KR20220017466A - Mrna 전달을 위한 합성 지질 - Google Patents

Mrna 전달을 위한 합성 지질 Download PDF

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KR20220017466A
KR20220017466A KR1020227000096A KR20227000096A KR20220017466A KR 20220017466 A KR20220017466 A KR 20220017466A KR 1020227000096 A KR1020227000096 A KR 1020227000096A KR 20227000096 A KR20227000096 A KR 20227000096A KR 20220017466 A KR20220017466 A KR 20220017466A
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mrna
lipid
group
bamea
nanoparticles
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Korean (ko)
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차오빙 수
밍 왕
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트러스티즈 오브 터프츠 칼리지
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
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    • C12N2310/00—Structure or type of the nucleic acid
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KR1020227000096A 2019-06-04 2020-06-04 Mrna 전달을 위한 합성 지질 Ceased KR20220017466A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962857111P 2019-06-04 2019-06-04
US62/857,111 2019-06-04
PCT/US2020/036085 WO2020247604A1 (en) 2019-06-04 2020-06-04 Synthetic lipids for mrna delivery

Publications (1)

Publication Number Publication Date
KR20220017466A true KR20220017466A (ko) 2022-02-11

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KR1020227000096A Ceased KR20220017466A (ko) 2019-06-04 2020-06-04 Mrna 전달을 위한 합성 지질

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US (1) US20220168231A1 (https=)
EP (1) EP3979988B1 (https=)
JP (1) JP7691742B2 (https=)
KR (1) KR20220017466A (https=)
CN (1) CN114173762A (https=)
AU (1) AU2020287624A1 (https=)
CA (1) CA3142725A1 (https=)
MX (1) MX2021014911A (https=)
WO (1) WO2020247604A1 (https=)

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Publication number Priority date Publication date Assignee Title
EP3585895A1 (en) 2017-02-22 2020-01-01 CRISPR Therapeutics AG Compositions and methods for gene editing
CZ310613B6 (cs) 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
AU2022208484A1 (en) * 2021-01-15 2023-08-24 The Brigham And Women's Hospital, Inc. Lipid nanoparticles for targeted delivery of mrna
CN113402404B (zh) * 2021-04-30 2022-03-11 苏州科锐迈德生物医药科技有限公司 脂质化合物及包含其的脂质载体、核酸脂质纳米粒组合物和药物制剂
CN113209022A (zh) * 2021-04-30 2021-08-06 中国科学院化学研究所 一种阳离子脂质体与制备方法及其在细菌效应蛋白的递送与抗肿瘤中的应用
CZ310443B6 (cs) 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
WO2023166425A1 (en) * 2022-03-01 2023-09-07 Crispr Therapeutics Ag Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions
KR20240155955A (ko) * 2022-03-04 2024-10-29 베이징 카리우스 바이오 엘티디. 활성 분자 전달을 위한 분해성 리포솜 및 이의 나노 복합체
GB2634837A (en) 2022-06-07 2025-04-23 Scribe Therapeutics Inc Compositions and methods for the targeting of PCSK9
WO2024032677A1 (zh) * 2022-08-11 2024-02-15 益杰立科(上海)生物科技有限公司 一种表观编辑靶点的方法及用途
CN115745788B (zh) * 2022-11-21 2025-06-24 国家纳米科学中心 一种可电离脂质化合物及其制备方法和应用
CN120916753A (zh) * 2023-03-29 2025-11-07 星锐医药(苏州)有限公司 编码治疗性多肽的核酸及包含所述核酸的脂质纳米颗粒组合物
AU2024279278A1 (en) 2023-05-31 2025-12-18 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
WO2025080867A1 (en) * 2023-10-10 2025-04-17 The Board Of Regents Of The University Of Texas System Ionizable lipids for improved mrna delivery
WO2025182865A1 (ja) * 2024-03-01 2025-09-04 国立大学法人東海国立大学機構 脂質粒子

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101484588B (zh) 2006-05-11 2013-11-06 阿尔尼拉姆医药品有限公司 抑制pcsk9基因表达的组合物和方法
FR2921838A1 (fr) * 2007-10-05 2009-04-10 Guerbet Sa Nouveau procede de preparation de nanoparticules recouvertes d'une couche stabilisatrice gem-bisphosphonate couplee a des ligands de biodistribution hydrophile
WO2009097332A2 (en) * 2008-01-29 2009-08-06 Shire Human Genetic Therapies, Inc. Therapeutic compositions
ES2859923T3 (es) * 2013-02-28 2021-10-04 Univ Tufts Compuestos de disulfuro para el suministro de agentes farmacéuticos
WO2014186348A2 (en) * 2013-05-14 2014-11-20 Tufts University Nanocomplexes of modified peptides or proteins
EP3315125A1 (en) * 2016-10-31 2018-05-02 Silence Therapeutics (London) Ltd Lipid nanoparticle formulation
WO2018191750A2 (en) * 2017-04-14 2018-10-18 The Broad Institute Inc. Novel delivery of large payloads

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WO2020247604A1 (en) 2020-12-10
EP3979988A1 (en) 2022-04-13
AU2020287624A1 (en) 2022-01-06
US20220168231A1 (en) 2022-06-02
CN114173762A (zh) 2022-03-11
JP7691742B2 (ja) 2025-06-12
MX2021014911A (es) 2022-02-21
EP3979988B1 (en) 2025-02-26
CA3142725A1 (en) 2020-12-10
EP3979988A4 (en) 2023-06-21
JP2022535535A (ja) 2022-08-09

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