JP2022528851A5 - - Google Patents
Info
- Publication number
- JP2022528851A5 JP2022528851A5 JP2021557758A JP2021557758A JP2022528851A5 JP 2022528851 A5 JP2022528851 A5 JP 2022528851A5 JP 2021557758 A JP2021557758 A JP 2021557758A JP 2021557758 A JP2021557758 A JP 2021557758A JP 2022528851 A5 JP2022528851 A5 JP 2022528851A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- residue
- val
- cit
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023002495A JP7680658B2 (ja) | 2019-03-29 | 2023-01-11 | 化合物及びその複合体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962826393P | 2019-03-29 | 2019-03-29 | |
| US62/826,393 | 2019-03-29 | ||
| US202062964177P | 2020-01-22 | 2020-01-22 | |
| US62/964,177 | 2020-01-22 | ||
| PCT/EP2020/057984 WO2020200880A1 (en) | 2019-03-29 | 2020-03-23 | Compounds and conjugates thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023002495A Division JP7680658B2 (ja) | 2019-03-29 | 2023-01-11 | 化合物及びその複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022528851A JP2022528851A (ja) | 2022-06-16 |
| JP2022528851A5 true JP2022528851A5 (https=) | 2022-08-24 |
| JP7210770B2 JP7210770B2 (ja) | 2023-01-23 |
Family
ID=69960637
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021557758A Active JP7210770B2 (ja) | 2019-03-29 | 2020-03-23 | 化合物及びその複合体 |
| JP2023002495A Active JP7680658B2 (ja) | 2019-03-29 | 2023-01-11 | 化合物及びその複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023002495A Active JP7680658B2 (ja) | 2019-03-29 | 2023-01-11 | 化合物及びその複合体 |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US20220211863A1 (https=) |
| EP (2) | EP4176904A1 (https=) |
| JP (2) | JP7210770B2 (https=) |
| KR (3) | KR102498681B1 (https=) |
| CN (4) | CN118240003A (https=) |
| AU (1) | AU2020252034B2 (https=) |
| BR (1) | BR112021018986A2 (https=) |
| CA (1) | CA3133757A1 (https=) |
| CL (1) | CL2021002498A1 (https=) |
| CO (1) | CO2021014566A2 (https=) |
| CR (1) | CR20210541A (https=) |
| DK (1) | DK3946464T3 (https=) |
| EC (1) | ECSP21078204A (https=) |
| ES (1) | ES2930295T3 (https=) |
| HR (1) | HRP20221280T1 (https=) |
| HU (1) | HUE060364T2 (https=) |
| IL (1) | IL286291B2 (https=) |
| LT (1) | LT3946464T (https=) |
| MX (1) | MX2021011812A (https=) |
| PH (1) | PH12021552363A1 (https=) |
| PL (1) | PL3946464T3 (https=) |
| PT (1) | PT3946464T (https=) |
| RS (1) | RS63715B1 (https=) |
| SG (1) | SG11202110524VA (https=) |
| SM (1) | SMT202200439T1 (https=) |
| TW (2) | TWI886667B (https=) |
| UA (1) | UA129129C2 (https=) |
| WO (1) | WO2020200880A1 (https=) |
| ZA (1) | ZA202106612B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3823974A1 (en) | 2018-07-20 | 2021-05-26 | F. Hoffmann-La Roche AG | Sulfonimidamide compounds as inhibitors of interleukin-1 activity |
| US11493668B2 (en) * | 2018-09-26 | 2022-11-08 | Johnson & Johnson Vision Care, Inc. | Polymerizable absorbers of UV and high energy visible light |
| MX2021011812A (es) * | 2019-03-29 | 2021-10-22 | Medimmune Ltd | Compuestos y conjugados de estos. |
| US11555019B2 (en) | 2019-07-10 | 2023-01-17 | Cybrexa 3, Inc. | Peptide conjugates of microtubule-targeting agents as therapeutics |
| MX2022000449A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 2 Inc | Conjugados peptídicos de citotoxinas como terapéuticos. |
| EP4093439A1 (en) * | 2020-01-22 | 2022-11-30 | MedImmune Limited | Compounds and conjugates thereof |
| TW202140076A (zh) * | 2020-01-22 | 2021-11-01 | 英商梅迪繆思有限公司 | 化合物及其軛合物 |
| EP4628165A3 (en) * | 2021-02-05 | 2026-03-11 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Camptothecin compound, preparation method therefor, and application thereof |
| EP4389732A4 (en) | 2021-08-17 | 2025-08-27 | Jiangsu Mabwell Health Pharmaceutical R&D Co Ltd | PROCESS FOR THE SYNTHESIS OF 5,8-DIAMINO-3,4-DIHYDRO-2H-1-NAPHTHALENONE AND INTERMEDIATE COMPOUND USED IN THIS PROCESS |
| CA3241157A1 (en) * | 2021-12-16 | 2023-06-22 | Wei Zhou | Camptothecin compound and conjugate thereof |
| TW202348252A (zh) | 2022-02-16 | 2023-12-16 | 英商梅迪繆思有限公司 | 用治療性結合分子治療癌症的組合療法 |
| EP4489859A1 (en) | 2022-03-09 | 2025-01-15 | Astrazeneca AB | Binding molecules against fr alpha |
| KR20240162086A (ko) | 2022-03-11 | 2024-11-14 | 아스트라제네카 아베 | 항-FRα 항체-약물 접합체 치료법에 대한 점수 산정 방법 |
| IL315366A (en) | 2022-03-23 | 2024-11-01 | Synaffix Bv | Antibody pairs for targeting PTK7-expressing tumors |
| CA3253220A1 (en) | 2022-03-23 | 2023-09-28 | Synaffix B.V. | ANTIBODIES CONJUGATED FOR TARGETING TUMORS EXPRESSING TROP-2 |
| KR20250024741A (ko) | 2022-03-23 | 2025-02-19 | 시나픽스 비.브이. | 암배아성 항원을 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트 |
| US20250205353A1 (en) | 2022-03-23 | 2025-06-26 | Synaffix B.V. | Antibody-conjugates for targeting of tumours expressing nectin-4 |
| AU2023239448A1 (en) | 2022-03-25 | 2024-11-07 | Zymeworks Bc Inc. | Antibody-drug conjugates targeting folate receptor alpha and methods of use |
| CN115160403B (zh) * | 2022-07-05 | 2025-06-27 | 博石丰生命科技(南通)有限公司 | 特异性拓扑异构酶抑制剂和可用于抗体药物偶联物及其制备方法 |
| KR20250057869A (ko) * | 2022-09-07 | 2025-04-29 | 잭세라 바이오파마슈티컬 (수조우) 씨오., 엘티디. | 항-trop2/egfr 항체 및 이의 용도 |
| CN120936382A (zh) | 2023-02-16 | 2025-11-11 | 阿斯利康(瑞典)有限公司 | 采用治疗性结合分子治疗癌症的组合疗法 |
| TW202506194A (zh) | 2023-04-28 | 2025-02-16 | 英商梅迪繆思有限公司 | 用於治療癌症的ｂ７－ｈ４治療性結合分子 |
| AU2024271903A1 (en) * | 2023-05-12 | 2025-10-09 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Linker compounds and ligand-drug conjugates, preparation methods and uses thereof |
| KR20260020468A (ko) | 2023-06-05 | 2026-02-11 | 장쑤 맵웰 헬스 파마수티컬 알앤디 컴퍼니, 리미티드 | 항-b7-h3 항체 또는 그 단편 및 b7-h3를 표적으로 하는 항체 약물 접합체(anti-b7-h3 antibody or fragment thereof, and antibody drug conjugate targeting b7-h3) |
| AU2024318876A1 (en) | 2023-07-31 | 2026-03-19 | Astrazeneca Ab | Cd123 antibody-drug conjugates and methods of using the same |
| WO2025103192A1 (zh) * | 2023-11-16 | 2025-05-22 | 上海齐鲁制药研究中心有限公司 | 一种氘代喜树碱化合物及其制备和应用 |
| WO2025167743A1 (zh) * | 2024-02-06 | 2025-08-14 | 四川科伦博泰生物医药股份有限公司 | 抗体药物偶联物及其制备方法和用途 |
| WO2025167742A1 (zh) * | 2024-02-06 | 2025-08-14 | 四川科伦博泰生物医药股份有限公司 | 抗体药物偶联物及其制备方法和用途 |
| WO2025191470A1 (en) | 2024-03-12 | 2025-09-18 | Astrazeneca Ab | Processes and compounds for the preparation of topoisomerase i inhibitor linker-payloads |
| WO2026057740A1 (en) | 2024-09-12 | 2026-03-19 | Astrazeneca Ab | Treatment of cancer with therapeutic binding molecules |
| WO2026078620A1 (en) | 2024-10-11 | 2026-04-16 | Medimmune Llc | Cd22 antibody and drug conjugates and uses thereof |
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| JP3024013B2 (ja) * | 1990-08-14 | 2000-03-21 | 杏林製薬株式会社 | フルオロエチルカンプトテシン誘導体 |
| US6407115B1 (en) | 1991-01-16 | 2002-06-18 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic compound |
| US5658920A (en) | 1991-01-16 | 1997-08-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound |
| JP3008226B2 (ja) | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
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| US6403604B1 (en) | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| DE60230097D1 (de) | 2001-05-08 | 2009-01-15 | Mitsui Chemicals Polyurethanes | Verfahren zur herstellung von 1,5-diaminonaphthalinen |
| ATE398131T1 (de) | 2001-11-30 | 2008-07-15 | Chugai Pharmaceutical Co Ltd | Kondensierte camptothecine als antitumormittel |
| US7595400B2 (en) | 2003-02-21 | 2009-09-29 | Chugai Seiyaku Kabushiki Kaisha | Process for the preparation of hexacyclic compounds |
| TWI351284B (en) | 2004-04-09 | 2011-11-01 | Chugai Pharmaceutical Co Ltd | Novel water-soluble prodrugs |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
| SI1934174T1 (sl) | 2005-10-07 | 2011-08-31 | Exelixis Inc | Inhibitorji MEK in postopki za njihovo uporabo |
| RS52060B (sr) | 2006-01-25 | 2012-04-30 | Sanofi | Citotoksični agensi koji sadrže nove derivate tomaimicina |
| CL2008001334A1 (es) | 2007-05-08 | 2008-09-22 | Genentech Inc | Anticuerpo anti-muc16 disenado con cisteina; conjugado que lo comprende; metodo de produccion; formulacion farmaceutica que lo comprende; y su uso para tratar el cancer. |
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| WO2014061277A1 (ja) | 2012-10-19 | 2014-04-24 | 第一三共株式会社 | 親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート |
| WO2014121033A1 (en) | 2013-02-04 | 2014-08-07 | Fl Therapeutics Llc | Soluble complexes of drug analogs and albumin |
| CN115504924A (zh) | 2013-11-27 | 2022-12-23 | 雷德伍德生物科技股份有限公司 | 肼基-吡咯并化合物及用于生成缀合物的方法 |
| AU2014371934B2 (en) | 2013-12-25 | 2020-01-23 | Daiichi Sankyo Company, Limited | Anti-TROP2 antibody-drug conjugate |
| IL310627B2 (en) | 2014-01-31 | 2026-04-01 | Daiichi Sankyo Co Ltd | Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof |
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| KR102445502B1 (ko) | 2014-04-10 | 2022-09-21 | 다이이찌 산쿄 가부시키가이샤 | 항her3 항체-약물 콘주게이트 |
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| CN107106701B (zh) | 2014-10-03 | 2020-11-06 | 西纳福克斯股份有限公司 | 磺酰胺接头、其缀合物及制备方法 |
| PT3250237T (pt) | 2015-01-30 | 2021-06-30 | Sutro Biopharma Inc | Derivados de hemiasterlina para conjugação e terapêutica |
| GB201506393D0 (en) * | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
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| MA43354A (fr) * | 2015-10-16 | 2018-08-22 | Genentech Inc | Conjugués médicamenteux à pont disulfure encombré |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| KR20190066026A (ko) | 2016-10-07 | 2019-06-12 | 다이이찌 산쿄 가부시키가이샤 | 항 her2 항체-약물 콘주게이트 투여에 의한 내성암의 치료 |
| AU2017359155A1 (en) | 2016-11-10 | 2019-06-13 | Medimmune, Llc | Binding molecules specific for ASCT2 and uses thereof |
| US11273155B2 (en) | 2016-12-12 | 2022-03-15 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
| JP6679762B2 (ja) | 2017-01-17 | 2020-04-15 | 第一三共株式会社 | 抗ｇｐｒ２０抗体及び抗ｇｐｒ２０抗体−薬物コンジュゲート |
| CN117982673A (zh) | 2017-02-28 | 2024-05-07 | 第一三共株式会社 | 抗her3抗体-药物偶联物的应用 |
| TW202532104A (zh) | 2017-05-15 | 2025-08-16 | 日商第一三共股份有限公司 | 抗體－藥物結合物及其用途 |
| WO2019034176A1 (zh) | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | 一种喜树碱-抗体偶联物 |
| WO2019034177A1 (zh) | 2017-08-18 | 2019-02-21 | 四川百利药业有限责任公司 | 具有两种不同药物的抗体药物偶联物 |
| MX2021011812A (es) * | 2019-03-29 | 2021-10-22 | Medimmune Ltd | Compuestos y conjugados de estos. |
-
2020
- 2020-03-23 MX MX2021011812A patent/MX2021011812A/es unknown
- 2020-03-23 UA UAA202105856A patent/UA129129C2/uk unknown
- 2020-03-23 HU HUE20713873A patent/HUE060364T2/hu unknown
- 2020-03-23 CN CN202410334103.5A patent/CN118240003A/zh active Pending
- 2020-03-23 KR KR1020217035043A patent/KR102498681B1/ko active Active
- 2020-03-23 CN CN202311084298.4A patent/CN117263948B/zh active Active
- 2020-03-23 WO PCT/EP2020/057984 patent/WO2020200880A1/en not_active Ceased
- 2020-03-23 PH PH1/2021/552363A patent/PH12021552363A1/en unknown
- 2020-03-23 LT LTEPPCT/EP2020/057984T patent/LT3946464T/lt unknown
- 2020-03-23 CN CN202080025199.7A patent/CN113631196B/zh active Active
- 2020-03-23 SG SG11202110524VA patent/SG11202110524VA/en unknown
- 2020-03-23 DK DK20713873.6T patent/DK3946464T3/da active
- 2020-03-23 SM SM20220439T patent/SMT202200439T1/it unknown
- 2020-03-23 EP EP22189090.8A patent/EP4176904A1/en active Pending
- 2020-03-23 CN CN202410334111.XA patent/CN118221763A/zh active Pending
- 2020-03-23 RS RS20221023A patent/RS63715B1/sr unknown
- 2020-03-23 US US17/599,374 patent/US20220211863A1/en active Pending
- 2020-03-23 CR CR20210541A patent/CR20210541A/es unknown
- 2020-03-23 HR HRP20221280TT patent/HRP20221280T1/hr unknown
- 2020-03-23 PT PT207138736T patent/PT3946464T/pt unknown
- 2020-03-23 AU AU2020252034A patent/AU2020252034B2/en active Active
- 2020-03-23 KR KR1020247021308A patent/KR20240104214A/ko active Pending
- 2020-03-23 PL PL20713873.6T patent/PL3946464T3/pl unknown
- 2020-03-23 EP EP20713873.6A patent/EP3946464B1/en active Active
- 2020-03-23 KR KR1020237003605A patent/KR102679892B1/ko active Active
- 2020-03-23 ES ES20713873T patent/ES2930295T3/es active Active
- 2020-03-23 BR BR112021018986A patent/BR112021018986A2/pt unknown
- 2020-03-23 IL IL286291A patent/IL286291B2/en unknown
- 2020-03-23 US US16/826,405 patent/US20200306243A1/en not_active Abandoned
- 2020-03-23 CA CA3133757A patent/CA3133757A1/en active Pending
- 2020-03-23 JP JP2021557758A patent/JP7210770B2/ja active Active
- 2020-03-27 TW TW112146860A patent/TWI886667B/zh active
- 2020-03-27 TW TW109110410A patent/TWI826676B/zh active
-
2021
- 2021-06-15 US US17/348,236 patent/US11446292B2/en active Active
- 2021-09-08 ZA ZA2021/06612A patent/ZA202106612B/en unknown
- 2021-09-27 CL CL2021002498A patent/CL2021002498A1/es unknown
- 2021-10-22 EC ECSENADI202178204A patent/ECSP21078204A/es unknown
- 2021-10-28 CO CONC2021/0014566A patent/CO2021014566A2/es unknown
-
2023
- 2023-01-11 JP JP2023002495A patent/JP7680658B2/ja active Active
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