JP2022537782A - スズイオンを含む歯磨剤組成物 - Google Patents
スズイオンを含む歯磨剤組成物 Download PDFInfo
- Publication number
- JP2022537782A JP2022537782A JP2021576351A JP2021576351A JP2022537782A JP 2022537782 A JP2022537782 A JP 2022537782A JP 2021576351 A JP2021576351 A JP 2021576351A JP 2021576351 A JP2021576351 A JP 2021576351A JP 2022537782 A JP2022537782 A JP 2022537782A
- Authority
- JP
- Japan
- Prior art keywords
- dentifrice composition
- dentifrice
- fluoride
- tin
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 260
- 239000000551 dentifrice Substances 0.000 title claims abstract description 163
- 229910001432 tin ion Inorganic materials 0.000 title abstract description 84
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000011575 calcium Substances 0.000 claims abstract description 34
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 34
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 33
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 20
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims abstract description 15
- 229960002799 stannous fluoride Drugs 0.000 claims abstract description 15
- 229910021626 Tin(II) chloride Inorganic materials 0.000 claims abstract description 9
- 235000011150 stannous chloride Nutrition 0.000 claims abstract description 9
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000001119 stannous chloride Substances 0.000 claims abstract description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 64
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 33
- 239000000377 silicon dioxide Substances 0.000 claims description 30
- 239000003906 humectant Substances 0.000 claims description 18
- 239000002562 thickening agent Substances 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 13
- 239000004094 surface-active agent Substances 0.000 claims description 12
- 150000002500 ions Chemical class 0.000 claims description 11
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 229920001525 carrageenan Polymers 0.000 claims description 8
- 235000010418 carrageenan Nutrition 0.000 claims description 8
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 claims description 8
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 7
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 7
- 239000000679 carrageenan Substances 0.000 claims description 7
- 229940113118 carrageenan Drugs 0.000 claims description 7
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 7
- 235000010447 xylitol Nutrition 0.000 claims description 7
- 239000000811 xylitol Substances 0.000 claims description 7
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 7
- 229960002675 xylitol Drugs 0.000 claims description 7
- 229910052725 zinc Inorganic materials 0.000 claims description 7
- 239000011701 zinc Substances 0.000 claims description 7
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 6
- 239000000600 sorbitol Substances 0.000 claims description 6
- 235000010356 sorbitol Nutrition 0.000 claims description 6
- 229920002125 Sokalan® Polymers 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004386 Erythritol Substances 0.000 claims description 4
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 4
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 4
- 235000019414 erythritol Nutrition 0.000 claims description 4
- 229940009714 erythritol Drugs 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000011775 sodium fluoride Substances 0.000 claims description 3
- 235000013024 sodium fluoride Nutrition 0.000 claims description 3
- 239000001488 sodium phosphate Substances 0.000 claims description 3
- 229960002920 sorbitol Drugs 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 229960005150 glycerol Drugs 0.000 claims description 2
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 claims description 2
- 229960001245 olaflur Drugs 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- 229910000162 sodium phosphate Inorganic materials 0.000 claims 1
- DFNPRTKVCGZMMC-UHFFFAOYSA-M tributyl(fluoro)stannane Chemical compound CCCC[Sn](F)(CCCC)CCCC DFNPRTKVCGZMMC-UHFFFAOYSA-M 0.000 abstract 1
- 238000009472 formulation Methods 0.000 description 37
- -1 stannous fluoride Chemical class 0.000 description 25
- 229920000388 Polyphosphate Polymers 0.000 description 22
- 239000001205 polyphosphate Substances 0.000 description 22
- 235000011176 polyphosphates Nutrition 0.000 description 22
- 229940091249 fluoride supplement Drugs 0.000 description 20
- 235000010216 calcium carbonate Nutrition 0.000 description 18
- 239000003082 abrasive agent Substances 0.000 description 17
- 239000002738 chelating agent Substances 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 15
- 229920005862 polyol Polymers 0.000 description 15
- 150000003077 polyols Chemical class 0.000 description 15
- 239000000243 solution Substances 0.000 description 13
- 239000004615 ingredient Substances 0.000 description 12
- 239000002002 slurry Substances 0.000 description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 10
- 210000000214 mouth Anatomy 0.000 description 10
- 239000000523 sample Substances 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 239000003086 colorant Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 235000013355 food flavoring agent Nutrition 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- 150000004676 glycans Chemical class 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 239000002324 mouth wash Substances 0.000 description 6
- 229920001282 polysaccharide Polymers 0.000 description 6
- 239000005017 polysaccharide Substances 0.000 description 6
- 230000009257 reactivity Effects 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- IUTCEZPPWBHGIX-UHFFFAOYSA-N tin(2+) Chemical compound [Sn+2] IUTCEZPPWBHGIX-UHFFFAOYSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 235000003599 food sweetener Nutrition 0.000 description 5
- 238000002354 inductively-coupled plasma atomic emission spectroscopy Methods 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 239000003765 sweetening agent Substances 0.000 description 5
- 239000000606 toothpaste Substances 0.000 description 5
- 229940034610 toothpaste Drugs 0.000 description 5
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 4
- 229910001634 calcium fluoride Inorganic materials 0.000 description 4
- 229910001424 calcium ion Inorganic materials 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000002826 coolant Substances 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 239000006072 paste Substances 0.000 description 4
- 239000011591 potassium Chemical group 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 150000005846 sugar alcohols Chemical class 0.000 description 4
- 239000004408 titanium dioxide Substances 0.000 description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 239000004909 Moisturizer Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 239000006172 buffering agent Substances 0.000 description 3
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 229940043256 calcium pyrophosphate Drugs 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 235000015165 citric acid Nutrition 0.000 description 3
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 229910052733 gallium Inorganic materials 0.000 description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 239000000832 lactitol Substances 0.000 description 3
- 235000010448 lactitol Nutrition 0.000 description 3
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 3
- 229960003451 lactitol Drugs 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
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- 239000000126 substance Substances 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- 241001474374 Blennius Species 0.000 description 2
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- 235000019739 Dicalciumphosphate Nutrition 0.000 description 2
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 2
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- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
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- 150000001298 alcohols Chemical class 0.000 description 2
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 2
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- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical compound CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 description 2
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- 238000002474 experimental method Methods 0.000 description 2
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- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 2
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Abstract
Description
本明細書で使用される用語をより明確に定義するために、以下の定義が提供される。別途記載のない限り、以下の定義は、本開示に適用可能である。ある用語が本開示で使用されているが本明細書で具体的に定義されていない場合、その定義が、本明細書に適用される任意の他の開示又は定義と矛盾しない限り、又はその定義が適用される任意の請求項を不明確に又は不可能にしない限り、IUPAC Compendium of Chemical Terminology,2nd Ed(1997)からの定義を適用することができる。
本発明の歯磨剤組成物は、スズを含む。スズは、スズイオン源によって提供することができる。スズイオン源は、歯磨剤組成物中にスズイオンを提供することができ、及び/又は歯磨剤組成物が口腔に適用されるときに、口腔にスズイオンを供給することができる任意の好適な化合物であり得る。スズイオン源は、フッ化第一スズ、塩化第一スズ、臭化第一スズ、ヨウ化第一スズ、酸化第一スズ、シュウ酸第一スズ、硫酸第一スズ、硫化第一スズ、フッ化第二スズ、塩化第二スズ、臭化第二スズ、ヨウ化第二スズ、硫化第二スズ、及び/又はそれらの混合物などの1つ以上のスズ含有化合物を含み得る。好ましくは、スズイオン源は、フッ化第一スズ、塩化第一スズ、及び/又はこれらの混合物を含み得る。
本発明の歯磨剤組成物は、カルシウムを含む。カルシウムは、カルシウム研磨剤によって提供することができる。研磨剤は、歯から表面の着色汚れを除去するのを助けるために歯磨剤製剤に添加され得る。カルシウム研磨剤は、歯磨剤組成物中にカルシウムイオンを提供することができ、及び/又は歯磨剤組成物が口腔に適用されるときに、口腔にカルシウムイオンを供給することができる任意の好適な研磨剤化合物であり得る。
本発明の口腔ケア組成物は、ポリオールを含むことができる。ポリオールは、2つ以上のヒドロキシル官能基を有する有機化合物である。ポリオールは、口腔ケア組成物が使用前に保存されている間、スズイオンに弱く会合、相互作用、又は結合することができる任意の好適な化合物であり得る。ポリオールは、糖アルコール、単糖類、二糖類、多糖類、又は非還元糖であり得る。糖アルコールは、糖化合物の水素化によって得ることができるポリオールの部類であり、式(CHOH)nH2を有し、n=4~6である。好ましくは、nは5及び/又は6であり、なぜなら、これらの化合物は、本明細書に記載されるように、スズイオン源と予期せず相互作用して可溶性錯体を生成することが示されているからである。
本発明の歯磨剤組成物は、無水、低含水製剤、又は高含水製剤であり得る。合計で、口腔ケア組成物は、組成物の0重量%~約99重量%、約5重量%~約75重量%、約20重量%以上、約30重量%以上、又は約50重量%以上の水を含むことができる。好ましくは、水は、USP水である。
歯磨剤組成物は、1種以上の緩衝剤を含み得る。緩衝剤は、本発明で使用する場合、歯磨剤組成物のスラリーpHを7超、7超~約14、約7.5超、約8超、約7.5~10、7超~約10、又は約8~約10の範囲に調整するために使用することができる薬剤を指す。緩衝剤としては、アルカリ金属水酸化物、カーボネート、セスキカーボネート、ボレート、シリケート、ホスフェート、イミダゾール、及びこれらの混合物が挙げられる。具体的な緩衝剤としては、リン酸一ナトリウム、リン酸三ナトリウム、水酸化ナトリウム、水酸化カリウム、アルカリ金属炭酸塩、炭酸ナトリウム、イミダゾール、ピロホスフェート、クエン酸、及びクエン酸ナトリウムが挙げられる。歯磨剤組成物は、1種以上の緩衝剤を各々が本組成物の約0.1重量%~約30重量%、約1重量%~約10重量%、又は約1.5重量%~約3重量%の濃度で含み得る。
歯磨剤組成物は、亜鉛を含み得る。亜鉛は、亜鉛イオン源によって提供することができる。亜鉛イオン源は、フッ化亜鉛、乳酸亜鉛、酸化亜鉛、リン酸亜鉛、塩化亜鉛、酢酸亜鉛、ヘキサフルオロジルコン酸亜鉛、硫酸亜鉛、酒石酸亜鉛、グルコン酸亜鉛、クエン酸亜鉛、リンゴ酸亜鉛、グリシン酸亜鉛、ピロリン酸亜鉛、メタリン酸亜鉛、シュウ酸亜鉛、及び/又は炭酸亜鉛などの1つ以上の亜鉛含有化合物を含み得る。
歯磨剤組成物は、フッ化物を含み得る。フッ化物は、フッ化物イオン源によって提供することができる。フッ化物イオン源は、フッ化第一スズ、フッ化ナトリウム、フッ化カリウム、フッ化アミン、モノフルオロリン酸ナトリウム、フッ化亜鉛、及び/又はこれらの混合物などの1つ以上のフッ化物含有化合物を含むことができる。
歯磨剤組成物は、ポリホスフェートを含み得る。ポリホスフェートは、ポリホスフェート源によって提供することができる。ポリホスフェート源は、1つ以上のポリホスフェート分子を含み得る。ポリホスフェートは、オルトホスフェートの脱水及び縮合によって様々な鎖長の直鎖及び環状ポリホスフェートをもたらすことにより、得られる物質の部類である。したがって、ポリホスフェート分子は、一般に、以下に記載されるように、ポリホスフェート分子の平均数(n)で同定される。ポリホスフェートは一般に、主に直鎖構造に配置された2つ以上のホスフェート分子からなると理解されているが、いくつかの環状誘導体が存在する場合もある。
歯磨剤組成物は、保湿剤を含んでもよく、低濃度の保湿剤を含んでもよく、又は保湿剤を含まなくてもよい。湿潤剤は、口腔ケア組成物又は歯磨剤に濃度(body)又は「口当たり」を加えるだけでなく、歯磨剤が乾燥するのを防止する役割を果たす。適切な保湿剤としては、ポリエチレングリコール(様々な異なる分子量で)、プロピレングリコール、グリセリン(グリセロール)、エリスリトール、キシリトール、ソルビトール、マンニトール、ブチレングリコール、ラクチトール、加水分解水添デンプン、及び/又はこれらの混合物が挙げられる。歯磨剤組成物は、1種以上の保湿剤を各々が歯磨剤組成物の0~約70重量%、約5重量%~約50重量%、約10重量%~約60重量%、又は約20重量%~約80重量%の濃度で含み得る。
歯磨剤組成物は、1種以上の界面活性剤を含み得る。界面活性剤は、組成物をより美容的に許容可能にするために使用することができる。界面活性剤は、好ましくは、組成物に洗浄性及び起泡性を付与する洗浄性材料である。好適な界面活性剤は、安全かつ有効な量のアニオン性、カチオン性、非イオン性、双性イオン性、両性及びベタイン界面活性剤、例えば、ラウリル硫酸ナトリウム、ラウリルイセチオン酸ナトリウム、ラウロイルメチルイセチオン酸ナトリウム、グルタミン酸ココイルナトリウム、ドデシルベンゼンスルホン酸ナトリウム、ラウロイルサルコシン酸、ミリストイルサルコシン酸、パルミトイルサルコシン酸、ステアロイルサルコシン酸及びオレオイルサルコシン酸のアルカリ金属塩又はアンモニウム塩、モノステアリン酸ポリオキシエチレンソルビタン、イソステアリン酸ポリオキシエチレンソルビタン及びラウリン酸ポリオキシエチレンソルビタン、ラウリルスルホ酢酸ナトリウム、N-ラウロイルサルコシン、N-ラウロイル、N-ミリストイル、又はN-パルミトイルサルコシンのナトリウム、カリウム、及びエタノールアミン塩、アルキルフェノールのポリエチレンオキシド縮合物、ココアミドプロピルベタイン、ラウラミドプロピルベタイン、パルミチルベタイン、ココイルグルタミン酸ナトリウムなどである。ラウリル硫酸ナトリウムが、好ましい界面活性剤である。歯磨剤組成物は、1種以上の界面活性剤を各々が歯磨剤組成物の約0.01重量%~約15重量%、約0.3重量%~約10重量%、又は約0.3重量%~約2.5重量%の濃度で含み得る。
歯磨剤組成物は、1種以上の増粘剤を含み得る。増粘剤は、歯磨剤組成物において、練り歯磨きを相分離に対して安定化させるゼラチン構造を提供するのに有用である。好適な増粘剤としては、多糖類、ポリマー、及び/又はシリカ増粘剤が挙げられる。多糖類のいくつかの非限定例としては、デンプン;デンプンのグリセライト;ガム、例えばカラヤガム(ステルクルアガム)、トラガカントガム、アラビアガム、ガティガム、アカシアガム、キサンタンガム、グアーガム及びセルロースガム;ケイ酸アルミニウムマグネシウム(Veegum);カラギーナン;アルギン酸ナトリウム;寒天;ペクチン;ゼラチン;セルロース化合物、例えばセルロース、カルボキシメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシメチルセルロース、ヒドロキシメチルカルボキシプロピルセルロース、メチルセルロース、エチルセルロース、及び硫酸化セルロース;天然及び合成粘土、例えばヘクトライト粘土;及びこれらの混合物が挙げられる。
歯磨剤組成物は、1000未満の分子量(MW)を有する1種以上のキレート剤を含み得る。本発明で使用する場合、用語「キレート剤」は、二価金属イオンに結合することができる少なくとも2つの基を有する二座又は多座配位子を意味する。典型的には、本明細書で有用なそれらのキレート剤はまた、スズイオンと水溶性錯体を形成する。シリカ研磨剤を含む歯磨剤組成物は、典型的には、スズイオンがシリカ粒子の表面に不可逆的に結合するのを防止するために、スズイオンを可逆的に結合するための1種以上のキレート剤を含む。本明細書における好適なキレート剤としては、コハク酸、リンゴ酸、酒石酸、及びクエン酸などのC2~C6ジカルボン酸及びトリカルボン酸;グルコン酸などの、ヒドロキシルで置換されたC3~C6モノカルボン酸;ピコリン酸;グリシンなどのアミノ酸;フィチン酸、それらの塩及びそれらの混合物が挙げられる。好ましくは、キレート剤は、グルコン酸ナトリウム又はクエン酸の塩である。
歯磨剤組成物は、以下に記載されるように、着香剤、甘味料、着色剤、防腐剤、緩衝剤、又は口腔ケア組成物での使用に好適な他の成分などの様々な他の成分を含み得る。
歯磨剤組成物は、そのスズイオン利用能及び/又はそのフッ化物イオン利用能によって説明することができる。歯磨剤組成物は、40℃での加速安定性測定を使用して、混合直後、少なくとも1ヶ月後、少なくとも2ヶ月後、又は少なくとも3ヶ月後に、少なくとも約70%、少なくとも約75%、少なくとも約80%、又は少なくとも約85%のスズイオン利用能を有することができる。歯磨剤組成物は、40℃での加速安定性測定を使用して、混合直後、少なくとも1ヶ月後、少なくとも2ヶ月後、又は少なくとも3ヶ月後に、少なくとも約70%、少なくとも約75%、少なくとも約80%、又は少なくとも約85%のフッ化物イオンの利用能を有することができる。40℃での1ヶ月間の貯蔵は、室温(約22~23℃)で少なくとも8ヶ月の貯蔵に相当する。
スズイオン利用能
この方法は、水性スラリー上清中の約5~約5,000ppmのSnの口腔ケア用練り歯磨き又は歯磨剤組成物中の可溶性スズの測定に適している。1部の練り歯磨きを3部の水と混合することによってスラリーを調製した。スラリーのアリコートを酸消化し、希釈し、測定された各練り歯磨きの誘導結合プラズマ発光分光法(ICP-OES)により分析した。結果は、本明細書では、練り歯磨き及び/又は歯磨剤の純水相中のppmとして報告される。
1.ICP-OESを、製造業者のガイドラインに従って予熱し、最適化した。推奨されるシステムチェックを実行した。分析の前に、HCl/HNO3リンス溶液を試料導入システムに通して、システムを30分間コンディショニングした。
2.製造業者が推奨する波長、積分時間、及び観察モードでガリウム内部標準を使用してスズを測定する方法を、操作コンピュータにロードした。
3.5%HCl/5%HNO3リンス溶液を使用して、各ブランク、標準、又は試験溶液の分析の間に試料導入システムをすすぎ洗いした。
4.分析中、全ての溶液について3~5回の読み取り値を記録した。
5.較正ブランクを分析した。
6.10ppmのSn標準を測定した。
7.5ppmのSn標準を測定した。
8.0.5ppmのLLOQスズ標準を測定した。
9.方法のブランクを測定した。
10.試験溶液を測定した。
11.5ppmのSn標準を、6番目毎の試験溶液の後及び最後の試料の後に再測定した。分析を完了するために十分な標準を作成した。
12.試料分析の終了時に、0.5ppmのLLOQスズ標準を測定した。
配合物A~Eを、加速安定性実験において40℃で保存した。各製剤の試料を1、2、及び/又は3ヶ月で分析した。40℃で1ヶ月間保存された試料は、室温(約22~23℃)で少なくとも8ヶ月間保存された同等の試料に近いと予想される。
Claims (9)
- 歯磨剤組成物であって、
(a)前記歯磨剤組成物の約0.0025重量%~約5重量%のスズであって、好ましくは前記スズが、フッ化第一スズ、塩化第一スズ、又はこれらの組み合わせを含む、スズと、
(b)前記歯磨剤組成物の約10重量%~約50重量%のカルシウム研磨剤であって、好ましくは前記カルシウム研磨剤が、炭酸カルシウムである、カルシウム研磨剤と、
(c)前記歯磨剤組成物の最大約45重量%又は好ましくは約5%未満の水と、
を含み、前記歯磨剤組成物が、7超のpHを有する、歯磨剤組成物。 - 前記歯磨剤組成物が、40℃で3ヶ月後に、約70%以上の利用可能なスズイオンを有する、請求項1に記載の歯磨剤組成物。
- 前記歯磨剤組成物が、前記歯磨剤組成物の約0.01重量%~約5重量%の亜鉛を含む、請求項1又は2に記載の歯磨剤組成物。
- 前記歯磨剤組成物がシリカ研磨剤を含む、請求項1~3のいずれか一項に記載の歯磨剤組成物。
- 前記歯磨剤組成物が、約20%~約80%の保湿剤を含み、好ましくは、前記保湿剤が、グリセリン、ソルビトール、エリスリトール、キシリトール、ブチレングリコール、プロピレングリコール、ポリエチレングリコール、又はこれらの組み合わせを含む、請求項1~4のいずれか一項に記載の歯磨剤組成物。
- 前記歯磨剤組成物が、前記歯磨剤組成物の約0.01重量%~約15重量%の1種以上の界面活性剤を含む、請求項1~5のいずれか一項に記載の歯磨剤組成物。
- 前記歯磨剤組成物が、前記歯磨剤組成物の約1重量%以下のシリカを含む、請求項1~6のいずれか一項に記載の歯磨剤組成物。
- 前記歯磨剤組成物が増粘剤を含み、好ましくは前記増粘剤が、キサンタンガム、カラギーナン、ポリエチレングリコール、架橋ポリアクリル酸ポリマー、ポリビニルピロリドン、脂肪族アルコール、又はこれらの組み合わせを含む、請求項1~7のいずれか一項に記載の歯磨剤組成物。
- 前記歯磨剤組成物が、前記歯磨剤組成物の約0.01重量%~約5重量%のフッ化物を含み、好ましくは、前記フッ化物が、フッ化ナトリウム、フッ化第一スズ、モノフルオロリン酸ナトリウム、フッ化アミン、フッ化亜鉛、又はこれらの組み合わせを含む、請求項33に記載の歯磨剤組成物。
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AU (2) | AU2020303738A1 (ja) |
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WO2020264562A1 (en) | 2019-06-28 | 2020-12-30 | The Procter & Gamble Company | Oral care compositions comprising tin ions |
AU2020303738A1 (en) | 2019-06-28 | 2021-12-16 | The Procter & Gamble Company | Dentifrice compositions comprising tin ions |
US11135143B2 (en) | 2020-06-25 | 2021-10-05 | The Procter & Gamble Company | Oral care compositions comprising tin ions |
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JP7295279B2 (ja) | 2023-06-20 |
WO2020264563A1 (en) | 2020-12-30 |
MX2021015658A (es) | 2022-08-04 |
US11135142B2 (en) | 2021-10-05 |
CN114040741A (zh) | 2022-02-11 |
US20240058231A1 (en) | 2024-02-22 |
US20200405594A1 (en) | 2020-12-31 |
BR112021024290A2 (pt) | 2022-01-11 |
AU2020303738A1 (en) | 2021-12-16 |
US11839672B2 (en) | 2023-12-12 |
US11135141B2 (en) | 2021-10-05 |
US20210378922A1 (en) | 2021-12-09 |
CA3144434A1 (en) | 2020-12-30 |
US20200405593A1 (en) | 2020-12-31 |
EP3990121A1 (en) | 2022-05-04 |
AU2023254930A1 (en) | 2023-11-16 |
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