JP2022069446A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2022069446A5 JP2022069446A5 JP2022017497A JP2022017497A JP2022069446A5 JP 2022069446 A5 JP2022069446 A5 JP 2022069446A5 JP 2022017497 A JP2022017497 A JP 2022017497A JP 2022017497 A JP2022017497 A JP 2022017497A JP 2022069446 A5 JP2022069446 A5 JP 2022069446A5
- Authority
- JP
- Japan
- Prior art keywords
- fragment
- analyte
- control
- light chain
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012491 analyte Substances 0.000 claims description 19
- 239000012634 fragment Substances 0.000 claims description 15
- 108060003951 Immunoglobulin Proteins 0.000 claims description 7
- 102000018358 immunoglobulin Human genes 0.000 claims description 7
- 238000000746 purification Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims 11
- 239000000523 sample Substances 0.000 claims 5
- 150000001413 amino acids Chemical group 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 1
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 2
- RPENMORRBUTCPR-UHFFFAOYSA-M sodium;1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].ON1C(=O)CC(S([O-])(=O)=O)C1=O RPENMORRBUTCPR-UHFFFAOYSA-M 0.000 description 2
- UTRLJOWPWILGSB-UHFFFAOYSA-N 1-[(2,5-dioxopyrrol-1-yl)methoxymethyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1COCN1C(=O)C=CC1=O UTRLJOWPWILGSB-UHFFFAOYSA-N 0.000 description 1
- IPJGAEWUPXWFPL-UHFFFAOYSA-N 1-[3-(2,5-dioxopyrrol-1-yl)phenyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C1=CC=CC(N2C(C=CC2=O)=O)=C1 IPJGAEWUPXWFPL-UHFFFAOYSA-N 0.000 description 1
- XQUPVDVFXZDTLT-UHFFFAOYSA-N 1-[4-[[4-(2,5-dioxopyrrol-1-yl)phenyl]methyl]phenyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C(C=C1)=CC=C1CC1=CC=C(N2C(C=CC2=O)=O)C=C1 XQUPVDVFXZDTLT-UHFFFAOYSA-N 0.000 description 1
- RQKQQZAZSOOCFT-UHFFFAOYSA-N 1-[5-(2,5-dioxopyrrol-1-yl)naphthalen-1-yl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C1=CC=CC2=C(N3C(C=CC3=O)=O)C=CC=C12 RQKQQZAZSOOCFT-UHFFFAOYSA-N 0.000 description 1
- PBFKSBAPGGMKKJ-UHFFFAOYSA-N 1-[6-(2,5-dioxopyrrolidin-1-yl)hexyl]pyrrolidine-2,5-dione Chemical compound O=C1CCC(=O)N1CCCCCCN1C(=O)CCC1=O PBFKSBAPGGMKKJ-UHFFFAOYSA-N 0.000 description 1
- CXCHEKCRJQRVNG-UHFFFAOYSA-N 2,2,2-trifluoroethanesulfonyl chloride Chemical compound FC(F)(F)CS(Cl)(=O)=O CXCHEKCRJQRVNG-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 150000007942 carboxylates Chemical group 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 1
- 229920003192 poly(bis maleimide) Polymers 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1603291.4 | 2016-02-25 | ||
| GBGB1603291.4A GB201603291D0 (en) | 2016-02-25 | 2016-02-25 | Antibodies |
| US201662368606P | 2016-07-29 | 2016-07-29 | |
| US62/368,606 | 2016-07-29 | ||
| PCT/GB2017/050489 WO2017144900A1 (en) | 2016-02-25 | 2017-02-24 | Mass spectrometry kit |
| JP2018544901A JP7246927B2 (ja) | 2016-02-25 | 2017-02-24 | 質量分析キット |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544901A Division JP7246927B2 (ja) | 2016-02-25 | 2017-02-24 | 質量分析キット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022069446A JP2022069446A (ja) | 2022-05-11 |
| JP2022069446A5 true JP2022069446A5 (https=) | 2023-09-15 |
| JP7541045B2 JP7541045B2 (ja) | 2024-08-27 |
Family
ID=55806928
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544901A Active JP7246927B2 (ja) | 2016-02-25 | 2017-02-24 | 質量分析キット |
| JP2022017497A Active JP7541045B2 (ja) | 2016-02-25 | 2022-02-07 | 質量分析キット |
| JP2022198753A Active JP7541070B2 (ja) | 2016-02-25 | 2022-12-13 | 質量分析キット |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018544901A Active JP7246927B2 (ja) | 2016-02-25 | 2017-02-24 | 質量分析キット |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022198753A Active JP7541070B2 (ja) | 2016-02-25 | 2022-12-13 | 質量分析キット |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12461108B2 (https=) |
| EP (2) | EP3420361B1 (https=) |
| JP (3) | JP7246927B2 (https=) |
| KR (1) | KR102851057B1 (https=) |
| CN (2) | CN108885218A (https=) |
| AU (1) | AU2017222399B2 (https=) |
| DK (1) | DK3420361T3 (https=) |
| ES (1) | ES2936783T3 (https=) |
| GB (1) | GB201603291D0 (https=) |
| WO (1) | WO2017144900A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201708262D0 (en) | 2017-05-23 | 2017-07-05 | Binding Site Group Ltd | Assay for plasma cell associated disease |
| JP2022519246A (ja) * | 2019-01-31 | 2022-03-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗体電荷不均一性についてのネイティブマイクロ流体ｃｅ－ｍｓ解析法 |
| CN110009008B (zh) * | 2019-03-18 | 2020-11-06 | 四川大学 | 基于提取的免疫固定电泳图特征对其进行自动分类的方法 |
| CN113811772B (zh) * | 2019-05-10 | 2024-12-06 | 结合点集团有限公司 | 质谱分析校准物 |
| GB201906599D0 (en) | 2019-05-10 | 2019-06-26 | Binding Site Group Ltd | Mass spectrometry calibrator |
| GB201915946D0 (en) | 2019-11-01 | 2019-12-18 | Binding Site Group Ltd | Quantitation of immunoglobulins i n mass spectrometry |
| GB202007047D0 (en) * | 2020-05-13 | 2020-06-24 | Binding Site Group Ltd | Mass spectrometry controls |
| GB202008887D0 (en) * | 2020-06-11 | 2020-07-29 | Binding Site Group Ltd | A method of identifying or characterising an immune response in a subject |
| GB202016822D0 (en) | 2020-10-23 | 2020-12-09 | Binding Site Group Ltd | Quantitation of immunoglobulins in mass spectrometry |
| CN113720900A (zh) * | 2021-09-14 | 2021-11-30 | 首都医科大学附属北京朝阳医院 | 一种基于madli-tof ms技术检测血清中m蛋白的方法 |
| CN114324557B (zh) * | 2021-12-03 | 2024-05-10 | 融智生物科技（青岛）有限公司 | 一种基于MALDI-TOF MS的ζ-珠蛋白的检测方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991003493A1 (en) | 1989-08-29 | 1991-03-21 | The University Of Southampton | Bi-or trispecific (fab)3 or (fab)4 conjugates |
| WO1991006570A1 (en) * | 1989-10-25 | 1991-05-16 | The University Of Melbourne | HYBRID Fc RECEPTOR MOLECULES |
| EP1400536A1 (en) * | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| AU691297B2 (en) * | 1994-05-13 | 1998-05-14 | Miltenyi Biotec Gmbh | Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood |
| JP2826965B2 (ja) * | 1995-01-12 | 1998-11-18 | オリエンタル酵母工業株式会社 | 免疫吸着体とその製造法 |
| ATE285417T1 (de) | 1995-11-03 | 2005-01-15 | Binding Site Ltd | Herstellung von antikörpern |
| US6207370B1 (en) * | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| US6897044B1 (en) | 1999-01-28 | 2005-05-24 | Biogen Idec, Inc. | Production of tetravalent antibodies |
| JP2008500269A (ja) * | 2003-10-08 | 2008-01-10 | イーバイオサイエンス | 天然免疫グロブリン結合試薬とその作製及び使用方法 |
| GB0501741D0 (en) * | 2005-01-27 | 2005-03-02 | Binding Site The Ltd | Antibody |
| US20090030187A1 (en) | 2005-03-14 | 2009-01-29 | Tous Guillermo I | Macromolecules comprising a thioether cross-link |
| JP4950879B2 (ja) | 2005-04-12 | 2012-06-13 | 松森 昭 | 心疾患診断用バイオマーカー及びその利用 |
| US7893616B2 (en) * | 2006-02-27 | 2011-02-22 | Ohio State University | Process to determine enzyme activity |
| JP2010515020A (ja) | 2006-12-21 | 2010-05-06 | ノバルティス アーゲー | 抗体定量法 |
| MX2012003538A (es) | 2009-10-09 | 2012-08-03 | Symphogen As | Cuantificacion multiple de proteinas recombinantes individuales en una mezcla mediante peptidos distintivos y espectrometria de masas. |
| GB201001946D0 (en) | 2010-02-05 | 2010-03-24 | Binding Site Group The Ltd | Cancer prognostic assay |
| GB2478520A (en) | 2010-03-02 | 2011-09-14 | Binding Site Group Ltd | Kidney prognostic assay |
| GB201117172D0 (en) | 2011-10-05 | 2011-11-16 | Binding Site Group The Ltd | Diabetes |
| GB201121265D0 (en) | 2011-12-12 | 2012-01-18 | Binding Site Group The Ltd | Assay |
| CA2866699A1 (en) | 2012-03-09 | 2013-09-12 | Ucl Business Plc | Chemical modification of antibodies |
| WO2014121031A1 (en) * | 2013-01-31 | 2014-08-07 | Excelimmune, Inc. | Characterization of antibody mixtures by mass spectrometry |
| WO2015131169A2 (en) * | 2014-02-28 | 2015-09-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Personalized myeloma detection |
| CA2944767C (en) | 2014-04-04 | 2022-07-12 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
| EP3175242A4 (en) * | 2014-07-29 | 2017-12-27 | Mayo Foundation for Medical Education and Research | Quantifying monoclonal antibody therapeutics by lc-ms/ms |
| PL3209767T3 (pl) * | 2014-10-21 | 2021-01-11 | Gennova Biopharmaceuticals Ltd. | Nowy sposób oczyszczania do izolacji i komercyjnej produkcji zrekombinowanego tnk-tpa (tenekteplazy) |
| EP3353200A4 (en) | 2015-09-24 | 2019-06-26 | Mayo Foundation for Medical Education and Research | IDENTIFICATION OF FREE LIGHT CHAINS FROM IMMOBILIZED LOBULIN BY MASS SPECTROMETRY |
| GB201708262D0 (en) * | 2017-05-23 | 2017-07-05 | Binding Site Group Ltd | Assay for plasma cell associated disease |
-
2016
- 2016-02-25 GB GBGB1603291.4A patent/GB201603291D0/en not_active Ceased
-
2017
- 2017-02-24 US US16/078,986 patent/US12461108B2/en active Active
- 2017-02-24 EP EP17708320.1A patent/EP3420361B1/en active Active
- 2017-02-24 JP JP2018544901A patent/JP7246927B2/ja active Active
- 2017-02-24 DK DK17708320.1T patent/DK3420361T3/da active
- 2017-02-24 KR KR1020187027703A patent/KR102851057B1/ko active Active
- 2017-02-24 AU AU2017222399A patent/AU2017222399B2/en active Active
- 2017-02-24 EP EP22190012.9A patent/EP4123308A1/en active Pending
- 2017-02-24 WO PCT/GB2017/050489 patent/WO2017144900A1/en not_active Ceased
- 2017-02-24 CN CN201780013491.5A patent/CN108885218A/zh active Pending
- 2017-02-24 ES ES17708320T patent/ES2936783T3/es active Active
- 2017-02-24 CN CN202211574983.0A patent/CN116148479A/zh active Pending
-
2022
- 2022-02-07 JP JP2022017497A patent/JP7541045B2/ja active Active
- 2022-12-13 JP JP2022198753A patent/JP7541070B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022069446A5 (https=) | ||
| JP2023033281A5 (https=) | ||
| JP7541070B2 (ja) | 質量分析キット | |
| JP2021042257A5 (https=) | ||
| Atmanene et al. | Extending mass spectrometry contribution to therapeutic monoclonal antibody lead optimization: characterization of immune complexes using noncovalent ESI-MS | |
| JP2005539067A5 (https=) | ||
| JP2018526642A (ja) | リン酸化アルファ−シヌクレインを検出するための方法 | |
| JP2019509483A5 (https=) | ||
| JP2016540212A (ja) | 多価多重特異性分子の生物学的活性を決定するためのｓｐｒベースの架橋アッセイ | |
| US20250231191A1 (en) | Lc-ms methods for antibody isotyping and quantification | |
| Peronnet et al. | SELDI‐TOF MS analysis of the Cardiac Troponin I forms present in plasma from patients with myocardial infarction | |
| JP2020170001A (ja) | エフェクター機能抑制型ヒトまたはヒト化薬物抗体に対する抗薬物抗体の決定方法 | |
| CN112625129B (zh) | 一种抗人白介素23及包含其的试剂盒及其检测方法 | |
| Tam et al. | Depletion and fractionation technologies in plasma proteomic analysis | |
| Chen et al. | Aleuria Aurantia Lectin (AAL)-reactive immunoglobulin G rapidly appears in sera of animals following antigen exposure | |
| JP5821198B2 (ja) | 抗ｉｌ２８ｂ抗体及びこれを用いたｉｌ２８ｂの測定方法 | |
| CN117304327B (zh) | 一种抗山羊IgG的兔单克隆抗体及其应用 | |
| EP3856347A1 (en) | Antibody quantification in biological samples | |
| JP6420281B2 (ja) | タンパク質解析用固相担体及びその製造方法 | |
| KR20240032972A (ko) | 위치 선택적 다이메틸화에 의한 단백질 n-말단 신규 서열분석 | |
| US20260126453A1 (en) | Mass Spectrometry Kit Including a Cross-linked Antibody or Fragment Thereof | |
| WO2025207846A1 (en) | Methods for characterizing proteins in serum samples | |
| WO2026079160A1 (ja) | 抗体の分析方法 | |
| JP6548115B2 (ja) | 動脈硬化症マーカー及びその利用 | |
| CN115698724A (zh) | 质谱对照 |