JP2022512945A5 - - Google Patents

Info

Publication number
JP2022512945A5
JP2022512945A5 JP2021524374A JP2021524374A JP2022512945A5 JP 2022512945 A5 JP2022512945 A5 JP 2022512945A5 JP 2021524374 A JP2021524374 A JP 2021524374A JP 2021524374 A JP2021524374 A JP 2021524374A JP 2022512945 A5 JP2022512945 A5 JP 2022512945A5
Authority
JP
Japan
Application number
JP2021524374A
Other languages
Japanese (ja)
Other versions
JP2022512945A (ja
JPWO2020097384A5 (https=
JP7483294B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/060344 external-priority patent/WO2020097384A1/en
Publication of JP2022512945A publication Critical patent/JP2022512945A/ja
Publication of JP2022512945A5 publication Critical patent/JP2022512945A5/ja
Publication of JPWO2020097384A5 publication Critical patent/JPWO2020097384A5/ja
Priority to JP2024069435A priority Critical patent/JP2024099679A/ja
Application granted granted Critical
Publication of JP7483294B2 publication Critical patent/JP7483294B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021524374A 2018-11-09 2019-11-07 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む2,5-ジオキソピペラジン脂質 Active JP7483294B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024069435A JP2024099679A (ja) 2018-11-09 2024-04-23 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む2,5-ジオキソピペラジン脂質

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862758179P 2018-11-09 2018-11-09
US62/758,179 2018-11-09
US201962871510P 2019-07-08 2019-07-08
US62/871,510 2019-07-08
PCT/US2019/060344 WO2020097384A1 (en) 2018-11-09 2019-11-07 2,5-dioxopiperazine lipids with intercalated ester, thioester, disulfide and anhydride moieities

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024069435A Division JP2024099679A (ja) 2018-11-09 2024-04-23 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む2,5-ジオキソピペラジン脂質

Publications (4)

Publication Number Publication Date
JP2022512945A JP2022512945A (ja) 2022-02-07
JP2022512945A5 true JP2022512945A5 (https=) 2022-11-14
JPWO2020097384A5 JPWO2020097384A5 (https=) 2022-11-14
JP7483294B2 JP7483294B2 (ja) 2024-05-15

Family

ID=69165524

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021524374A Active JP7483294B2 (ja) 2018-11-09 2019-11-07 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む2,5-ジオキソピペラジン脂質
JP2024069435A Pending JP2024099679A (ja) 2018-11-09 2024-04-23 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む2,5-ジオキソピペラジン脂質

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024069435A Pending JP2024099679A (ja) 2018-11-09 2024-04-23 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む2,5-ジオキソピペラジン脂質

Country Status (11)

Country Link
US (1) US20230071228A1 (https=)
EP (1) EP3877368A1 (https=)
JP (2) JP7483294B2 (https=)
KR (1) KR102860605B1 (https=)
CN (1) CN113272282B (https=)
AU (1) AU2019376660B2 (https=)
BR (1) BR112021008974A2 (https=)
CA (1) CA3117882A1 (https=)
IL (1) IL282723B1 (https=)
MX (1) MX2021005482A (https=)
WO (1) WO2020097384A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210220449A1 (en) * 2018-05-15 2021-07-22 Translate Bio, Inc. Subcutaneous Delivery of Messenger RNA
WO2020227085A1 (en) * 2019-05-03 2020-11-12 Translate Bio, Inc. Di-thioester cationic lipids
US20230181483A1 (en) * 2019-07-08 2023-06-15 Translate Bio, Inc. Improved mrna-loaded lipid nanoparticles and processes of making the same
US12605399B2 (en) 2020-05-07 2026-04-21 Translate Bio, Inc. Compositions for CFTR MRNA therapy
US20230242720A1 (en) * 2020-06-29 2023-08-03 Zymergen Inc. Modulus modifiers and films thereof
CA3193347A1 (en) * 2020-09-23 2022-03-31 Saswata KARMAKAR Piperazine-based cationic lipids
EP4313115A1 (en) 2021-03-25 2024-02-07 Translate Bio, Inc. Optimized nucleotide sequences encoding the extracellular domain of human ace2 protein or a portion thereof
US20240270707A1 (en) * 2021-04-15 2024-08-15 Translate Bio, Inc. "Good" buffer-based cationic lipids
CN115710196B (zh) * 2021-08-23 2025-06-10 广州谷森制药有限公司 阳离子脂质化合物
MX2024002726A (es) 2021-09-03 2024-03-20 CureVac SE Nuevas nanoparticulas lipidicas para la administracion de acidos nucleicos.
WO2023073228A1 (en) 2021-10-29 2023-05-04 CureVac SE Improved circular rna for expressing therapeutic proteins
US20250099614A1 (en) 2022-01-28 2025-03-27 CureVac SE Nucleic acid encoded transcription factor inhibitors
WO2023227608A1 (en) 2022-05-25 2023-11-30 Glaxosmithkline Biologicals Sa Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide
WO2024089638A1 (en) 2022-10-28 2024-05-02 Glaxosmithkline Biologicals Sa Nucleic acid based vaccine
EP4633673A1 (en) 2022-12-15 2025-10-22 Sanofi Pasteur Inc. Mrna encoding influenza virus-like particle
WO2024133515A1 (en) 2022-12-20 2024-06-27 Sanofi Rhinovirus mrna vaccine
KR20250153298A (ko) 2023-03-08 2025-10-24 큐어백 에스이 핵산 전달을 위한 신규의 지질 나노입자 제형
WO2024230934A1 (en) 2023-05-11 2024-11-14 CureVac SE Therapeutic nucleic acid for the treatment of ophthalmic diseases
WO2025049925A2 (en) * 2023-09-01 2025-03-06 Poseida Therapeutics, Inc. Lipidoid compounds and related compositions and uses
WO2025164564A1 (ja) * 2024-01-31 2025-08-07 公立大学法人名古屋市立大学 核酸封入脂質ナノ粒子の製造方法
WO2026008743A1 (en) 2024-07-02 2026-01-08 Sanofi Pasteur Inc. Water-soluble polyanionic polymer as adjuvant for carrier-formulated nucleic acid
WO2026033123A1 (en) 2024-08-08 2026-02-12 Sanofi Pasteur Inc. Lipid nanoparticle formulations for mrna delivery

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4500707A (en) 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US5132418A (en) 1980-02-29 1992-07-21 University Patents, Inc. Process for preparing polynucleotides
US4668777A (en) 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4415732A (en) 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
US4973679A (en) 1981-03-27 1990-11-27 University Patents, Inc. Process for oligonucleo tide synthesis using phosphormidite intermediates
US4373071A (en) 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4401796A (en) 1981-04-30 1983-08-30 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4897355A (en) 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US5153319A (en) 1986-03-31 1992-10-06 University Patents, Inc. Process for preparing polynucleotides
US5262530A (en) 1988-12-21 1993-11-16 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5047524A (en) 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
FR2645866B1 (fr) 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
US5334761A (en) 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US7799565B2 (en) 2004-06-07 2010-09-21 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering RNA
EP2049665A2 (en) 2006-07-28 2009-04-22 Applera Corporation Dinucleotide mrna cap analogs
WO2009058911A2 (en) 2007-10-31 2009-05-07 Applied Biosystems Inc. Preparation and isolation of 5' capped mrna
CN104119242B (zh) 2008-10-09 2017-07-07 泰米拉制药公司 改善的氨基脂质和递送核酸的方法
ES2646630T3 (es) 2008-11-07 2017-12-14 Massachusetts Institute Of Technology Lipidoides aminoalcohólicos y usos de los mismos
MX342785B (es) 2009-06-10 2016-10-12 Alnylam Pharmaceuticals Inc Formulacion mejorada de lipido.
HUE042177T2 (hu) 2009-12-01 2019-06-28 Translate Bio Inc Szteroidszármazék mRNS szállítására humán genetikai betegségekben
EP3354644A1 (en) 2011-06-08 2018-08-01 Translate Bio, Inc. Cleavable lipids
KR102451116B1 (ko) 2011-10-27 2022-10-06 메사추세츠 인스티튜트 오브 테크놀로지 약물 캡슐화 마이크로스피어를 형성할 수 있는, n-말단 상에 관능화된 아미노산 유도체
ES2762873T3 (es) 2012-03-29 2020-05-26 Translate Bio Inc Lípidos catiónicos ionizables
SG11201507474QA (en) 2013-03-14 2015-10-29 Shire Human Genetic Therapies RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS
ES2895651T3 (es) 2013-12-19 2022-02-22 Novartis Ag Lípidos y composiciones lipídicas para la administración de agentes activos
JP6557722B2 (ja) 2014-05-30 2019-08-07 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 核酸の送達のための生分解性脂質
SMT202200502T1 (it) 2014-06-25 2023-01-13 Acuitas Therapeutics Inc Nuovi lipidi e formulazioni di nanoparticelle lipidiche per l'erogazione di acidi nucleici
BR112016030852A2 (pt) 2014-07-02 2018-01-16 Shire Human Genetic Therapies encapsulação de rna mensageiro
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
US20180000953A1 (en) 2015-01-21 2018-01-04 Moderna Therapeutics, Inc. Lipid nanoparticle compositions
WO2016118725A1 (en) 2015-01-23 2016-07-28 Moderna Therapeutics, Inc. Lipid nanoparticle compositions
ES2949540T3 (es) 2015-06-19 2023-09-29 Massachusetts Inst Technology 2,5-piperazinadionas sustituidas con alquenilo y su uso en composiciones para suministrar un agente a un sujeto o una célula
LT3313829T (lt) 2015-06-29 2024-08-12 Acuitas Therapeutics Inc. Lipidai ir lipidų nanodalelių sudėtys, skirtos nukleorūgščių tiekimui
US20180256730A1 (en) * 2015-09-16 2018-09-13 University Of Utah Research Foundation A polymeric carrier for delivery of a payload to a cell
EP4286012A3 (en) 2015-09-17 2024-05-29 ModernaTX, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
IL307179A (en) 2015-10-28 2023-11-01 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
EP3397613A1 (en) 2015-12-30 2018-11-07 Acuitas Therapeutics Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
TWI773666B (zh) 2016-03-30 2022-08-11 美商英特利亞醫療公司 Crispr/cas 組分之脂質奈米粒子調配物
MX2019005470A (es) 2016-11-10 2019-11-21 Translate Bio Inc Formulación de nanopartículas lipídicas basadas en ice mejorada para el suministro de arnm.
WO2018089801A1 (en) 2016-11-10 2018-05-17 Translate Bio, Inc. Improved process of preparing mrna-loaded lipid nanoparticles

Similar Documents

Publication Publication Date Title
JP2022512945A5 (https=)
BR112019017762A2 (https=)
BR112021018450A2 (https=)
BR112021016821A2 (https=)
BR112021016996A2 (https=)
BR112021008711A2 (https=)
BR112019016141A2 (https=)
AU2020104490A5 (https=)
BR112021018452A2 (https=)
BR112021018102A2 (https=)
BR112019016142A2 (https=)
BR112019016138A2 (https=)
BR112021017234A2 (https=)
BR112021018168A2 (https=)
BR112021017173A2 (https=)
BR112021017083A2 (https=)
BR112021015080A2 (https=)
BR112021012348A2 (https=)
BR112021018250A2 (https=)
BR112021018584A2 (https=)
BR112021017310A2 (https=)
BR112021013128A2 (https=)
BR112021018484A2 (https=)
BR112021018084A2 (https=)
AT524962A5 (https=)