｎｔｅｒｃｈａｉｎ ｃｒｏｓｓｌｉｎｋｉｎｇ ｏｆ ａｎｔｉｂｏｄｉｅｓ ｕｓｉｎｇ ｂｉｓｍａｌｅｉｍｉｄｅｓ．，Ｂｉｏｃｏｎｊｕｇａｔｅ Ｃｈｅｍｉｓｔｒｙ，１９９１年，Ｖｏｌ．２， Ｎｏ．４，ｐｐ．２７５－２８０
Ｒｏｂｅｒｔ Ｆ． Ｓｔｅｉｎｈｏｆｆ ｅｔ ａｌ．，Ｍｉｃｒｏａｒｒａｙ－ｂａｓｅｄ ＭＡＬＤＩ－ＴＯＦ ｍａｓｓ ｓｐｅｃｔｒｏｍｅｔｒｙ ｅｎａｂｌｅｓ ｍｏｎｉｔｏｒｉｎｇ ｏｆ ｍｏｎｏｃｌｏｎａｌ，Ｍｅｔｈｏｄｓ，２０１５年１２月１８日，Ｖｏｌ．１０４，ｐｐ．３３－４０
日本生化学会編，新生化学実験講座１２ 分子免疫学ＩＩＩ－抗原・抗体・補体－，１９９２年，第１版，３０－３１頁

Also Published As

Publication number Publication date
WO2017144900A1 (en) 2017-08-31
DK3420361T3 (da) 2023-01-23
AU2017222399A1 (en) 2018-08-30
JP7541070B2 (ja) 2024-08-27
US12461108B2 (en) 2025-11-04
JP7541045B2 (ja) 2024-08-27
CN108885218A (zh) 2018-11-23
KR20180132651A (ko) 2018-12-12
ES2936783T3 (es) 2023-03-22
CA3015296A1 (en) 2017-08-31
JP2023033281A (ja) 2023-03-10
GB201603291D0 (en) 2016-04-13
EP4123308A1 (en) 2023-01-25
EP3420361A1 (en) 2019-01-02
AU2017222399B2 (en) 2024-03-14
US20190094239A1 (en) 2019-03-28
KR102851057B1 (ko) 2025-08-28
JP2022069446A (ja) 2022-05-11
JP2019509483A (ja) 2019-04-04
CN116148479A (zh) 2023-05-23
BR112018067435A2 (pt) 2019-01-02
EP3420361B1 (en) 2023-01-04

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