CN108885218A - 质谱法试剂盒 - Google Patents

质谱法试剂盒 Download PDF

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Publication number
CN108885218A
CN108885218A CN201780013491.5A CN201780013491A CN108885218A CN 108885218 A CN108885218 A CN 108885218A CN 201780013491 A CN201780013491 A CN 201780013491A CN 108885218 A CN108885218 A CN 108885218A
Authority
CN
China
Prior art keywords
fragment
antibody
immunoglobulin
analyte
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780013491.5A
Other languages
English (en)
Chinese (zh)
Inventor
大卫·L·默里
斯蒂芬·哈丁
大卫·R·巴尼奇
格雷格·沃利斯
约翰·米尔斯
杰米·阿什比
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Binding Site Group Ltd
Mayo Clinic in Florida
Original Assignee
Binding Site Group Ltd
Mayo Clinic in Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55806928&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN108885218(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Binding Site Group Ltd, Mayo Clinic in Florida filed Critical Binding Site Group Ltd
Priority to CN202211574983.0A priority Critical patent/CN116148479A/zh
Publication of CN108885218A publication Critical patent/CN108885218A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
CN201780013491.5A 2016-02-25 2017-02-24 质谱法试剂盒 Pending CN108885218A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211574983.0A CN116148479A (zh) 2016-02-25 2017-02-24 质谱法试剂盒

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1603291.4 2016-02-25
GBGB1603291.4A GB201603291D0 (en) 2016-02-25 2016-02-25 Antibodies
US201662368606P 2016-07-29 2016-07-29
US62/368,606 2016-07-29
PCT/GB2017/050489 WO2017144900A1 (en) 2016-02-25 2017-02-24 Mass spectrometry kit

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202211574983.0A Division CN116148479A (zh) 2016-02-25 2017-02-24 质谱法试剂盒

Publications (1)

Publication Number Publication Date
CN108885218A true CN108885218A (zh) 2018-11-23

Family

ID=55806928

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780013491.5A Pending CN108885218A (zh) 2016-02-25 2017-02-24 质谱法试剂盒
CN202211574983.0A Pending CN116148479A (zh) 2016-02-25 2017-02-24 质谱法试剂盒

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202211574983.0A Pending CN116148479A (zh) 2016-02-25 2017-02-24 质谱法试剂盒

Country Status (10)

Country Link
US (1) US12461108B2 (https=)
EP (2) EP3420361B1 (https=)
JP (3) JP7246927B2 (https=)
KR (1) KR102851057B1 (https=)
CN (2) CN108885218A (https=)
AU (1) AU2017222399B2 (https=)
DK (1) DK3420361T3 (https=)
ES (1) ES2936783T3 (https=)
GB (1) GB201603291D0 (https=)
WO (1) WO2017144900A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110009008A (zh) * 2019-03-18 2019-07-12 四川大学 基于提取的免疫固定电泳图特征对其进行自动分类的方法
CN113646638A (zh) * 2019-01-31 2021-11-12 瑞泽恩制药公司 抗体电荷异质性的原生微流体ce-ms分析
CN113720900A (zh) * 2021-09-14 2021-11-30 首都医科大学附属北京朝阳医院 一种基于madli-tof ms技术检测血清中m蛋白的方法
CN113811772A (zh) * 2019-05-10 2021-12-17 结合点集团有限公司 质谱分析校准物
CN114324557A (zh) * 2021-12-03 2022-04-12 融智生物科技（青岛）有限公司 一种基于MALDI-TOF MS的ζ-珠蛋白的检测方法
CN115698724A (zh) * 2020-05-13 2023-02-03 结合点集团有限公司 质谱对照
CN115698723A (zh) * 2020-05-22 2023-02-03 结合点集团有限公司 鉴定或表征受试者中的免疫应答的方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201708262D0 (en) 2017-05-23 2017-07-05 Binding Site Group Ltd Assay for plasma cell associated disease
GB201906599D0 (en) 2019-05-10 2019-06-26 Binding Site Group Ltd Mass spectrometry calibrator
GB201915946D0 (en) 2019-11-01 2019-12-18 Binding Site Group Ltd Quantitation of immunoglobulins i n mass spectrometry
GB202016822D0 (en) 2020-10-23 2020-12-09 Binding Site Group Ltd Quantitation of immunoglobulins in mass spectrometry

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014121031A1 (en) * 2013-01-31 2014-08-07 Excelimmune, Inc. Characterization of antibody mixtures by mass spectrometry
WO2015131169A2 (en) * 2014-02-28 2015-09-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Personalized myeloma detection
WO2015154052A1 (en) * 2014-04-04 2015-10-08 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003493A1 (en) 1989-08-29 1991-03-21 The University Of Southampton Bi-or trispecific (fab)3 or (fab)4 conjugates
WO1991006570A1 (en) * 1989-10-25 1991-05-16 The University Of Melbourne HYBRID Fc RECEPTOR MOLECULES
EP1400536A1 (en) * 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
AU691297B2 (en) * 1994-05-13 1998-05-14 Miltenyi Biotec Gmbh Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood
JP2826965B2 (ja) * 1995-01-12 1998-11-18 オリエンタル酵母工業株式会社 免疫吸着体とその製造法
ATE285417T1 (de) 1995-11-03 2005-01-15 Binding Site Ltd Herstellung von antikörpern
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6897044B1 (en) 1999-01-28 2005-05-24 Biogen Idec, Inc. Production of tetravalent antibodies
JP2008500269A (ja) * 2003-10-08 2008-01-10 イーバイオサイエンス 天然免疫グロブリン結合試薬とその作製及び使用方法
GB0501741D0 (en) * 2005-01-27 2005-03-02 Binding Site The Ltd Antibody
US20090030187A1 (en) 2005-03-14 2009-01-29 Tous Guillermo I Macromolecules comprising a thioether cross-link
JP4950879B2 (ja) 2005-04-12 2012-06-13 松森　　昭 心疾患診断用バイオマーカー及びその利用
US7893616B2 (en) * 2006-02-27 2011-02-22 Ohio State University Process to determine enzyme activity
JP2010515020A (ja) 2006-12-21 2010-05-06 ノバルティス アーゲー 抗体定量法
MX2012003538A (es) 2009-10-09 2012-08-03 Symphogen As Cuantificacion multiple de proteinas recombinantes individuales en una mezcla mediante peptidos distintivos y espectrometria de masas.
GB201001946D0 (en) 2010-02-05 2010-03-24 Binding Site Group The Ltd Cancer prognostic assay
GB2478520A (en) 2010-03-02 2011-09-14 Binding Site Group Ltd Kidney prognostic assay
GB201117172D0 (en) 2011-10-05 2011-11-16 Binding Site Group The Ltd Diabetes
GB201121265D0 (en) 2011-12-12 2012-01-18 Binding Site Group The Ltd Assay
CA2866699A1 (en) 2012-03-09 2013-09-12 Ucl Business Plc Chemical modification of antibodies
EP3175242A4 (en) * 2014-07-29 2017-12-27 Mayo Foundation for Medical Education and Research Quantifying monoclonal antibody therapeutics by lc-ms/ms
PL3209767T3 (pl) * 2014-10-21 2021-01-11 Gennova Biopharmaceuticals Ltd. Nowy sposób oczyszczania do izolacji i komercyjnej produkcji zrekombinowanego tnk-tpa (tenekteplazy)
EP3353200A4 (en) 2015-09-24 2019-06-26 Mayo Foundation for Medical Education and Research IDENTIFICATION OF FREE LIGHT CHAINS FROM IMMOBILIZED LOBULIN BY MASS SPECTROMETRY
GB201708262D0 (en) * 2017-05-23 2017-07-05 Binding Site Group Ltd Assay for plasma cell associated disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014121031A1 (en) * 2013-01-31 2014-08-07 Excelimmune, Inc. Characterization of antibody mixtures by mass spectrometry
WO2015131169A2 (en) * 2014-02-28 2015-09-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Personalized myeloma detection
WO2015154052A1 (en) * 2014-04-04 2015-10-08 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALAIN BECK等: "《Characterization of Therapeutic Antibodies and Related Products》", 《ANALYTICAL CHEMISTRY》 *
CHRISTIAN LUPINEK等: "《Trimolecular IgE，Fc(epsilon)RI and a recombinant nonanaphylactic single一chain antibody fragment with high affinity for IgE》", 《THE JOURNAL OF IMMUNOLOGY》 *
MICHEL GOLDBERG等: "《Specific Interchain Cross-Linking of Antibodies Using Bismaleimides. Repression of Ligand Leakage in Immunoaffinity Chromatography》", 《BIOCONJUGATE CHEM.》 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113646638A (zh) * 2019-01-31 2021-11-12 瑞泽恩制药公司 抗体电荷异质性的原生微流体ce-ms分析
CN113646638B (zh) * 2019-01-31 2024-05-24 瑞泽恩制药公司 抗体电荷异质性的原生微流体ce-ms分析
CN110009008A (zh) * 2019-03-18 2019-07-12 四川大学 基于提取的免疫固定电泳图特征对其进行自动分类的方法
CN110009008B (zh) * 2019-03-18 2020-11-06 四川大学 基于提取的免疫固定电泳图特征对其进行自动分类的方法
CN113811772A (zh) * 2019-05-10 2021-12-17 结合点集团有限公司 质谱分析校准物
CN115698724A (zh) * 2020-05-13 2023-02-03 结合点集团有限公司 质谱对照
CN115698723A (zh) * 2020-05-22 2023-02-03 结合点集团有限公司 鉴定或表征受试者中的免疫应答的方法
CN113720900A (zh) * 2021-09-14 2021-11-30 首都医科大学附属北京朝阳医院 一种基于madli-tof ms技术检测血清中m蛋白的方法
CN114324557A (zh) * 2021-12-03 2022-04-12 融智生物科技（青岛）有限公司 一种基于MALDI-TOF MS的ζ-珠蛋白的检测方法
CN114324557B (zh) * 2021-12-03 2024-05-10 融智生物科技（青岛）有限公司 一种基于MALDI-TOF MS的ζ-珠蛋白的检测方法

Also Published As

Publication number Publication date
WO2017144900A1 (en) 2017-08-31
DK3420361T3 (da) 2023-01-23
AU2017222399A1 (en) 2018-08-30
JP7541070B2 (ja) 2024-08-27
US12461108B2 (en) 2025-11-04
JP7541045B2 (ja) 2024-08-27
KR20180132651A (ko) 2018-12-12
ES2936783T3 (es) 2023-03-22
CA3015296A1 (en) 2017-08-31
JP2023033281A (ja) 2023-03-10
GB201603291D0 (en) 2016-04-13
EP4123308A1 (en) 2023-01-25
EP3420361A1 (en) 2019-01-02
AU2017222399B2 (en) 2024-03-14
US20190094239A1 (en) 2019-03-28
KR102851057B1 (ko) 2025-08-28
JP2022069446A (ja) 2022-05-11
JP2019509483A (ja) 2019-04-04
CN116148479A (zh) 2023-05-23
BR112018067435A2 (pt) 2019-01-02
EP3420361B1 (en) 2023-01-04
JP7246927B2 (ja) 2023-03-28

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Application publication date: 20181123