JP2022537658A5 - - Google Patents
Info
- Publication number
- JP2022537658A5 JP2022537658A5 JP2021572305A JP2021572305A JP2022537658A5 JP 2022537658 A5 JP2022537658 A5 JP 2022537658A5 JP 2021572305 A JP2021572305 A JP 2021572305A JP 2021572305 A JP2021572305 A JP 2021572305A JP 2022537658 A5 JP2022537658 A5 JP 2022537658A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- sequence
- seq
- polypeptide
- nmdar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19178541 | 2019-06-05 | ||
| EP19178541.9 | 2019-06-05 | ||
| PCT/EP2020/065606 WO2020245343A1 (en) | 2019-06-05 | 2020-06-05 | Chimeric autoantibody receptor (caar) that binds autoantibodies targeting the central nervous system in neurological autoimmune disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022537658A JP2022537658A (ja) | 2022-08-29 |
| JP2022537658A5 true JP2022537658A5 (enExample) | 2023-06-09 |
| JP7702884B2 JP7702884B2 (ja) | 2025-07-04 |
Family
ID=66857629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021572305A Active JP7702884B2 (ja) | 2019-06-05 | 2020-06-05 | 神経学的自己免疫疾患における中枢神経系を標的とする自己抗体に結合するキメラ自己抗体受容体（ｃａａｒ） |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12617835B2 (enExample) |
| EP (1) | EP3980458A1 (enExample) |
| JP (1) | JP7702884B2 (enExample) |
| CN (1) | CN114008204B (enExample) |
| CA (1) | CA3141509A1 (enExample) |
| WO (1) | WO2020245343A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112457415A (zh) * | 2020-12-14 | 2021-03-09 | 成都仕康美生物科技有限公司 | 靶向MOG的嵌合抗原受体、编码基因、CAR-Tregs细胞及其制备方法、用途 |
| US20240041927A1 (en) * | 2020-12-22 | 2024-02-08 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) | Chimeric autoantibody receptor (caar) comprising a nicotinic acetylcholine receptor autoantigen |
| FR3120866B1 (fr) * | 2021-03-19 | 2025-02-28 | Univ Toulouse 3 Paul Sabatier | Molécule hybride comprenant un peptide citrulliné dérivé de la fibrine et un anticorps ou fragment d’anticorps se liant à CD38 et/ou CD138, et ses utilisations |
| JP2024545870A (ja) * | 2021-12-15 | 2024-12-13 | シャンハイ シンヴィダ バイオテクノロジー カンパニー リミテッド | 血小板減少症を治療するための製品及び方法 |
| CN114957446B (zh) * | 2022-05-31 | 2023-09-15 | 陕西脉元生物科技有限公司 | 与nmdar脑炎患者中的自身抗体结合的nmdar突变体及其构建方法 |
| WO2024151640A1 (en) * | 2023-01-09 | 2024-07-18 | Saliogen Therapeutics, Inc. | Transposase generated chimeric antigen receptor t cells |
| CN118566499B (zh) * | 2024-08-02 | 2024-10-08 | 成都海默云因医学检验实验室有限公司 | 一种GluN1和GluN2B亚基融合表达检测抗NMDAR抗体的CBA方法及检测试剂 |
| CN119708229B (zh) * | 2024-12-19 | 2025-12-09 | 陕西脉元生物科技有限公司 | 一种抗人lgi1蛋白的人鼠嵌合单克隆抗体及其产品和应用 |
| CN120098151B (zh) * | 2025-05-12 | 2025-07-25 | 成都海默云因医学检验实验室有限公司 | 一种检测抗gababr抗体脑炎的重组蛋白和检测试剂 |
| CN120485285A (zh) * | 2025-07-18 | 2025-08-15 | 天津医科大学总医院 | 一种质粒载体、嵌合mog抗体受体t细胞及其应用 |
| CN120624489B (zh) * | 2025-08-18 | 2025-12-02 | 天津医科大学总医院 | 一种嵌合aqp4抗体受体、caar-t细胞及应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| DK0973928T3 (da) | 1997-03-11 | 2010-08-09 | Univ Minnesota | DNA-baseret transposonsystem til indføring af nukleinsyre i DNA i en celle |
| CA2361124A1 (en) * | 1999-01-22 | 2000-07-27 | Matthew John During | Vaccine-mediated treatment of neurological disorders |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| HK1052372A1 (zh) | 2000-02-24 | 2003-09-11 | Xcyte Therapies, Inc. | 细胞的同步刺激和富集 |
| US7634360B2 (en) * | 2003-09-23 | 2009-12-15 | Prediction Sciences, LL | Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof |
| EP2057466B1 (en) * | 2006-08-15 | 2013-10-23 | The Trustees of the University of Pennsylvania | Methods and compositions for treatment and diagnosis of autoimmune encephalitis or epilepsy |
| US9228180B2 (en) | 2007-07-04 | 2016-01-05 | Max-Delbruck-Centrum Fur Molekulare Medizin | Polypeptide variants of sleeping beauty transposase |
| CN101874895B (zh) * | 2009-02-17 | 2013-01-02 | 南京大学医学院附属鼓楼医院 | Cart作为制备治疗阿尔茨海默病药物的应用 |
| EP2646578A4 (en) * | 2010-11-29 | 2014-04-30 | Kenneth Blum | METHODS OF EVALUATING RESULTS OF TREATMENT OF BEHAVIORS WITH DISSATISFACTION SYNDROME (RDS) USING EXPRESSION PROFILING |
| US8648198B2 (en) * | 2011-01-19 | 2014-02-11 | Cold Spring Harbor Laboratory | Phenylethanolamine-based NMDA receptor antagonists |
| EP3166968B1 (en) | 2014-05-02 | 2021-09-22 | The Trustees of the University of Pennsylvania | Compositions and methods of chimeric autoantibody receptor t cells |
| GB201409234D0 (en) | 2014-05-23 | 2014-07-09 | Isis Innovation | Method |
| RU2018109230A (ru) * | 2015-08-17 | 2019-09-19 | ДОЙЧЕС ЦЕНТРУМ ФЮР НОЙРОДЕГЕНЕРАТИВЕ ЭРКРАНКУНГЕН е.Ф. (ДЦНЭ) | Антитело, или фрагмент антитела, или неиммуноглобулиновый каркас, связывающийся с областью связывания антитела против рецептора n-метил-d-аспартата (nmda) |
| US12048718B2 (en) * | 2016-06-07 | 2024-07-30 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Geminschaft | Chimeric antigen receptor and CAR-T cells that bind BCMA |
| CN107857712B (zh) * | 2016-09-22 | 2022-09-09 | 烟台益诺依生物医药科技有限公司 | (r)-3-甲基-2-(3-氧代酰胺基)正丁酸酯 |
| EP3346001A1 (en) * | 2017-01-06 | 2018-07-11 | TXCell | Monospecific regulatory t cell population with cytotoxicity for b cells |
| WO2018127585A1 (en) | 2017-01-06 | 2018-07-12 | Txcell | Monospecific regulatory t cell population with cytotoxicity for b cells |
| MX421685B (es) | 2018-06-05 | 2025-03-14 | Univ Pennsylvania | Composiciones y metodos de celulas del receptor de autoanticuerpos quimericos de quinasa especifica del musculo |
-
2020
- 2020-06-05 JP JP2021572305A patent/JP7702884B2/ja active Active
- 2020-06-05 CN CN202080041341.7A patent/CN114008204B/zh active Active
- 2020-06-05 WO PCT/EP2020/065606 patent/WO2020245343A1/en not_active Ceased
- 2020-06-05 CA CA3141509A patent/CA3141509A1/en active Pending
- 2020-06-05 EP EP20732162.1A patent/EP3980458A1/en active Pending
- 2020-06-05 US US17/596,145 patent/US12617835B2/en active Active
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