JP2022545118A - Ｏ－メチルリッチ完全安定化オリゴヌクレオチド - Google Patents

Ｏ－メチルリッチ完全安定化オリゴヌクレオチド Download PDF

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JP2022545118A
JP2022545118A JP2022512459A JP2022512459A JP2022545118A JP 2022545118 A JP2022545118 A JP 2022545118A JP 2022512459 A JP2022512459 A JP 2022512459A JP 2022512459 A JP2022512459 A JP 2022512459A JP 2022545118 A JP2022545118 A JP 2022545118A
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nucleotides
oligonucleotide
double
nucleic acid
stranded nucleic
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コボロバ，アナスタシア
オルターマン，ジュリア
デイビス，サラ
トゥラノフ，アントン
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University of Massachusetts Amherst
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JP2022512459A 2019-08-23 2020-08-21 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド Pending JP2022545118A (ja)

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JP2025064358A JP2025123220A (ja) 2019-08-23 2025-04-09 Ｏ－メチルリッチ完全安定化オリゴヌクレオチド

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US201962891185P 2019-08-23 2019-08-23
US62/891,185 2019-08-23
US202062982534P 2020-02-27 2020-02-27
US62/982,534 2020-02-27
PCT/US2020/047492 WO2021041247A1 (en) 2019-08-23 2020-08-21 O-methyl rich fully stabilized oligonucleotides

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US (1) US20210115442A1 (https=)
EP (1) EP4017504A4 (https=)
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WO (1) WO2021041247A1 (https=)

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US20160319278A1 (en) 2015-04-03 2016-11-03 University Of Massachusetts Fully stabilized asymmetric sirna
WO2017030973A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
US10478503B2 (en) 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
CA3033368A1 (en) 2016-08-12 2018-02-15 University Of Massachusetts Conjugated oligonucleotides
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
US11279930B2 (en) * 2018-08-23 2022-03-22 University Of Massachusetts O-methyl rich fully stabilized oligonucleotides
CN113614232A (zh) 2019-01-18 2021-11-05 马萨诸塞大学 动态药代动力学修饰锚
KR20220047989A (ko) 2019-08-09 2022-04-19 유니버시티 오브 매사추세츠 Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드
US12365894B2 (en) 2019-09-16 2025-07-22 University Of Massachusetts Branched lipid conjugates of siRNA for specific tissue delivery
US20210363523A1 (en) * 2020-03-18 2021-11-25 University Of Massachusetts Oligonucleotides for mapt modulation
WO2021242883A1 (en) 2020-05-26 2021-12-02 University Of Massachusetts Synthetic oligonucleotides having regions of block and cluster modifications
WO2022204430A1 (en) * 2021-03-24 2022-09-29 Atalanta Therapeutics, Inc. Double-stranded sirna having patterned chemical modifications
CN117677699A (zh) * 2021-06-23 2024-03-08 马萨诸塞大学 用于治疗先兆子痫和其他血管生成病症的优化抗flt1寡核苷酸化合物
WO2023018705A1 (en) * 2021-08-10 2023-02-16 University Of Massachusetts Compositions and methods for sirna treatment of muscular dystrophy
JP2025532984A (ja) * 2022-09-30 2025-10-03 ユニバーシティー オブ マサチューセッツ オリゴヌクレオチドの眼送達

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JP2016506240A (ja) * 2012-12-05 2016-03-03 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＰＣＳＫ９ｉＲＮＡ組成物及びその使用方法
JP2018537952A (ja) * 2015-10-09 2018-12-27 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． オリゴヌクレオチド組成物およびその方法
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JP2025123220A (ja) 2025-08-22
EP4017504A4 (en) 2024-01-24
US20210115442A1 (en) 2021-04-22
EP4017504A1 (en) 2022-06-29

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