JP2022545118A5 - - Google Patents

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Publication number
JP2022545118A5
JP2022545118A5 JP2022512459A JP2022512459A JP2022545118A5 JP 2022545118 A5 JP2022545118 A5 JP 2022545118A5 JP 2022512459 A JP2022512459 A JP 2022512459A JP 2022512459 A JP2022512459 A JP 2022512459A JP 2022545118 A5 JP2022545118 A5 JP 2022545118A5
Authority
JP
Japan
Prior art keywords
nucleotides
oligonucleotide
positions
double
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022512459A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022545118A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/047492 external-priority patent/WO2021041247A1/en
Publication of JP2022545118A publication Critical patent/JP2022545118A/ja
Publication of JP2022545118A5 publication Critical patent/JP2022545118A5/ja
Priority to JP2025064358A priority Critical patent/JP2025123220A/ja
Pending legal-status Critical Current

Links

JP2022512459A 2019-08-23 2020-08-21 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド Pending JP2022545118A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025064358A JP2025123220A (ja) 2019-08-23 2025-04-09 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962891185P 2019-08-23 2019-08-23
US62/891,185 2019-08-23
US202062982534P 2020-02-27 2020-02-27
US62/982,534 2020-02-27
PCT/US2020/047492 WO2021041247A1 (en) 2019-08-23 2020-08-21 O-methyl rich fully stabilized oligonucleotides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025064358A Division JP2025123220A (ja) 2019-08-23 2025-04-09 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド

Publications (2)

Publication Number Publication Date
JP2022545118A JP2022545118A (ja) 2022-10-25
JP2022545118A5 true JP2022545118A5 (https=) 2023-06-30

Family

ID=74684325

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022512459A Pending JP2022545118A (ja) 2019-08-23 2020-08-21 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド
JP2025064358A Pending JP2025123220A (ja) 2019-08-23 2025-04-09 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025064358A Pending JP2025123220A (ja) 2019-08-23 2025-04-09 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド

Country Status (4)

Country Link
US (1) US20210115442A1 (https=)
EP (1) EP4017504A4 (https=)
JP (2) JP2022545118A (https=)
WO (1) WO2021041247A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160319278A1 (en) 2015-04-03 2016-11-03 University Of Massachusetts Fully stabilized asymmetric sirna
WO2017030973A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
US10478503B2 (en) 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
CA3033368A1 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
US11279930B2 (en) * 2018-08-23 2022-03-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
CN113614232A (zh) 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
KR20220047989A (ko) 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
US20210363523A1 (en) * 2020-03-18 2021-11-25 University Of Massachusetts Oligonucleotides for mapt modulation
WO2021242883A1 (en) 2020-05-26 2021-12-02 University Of Massachusetts Synthetic oligonucleotides having regions of block and cluster modifications
WO2022204430A1 (en) * 2021-03-24 2022-09-29 Atalanta Therapeutics, Inc. Double-stranded sirna having patterned chemical modifications
CN117677699A (zh) * 2021-06-23 2024-03-08 马萨诸塞大学 用于治疗先兆子痫和其他血管生成病症的优化抗flt1寡核苷酸化合物
WO2023018705A1 (en) * 2021-08-10 2023-02-16 University Of Massachusetts Compositions and methods for sirna treatment of muscular dystrophy
JP2025532984A (ja) * 2022-09-30 2025-10-03 ユニバーシティー オブ マサチューセッツ オリゴヌクレオチドの眼送達

Family Cites Families (18)

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NL2000439C2 (nl) * 2006-01-20 2009-03-16 Quark Biotech Therapeutische toepassingen van inhibitoren van RTP801.
AU2007299705B2 (en) * 2006-09-22 2012-09-06 Dharmacon, Inc. Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
CA2715289C (en) * 2008-02-11 2019-12-24 Rxi Pharmaceuticals Corporation Modified rnai polynucleotides and uses thereof
JP2012521766A (ja) * 2009-03-27 2012-09-20 メルク・シャープ・エンド・ドーム・コーポレイション 低分子干渉核酸（ｓｉＮＡ）を用いた高親和性ＩｇＥ受容体α鎖（ＦＣεＲ１α）遺伝子発現のＲＮＡ干渉媒介性阻害
WO2012058210A1 (en) * 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
IL292159B1 (en) * 2012-12-05 2026-04-01 Alnylam Pharmaceuticals Inc PCSK9 iRNA compositions and methods of using them
US20160319278A1 (en) * 2015-04-03 2016-11-03 University Of Massachusetts Fully stabilized asymmetric sirna
IL295755A (en) * 2015-10-09 2022-10-01 Wave Life Sciences Ltd Oligonucleotide compositions and methods thereof
US10478503B2 (en) * 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
DK3607069T3 (da) * 2017-04-05 2022-11-21 Silence Therapeutics Gmbh Produkter og sammensætninger
WO2019075419A1 (en) * 2017-10-13 2019-04-18 Dicerna Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR INHIBITING LDHA EXPRESSION
WO2020033899A1 (en) * 2018-08-10 2020-02-13 University Of Massachusetts Modified oligonucleotides targeting snps
US11279930B2 (en) * 2018-08-23 2022-03-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
CN113811311A (zh) * 2019-03-15 2021-12-17 马萨诸塞大学 用于组织特异性apoe调节的寡核苷酸
JP2022528487A (ja) * 2019-03-29 2022-06-13 ユニバーシティ・オブ・マサチューセッツ Ｃ９ｏｒｆ７２のオリゴヌクレオチドベースの調節
KR20220047989A (ko) * 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
WO2021195510A1 (en) * 2020-03-27 2021-09-30 University Of Massachusetts Dual-acting sirna based modulation of c9orf72
EP4158028A4 (en) * 2020-05-28 2024-10-02 University Of Massachusetts OLIGONUCLEOTIDES FOR THE MODULATION OF SARS-COV-2

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