JP2022535535A5 - - Google Patents
Info
- Publication number
- JP2022535535A5 JP2022535535A5 JP2021571709A JP2021571709A JP2022535535A5 JP 2022535535 A5 JP2022535535 A5 JP 2022535535A5 JP 2021571709 A JP2021571709 A JP 2021571709A JP 2021571709 A JP2021571709 A JP 2021571709A JP 2022535535 A5 JP2022535535 A5 JP 2022535535A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- lipid
- lipids
- integer selected
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962857111P | 2019-06-04 | 2019-06-04 | |
| US62/857,111 | 2019-06-04 | ||
| PCT/US2020/036085 WO2020247604A1 (en) | 2019-06-04 | 2020-06-04 | Synthetic lipids for mrna delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022535535A JP2022535535A (ja) | 2022-08-09 |
| JP2022535535A5 true JP2022535535A5 (https=) | 2023-06-06 |
| JP7691742B2 JP7691742B2 (ja) | 2025-06-12 |
Family
ID=73652953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021571709A Active JP7691742B2 (ja) | 2019-06-04 | 2020-06-04 | Ｍｒｎａ送達のための合成脂質 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220168231A1 (https=) |
| EP (1) | EP3979988B1 (https=) |
| JP (1) | JP7691742B2 (https=) |
| KR (1) | KR20220017466A (https=) |
| CN (1) | CN114173762A (https=) |
| AU (1) | AU2020287624A1 (https=) |
| CA (1) | CA3142725A1 (https=) |
| MX (1) | MX2021014911A (https=) |
| WO (1) | WO2020247604A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3585895A1 (en) | 2017-02-22 | 2020-01-01 | CRISPR Therapeutics AG | Compositions and methods for gene editing |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| AU2022208484A1 (en) * | 2021-01-15 | 2023-08-24 | The Brigham And Women's Hospital, Inc. | Lipid nanoparticles for targeted delivery of mrna |
| CN113402404B (zh) * | 2021-04-30 | 2022-03-11 | 苏州科锐迈德生物医药科技有限公司 | 脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| CN113209022A (zh) * | 2021-04-30 | 2021-08-06 | 中国科学院化学研究所 | 一种阳离子脂质体与制备方法及其在细菌效应蛋白的递送与抗肿瘤中的应用 |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| WO2023166425A1 (en) * | 2022-03-01 | 2023-09-07 | Crispr Therapeutics Ag | Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions |
| KR20240155955A (ko) * | 2022-03-04 | 2024-10-29 | 베이징 카리우스 바이오 엘티디. | 활성 분자 전달을 위한 분해성 리포솜 및 이의 나노 복합체 |
| GB2634837A (en) | 2022-06-07 | 2025-04-23 | Scribe Therapeutics Inc | Compositions and methods for the targeting of PCSK9 |
| WO2024032677A1 (zh) * | 2022-08-11 | 2024-02-15 | 益杰立科(上海)生物科技有限公司 | 一种表观编辑靶点的方法及用途 |
| CN115745788B (zh) * | 2022-11-21 | 2025-06-24 | 国家纳米科学中心 | 一种可电离脂质化合物及其制备方法和应用 |
| CN120916753A (zh) * | 2023-03-29 | 2025-11-07 | 星锐医药(苏州)有限公司 | 编码治疗性多肽的核酸及包含所述核酸的脂质纳米颗粒组合物 |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| WO2025080867A1 (en) * | 2023-10-10 | 2025-04-17 | The Board Of Regents Of The University Of Texas System | Ionizable lipids for improved mrna delivery |
| WO2025182865A1 (ja) * | 2024-03-01 | 2025-09-04 | 国立大学法人東海国立大学機構 | 脂質粒子 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101484588B (zh) | 2006-05-11 | 2013-11-06 | 阿尔尼拉姆医药品有限公司 | 抑制pcsk9基因表达的组合物和方法 |
| FR2921838A1 (fr) * | 2007-10-05 | 2009-04-10 | Guerbet Sa | Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice gem-bisphosphonate couplee a des ligands de biodistribution hydrophile |
| WO2009097332A2 (en) * | 2008-01-29 | 2009-08-06 | Shire Human Genetic Therapies, Inc. | Therapeutic compositions |
| ES2859923T3 (es) * | 2013-02-28 | 2021-10-04 | Univ Tufts | Compuestos de disulfuro para el suministro de agentes farmacéuticos |
| WO2014186348A2 (en) * | 2013-05-14 | 2014-11-20 | Tufts University | Nanocomplexes of modified peptides or proteins |
| EP3315125A1 (en) * | 2016-10-31 | 2018-05-02 | Silence Therapeutics (London) Ltd | Lipid nanoparticle formulation |
| WO2018191750A2 (en) * | 2017-04-14 | 2018-10-18 | The Broad Institute Inc. | Novel delivery of large payloads |
-
2020
- 2020-06-04 JP JP2021571709A patent/JP7691742B2/ja active Active
- 2020-06-04 AU AU2020287624A patent/AU2020287624A1/en not_active Abandoned
- 2020-06-04 KR KR1020227000096A patent/KR20220017466A/ko not_active Ceased
- 2020-06-04 EP EP20817914.3A patent/EP3979988B1/en active Active
- 2020-06-04 MX MX2021014911A patent/MX2021014911A/es unknown
- 2020-06-04 WO PCT/US2020/036085 patent/WO2020247604A1/en not_active Ceased
- 2020-06-04 CA CA3142725A patent/CA3142725A1/en active Pending
- 2020-06-04 CN CN202080054813.2A patent/CN114173762A/zh active Pending
-
2021
- 2021-12-06 US US17/543,173 patent/US20220168231A1/en active Pending
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