JP7702884B2 - 神経学的自己免疫疾患における中枢神経系を標的とする自己抗体に結合するキメラ自己抗体受容体（ｃａａｒ） - Google Patents

神経学的自己免疫疾患における中枢神経系を標的とする自己抗体に結合するキメラ自己抗体受容体（ｃａａｒ） Download PDF

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JP7702884B2
JP7702884B2 JP2021572305A JP2021572305A JP7702884B2 JP 7702884 B2 JP7702884 B2 JP 7702884B2 JP 2021572305 A JP2021572305 A JP 2021572305A JP 2021572305 A JP2021572305 A JP 2021572305A JP 7702884 B2 JP7702884 B2 JP 7702884B2
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caar
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プルス，ハーラル
ラインケ，エス．モンセン
エデス，イナン
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ドイチェス ツェントラム フューア ノイロデジェネラティヴ エアクランクンゲン エー． ファウ．（ディーゼットエヌイー）
マックス－デルブリュック－ツェントルム フューア モレキュラーレ メディツィン イン デア ヘルムホルツ－ゲマインシャフト
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JP2021572305A 2019-06-05 2020-06-05 神経学的自己免疫疾患における中枢神経系を標的とする自己抗体に結合するキメラ自己抗体受容体（ｃａａｒ） Active JP7702884B2 (ja)

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EP19178541 2019-06-05
EP19178541.9 2019-06-05
PCT/EP2020/065606 WO2020245343A1 (en) 2019-06-05 2020-06-05 Chimeric autoantibody receptor (caar) that binds autoantibodies targeting the central nervous system in neurological autoimmune disease

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JP2022537658A JP2022537658A (ja) 2022-08-29
JP2022537658A5 JP2022537658A5 (enExample) 2023-06-09
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Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112457415A (zh) * 2020-12-14 2021-03-09 成都仕康美生物科技有限公司 靶向MOG的嵌合抗原受体、编码基因、CAR-Tregs细胞及其制备方法、用途
US20240041927A1 (en) * 2020-12-22 2024-02-08 Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) Chimeric autoantibody receptor (caar) comprising a nicotinic acetylcholine receptor autoantigen
FR3120866B1 (fr) * 2021-03-19 2025-02-28 Univ Toulouse 3 Paul Sabatier Molécule hybride comprenant un peptide citrulliné dérivé de la fibrine et un anticorps ou fragment d’anticorps se liant à CD38 et/ou CD138, et ses utilisations
JP2024545870A (ja) * 2021-12-15 2024-12-13 シャンハイ シンヴィダ バイオテクノロジー カンパニー リミテッド 血小板減少症を治療するための製品及び方法
CN114957446B (zh) * 2022-05-31 2023-09-15 陕西脉元生物科技有限公司 与nmdar脑炎患者中的自身抗体结合的nmdar突变体及其构建方法
WO2024151640A1 (en) * 2023-01-09 2024-07-18 Saliogen Therapeutics, Inc. Transposase generated chimeric antigen receptor t cells
CN118566499B (zh) * 2024-08-02 2024-10-08 成都海默云因医学检验实验室有限公司 一种GluN1和GluN2B亚基融合表达检测抗NMDAR抗体的CBA方法及检测试剂
CN119708229B (zh) * 2024-12-19 2025-12-09 陕西脉元生物科技有限公司 一种抗人lgi1蛋白的人鼠嵌合单克隆抗体及其产品和应用
CN120098151B (zh) * 2025-05-12 2025-07-25 成都海默云因医学检验实验室有限公司 一种检测抗gababr抗体脑炎的重组蛋白和检测试剂
CN120485285A (zh) * 2025-07-18 2025-08-15 天津医科大学总医院 一种质粒载体、嵌合mog抗体受体t细胞及其应用
CN120624489B (zh) * 2025-08-18 2025-12-02 天津医科大学总医院 一种嵌合aqp4抗体受体、caar-t细胞及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015168613A2 (en) 2014-05-02 2015-11-05 The Trustees Of The University Of Pennsylvania Compositions and methods of chimeric autoantibody receptor t cells
WO2018127585A1 (en) 2017-01-06 2018-07-12 Txcell Monospecific regulatory t cell population with cytotoxicity for b cells

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
DK0973928T3 (da) 1997-03-11 2010-08-09 Univ Minnesota DNA-baseret transposonsystem til indføring af nukleinsyre i DNA i en celle
CA2361124A1 (en) * 1999-01-22 2000-07-27 Matthew John During Vaccine-mediated treatment of neurological disorders
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
HK1052372A1 (zh) 2000-02-24 2003-09-11 Xcyte Therapies, Inc. 细胞的同步刺激和富集
US7634360B2 (en) * 2003-09-23 2009-12-15 Prediction Sciences, LL Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
EP2057466B1 (en) * 2006-08-15 2013-10-23 The Trustees of the University of Pennsylvania Methods and compositions for treatment and diagnosis of autoimmune encephalitis or epilepsy
US9228180B2 (en) 2007-07-04 2016-01-05 Max-Delbruck-Centrum Fur Molekulare Medizin Polypeptide variants of sleeping beauty transposase
CN101874895B (zh) * 2009-02-17 2013-01-02 南京大学医学院附属鼓楼医院 Cart作为制备治疗阿尔茨海默病药物的应用
EP2646578A4 (en) * 2010-11-29 2014-04-30 Kenneth Blum METHODS OF EVALUATING RESULTS OF TREATMENT OF BEHAVIORS WITH DISSATISFACTION SYNDROME (RDS) USING EXPRESSION PROFILING
US8648198B2 (en) * 2011-01-19 2014-02-11 Cold Spring Harbor Laboratory Phenylethanolamine-based NMDA receptor antagonists
GB201409234D0 (en) 2014-05-23 2014-07-09 Isis Innovation Method
RU2018109230A (ru) * 2015-08-17 2019-09-19 ДОЙЧЕС ЦЕНТРУМ ФЮР НОЙРОДЕГЕНЕРАТИВЕ ЭРКРАНКУНГЕН е.Ф. (ДЦНЭ) Антитело, или фрагмент антитела, или неиммуноглобулиновый каркас, связывающийся с областью связывания антитела против рецептора n-метил-d-аспартата (nmda)
US12048718B2 (en) * 2016-06-07 2024-07-30 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Geminschaft Chimeric antigen receptor and CAR-T cells that bind BCMA
CN107857712B (zh) * 2016-09-22 2022-09-09 烟台益诺依生物医药科技有限公司 (r)-3-甲基-2-(3-氧代酰胺基)正丁酸酯
EP3346001A1 (en) * 2017-01-06 2018-07-11 TXCell Monospecific regulatory t cell population with cytotoxicity for b cells
MX421685B (es) 2018-06-05 2025-03-14 Univ Pennsylvania Composiciones y metodos de celulas del receptor de autoanticuerpos quimericos de quinasa especifica del musculo

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015168613A2 (en) 2014-05-02 2015-11-05 The Trustees Of The University Of Pennsylvania Compositions and methods of chimeric autoantibody receptor t cells
WO2018127585A1 (en) 2017-01-06 2018-07-12 Txcell Monospecific regulatory t cell population with cytotoxicity for b cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Greenfield et al.，Nucleic Acid-Based Therapeutics Relevant to Neuroimmune Conditions，Neurotherapeutics，2019年05月，16，314-318

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