JP2021006548A5 - - Google Patents
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- Publication number
- JP2021006548A5 JP2021006548A5 JP2020163766A JP2020163766A JP2021006548A5 JP 2021006548 A5 JP2021006548 A5 JP 2021006548A5 JP 2020163766 A JP2020163766 A JP 2020163766A JP 2020163766 A JP2020163766 A JP 2020163766A JP 2021006548 A5 JP2021006548 A5 JP 2021006548A5
- Authority
- JP
- Japan
- Prior art keywords
- ursodeoxycholic acid
- ester
- therapeutic
- acid
- prophylactic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 claims 25
- 229960001661 ursodiol Drugs 0.000 claims 25
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 12
- 230000001225 therapeutic effect Effects 0.000 claims 11
- 230000000069 prophylactic effect Effects 0.000 claims 9
- -1 Ursodeoxycholic acid methyl ester Chemical class 0.000 claims 7
- 239000000654 additive Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 230000000996 additive effect Effects 0.000 claims 5
- 150000001408 amides Chemical class 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 208000030533 eye disease Diseases 0.000 claims 3
- GHCZAUBVMUEKKP-NHIHLBCISA-N 2-[[(4R)-4-[(3R,5S,7S,10S,13R,17R)-3,7-Dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]acetic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)C1C2C2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)CC1 GHCZAUBVMUEKKP-NHIHLBCISA-N 0.000 claims 2
- 208000022873 Ocular disease Diseases 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- BHTRKEVKTKCXOH-UHFFFAOYSA-N Taurochenodesoxycholsaeure Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)CC2 BHTRKEVKTKCXOH-UHFFFAOYSA-N 0.000 claims 2
- 230000004308 accommodation Effects 0.000 claims 2
- 201000010041 presbyopia Diseases 0.000 claims 2
- 230000003449 preventive effect Effects 0.000 claims 2
- BHTRKEVKTKCXOH-LBSADWJPSA-N tauroursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)CC1 BHTRKEVKTKCXOH-LBSADWJPSA-N 0.000 claims 2
- GHCZAUBVMUEKKP-UHFFFAOYSA-N ursodeoxycholic acid glycine-conjugate Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)CC2 GHCZAUBVMUEKKP-UHFFFAOYSA-N 0.000 claims 2
- XXRCUYVCPSWGCC-UHFFFAOYSA-N Ethyl pyruvate Chemical compound CCOC(=O)C(C)=O XXRCUYVCPSWGCC-UHFFFAOYSA-N 0.000 claims 1
- HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- LVXHNCUCBXIIPE-UHFFFAOYSA-L disodium;hydrogen phosphate;hydrate Chemical compound O.[Na+].[Na+].OP([O-])([O-])=O LVXHNCUCBXIIPE-UHFFFAOYSA-L 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940117360 ethyl pyruvate Drugs 0.000 claims 1
- 239000003889 eye drop Substances 0.000 claims 1
- 229940012356 eye drops Drugs 0.000 claims 1
- 239000003885 eye ointment Substances 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018236717 | 2018-12-18 | ||
| JP2018236717 | 2018-12-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020520162A Division JP6771698B1 (ja) | 2018-12-18 | 2019-12-17 | ウルソデオキシコール酸を含有する老視の治療または予防剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021006548A JP2021006548A (ja) | 2021-01-21 |
| JP2021006548A5 true JP2021006548A5 (https=) | 2022-12-22 |
Family
ID=71100366
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020520162A Expired - Fee Related JP6771698B1 (ja) | 2018-12-18 | 2019-12-17 | ウルソデオキシコール酸を含有する老視の治療または予防剤 |
| JP2020163766A Pending JP2021006548A (ja) | 2018-12-18 | 2020-09-29 | ウルソデオキシコール酸を含有する老視の治療または予防剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020520162A Expired - Fee Related JP6771698B1 (ja) | 2018-12-18 | 2019-12-17 | ウルソデオキシコール酸を含有する老視の治療または予防剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20220072012A1 (https=) |
| EP (1) | EP3900728A4 (https=) |
| JP (2) | JP6771698B1 (https=) |
| KR (1) | KR20210105916A (https=) |
| CN (1) | CN113164499A (https=) |
| AU (1) | AU2019407391A1 (https=) |
| BR (1) | BR112021011653A2 (https=) |
| CA (1) | CA3123370A1 (https=) |
| EA (1) | EA202191684A1 (https=) |
| IL (1) | IL284004A (https=) |
| MX (1) | MX2021007161A (https=) |
| MY (1) | MY203280A (https=) |
| PH (1) | PH12021551412A1 (https=) |
| SG (1) | SG11202106216SA (https=) |
| TW (1) | TW202038966A (https=) |
| WO (1) | WO2020129964A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021007161A (es) * | 2018-12-18 | 2021-10-13 | Santen Pharmaceutical Co Ltd | Agente que contiene acido ursodesoxicolico para tratar o prevenir la presbicia. |
| WO2022173043A1 (ja) * | 2021-02-15 | 2022-08-18 | 参天製薬株式会社 | ウルソデオキシコール酸またはその塩を含有する水性医薬組成物 |
| US20220349486A1 (en) * | 2021-04-29 | 2022-11-03 | Baker Hughes Oilfield Operations Llc | Modulating pilot valve adapter |
| TW202412751A (zh) * | 2022-08-09 | 2024-04-01 | 日商參天製藥股份有限公司 | 含有udca或其鹽之水性醫藥組合物 |
| CN116211804B (zh) * | 2023-05-09 | 2025-09-05 | 北京汇诚益健医药科技有限责任公司 | 熊去氧胆酸脂质组合物及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3069612A3 (en) | 2009-06-15 | 2016-10-19 | Encore Health, LLC | Dithiol compounds, derivatives, and uses therefor |
| CN102178784B (zh) * | 2011-04-20 | 2013-06-12 | 威海康博尔生物药业有限公司 | 一种用于缓解视疲劳的药物组合物 |
| WO2013025840A1 (en) * | 2011-08-15 | 2013-02-21 | Massachusetts Eye And Ear Infirmary | Methods for preserving photoreceptor cell viability following retinal detachment |
| CN104083381A (zh) * | 2014-07-29 | 2014-10-08 | 上海中医药大学 | 熊去氧胆酸的医药用途 |
| WO2016029197A1 (en) * | 2014-08-22 | 2016-02-25 | Kang Zhang | Compositions and methods to treat and/or prevent vision disorders of the lens of the eye |
| CN106074568B (zh) * | 2015-09-02 | 2021-05-14 | 盛世泰科生物医药技术(苏州)有限公司 | 一种用于预防和治疗白内障的眼用制剂及其制备方法 |
| WO2018147685A1 (ko) * | 2017-02-09 | 2018-08-16 | 주식회사 유스바이오팜 | 우르소데옥시콜산을 함유하는 시각장애 예방 또는 치료용 조성물 |
| KR102252450B1 (ko) | 2017-02-09 | 2021-05-14 | 주식회사 아미코젠파마 | 우르소데옥시콜산을 함유하는 시각장애 예방 또는 치료용 조성물 |
| JP6637217B2 (ja) | 2017-03-06 | 2020-01-29 | 株式会社坪田ラボ | 近視予防又は抑制剤、マウス近視誘導モデルの作製方法、及び、近視予防又は抑制医薬スクリーニング方法 |
| MX2021007161A (es) | 2018-12-18 | 2021-10-13 | Santen Pharmaceutical Co Ltd | Agente que contiene acido ursodesoxicolico para tratar o prevenir la presbicia. |
-
2019
- 2019-12-17 MX MX2021007161A patent/MX2021007161A/es unknown
- 2019-12-17 SG SG11202106216SA patent/SG11202106216SA/en unknown
- 2019-12-17 PH PH1/2021/551412A patent/PH12021551412A1/en unknown
- 2019-12-17 JP JP2020520162A patent/JP6771698B1/ja not_active Expired - Fee Related
- 2019-12-17 MY MYPI2021003222A patent/MY203280A/en unknown
- 2019-12-17 WO PCT/JP2019/049352 patent/WO2020129964A1/ja not_active Ceased
- 2019-12-17 KR KR1020217019942A patent/KR20210105916A/ko not_active Ceased
- 2019-12-17 TW TW108146291A patent/TW202038966A/zh unknown
- 2019-12-17 AU AU2019407391A patent/AU2019407391A1/en not_active Abandoned
- 2019-12-17 EA EA202191684A patent/EA202191684A1/ru unknown
- 2019-12-17 CN CN201980081377.5A patent/CN113164499A/zh active Pending
- 2019-12-17 EP EP19899899.9A patent/EP3900728A4/en not_active Withdrawn
- 2019-12-17 CA CA3123370A patent/CA3123370A1/en active Pending
- 2019-12-17 US US17/414,285 patent/US20220072012A1/en not_active Abandoned
- 2019-12-17 BR BR112021011653-2A patent/BR112021011653A2/pt not_active Application Discontinuation
-
2020
- 2020-09-29 JP JP2020163766A patent/JP2021006548A/ja active Pending
-
2021
- 2021-06-15 IL IL284004A patent/IL284004A/en unknown
- 2021-12-09 US US17/546,895 patent/US11419880B2/en active Active
-
2022
- 2022-08-02 US US17/816,812 patent/US20230040386A1/en not_active Abandoned
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