JP2023017050A5 - - Google Patents
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- Publication number
- JP2023017050A5 JP2023017050A5 JP2022197027A JP2022197027A JP2023017050A5 JP 2023017050 A5 JP2023017050 A5 JP 2023017050A5 JP 2022197027 A JP2022197027 A JP 2022197027A JP 2022197027 A JP2022197027 A JP 2022197027A JP 2023017050 A5 JP2023017050 A5 JP 2023017050A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor according
- administered
- decrease
- acceptable salt
- period
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003112 inhibitor Substances 0.000 claims 6
- OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000004323 axial length Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229960002232 sodium phenylbutyrate Drugs 0.000 claims 1
- VPZRWNZGLKXFOE-UHFFFAOYSA-M sodium phenylbutyrate Chemical compound [Na+].[O-]C(=O)CCCC1=CC=CC=C1 VPZRWNZGLKXFOE-UHFFFAOYSA-M 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024002286A JP2024026709A (ja) | 2017-03-06 | 2024-01-11 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
| JP2024195194A JP2025013575A (ja) | 2017-03-06 | 2024-11-07 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017041349 | 2017-03-06 | ||
| JP2017041349 | 2017-03-06 | ||
| JP2021038816A JP7236753B2 (ja) | 2017-03-06 | 2021-03-11 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021038816A Division JP7236753B2 (ja) | 2017-03-06 | 2021-03-11 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024002286A Division JP2024026709A (ja) | 2017-03-06 | 2024-01-11 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023017050A JP2023017050A (ja) | 2023-02-02 |
| JP2023017050A5 true JP2023017050A5 (https=) | 2023-09-26 |
| JP7424676B2 JP7424676B2 (ja) | 2024-01-30 |
Family
ID=63448602
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504597A Active JP6637217B2 (ja) | 2017-03-06 | 2018-03-06 | 近視予防又は抑制剤、マウス近視誘導モデルの作製方法、及び、近視予防又は抑制医薬スクリーニング方法 |
| JP2019202287A Active JP6856275B2 (ja) | 2017-03-06 | 2019-11-07 | 近視予防、治療又は抑制用点眼剤 |
| JP2021038816A Active JP7236753B2 (ja) | 2017-03-06 | 2021-03-11 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
| JP2022197027A Active JP7424676B2 (ja) | 2017-03-06 | 2022-12-09 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
| JP2024002286A Withdrawn JP2024026709A (ja) | 2017-03-06 | 2024-01-11 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
| JP2024195194A Pending JP2025013575A (ja) | 2017-03-06 | 2024-11-07 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019504597A Active JP6637217B2 (ja) | 2017-03-06 | 2018-03-06 | 近視予防又は抑制剤、マウス近視誘導モデルの作製方法、及び、近視予防又は抑制医薬スクリーニング方法 |
| JP2019202287A Active JP6856275B2 (ja) | 2017-03-06 | 2019-11-07 | 近視予防、治療又は抑制用点眼剤 |
| JP2021038816A Active JP7236753B2 (ja) | 2017-03-06 | 2021-03-11 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024002286A Withdrawn JP2024026709A (ja) | 2017-03-06 | 2024-01-11 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
| JP2024195194A Pending JP2025013575A (ja) | 2017-03-06 | 2024-11-07 | マウス近視誘導モデル及び近視予防・抑制のための小胞体ストレス抑制剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US12478597B2 (https=) |
| EP (1) | EP3593817B1 (https=) |
| JP (6) | JP6637217B2 (https=) |
| KR (1) | KR102680012B1 (https=) |
| CN (3) | CN115645535B (https=) |
| DK (1) | DK3593817T3 (https=) |
| ES (1) | ES2997337T3 (https=) |
| FI (1) | FI3593817T3 (https=) |
| HR (1) | HRP20241734T1 (https=) |
| HU (1) | HUE069999T2 (https=) |
| PL (1) | PL3593817T3 (https=) |
| PT (1) | PT3593817T (https=) |
| WO (1) | WO2018164113A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7474706B2 (ja) * | 2018-12-18 | 2024-04-25 | 参天製薬株式会社 | ４－フェニル酪酸を含有する老視の治療または予防剤 |
| BR112021011653A2 (pt) * | 2018-12-18 | 2021-09-08 | Santen Pharmaceutical Co., Ltd. | Agente contendo ácido ursodesoxicólico para tratamento ou prevenção de presbiopia |
| JP7608707B2 (ja) * | 2019-02-25 | 2025-01-07 | 株式会社坪田ラボ | 近視進行抑制剤、機能性食品及び眼科用組成物 |
| US20220105061A1 (en) * | 2019-03-08 | 2022-04-07 | The Regents Of The University Of California | Compositions and methods for treating respiratory insufficiency |
| KR20230051155A (ko) * | 2020-06-11 | 2023-04-17 | 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 베르베리다세아엔 알칼로이드인 베르베린 및 이의 유도체를 이용한 근시의 예방 및 치료를 위한 방법 및 조성물 |
| JPWO2022123836A1 (https=) * | 2020-12-11 | 2022-06-16 | ||
| MX2023006724A (es) | 2020-12-11 | 2023-09-21 | Tsubota Lab Inc | Gotas oftálmicas para tratar el adelgazamiento escleral y método de detección para el agente terapéutico de adelgazamiento escleral. |
| CN112970666B (zh) * | 2021-02-04 | 2023-02-03 | 复旦大学附属眼耳鼻喉科医院 | 一种简便式动物近视诱导装置及制作方法 |
| JP2024069730A (ja) * | 2021-03-16 | 2024-05-22 | 慶應義塾 | 網膜変性抑制用組成物 |
| JPWO2023145578A1 (https=) * | 2022-01-25 | 2023-08-03 | ||
| WO2023182480A1 (ja) | 2022-03-25 | 2023-09-28 | 株式会社坪田ラボ | 水性組成物 |
| AU2023258808A1 (en) * | 2022-04-26 | 2024-11-07 | Tsubota Laboratory, Inc. | Method and composition for preventing or treating myopia |
| JPWO2024048697A1 (https=) * | 2022-08-31 | 2024-03-07 | ||
| CN115777618B (zh) * | 2022-11-14 | 2025-07-08 | 首都医科大学附属北京同仁医院 | 一种病理性近视动物模型的构建方法及用途 |
| CN116267712B (zh) * | 2023-02-23 | 2024-08-06 | 温州医科大学 | 一种近视眼动物模型的构建方法及其应用 |
| WO2024203727A1 (ja) * | 2023-03-24 | 2024-10-03 | 株式会社坪田ラボ | 水性組成物 |
| CN116918764B (zh) * | 2023-08-28 | 2025-11-28 | 河南省儿童医院郑州儿童医院 | 一种豚鼠近视模型的构建方法 |
| AU2024347518A1 (en) | 2023-09-22 | 2026-04-09 | Tsubota Laboratory, Inc. | Aqueous composition |
| WO2025089394A1 (ja) * | 2023-10-25 | 2025-05-01 | 株式会社坪田ラボ | 近視を予防または治療するための方法および組成物 |
| JP7781461B2 (ja) * | 2023-10-25 | 2025-12-08 | 株式会社坪田ラボ | 近視を予防または治療するための方法および組成物 |
| CN117797133A (zh) * | 2023-12-29 | 2024-04-02 | 上海交通大学医学院附属仁济医院 | 内质网应激抑制剂isrib在制备胎儿宫内生长受限药物中的应用 |
| WO2025182819A1 (ja) * | 2024-02-29 | 2025-09-04 | 慶應義塾 | 動物モデルの作製方法 |
| CN118892097A (zh) * | 2024-07-18 | 2024-11-05 | 海南省眼科医院(中山大学中山眼科中心海南眼科医院) | 一种基于自然光照明的近视延缓方法 |
| CN120392754B (zh) * | 2025-07-02 | 2025-09-09 | 深圳市中佳生物医疗科技有限公司 | 化合物在制备增强造血干细胞代谢活性、治疗异染性脑白质营养不良的产品中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3066561B2 (ja) | 1993-10-07 | 2000-07-17 | 武田薬品工業株式会社 | 近視予防・治療剤 |
| JPH09315954A (ja) | 1996-05-30 | 1997-12-09 | Kita:Kk | 眼科手術後の眼組織混濁防止剤。 |
| RU2002120485A (ru) | 2000-01-18 | 2004-04-10 | Волли Фордж Фармасьютикл, Инк. (Us) | Глазной рост и никотиновые антагонисты |
| CN1191074C (zh) * | 2002-09-18 | 2005-03-02 | 王力 | 熊胆粉滴眼液及其制备方法 |
| MXPA03011987A (es) | 2003-12-19 | 2005-06-23 | Osio Sancho Alberto | Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal. |
| US20060073213A1 (en) * | 2004-09-15 | 2006-04-06 | Hotamisligil Gokhan S | Reducing ER stress in the treatment of obesity and diabetes |
| EP1799263A4 (en) * | 2004-09-15 | 2009-07-29 | Harvard College | REDUCTION OF ER-STRESS IN THE TREATMENT OF ADIPOSITAS AND DIABETES |
| KR20110042054A (ko) * | 2008-07-24 | 2011-04-22 | 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 | 축성 근시의 예방 또는 치료제 |
| CA2794153C (en) * | 2010-03-25 | 2018-01-02 | Glaxosmithkline Llc | Substituted indoline derivatives as perk inhibitors |
| UY33288A (es) * | 2010-03-25 | 2011-10-31 | Glaxosmithkline Llc | Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico |
| US8962686B2 (en) | 2010-04-28 | 2015-02-24 | The Chinese University Of Hong Kong | Method and medication for prevention and treatment of ocular hypertension and glaucoma |
| TWI631334B (zh) * | 2011-01-14 | 2018-08-01 | University Of Washington Through Its Center For Commercialization | 診斷及治療眼球長度相關病症之方法 |
| WO2013025840A1 (en) * | 2011-08-15 | 2013-02-21 | Massachusetts Eye And Ear Infirmary | Methods for preserving photoreceptor cell viability following retinal detachment |
| GB201217296D0 (en) * | 2012-09-27 | 2012-11-14 | Alta Innovations Ltd | Method of treatment and/or prevention |
| WO2015056180A1 (en) * | 2013-10-15 | 2015-04-23 | Glaxosmithkline Intellectual Property (No.2) Limited | Indoline derivatives as inhibitors of perk |
| CA2927898C (en) | 2013-10-31 | 2021-11-16 | Kyoto Prefectural Public University Corporation | Therapeutic drug for diseases related to endoplasmic reticulum cell death in corneal endothelium |
| WO2016171282A1 (ja) * | 2015-04-24 | 2016-10-27 | 学校法人慶應義塾 | 近視予防剤及び近視進行抑制剤 |
-
2018
- 2018-03-06 WO PCT/JP2018/008554 patent/WO2018164113A1/ja not_active Ceased
- 2018-03-06 KR KR1020197029237A patent/KR102680012B1/ko active Active
- 2018-03-06 EP EP18764652.6A patent/EP3593817B1/en active Active
- 2018-03-06 PL PL18764652.6T patent/PL3593817T3/pl unknown
- 2018-03-06 JP JP2019504597A patent/JP6637217B2/ja active Active
- 2018-03-06 CN CN202211310191.2A patent/CN115645535B/zh active Active
- 2018-03-06 HR HRP20241734TT patent/HRP20241734T1/hr unknown
- 2018-03-06 DK DK18764652.6T patent/DK3593817T3/da active
- 2018-03-06 FI FIEP18764652.6T patent/FI3593817T3/fi active
- 2018-03-06 PT PT187646526T patent/PT3593817T/pt unknown
- 2018-03-06 HU HUE18764652A patent/HUE069999T2/hu unknown
- 2018-03-06 ES ES18764652T patent/ES2997337T3/es active Active
- 2018-03-06 CN CN202211310272.2A patent/CN115645536A/zh active Pending
- 2018-03-06 CN CN201880016406.5A patent/CN110392579B/zh active Active
-
2019
- 2019-09-05 US US16/561,776 patent/US12478597B2/en active Active
- 2019-11-07 JP JP2019202287A patent/JP6856275B2/ja active Active
-
2021
- 2021-03-11 JP JP2021038816A patent/JP7236753B2/ja active Active
-
2022
- 2022-12-09 JP JP2022197027A patent/JP7424676B2/ja active Active
-
2024
- 2024-01-11 JP JP2024002286A patent/JP2024026709A/ja not_active Withdrawn
- 2024-03-11 US US18/600,985 patent/US20240210736A1/en active Pending
- 2024-11-07 JP JP2024195194A patent/JP2025013575A/ja active Pending
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