|
US5288609A
(en)
|
1984-04-27 |
1994-02-22 |
Enzo Diagnostics, Inc. |
Capture sandwich hybridization method and composition
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5011769A
(en)
|
1985-12-05 |
1991-04-30 |
Meiogenics U.S. Limited Partnership |
Methods for detecting nucleic acid sequences
|
|
US5359100A
(en)
|
1987-10-15 |
1994-10-25 |
Chiron Corporation |
Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
|
|
US5124246A
(en)
|
1987-10-15 |
1992-06-23 |
Chiron Corporation |
Nucleic acid multimers and amplified nucleic acid hybridization assays using same
|
|
US5403711A
(en)
|
1987-11-30 |
1995-04-04 |
University Of Iowa Research Foundation |
Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
|
|
CA1340807C
(en)
|
1988-02-24 |
1999-11-02 |
Lawrence T. Malek |
Nucleic acid amplification process
|
|
US5639611A
(en)
|
1988-12-12 |
1997-06-17 |
City Of Hope |
Allele specific polymerase chain reaction
|
|
CA2036946C
(en)
|
1990-04-06 |
2001-10-16 |
Kenneth V. Deugau |
Indexing linkers
|
|
US5494810A
(en)
|
1990-05-03 |
1996-02-27 |
Cornell Research Foundation, Inc. |
Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
|
|
US5849481A
(en)
|
1990-07-27 |
1998-12-15 |
Chiron Corporation |
Nucleic acid hybridization assays employing large comb-type branched polynucleotides
|
|
US5846717A
(en)
|
1996-01-24 |
1998-12-08 |
Third Wave Technologies, Inc. |
Detection of nucleic acid sequences by invader-directed cleavage
|
|
US5994069A
(en)
|
1996-01-24 |
1999-11-30 |
Third Wave Technologies, Inc. |
Detection of nucleic acids by multiple sequential invasive cleavages
|
|
US6872816B1
(en)
|
1996-01-24 |
2005-03-29 |
Third Wave Technologies, Inc. |
Nucleic acid detection kits
|
|
US5338671A
(en)
|
1992-10-07 |
1994-08-16 |
Eastman Kodak Company |
DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody
|
|
SE501439C2
(sv)
|
1993-06-22 |
1995-02-13 |
Pharmacia Lkb Biotech |
Sätt och anordning för analys av polynukleotidsekvenser
|
|
WO1995014106A2
(en)
|
1993-11-17 |
1995-05-26 |
Id Biomedical Corporation |
Cycling probe cleavage detection of nucleic acid sequences
|
|
EP0734436B1
(en)
|
1993-11-30 |
1999-04-14 |
McGILL UNIVERSITY |
Inhibition of dna methyltransferase
|
|
US5851770A
(en)
|
1994-04-25 |
1998-12-22 |
Variagenics, Inc. |
Detection of mismatches by resolvase cleavage using a magnetic bead support
|
|
AU693198B2
(en)
|
1994-04-25 |
1998-06-25 |
Avitech Diagnostics, Inc. |
Detection of mutation by resolvase cleavage
|
|
ES2185719T3
(es)
|
1994-12-23 |
2003-05-01 |
Dade Behring Inc |
Deteccion de acidos nucleicos por formacion de un producto catalizada por diana.
|
|
US5882867A
(en)
|
1995-06-07 |
1999-03-16 |
Dade Behring Marburg Gmbh |
Detection of nucleic acids by formation of template-dependent product
|
|
US5773258A
(en)
|
1995-08-25 |
1998-06-30 |
Roche Molecular Systems, Inc. |
Nucleic acid amplification using a reversibly inactivated thermostable enzyme
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
US5965408A
(en)
|
1996-07-09 |
1999-10-12 |
Diversa Corporation |
Method of DNA reassembly by interrupting synthesis
|
|
CA2239683A1
(en)
|
1995-12-22 |
1997-07-03 |
Dade Behring Marburg Gmbh |
Homogeneous amplification and detection of nucleic acids
|
|
US5985557A
(en)
|
1996-01-24 |
1999-11-16 |
Third Wave Technologies, Inc. |
Invasive cleavage of nucleic acids
|
|
AU713667B2
(en)
|
1996-04-12 |
1999-12-09 |
Phri Properties, Inc. |
Detection probes, kits and assays
|
|
US6017704A
(en)
|
1996-06-03 |
2000-01-25 |
The Johns Hopkins University School Of Medicine |
Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
|
|
US5786146A
(en)
|
1996-06-03 |
1998-07-28 |
The Johns Hopkins University School Of Medicine |
Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
|
|
US6096273A
(en)
|
1996-11-05 |
2000-08-01 |
Clinical Micro Sensors |
Electrodes linked via conductive oligomers to nucleic acids
|
|
US6251594B1
(en)
|
1997-06-09 |
2001-06-26 |
Usc/Norris Comprehensive Cancer Ctr. |
Cancer diagnostic method based upon DNA methylation differences
|
|
US6013459A
(en)
|
1997-06-12 |
2000-01-11 |
Clinical Micro Sensors, Inc. |
Detection of analytes using reorganization energy
|
|
DE19754482A1
(de)
|
1997-11-27 |
1999-07-01 |
Epigenomics Gmbh |
Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
|
|
US6063573A
(en)
|
1998-01-27 |
2000-05-16 |
Clinical Micro Sensors, Inc. |
Cycling probe technology using electron transfer detection
|
|
EP1053352B1
(en)
|
1998-02-04 |
2002-09-18 |
Variagenics, Inc. |
Mismatch detection techniques
|
|
US6235502B1
(en)
|
1998-09-18 |
2001-05-22 |
Molecular Staging Inc. |
Methods for selectively isolating DNA using rolling circle amplification
|
|
US7700324B1
(en)
|
1998-11-03 |
2010-04-20 |
The Johns Hopkins University School Of Medicine |
Methylated CpG island amplification (MCA)
|
|
US7662594B2
(en)
|
2002-09-20 |
2010-02-16 |
New England Biolabs, Inc. |
Helicase-dependent amplification of RNA
|
|
WO2005023091A2
(en)
|
2003-09-05 |
2005-03-17 |
The Trustees Of Boston University |
Method for non-invasive prenatal diagnosis
|
|
CA2540310A1
(en)
|
2003-10-09 |
2005-04-28 |
Epigenomics Ag |
Improved bisulfite conversion of dna
|
|
US20110077215A1
(en)
*
|
2005-12-07 |
2011-03-31 |
The University Of Utah Research Foundation |
DNA Methylation As A Target For Diagnosis And Treatment Of Chronic Lymphocytic Leukema (CLL)
|
|
EP3591068A1
(en)
|
2006-02-02 |
2020-01-08 |
The Board of Trustees of the Leland Stanford Junior University |
Non-invasive fetal genetic screening by digital analysis
|
|
GB0700374D0
(en)
|
2007-01-09 |
2007-02-14 |
Oncomethylome Sciences S A |
NDRG family methylation markers
|
|
US20090075265A1
(en)
|
2007-02-02 |
2009-03-19 |
Orion Genomics Llc |
Gene methylation in thyroid cancer diagnosis
|
|
ITTO20070201A1
(it)
|
2007-03-19 |
2007-10-08 |
Elena Miotto |
Nuovi marcatori di metilazione del dna utili per la diagnosi di malattie neoplastiche
|
|
US9670552B2
(en)
*
|
2007-11-30 |
2017-06-06 |
Genomictree, Inc. |
Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
|
|
US10113203B2
(en)
*
|
2007-11-30 |
2018-10-30 |
Genomictree, Inc. |
Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene
|
|
EP2816122A1
(en)
|
2008-02-15 |
2014-12-24 |
Mayo Foundation For Medical Education And Research |
Detecting neoplasm from a stool sample
|
|
WO2009117327A2
(en)
|
2008-03-15 |
2009-09-24 |
Hologic, Inc. |
Compositions and methods for analysis of nucleic acid molecules during amplification reactions
|
|
EP2304057B1
(en)
*
|
2008-06-17 |
2014-09-17 |
Signature Diagnostics AG |
Method for the detection of ovarian cancer
|
|
US8962247B2
(en)
|
2008-09-16 |
2015-02-24 |
Sequenom, Inc. |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
|
|
WO2010062914A1
(en)
|
2008-11-26 |
2010-06-03 |
The Johns Hopkins University |
Methods for identifying cancer risk
|
|
ES2541178T3
(es)
|
2009-02-03 |
2015-07-16 |
Mdxhealth Sa |
Método de detección de cáncer colorrectal
|
|
EP2308998A1
(de)
|
2009-09-18 |
2011-04-13 |
Universitätsklinikum Jena Körperschaft des öffentlichen Rechts und Teilkörperschaft der Friedrich-Schiller-Universität Jena |
Verfahren zur frühen Diagnose von Karzinomen des Anogenitaltraktes
|
|
EP2553463B1
(en)
|
2010-03-26 |
2017-05-03 |
Hongzhi Zou |
Methods and materials for detecting colorectal neoplasm
|
|
WO2011127136A1
(en)
|
2010-04-06 |
2011-10-13 |
University Of Chicago |
Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmc)
|
|
US8715937B2
(en)
|
2010-11-15 |
2014-05-06 |
Exact Sciences Corporation |
Mutation detection assay
|
|
US8361720B2
(en)
|
2010-11-15 |
2013-01-29 |
Exact Sciences Corporation |
Real time cleavage assay
|
|
US8916344B2
(en)
|
2010-11-15 |
2014-12-23 |
Exact Sciences Corporation |
Methylation assay
|
|
CA2826696C
(en)
|
2011-02-02 |
2019-12-03 |
Mayo Foundation For Medical Education And Research |
Digital sequence analysis of dna methylation
|
|
GB201102014D0
(en)
|
2011-02-04 |
2011-03-23 |
Ucl Business Plc |
Method for predicting risk of developing cancer
|
|
PT105553B
(pt)
|
2011-03-01 |
2020-04-20 |
Infogene Lda |
Dispositivo portátil para o armazenamento, transporte e recuperação de material biológico
|
|
EP2520661A1
(en)
|
2011-05-02 |
2012-11-07 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Blood-based gene expression signatures in lung cancer
|
|
EP2527459A1
(en)
|
2011-05-02 |
2012-11-28 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Blood-based gene detection of non-small cell lung cancer
|
|
US8808990B2
(en)
|
2011-05-12 |
2014-08-19 |
Exact Sciences Corporation |
Serial isolation of multiple DNA targets from stool
|
|
CN104450680A
(zh)
|
2011-05-12 |
2015-03-25 |
精密科学公司 |
核酸的分离
|
|
WO2013070950A1
(en)
*
|
2011-11-08 |
2013-05-16 |
University Of Southern California |
Identification of a dna methylation marker for blood-based detection of ovarian cancer
|
|
WO2013096661A1
(en)
*
|
2011-12-22 |
2013-06-27 |
Illumina, Inc. |
Methylation biomarkers for ovarian cancer
|
|
CA2860338C
(en)
|
2012-01-06 |
2022-08-02 |
Viomics, Inc. |
System and method of detecting rnas altered by cancer in peripheral blood
|
|
US9315853B2
(en)
|
2012-01-30 |
2016-04-19 |
Exact Sciences Corporation |
Modification of DNA on magnetic beads
|
|
EP2828405B1
(en)
|
2012-03-20 |
2017-06-28 |
Exact Sciences Corporation |
Marker panel for detecting cancer
|
|
AU2012380717B2
(en)
|
2012-05-24 |
2018-08-16 |
Fundacio Institucio Catalana De Recerca I Estudis Avancats |
Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
|
|
EP2899275B1
(en)
|
2012-09-19 |
2018-06-27 |
Sysmex Corporation |
Method for obtaining information about endometrial cancer, and marker and kit for obtaining information about endometrial cancer
|
|
US9212392B2
(en)
|
2012-09-25 |
2015-12-15 |
Exact Sciences Corporation |
Normalization of polymerase activity
|
|
US10041124B2
(en)
*
|
2013-01-14 |
2018-08-07 |
King Abdullah University Of Science And Technology |
Methylation biomarkers for ovarian cancer
|
|
CA2902916C
(en)
|
2013-03-14 |
2018-08-28 |
Mayo Foundation For Medical Education And Research |
Detecting neoplasm
|
|
US10253358B2
(en)
|
2013-11-04 |
2019-04-09 |
Exact Sciences Development Company, Llc |
Multiple-control calibrators for DNA quantitation
|
|
US10138524B2
(en)
|
2013-12-19 |
2018-11-27 |
Exact Sciences Development Company, Llc |
Synthetic nucleic acid control molecules
|
|
US20160340740A1
(en)
*
|
2014-01-30 |
2016-11-24 |
The Regents Of The University Of California |
Methylation haplotyping for non-invasive diagnosis (monod)
|
|
CN120700143A
(zh)
|
2014-03-31 |
2025-09-26 |
梅奥医学教育和研究基金会 |
检测结直肠赘生物
|
|
JP6681841B2
(ja)
*
|
2014-05-09 |
2020-04-15 |
ライフコーデックス アーゲー |
特別な細胞タイプに由来するｄｎａの検出とそれに関連する方法
|
|
US20160010081A1
(en)
|
2014-07-11 |
2016-01-14 |
Exact Sciences Corporation |
Systems, methods and kits for extracting nucleic acid from digestive fluid
|
|
US10184154B2
(en)
|
2014-09-26 |
2019-01-22 |
Mayo Foundation For Medical Education And Research |
Detecting cholangiocarcinoma
|
|
CA3183545C
(en)
|
2014-12-12 |
2026-01-13 |
Exact Sciences Corporation |
Compositions and methods for performing methylation detection assays
|
|
WO2016094839A2
(en)
|
2014-12-12 |
2016-06-16 |
Exact Sciences Corporation |
Compositions and methods for performing methylation detection assays
|
|
TW201632629A
(zh)
*
|
2015-01-14 |
2016-09-16 |
臺北醫學大學 |
用於癌症診斷與預後的方法
|
|
US10030272B2
(en)
|
2015-02-27 |
2018-07-24 |
Mayo Foundation For Medical Education And Research |
Detecting gastrointestinal neoplasms
|
|
US10435755B2
(en)
|
2015-03-27 |
2019-10-08 |
Exact Sciences Development Company, Llc |
Detecting esophageal disorders
|
|
CN114574585A
(zh)
|
2015-08-31 |
2022-06-03 |
梅约医药教育及研究基金会 |
检测胃肿瘤
|
|
CN108350485A
(zh)
|
2015-10-30 |
2018-07-31 |
精密科学发展有限责任公司 |
血浆dna的多重扩增检测测定以及分离和检测
|
|
WO2017176630A1
(en)
|
2016-04-07 |
2017-10-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free dna
|
|
US10370726B2
(en)
|
2016-04-14 |
2019-08-06 |
Mayo Foundation For Medical Education And Research |
Detecting colorectal neoplasia
|
|
JP7481804B2
(ja)
|
2016-04-14 |
2024-05-13 |
マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ |
高度膵異形成の検出
|
|
CN109563546B
(zh)
|
2016-05-05 |
2022-09-09 |
精密科学发展有限责任公司 |
通过分析甲基化dna来检测肺肿瘤
|
|
US20170321286A1
(en)
|
2016-05-05 |
2017-11-09 |
Exact Sciences Corporation |
Detection of lung neoplasia by amplification of rna sequences
|
|
EP3464593B1
(en)
|
2016-05-31 |
2022-03-09 |
The Translational Genomics Research Institute |
Molecular tagging methods and sequencing libraries
|
|
EP3978624B1
(en)
|
2016-07-19 |
2025-03-26 |
Exact Sciences Corporation |
Methylated control dna
|
|
CN107727865A
(zh)
*
|
2016-08-11 |
2018-02-23 |
博尔诚（北京）科技有限公司 |
肿瘤标志物的系统性检测方法及其应用
|
|
EP3507298B1
(en)
|
2016-09-02 |
2023-08-30 |
Mayo Foundation for Medical Education and Research |
Detecting hepatocellular carcinoma
|
|
KR102892245B1
(ko)
|
2017-01-27 |
2025-11-27 |
이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 |
메틸화된 dna 분석에 의한 결장 신조직형성의 검출
|
|
JP7356349B2
(ja)
|
2017-02-28 |
2023-10-04 |
マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ |
前立腺癌検出
|
|
CN111868260B
(zh)
|
2017-08-07 |
2025-02-21 |
约翰斯霍普金斯大学 |
用于评估和治疗癌症的方法和材料
|
|
JP7277460B2
(ja)
|
2017-11-30 |
2023-05-19 |
マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ |
乳癌の検出
|
|
US10648025B2
(en)
|
2017-12-13 |
2020-05-12 |
Exact Sciences Development Company, Llc |
Multiplex amplification detection assay II
|
|
WO2019160994A1
(en)
|
2018-02-14 |
2019-08-22 |
Bluestar Genomics, Inc. |
Methods for the epigenetic analysis of dna, particularly cell-free dna
|
|
US20210388445A1
(en)
*
|
2018-04-12 |
2021-12-16 |
Singlera Genomics, Inc. |
Compositions and methods for cancer and neoplasia assessment
|
|
CN113748215B
(zh)
|
2018-11-04 |
2024-07-23 |
Pfs基因组学公司 |
用于乳腺癌的预后和预测来自辅助放射疗法的益处的方法和基因组分类器
|
|
WO2020112869A1
(en)
|
2018-11-27 |
2020-06-04 |
Exact Sciences Development Company, Llc |
Characterizing methylated dna, rna, and proteins in the detection of lung neoplasia
|
|
BR112021010640A2
(pt)
|
2018-12-04 |
2021-09-08 |
Hkg Epitherapeutics Limited |
Método in-vitro para obter preditores precoces de câncer cervical, painel de biomarcadores de metilação de dna para rastreamento e detecção precoce de câncer cervical, combinação de biomarcadores de metilação de dna para rastreamento e detecção precoce de câncer cervical, kit para detecção de câncer cervical, uso de equação de regressão linear multivariável ou análise de rede neura, uso de ensaios decaracterísticas de operação do receptor (roc), e método implementado por computador para obter biomarcadores de metilação de dna candidatos para detecção precoce dediagnóstico de câncer cervical
|
|
SG11202106130UA
(en)
|
2018-12-08 |
2021-07-29 |
Pfs Genomics Inc |
Transcriptomic profiling for prognosis of breast cancer
|
|
CA3127329A1
(en)
|
2019-01-24 |
2020-07-30 |
Mayo Foundation For Medical Education And Research |
Detecting endometrial cancer
|
|
KR20210146983A
(ko)
|
2019-04-03 |
2021-12-06 |
메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 |
혈장에서 췌장 관상 선암종의 검출
|
|
JP2022530920A
(ja)
|
2019-05-03 |
2022-07-04 |
コーネル ユニバーシティー |
核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー
|
|
WO2020236939A2
(en)
|
2019-05-23 |
2020-11-26 |
Paradigm Diagnostics |
Tissue preparation using nuclease
|
|
US11396679B2
(en)
|
2019-05-31 |
2022-07-26 |
Universal Diagnostics, S.L. |
Detection of colorectal cancer
|
|
WO2020264220A1
(en)
|
2019-06-25 |
2020-12-30 |
The Translational Genomics Research Institute |
Detection and treatment of residual disease using circulating tumor dna analysis
|
|
CA3149601A1
(en)
|
2019-08-27 |
2021-03-04 |
Scott Morris |
Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia
|
|
AU2020365127B2
(en)
|
2019-10-18 |
2026-04-09 |
Exact Sciences Corporation |
Multiple analyte fecal antigen testing
|
|
US11702704B2
(en)
*
|
2019-10-31 |
2023-07-18 |
Mayo Foundation For Medical Education And Research |
Detecting ovarian cancer
|
|
CN115605138A
(zh)
|
2020-04-17 |
2023-01-13 |
精密科学公司（Us） |
可摄取取样装置
|
|
JP2023524750A
(ja)
|
2020-05-04 |
2023-06-13 |
マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ |
メラノーマの検出
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AU2021268631A1
(en)
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2020-05-04 |
2023-01-05 |
Mayo Foundation For Medical Education And Research |
Detecting pancreatic neuroendocrine tumors
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AU2021329235A1
(en)
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2020-07-29 |
2023-02-23 |
Exact Sciences Corporation |
Purification of sulfonated DNA
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AU2021329899A1
(en)
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2020-08-19 |
2023-03-09 |
Exact Sciences Corporation |
Detecting non-hodgkin lymphoma
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KR20230150814A
(ko)
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2021-01-29 |
2023-10-31 |
메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 |
다양한 유형의 암에 대한 존재 또는 부재의 검출
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EP4301867A1
(en)
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2021-03-01 |
2024-01-10 |
PFS Genomics, Inc. |
Methods and genomic classifiers for prognosis of breast cancer and identifying subjects not likely to benefit from radiotherapy
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CA3211005A1
(en)
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2021-03-05 |
2022-09-09 |
Mayo Foundation For Medical Education And Research |
Detecting cervical cancer
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US20220349009A1
(en)
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2021-04-23 |
2022-11-03 |
Mayo Foundation For Medical Education And Research |
Detecting esophageal disorders
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CA3236697A1
(en)
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2021-11-05 |
2023-05-11 |
William R. Taylor |
Compositions and methods for detecting oropharyngeal cancer
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