AU2017222399B2 - Mass spectrometry kit - Google Patents
Mass spectrometry kit Download PDFInfo
- Publication number
- AU2017222399B2 AU2017222399B2 AU2017222399A AU2017222399A AU2017222399B2 AU 2017222399 B2 AU2017222399 B2 AU 2017222399B2 AU 2017222399 A AU2017222399 A AU 2017222399A AU 2017222399 A AU2017222399 A AU 2017222399A AU 2017222399 B2 AU2017222399 B2 AU 2017222399B2
- Authority
- AU
- Australia
- Prior art keywords
- immunoglobulin
- fragment
- antibody
- sample
- cross
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1603291.4 | 2016-02-25 | ||
| GBGB1603291.4A GB201603291D0 (en) | 2016-02-25 | 2016-02-25 | Antibodies |
| US201662368606P | 2016-07-29 | 2016-07-29 | |
| US62/368,606 | 2016-07-29 | ||
| PCT/GB2017/050489 WO2017144900A1 (en) | 2016-02-25 | 2017-02-24 | Mass spectrometry kit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017222399A1 AU2017222399A1 (en) | 2018-08-30 |
| AU2017222399B2 true AU2017222399B2 (en) | 2024-03-14 |
Family
ID=55806928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017222399A Active AU2017222399B2 (en) | 2016-02-25 | 2017-02-24 | Mass spectrometry kit |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12461108B2 (https=) |
| EP (2) | EP3420361B1 (https=) |
| JP (3) | JP7246927B2 (https=) |
| KR (1) | KR102851057B1 (https=) |
| CN (2) | CN108885218A (https=) |
| AU (1) | AU2017222399B2 (https=) |
| DK (1) | DK3420361T3 (https=) |
| ES (1) | ES2936783T3 (https=) |
| GB (1) | GB201603291D0 (https=) |
| WO (1) | WO2017144900A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201708262D0 (en) | 2017-05-23 | 2017-07-05 | Binding Site Group Ltd | Assay for plasma cell associated disease |
| JP2022519246A (ja) * | 2019-01-31 | 2022-03-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗体電荷不均一性についてのネイティブマイクロ流体ｃｅ－ｍｓ解析法 |
| CN110009008B (zh) * | 2019-03-18 | 2020-11-06 | 四川大学 | 基于提取的免疫固定电泳图特征对其进行自动分类的方法 |
| CN113811772B (zh) * | 2019-05-10 | 2024-12-06 | 结合点集团有限公司 | 质谱分析校准物 |
| GB201906599D0 (en) | 2019-05-10 | 2019-06-26 | Binding Site Group Ltd | Mass spectrometry calibrator |
| GB201915946D0 (en) | 2019-11-01 | 2019-12-18 | Binding Site Group Ltd | Quantitation of immunoglobulins i n mass spectrometry |
| GB202007047D0 (en) * | 2020-05-13 | 2020-06-24 | Binding Site Group Ltd | Mass spectrometry controls |
| GB202008887D0 (en) * | 2020-06-11 | 2020-07-29 | Binding Site Group Ltd | A method of identifying or characterising an immune response in a subject |
| GB202016822D0 (en) | 2020-10-23 | 2020-12-09 | Binding Site Group Ltd | Quantitation of immunoglobulins in mass spectrometry |
| CN113720900A (zh) * | 2021-09-14 | 2021-11-30 | 首都医科大学附属北京朝阳医院 | 一种基于madli-tof ms技术检测血清中m蛋白的方法 |
| CN114324557B (zh) * | 2021-12-03 | 2024-05-10 | 融智生物科技（青岛）有限公司 | 一种基于MALDI-TOF MS的ζ-珠蛋白的检测方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006099481A2 (en) * | 2005-03-14 | 2006-09-21 | Medimmune, Inc. | Macromolecules comprising a thioether cross-link |
| WO2015154052A1 (en) * | 2014-04-04 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991003493A1 (en) | 1989-08-29 | 1991-03-21 | The University Of Southampton | Bi-or trispecific (fab)3 or (fab)4 conjugates |
| WO1991006570A1 (en) * | 1989-10-25 | 1991-05-16 | The University Of Melbourne | HYBRID Fc RECEPTOR MOLECULES |
| EP1400536A1 (en) * | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| AU691297B2 (en) * | 1994-05-13 | 1998-05-14 | Miltenyi Biotec Gmbh | Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood |
| JP2826965B2 (ja) * | 1995-01-12 | 1998-11-18 | オリエンタル酵母工業株式会社 | 免疫吸着体とその製造法 |
| ATE285417T1 (de) | 1995-11-03 | 2005-01-15 | Binding Site Ltd | Herstellung von antikörpern |
| US6207370B1 (en) * | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| US6897044B1 (en) | 1999-01-28 | 2005-05-24 | Biogen Idec, Inc. | Production of tetravalent antibodies |
| JP2008500269A (ja) * | 2003-10-08 | 2008-01-10 | イーバイオサイエンス | 天然免疫グロブリン結合試薬とその作製及び使用方法 |
| GB0501741D0 (en) * | 2005-01-27 | 2005-03-02 | Binding Site The Ltd | Antibody |
| JP4950879B2 (ja) | 2005-04-12 | 2012-06-13 | 松森 昭 | 心疾患診断用バイオマーカー及びその利用 |
| US7893616B2 (en) * | 2006-02-27 | 2011-02-22 | Ohio State University | Process to determine enzyme activity |
| JP2010515020A (ja) | 2006-12-21 | 2010-05-06 | ノバルティス アーゲー | 抗体定量法 |
| MX2012003538A (es) | 2009-10-09 | 2012-08-03 | Symphogen As | Cuantificacion multiple de proteinas recombinantes individuales en una mezcla mediante peptidos distintivos y espectrometria de masas. |
| GB201001946D0 (en) | 2010-02-05 | 2010-03-24 | Binding Site Group The Ltd | Cancer prognostic assay |
| GB2478520A (en) | 2010-03-02 | 2011-09-14 | Binding Site Group Ltd | Kidney prognostic assay |
| GB201117172D0 (en) | 2011-10-05 | 2011-11-16 | Binding Site Group The Ltd | Diabetes |
| GB201121265D0 (en) | 2011-12-12 | 2012-01-18 | Binding Site Group The Ltd | Assay |
| CA2866699A1 (en) | 2012-03-09 | 2013-09-12 | Ucl Business Plc | Chemical modification of antibodies |
| WO2014121031A1 (en) * | 2013-01-31 | 2014-08-07 | Excelimmune, Inc. | Characterization of antibody mixtures by mass spectrometry |
| WO2015131169A2 (en) * | 2014-02-28 | 2015-09-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Personalized myeloma detection |
| EP3175242A4 (en) * | 2014-07-29 | 2017-12-27 | Mayo Foundation for Medical Education and Research | Quantifying monoclonal antibody therapeutics by lc-ms/ms |
| PL3209767T3 (pl) * | 2014-10-21 | 2021-01-11 | Gennova Biopharmaceuticals Ltd. | Nowy sposób oczyszczania do izolacji i komercyjnej produkcji zrekombinowanego tnk-tpa (tenekteplazy) |
| EP3353200A4 (en) | 2015-09-24 | 2019-06-26 | Mayo Foundation for Medical Education and Research | IDENTIFICATION OF FREE LIGHT CHAINS FROM IMMOBILIZED LOBULIN BY MASS SPECTROMETRY |
| GB201708262D0 (en) * | 2017-05-23 | 2017-07-05 | Binding Site Group Ltd | Assay for plasma cell associated disease |
-
2016
- 2016-02-25 GB GBGB1603291.4A patent/GB201603291D0/en not_active Ceased
-
2017
- 2017-02-24 US US16/078,986 patent/US12461108B2/en active Active
- 2017-02-24 EP EP17708320.1A patent/EP3420361B1/en active Active
- 2017-02-24 JP JP2018544901A patent/JP7246927B2/ja active Active
- 2017-02-24 DK DK17708320.1T patent/DK3420361T3/da active
- 2017-02-24 KR KR1020187027703A patent/KR102851057B1/ko active Active
- 2017-02-24 AU AU2017222399A patent/AU2017222399B2/en active Active
- 2017-02-24 EP EP22190012.9A patent/EP4123308A1/en active Pending
- 2017-02-24 WO PCT/GB2017/050489 patent/WO2017144900A1/en not_active Ceased
- 2017-02-24 CN CN201780013491.5A patent/CN108885218A/zh active Pending
- 2017-02-24 ES ES17708320T patent/ES2936783T3/es active Active
- 2017-02-24 CN CN202211574983.0A patent/CN116148479A/zh active Pending
-
2022
- 2022-02-07 JP JP2022017497A patent/JP7541045B2/ja active Active
- 2022-12-13 JP JP2022198753A patent/JP7541070B2/ja active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006099481A2 (en) * | 2005-03-14 | 2006-09-21 | Medimmune, Inc. | Macromolecules comprising a thioether cross-link |
| WO2015154052A1 (en) * | 2014-04-04 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
Non-Patent Citations (1)
| Title |
|---|
| GOLDBERG, M. ET AL: "Specific Interchain Cross-Linking of Antibodies Using Bismaleimides. Repression of Ligand Leakage in Immunoaffinity Chromatography", BIOCONJUGATE CHEM. 1991, vol. 2, pages 275 - 280 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017144900A1 (en) | 2017-08-31 |
| DK3420361T3 (da) | 2023-01-23 |
| AU2017222399A1 (en) | 2018-08-30 |
| JP7541070B2 (ja) | 2024-08-27 |
| US12461108B2 (en) | 2025-11-04 |
| JP7541045B2 (ja) | 2024-08-27 |
| CN108885218A (zh) | 2018-11-23 |
| KR20180132651A (ko) | 2018-12-12 |
| ES2936783T3 (es) | 2023-03-22 |
| CA3015296A1 (en) | 2017-08-31 |
| JP2023033281A (ja) | 2023-03-10 |
| GB201603291D0 (en) | 2016-04-13 |
| EP4123308A1 (en) | 2023-01-25 |
| EP3420361A1 (en) | 2019-01-02 |
| US20190094239A1 (en) | 2019-03-28 |
| KR102851057B1 (ko) | 2025-08-28 |
| JP2022069446A (ja) | 2022-05-11 |
| JP2019509483A (ja) | 2019-04-04 |
| CN116148479A (zh) | 2023-05-23 |
| BR112018067435A2 (pt) | 2019-01-02 |
| EP3420361B1 (en) | 2023-01-04 |
| JP7246927B2 (ja) | 2023-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ MASS SPECTROMETRY KIT |