JP2022536755A5 - - Google Patents
Info
- Publication number
- JP2022536755A5 JP2022536755A5 JP2021573832A JP2021573832A JP2022536755A5 JP 2022536755 A5 JP2022536755 A5 JP 2022536755A5 JP 2021573832 A JP2021573832 A JP 2021573832A JP 2021573832 A JP2021573832 A JP 2021573832A JP 2022536755 A5 JP2022536755 A5 JP 2022536755A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- independently selected
- alkyl
- group
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024208554A JP2025037981A (ja) | 2019-06-14 | 2024-11-29 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962861714P | 2019-06-14 | 2019-06-14 | |
| US62/861,714 | 2019-06-14 | ||
| US201962955924P | 2019-12-31 | 2019-12-31 | |
| US62/955,924 | 2019-12-31 | ||
| PCT/US2020/037403 WO2020252240A1 (en) | 2019-06-14 | 2020-06-12 | Compounds and compositions for treating conditions associated with sting activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024208554A Division JP2025037981A (ja) | 2019-06-14 | 2024-11-29 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022536755A JP2022536755A (ja) | 2022-08-18 |
| JP2022536755A5 true JP2022536755A5 (enExample) | 2023-06-19 |
Family
ID=71465411
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021573832A Pending JP2022536755A (ja) | 2019-06-14 | 2020-06-12 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| JP2024208554A Pending JP2025037981A (ja) | 2019-06-14 | 2024-11-29 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024208554A Pending JP2025037981A (ja) | 2019-06-14 | 2024-11-29 | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230092163A1 (enExample) |
| EP (1) | EP3983383A1 (enExample) |
| JP (2) | JP2022536755A (enExample) |
| MA (1) | MA56193A (enExample) |
| PY (1) | PY2026348A (enExample) |
| TW (1) | TWI873145B (enExample) |
| UY (1) | UY38751A (enExample) |
| WO (1) | WO2020252240A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120004785A (zh) | 2018-07-03 | 2025-05-16 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| JP2022517797A (ja) * | 2019-01-17 | 2022-03-10 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| TW202200136A (zh) | 2020-04-10 | 2022-01-01 | 日商小野藥品工業股份有限公司 | 癌治療方法 |
| US20240051970A1 (en) * | 2020-12-16 | 2024-02-15 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| JP2023554393A (ja) * | 2020-12-16 | 2023-12-27 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| JP2024500874A (ja) | 2020-12-22 | 2024-01-10 | アイエフエム デュー インコーポレイテッド | がんを処置する方法 |
| US20240060982A1 (en) * | 2020-12-22 | 2024-02-22 | Ifm Due, Inc. | Methods of treating cancer |
| EP4267128A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| EP4267129A1 (en) | 2020-12-22 | 2023-11-01 | IFM Due, Inc. | Methods of treating cancer |
| EP4274824A1 (en) | 2021-01-08 | 2023-11-15 | IFM Due, Inc. | Heterobicyclic compounds having an urea or analogue and their compositions for treating conditions associated with sting activity |
| CN112920170B (zh) * | 2021-01-29 | 2023-06-20 | 中国医科大学 | N-（吲哚-5-基）芳香杂环酰胺类化合物及其制备方法和用途 |
| CN116981668A (zh) * | 2021-04-09 | 2023-10-31 | 百济神州(北京)生物科技有限公司 | 制备bcl-2抑制剂的中间体的方法 |
| IL310724A (en) | 2021-08-10 | 2024-04-01 | Ifm Due Inc | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH STING ACTIVITY |
| CN115710255B (zh) * | 2021-08-23 | 2025-05-06 | 上海交通大学 | 一类含有苯并杂环取代的脲类衍生物及其制备和用途 |
| WO2024064358A1 (en) | 2022-09-23 | 2024-03-28 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2024096753A1 (en) | 2022-11-02 | 2024-05-10 | Captor Therapeutics S.A. | Nek7 degraders and methods of use thereof |
| IT202200024963A1 (it) * | 2022-12-05 | 2024-06-05 | Angelini Pharma S P A | Composti attivatori dei canali potassio Kv7.2/Kv7.3 |
| CN117756698A (zh) * | 2022-12-16 | 2024-03-26 | 中国药科大学 | 脲类化合物及其作为sting抑制剂的医药用途 |
| WO2024151919A1 (en) * | 2023-01-13 | 2024-07-18 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| KR20260008767A (ko) * | 2023-05-09 | 2026-01-16 | 안젤리니 파마 에스피에이 | 신규한 카복사마이드 유도체 |
| WO2024263860A1 (en) * | 2023-06-22 | 2024-12-26 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| CN121532389A (zh) * | 2023-08-30 | 2026-02-13 | 江苏正大丰海制药有限公司 | 用于调节微小rna-124活性的化合物 |
| WO2025079045A1 (en) * | 2023-10-12 | 2025-04-17 | Novartis Pharma Ag | Compounds and compositions for treating conditions associated with sting activity |
| WO2025153990A1 (en) * | 2024-01-19 | 2025-07-24 | Novartis Pharma Ag | Compounds and compositions for treating conditions associated with sting activity |
| WO2025188646A1 (en) * | 2024-03-04 | 2025-09-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for treating cancer |
| CN120794982A (zh) * | 2024-05-14 | 2025-10-17 | 中国药科大学 | 吡唑类sting抑制剂及其医药用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE913204A1 (en) * | 1990-09-13 | 1992-02-25 | Beecham Group Plc | Novel compounds |
| US5439906A (en) * | 1993-11-22 | 1995-08-08 | Merck & Co., Inc. | Antiarrhythmic benzodiazepines |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| GB9823873D0 (en) * | 1998-10-30 | 1998-12-30 | Pharmacia & Upjohn Spa | 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents |
| EP1150977B1 (en) * | 1999-02-12 | 2004-08-25 | SmithKline Beecham plc | Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists |
| US6387900B1 (en) * | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
| EP1256578B1 (en) * | 2001-05-11 | 2006-01-11 | Pfizer Products Inc. | Thiazole derivatives and their use as cdk inhibitors |
| JP2003192587A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US7557129B2 (en) * | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| EP1858879B1 (en) * | 2005-01-14 | 2012-06-06 | Gilead Connecticut, Inc. | 1,3-diaryl substituted ureas as modulators of kinase activity |
| RU2008110908A (ru) * | 2005-08-25 | 2009-09-27 | Шеринг Корпорейшн (US) | Производные имидазола в качестве функционально селективных агонистов альфа2с адренорецепторов |
| JP5070067B2 (ja) * | 2007-01-15 | 2012-11-07 | 参天製薬株式会社 | ＩκＢキナーゼβ阻害活性を有する新規インドール誘導体 |
| JPWO2009084695A1 (ja) * | 2007-12-28 | 2011-05-19 | カルナバイオサイエンス株式会社 | ２−アミノキナゾリン誘導体 |
| US8497285B2 (en) | 2010-12-03 | 2013-07-30 | The Trustees Of The University Of Pennsylvania | Therapy of autoimmune colitis using a TIP60 inhibitor |
| CA2927009C (en) | 2013-10-21 | 2019-04-23 | Drexel University | Use of sting agonists to treat chronic hepatitis b virus infection |
| US10745350B2 (en) * | 2015-07-30 | 2020-08-18 | Calgent Biotechnology Co., Ltd. | Compounds and pharmaceutical composition associated with ubiquitination-proteasome system |
| US20170146519A1 (en) * | 2015-11-20 | 2017-05-25 | Oregon Health & Science University | Sting agonists and methods of selecting sting agonists |
| UA125730C2 (uk) * | 2017-06-22 | 2022-05-25 | Курадев Фарма Лімітед | Низькомолекулярні модулятори sting людини |
| WO2018234807A1 (en) * | 2017-06-22 | 2018-12-27 | Curadev Pharma Limited | Heterocyclic small molecule modulators of human sting |
| TW201920104A (zh) * | 2017-08-31 | 2019-06-01 | 美商馬愈法瑪公司 | 外核苷酸焦磷酸酶-磷酸二酯酶1(enpp-1)抑制劑及其用途 |
| EP3556362A1 (en) * | 2018-04-16 | 2019-10-23 | Ecole Polytechnique Federale De Lausanne (Epfl) | Sting inhibitors |
| JP7482122B2 (ja) * | 2018-07-03 | 2024-05-13 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| CN120004785A (zh) * | 2018-07-03 | 2025-05-16 | 诺华制药股份有限公司 | 用于治疗与sting活性有关的疾病的化合物和组合物 |
| CN109734677A (zh) * | 2019-03-07 | 2019-05-10 | 四川大学 | 抑制组蛋白赖氨酸甲基转移酶nsd2的小分子化合物及其应用 |
-
2020
- 2020-06-12 WO PCT/US2020/037403 patent/WO2020252240A1/en not_active Ceased
- 2020-06-12 EP EP20736815.0A patent/EP3983383A1/en not_active Withdrawn
- 2020-06-12 MA MA056193A patent/MA56193A/fr unknown
- 2020-06-12 JP JP2021573832A patent/JP2022536755A/ja active Pending
- 2020-06-12 US US17/618,345 patent/US20230092163A1/en not_active Abandoned
- 2020-06-15 TW TW109120089A patent/TWI873145B/zh active
- 2020-06-15 UY UY0001038751A patent/UY38751A/es not_active Application Discontinuation
- 2020-06-15 PY PY202002026348A patent/PY2026348A/es unknown
-
2024
- 2024-11-29 JP JP2024208554A patent/JP2025037981A/ja active Pending