JP2022534302A5 - - Google Patents
Info
- Publication number
- JP2022534302A5 JP2022534302A5 JP2021570919A JP2021570919A JP2022534302A5 JP 2022534302 A5 JP2022534302 A5 JP 2022534302A5 JP 2021570919 A JP2021570919 A JP 2021570919A JP 2021570919 A JP2021570919 A JP 2021570919A JP 2022534302 A5 JP2022534302 A5 JP 2022534302A5
- Authority
- JP
- Japan
- Prior art keywords
- ethynyl
- pyrimidine
- phenyl
- hydroxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024146717A JP7872322B2 (ja) | 2019-05-31 | 2024-08-28 | ＮＦ－κＢ誘導キナーゼの低分子阻害剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962855144P | 2019-05-31 | 2019-05-31 | |
| US62/855,144 | 2019-05-31 | ||
| US201962907833P | 2019-09-30 | 2019-09-30 | |
| US62/907,833 | 2019-09-30 | ||
| PCT/EP2020/065024 WO2020239999A1 (en) | 2019-05-31 | 2020-05-29 | SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024146717A Division JP7872322B2 (ja) | 2019-05-31 | 2024-08-28 | ＮＦ－κＢ誘導キナーゼの低分子阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022534302A JP2022534302A (ja) | 2022-07-28 |
| JP2022534302A5 true JP2022534302A5 (enExample) | 2023-06-05 |
| JP7547387B2 JP7547387B2 (ja) | 2024-09-09 |
Family
ID=71108552
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021570919A Active JP7547387B2 (ja) | 2019-05-31 | 2020-05-29 | ＮＦ－κＢ誘導キナーゼの低分子阻害剤 |
| JP2024146717A Active JP7872322B2 (ja) | 2019-05-31 | 2024-08-28 | ＮＦ－κＢ誘導キナーゼの低分子阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024146717A Active JP7872322B2 (ja) | 2019-05-31 | 2024-08-28 | ＮＦ－κＢ誘導キナーゼの低分子阻害剤 |
Country Status (37)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11458149B1 (en) | 2019-05-31 | 2022-10-04 | Ikena Oncology, Inc. | TEAD inhibitors and uses thereof |
| BR112021024108A2 (pt) | 2019-05-31 | 2022-03-22 | Ikena Oncology Inc | Inibidores de tead e usos dos mesmos |
| CR20210587A (es) * | 2019-05-31 | 2022-02-11 | Janssen Pharmaceutica Nv | Inhibidores de molécula pequeña de quinasa inductora de nf-kb |
| CA3257152A1 (en) * | 2022-05-11 | 2023-11-16 | Janssen Pharmaceutica Nv | Pyrrolidine derivatives useful as NF-κB induction kinase inhibitors |
| JP2025516559A (ja) * | 2022-05-11 | 2025-05-30 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｆ－カッパｂ誘導性キナーゼの阻害剤としてのピロリジオン（ｐｙｒｒｏｌｉｄｉｏｎｅ）誘導体 |
| AU2023410324A1 (en) | 2022-12-22 | 2025-05-15 | Boehringer Ingelheim International Gmbh | Crystalline forms of a her2 inhibitor |
| WO2025020886A1 (zh) * | 2023-07-27 | 2025-01-30 | 浙江星浩澎博医药有限公司 | 氮杂喹唑啉环衍生物及其用途 |
| CN121568696A (zh) | 2023-07-28 | 2026-02-24 | 勃林格殷格翰国际有限公司 | 制备her2抑制剂的方法 |
| WO2025235874A1 (en) * | 2024-05-10 | 2025-11-13 | Schrödinger, Inc. | Heterocyclics as egfr inhibitors |
| WO2026029041A1 (ja) * | 2024-07-30 | 2026-02-05 | 日本たばこ産業株式会社 | ピラゾロピリミジン化合物及びその医薬用途 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| US7132428B2 (en) | 2003-07-03 | 2006-11-07 | Aventis Pharmaceuticals Inc. | Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders |
| JP4828421B2 (ja) | 2003-08-14 | 2011-11-30 | アレイ バイオファーマ、インコーポレイテッド | 受容体チロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
| MXPA06011423A (es) | 2004-04-02 | 2007-01-23 | Osi Pharm Inc | Inhibidores de proteina cinasa heterobiciclica sustituida en el anillo 6,6-biciclico. |
| GT200500208A (es) * | 2004-08-03 | 2006-03-02 | Indazoles ùtiles para tratar enfermedades cardiovasculares | |
| JP2008519850A (ja) | 2004-11-10 | 2008-06-12 | シンタ ファーマシューティカルズ コーポレーション | Ｉｌ−１２調節化合物 |
| TWI368974B (en) | 2004-11-12 | 2012-07-21 | Chippac Inc | Ball-on-trace wire bond interconnection |
| AU2009263037B2 (en) * | 2008-06-26 | 2011-10-06 | Amgen Inc. | Alkynyl alcohols as kinase inhibitors |
| WO2010042337A1 (en) | 2008-10-07 | 2010-04-15 | Merck Sharp & Dohme Corp. | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| AR085908A1 (es) * | 2011-03-16 | 2013-11-06 | Hoffmann La Roche | DERIVADOS DE 3-BUTIN-2-OL Y DE CARBONITRILO CON ACTIVIDAD INHIBIDORA DE LA QUINASA INDUCTORA DE NF-kB (NIK) |
| AR089999A1 (es) * | 2012-02-17 | 2014-10-01 | Hoffmann La Roche | Compuestos triciclicos y metodos para el uso de los mismos |
| US9159402B2 (en) | 2012-07-02 | 2015-10-13 | Stmicroelectronics International N.V. | SRAM bitcell implemented in double gate technology |
| US8859553B2 (en) * | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
| BR112015010225A2 (pt) | 2012-11-05 | 2017-07-11 | Zafgen Inc | compostos tricíclicos e seus métodos de produção e utilização |
| TWI663166B (zh) | 2013-04-24 | 2019-06-21 | 健生藥品公司 | 新化合物 |
| JP2016533385A (ja) * | 2013-08-22 | 2016-10-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | アルキニルアルコール及び使用方法 |
| WO2015025026A1 (en) * | 2013-08-22 | 2015-02-26 | F. Hoffmann-La Roche Ag | Alkynyl alcohols and methods of use |
| TWI627173B (zh) | 2013-09-26 | 2018-06-21 | 比利時商健生藥品公司 | 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物 |
| TWI704146B (zh) | 2013-09-26 | 2020-09-11 | 比利時商健生藥品公司 | 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物 |
| EP4649963A3 (en) | 2014-04-14 | 2026-05-13 | Arvinas Operations, Inc. | Imide-based modulators of proteolysis and associated methods of use |
| WO2016062792A1 (en) | 2014-10-23 | 2016-04-28 | Janssen Pharmaceutica Nv | New compounds as nik inhibitors |
| AU2015334914B2 (en) | 2014-10-23 | 2019-09-19 | Janssen Pharmaceutica Nv | New thienopyrimidine derivatives as NIK inhibitors |
| JP6616411B2 (ja) | 2014-10-23 | 2019-12-04 | ヤンセン ファーマシューティカ エヌ．ベー． | 新規な、ｎｉｋ阻害剤としてのピラゾール誘導体 |
| EA033237B1 (ru) | 2014-10-23 | 2019-09-30 | Янссен Фармацевтика Нв | Новые производные пиразолопиримидина в качестве ингибиторов nik, фармацевтическая композиция и лекарственное средство, содержащее ее |
| WO2016135163A1 (en) | 2015-02-25 | 2016-09-01 | F. Hoffmann-La Roche Ag | Alkynyl alcohols and methods of use |
| EP3405464B1 (en) | 2016-01-22 | 2019-12-04 | Janssen Pharmaceutica NV | New 6-membered heteroaromatic substituted cyanoindoline derivatives as nik inhibitors |
| HRP20200133T1 (hr) | 2016-01-22 | 2020-05-15 | Janssen Pharmaceutica Nv | Novi supstituirani derivati cijanoindolina kao inhibitori nik |
| EP3478675B1 (en) | 2016-06-30 | 2020-04-22 | Janssen Pharmaceutica NV | Heteroaromatic derivatives as nik inhibitors |
| WO2018002219A1 (en) | 2016-06-30 | 2018-01-04 | Janssen Pharmaceutica Nv | Cyanoindoline derivatives as nik inhibitors |
| JP7140751B2 (ja) | 2016-08-24 | 2022-09-21 | エフ．ホフマン－ラ ロシュ アーゲー | ２－アザビシクロ［３．１．０］ヘキサン－３－オン誘導体及び使用方法 |
| CN109863142B (zh) * | 2016-08-24 | 2022-06-10 | 豪夫迈·罗氏有限公司 | 2-氮杂双环[3.1.0]己烷-3-酮衍生物及使用方法 |
| AU2018297592B2 (en) | 2017-07-06 | 2021-12-16 | Janssen Pharmaceutica Nv | New substituted azaindoline derivatives as NIK inhibitors |
| CN109810110B (zh) * | 2017-11-22 | 2023-01-24 | 中国科学院上海药物研究所 | 一种具有2-氨基嘧啶结构的化合物，其制备方法和用途 |
| BR112021024108A2 (pt) | 2019-05-31 | 2022-03-22 | Ikena Oncology Inc | Inibidores de tead e usos dos mesmos |
| CR20210587A (es) * | 2019-05-31 | 2022-02-11 | Janssen Pharmaceutica Nv | Inhibidores de molécula pequeña de quinasa inductora de nf-kb |
| JP7670626B2 (ja) | 2019-05-31 | 2025-04-30 | セージ セラピューティクス， インコーポレイテッド | 神経刺激性ステロイド及びその組成物 |
| US11458149B1 (en) | 2019-05-31 | 2022-10-04 | Ikena Oncology, Inc. | TEAD inhibitors and uses thereof |
| MA56022A (fr) | 2019-05-31 | 2022-04-06 | Chiesi Farm Spa | Dérivés d'amino quinazoline servant d'inhibiteurs de p2x3 |
| JP7559059B2 (ja) | 2019-09-30 | 2024-10-01 | インサイト・コーポレイション | 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 |
| JP2025516564A (ja) | 2022-05-11 | 2025-05-30 | ヤンセン ファーマシューティカ エヌ．ベー． | ＮＦ－κＢ誘導性キナーゼの阻害剤としてのピロリジノン誘導体 |
-
2020
- 2020-05-29 CR CR20210587A patent/CR20210587A/es unknown
- 2020-05-29 KR KR1020217042635A patent/KR102995125B1/ko active Active
- 2020-05-29 US US16/887,889 patent/US11254673B2/en active Active
- 2020-05-29 IL IL288387A patent/IL288387B2/en unknown
- 2020-05-29 MD MDE20220374T patent/MD3976597T2/ro unknown
- 2020-05-29 TW TW113125993A patent/TWI906955B/zh active
- 2020-05-29 PT PT207336884T patent/PT3976597T/pt unknown
- 2020-05-29 RS RS20241148A patent/RS66105B1/sr unknown
- 2020-05-29 AU AU2020282005A patent/AU2020282005B2/en active Active
- 2020-05-29 MX MX2021014679A patent/MX2021014679A/es unknown
- 2020-05-29 WO PCT/EP2020/065024 patent/WO2020239999A1/en not_active Ceased
- 2020-05-29 PH PH1/2021/553011A patent/PH12021553011A1/en unknown
- 2020-05-29 SM SM20240418T patent/SMT202400418T1/it unknown
- 2020-05-29 UY UY0001038721A patent/UY38721A/es unknown
- 2020-05-29 SI SI202030499T patent/SI3976597T1/sl unknown
- 2020-05-29 EP EP24188073.1A patent/EP4467199A3/en active Pending
- 2020-05-29 MY MYPI2021007053A patent/MY205653A/en unknown
- 2020-05-29 SG SG11202112994WA patent/SG11202112994WA/en unknown
- 2020-05-29 FI FIEP20733688.4T patent/FI3976597T3/fi active
- 2020-05-29 HU HUE20733688A patent/HUE068694T2/hu unknown
- 2020-05-29 BR BR112021023796A patent/BR112021023796A2/pt unknown
- 2020-05-29 PE PE2021001987A patent/PE20220768A1/es unknown
- 2020-05-29 UA UAA202107796A patent/UA130430C2/uk unknown
- 2020-05-29 CN CN202080057418.XA patent/CN114222737B/zh active Active
- 2020-05-29 TW TW109118004A patent/TWI850390B/zh active
- 2020-05-29 CN CN202410972792.2A patent/CN118908957A/zh active Pending
- 2020-05-29 JP JP2021570919A patent/JP7547387B2/ja active Active
- 2020-05-29 LT LTEPPCT/EP2020/065024T patent/LT3976597T/lt unknown
- 2020-05-29 PL PL20733688.4T patent/PL3976597T3/pl unknown
- 2020-05-29 HR HRP20241352TT patent/HRP20241352T1/hr unknown
- 2020-05-29 DK DK20733688.4T patent/DK3976597T3/da active
- 2020-05-29 EP EP20733688.4A patent/EP3976597B1/en active Active
- 2020-05-29 MA MA56038A patent/MA56038B1/fr unknown
- 2020-05-29 ES ES20733688T patent/ES2989387T3/es active Active
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2021
- 2021-11-25 CL CL2021003142A patent/CL2021003142A1/es unknown
- 2021-11-26 DO DO2021000244A patent/DOP2021000244A/es unknown
- 2021-11-29 JO JOJO/P/2021/0318A patent/JOP20210318B1/ar active
- 2021-11-30 SA SA521430960A patent/SA521430960B1/ar unknown
- 2021-12-13 US US17/549,057 patent/US11827634B2/en active Active
- 2021-12-27 CO CONC2021/0017838A patent/CO2021017838A2/es unknown
- 2021-12-28 EC ECSENADI202193623A patent/ECSP21093623A/es unknown
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2023
- 2023-09-27 US US18/475,499 patent/US12617789B2/en active Active
-
2024
- 2024-08-28 JP JP2024146717A patent/JP7872322B2/ja active Active
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