JP2021046394A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021046394A5 JP2021046394A5 JP2020153876A JP2020153876A JP2021046394A5 JP 2021046394 A5 JP2021046394 A5 JP 2021046394A5 JP 2020153876 A JP2020153876 A JP 2020153876A JP 2020153876 A JP2020153876 A JP 2020153876A JP 2021046394 A5 JP2021046394 A5 JP 2021046394A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- intraocular pressure
- pharmaceutically acceptable
- acceptable salt
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 58
- 230000004410 intraocular pressure Effects 0.000 claims 23
- 150000003839 salts Chemical class 0.000 claims 20
- 230000000007 visual effect Effects 0.000 claims 15
- 230000005856 abnormality Effects 0.000 claims 14
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims 10
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical compound C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 10
- 208000010412 Glaucoma Diseases 0.000 claims 10
- 229960003679 brimonidine Drugs 0.000 claims 10
- 229960004605 timolol Drugs 0.000 claims 10
- 230000004493 normal intraocular pressure Effects 0.000 claims 9
- IWEGDQUCWQFKHS-UHFFFAOYSA-N 1-(1,3-dioxolan-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C1=CN(CC2OCCO2)N=C1 IWEGDQUCWQFKHS-UHFFFAOYSA-N 0.000 claims 5
- 229960001724 brimonidine tartrate Drugs 0.000 claims 5
- WLRMANUAADYWEA-NWASOUNVSA-N (S)-timolol maleate Chemical compound OC(=O)\C=C/C(O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 WLRMANUAADYWEA-NWASOUNVSA-N 0.000 claims 3
- 229960005221 timolol maleate Drugs 0.000 claims 3
- 206010067013 Normal tension glaucoma Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003889 eye drop Substances 0.000 claims 2
- 201000002978 low tension glaucoma Diseases 0.000 claims 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 229960000686 benzalkonium chloride Drugs 0.000 claims 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims 1
- LVXHNCUCBXIIPE-UHFFFAOYSA-L disodium;hydrogen phosphate;hydrate Chemical compound O.[Na+].[Na+].OP([O-])([O-])=O LVXHNCUCBXIIPE-UHFFFAOYSA-L 0.000 claims 1
- 239000006196 drop Substances 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- BBMHARZCALWXSL-UHFFFAOYSA-M sodium dihydrogenphosphate monohydrate Chemical compound O.[Na+].OP(O)([O-])=O BBMHARZCALWXSL-UHFFFAOYSA-M 0.000 claims 1
- 229940037001 sodium edetate Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 239000012929 tonicity agent Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025017822A JP2025069397A (ja) | 2019-09-12 | 2025-02-05 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019166276 | 2019-09-12 | ||
| JP2019166276 | 2019-09-12 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017822A Division JP2025069397A (ja) | 2019-09-12 | 2025-02-05 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021046394A JP2021046394A (ja) | 2021-03-25 |
| JP2021046394A5 true JP2021046394A5 (https=) | 2023-09-25 |
| JP7630944B2 JP7630944B2 (ja) | 2025-02-18 |
Family
ID=74877765
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020153876A Active JP7630944B2 (ja) | 2019-09-12 | 2020-09-14 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
| JP2025017822A Pending JP2025069397A (ja) | 2019-09-12 | 2025-02-05 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025017822A Pending JP2025069397A (ja) | 2019-09-12 | 2025-02-05 | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP7630944B2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021090883A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
| JP2021090880A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
| JP2021090879A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
| JP2021090881A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
| JP2021090884A (ja) * | 2021-03-19 | 2021-06-17 | 株式会社三洋物産 | 遊技機 |
| CN120617269A (zh) * | 2025-06-16 | 2025-09-12 | 鲁南贝特制药有限公司 | 一种溴莫尼定噻吗洛尔滴眼液及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170129823A (ko) * | 2015-03-19 | 2017-11-27 | 알러간, 인코포레이티드 | 브리모니딘 및 티몰롤의 고정된 용량 조합 |
-
2020
- 2020-09-14 JP JP2020153876A patent/JP7630944B2/ja active Active
-
2025
- 2025-02-05 JP JP2025017822A patent/JP2025069397A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021046394A5 (https=) | ||
| JP6383058B2 (ja) | スルホンアミド化合物の組み合わせ | |
| US10792288B2 (en) | Preservative free brimonidine and timolol solutions | |
| JP6014033B2 (ja) | 防腐剤無添加ビマトプロストおよびチモロール溶液 | |
| JP7630944B2 (ja) | ブリモニジンとチモロールとを含む、緑内障罹患患者における眼圧を下降させるための組成物 | |
| CN102365093A (zh) | 用于视网膜疾病的预防剂或治疗剂和使用JNK(c-Jun氨基末端激酶)抑制肽预防或治疗视网膜疾病的方法以及所述肽的用途 | |
| US20120277239A1 (en) | Compositions and Methods for Improving Night Vision | |
| JP2025138790A (ja) | 水性の組成物－伍－ | |
| JPH07258084A (ja) | ジピリダモールを必須成分とする眼圧降下剤 | |
| IE51764B1 (en) | Pharmaceutical preparations containing trimetazidine salts,for treating the metabolic effects of ischaemia | |
| JP2015523986A5 (https=) | ||
| Franks et al. | A 6-week, double-masked, paralle-group study of the efficacy and safety of travoprost 0.004% compared with latanoprost 0: 005%/timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension | |
| WO2019024433A1 (zh) | 氨基金刚烷胺单硝酸酯类化合物眼用组合物及其制剂和应用 | |
| JP2011144111A (ja) | 軸性近視の予防または治療剤 | |
| TW202408474A (zh) | 疼痛抑制劑 | |
| JP2020514347A (ja) | チオトロピウムを有効成分として含有する近視予防、近視治療および／または近視進行抑制剤 | |
| TW304879B (https=) | ||
| JP2610619B2 (ja) | 高眼圧症治療用点眼剤 | |
| Abu Bakar et al. | Medical Management of Open-Angle Glaucoma: Focus on Mechanisms of Action and Adverse Drug Reactions | |
| US20140038974A1 (en) | Compositions and Methods for Eye Whitening | |
| JPH06172176A (ja) | アジマリンを必須成分とする眼圧降下剤 | |
| JPH04247036A (ja) | 縮瞳をおこすことなく眼圧を下げる治療方法 | |
| JPH08231400A (ja) | イフェンプロジルを必須成分とする眼圧降下剤 | |
| Nowak et al. | Protective effect on visual functions of long-term use of trimetazidine in treatment of primary open angle glaucoma and degenerative myopia | |
| WO2023125544A1 (zh) | 组合物及其在制备用于治疗老花眼的药物中的用途 |