JP2022526985A5 - - Google Patents
Info
- Publication number
- JP2022526985A5 JP2022526985A5 JP2021559266A JP2021559266A JP2022526985A5 JP 2022526985 A5 JP2022526985 A5 JP 2022526985A5 JP 2021559266 A JP2021559266 A JP 2021559266A JP 2021559266 A JP2021559266 A JP 2021559266A JP 2022526985 A5 JP2022526985 A5 JP 2022526985A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- linker
- drug
- group
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024176403A JP2025011192A (ja) | 2019-04-05 | 2024-10-08 | 改良されたコンジュゲーションリンカー |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962830280P | 2019-04-05 | 2019-04-05 | |
| US62/830,280 | 2019-04-05 | ||
| PCT/US2020/026726 WO2020206358A1 (en) | 2019-04-05 | 2020-04-03 | Improved conjugation linkers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024176403A Division JP2025011192A (ja) | 2019-04-05 | 2024-10-08 | 改良されたコンジュゲーションリンカー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022526985A JP2022526985A (ja) | 2022-05-27 |
| JP2022526985A5 true JP2022526985A5 (https=) | 2023-04-12 |
Family
ID=72666279
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021559266A Pending JP2022526985A (ja) | 2019-04-05 | 2020-04-03 | 改良されたコンジュゲーションリンカー |
| JP2024176403A Pending JP2025011192A (ja) | 2019-04-05 | 2024-10-08 | 改良されたコンジュゲーションリンカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024176403A Pending JP2025011192A (ja) | 2019-04-05 | 2024-10-08 | 改良されたコンジュゲーションリンカー |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12364771B2 (https=) |
| EP (1) | EP3946460A4 (https=) |
| JP (2) | JP2022526985A (https=) |
| KR (1) | KR20210150496A (https=) |
| CN (2) | CN119970617A (https=) |
| AU (1) | AU2020253560B2 (https=) |
| BR (1) | BR112021020023A2 (https=) |
| CA (1) | CA3134838A1 (https=) |
| MX (2) | MX2021011997A (https=) |
| SG (1) | SG11202110436UA (https=) |
| WO (1) | WO2020206358A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119970617A (zh) * | 2019-04-05 | 2025-05-13 | 普罗林科斯有限责任公司 | 改良偶联接头 |
| CA3151529A1 (en) * | 2019-08-28 | 2021-03-04 | Prolynx Llc | Conjugated inhibitors of dna damage response |
| JP7851853B2 (ja) | 2020-01-03 | 2026-04-27 | アセンディス ファーマ エー／エス | 分子内転位を受けるコンジュゲート |
| MX2022007371A (es) | 2020-01-13 | 2022-07-12 | Ascendis Pharma Bone Diseases As | Tratamiento del hipoparatiroidismo. |
| EP4146281A1 (en) | 2020-05-04 | 2023-03-15 | Ascendis Pharma A/S | Hydrogel irradiation |
| KR20230019889A (ko) | 2020-06-03 | 2023-02-09 | 아센디스 파마 온콜로지 디비전 에이/에스 | Il-2 서열 및 이의 용도 |
| WO2022029178A1 (en) | 2020-08-05 | 2022-02-10 | Ascendis Pharma A/S | Conjugates comprising reversible linkers and uses thereof |
| TW202219060A (zh) | 2020-08-28 | 2022-05-16 | 丹麥商阿森迪斯腫瘤製藥有限公司 | 醣基化il-2蛋白及其用途 |
| WO2022064035A1 (en) | 2020-09-28 | 2022-03-31 | Ascendis Pharma Bone Diseases A/S | Improvement of physical and mental well-being of patients with hypoparathyroidism |
| WO2022115563A1 (en) * | 2020-11-25 | 2022-06-02 | Prolynx Llc | Extended release hydrogel conjugates of c-natriuretic peptides |
| JP2024514095A (ja) | 2021-04-01 | 2024-03-28 | アセンディス ファーマ エー／エス | 炎症によって誘発される疾患を治療するための長時間作用型成長ホルモンの使用 |
| IL311539A (en) | 2021-09-22 | 2024-05-01 | Ascendis Pharma Bone Diseases As | Long-acting pth compound treatments |
| JP2025537527A (ja) | 2022-11-02 | 2025-11-18 | アセンディス ファーマ ボーン ディジージズ エー／エス | ２つのｐｔｈ化合物を含むｐｔｈ治療レジメン |
| TW202430223A (zh) | 2023-01-05 | 2024-08-01 | 丹麥商阿仙帝斯眼科製藥有限公司 | 用於治療眼部病症之藥物結合物 |
| TW202434299A (zh) | 2023-01-05 | 2024-09-01 | 丹麥商阿仙帝斯製藥公司 | 製造水凝膠微球之方法 |
| JP2026509773A (ja) | 2023-03-06 | 2026-03-25 | アセンディス ファーマ エー／エス | アルブミン結合性部分を含む薬物化合物 |
| WO2024184351A1 (en) | 2023-03-06 | 2024-09-12 | Ascendis Pharma A/S | Compounds of drugs with an albumin binding moiety |
| EP4676535A1 (en) | 2023-03-06 | 2026-01-14 | Ascendis Pharma A/S | Multi-albumin binding compounds |
| CN121175071A (zh) | 2023-05-09 | 2025-12-19 | 阿森迪斯药物肿瘤股份有限公司 | 使用il-2缀合物的新型癌症治疗方法 |
| IL326658A (en) | 2023-09-04 | 2026-04-01 | Ascendis Pharma Bone Diseases As | PTH treatment in chronic kidney disease |
| WO2025174913A1 (en) * | 2024-02-12 | 2025-08-21 | Prolynx Llc | Locoregional therapies using slow-release conjugates |
| WO2026013138A1 (en) | 2024-07-10 | 2026-01-15 | Ascendis Pharma A/S | Compounds with improved albumin-binding |
| WO2026013136A1 (en) | 2024-07-10 | 2026-01-15 | Ascendis Pharma A/S | Albumin-binding compounds |
| WO2026013135A1 (en) | 2024-07-10 | 2026-01-15 | Ascendis Pharma A/S | Albumin-binding reagents |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62281867A (ja) * | 1986-01-16 | 1987-12-07 | Otsuka Chem Co Ltd | イミダゾ−ルカルボン酸エステル誘導体、その製造方法及び該誘導体を有効成分とする殺菌剤 |
| US6258898B1 (en) | 1996-12-23 | 2001-07-10 | Basf Corporation | Amino resins functionalized with carbamate groups and coating compositions containing the same |
| WO1999043656A1 (en) * | 1998-02-25 | 1999-09-02 | Maruho Kabushikikaisha | Propylamine derivatives and use thereof |
| ES2278589T3 (es) | 1999-01-14 | 2007-08-16 | Amylin Pharmaceuticals, Inc. | Excendinas destinadas a la inhibicion de glucagon. |
| US7074878B1 (en) | 1999-12-10 | 2006-07-11 | Harris J Milton | Hydrolytically degradable polymers and hydrogels made therefrom |
| US6413507B1 (en) * | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
| JP2004500388A (ja) * | 2000-03-01 | 2004-01-08 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロン、その中間体およびその類似体の合成 |
| EP1531846A4 (en) * | 2002-02-27 | 2006-04-19 | Us Gov Health & Human Serv | Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use |
| JP2006501820A (ja) | 2002-09-06 | 2006-01-19 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 修飾ｇｌｐ−１受容体アゴニストおよびそれらの薬理学的使用法 |
| BR0314996A (pt) | 2002-10-02 | 2005-08-09 | Zealand Pharma As | Composição, composição farmaceuticamente aceitável, método para produzir a composição, métodos para estabilizar a exendina-4 (1-39) ou uma sua variante, derivado ou análogo contra a degradação, antes, durante ou após o uso pretendido, para tratar doenças, para tratar de estados de doenças associados com nìveis elevados de glicose do sangue, para a regulação dos nìveis de glicose do sangue, para a regulação do esvaziamento gástrico, para estimular a liberação de insulina em um mamìfero para reduzir o nìvel de glicose do sangue em um mamìfero, para reduzir o nìvel de lipìdeos plasmáticos em um mamìfero, para reduzir a mortalidade e a morbidez após o infarto miocárdico em um mamìfero, para estimular a liberação de insulina em um mamìfero, e para produzir uma exendina (1-39) estabilizada, e, exendina (1-39) estabilizada |
| US7943593B2 (en) * | 2002-12-06 | 2011-05-17 | Vertex Pharmaceuticals Incorporated | Compositions comprising inhibitors of IMPDH enzyme |
| DE60322111D1 (de) | 2002-12-31 | 2008-08-21 | Nektar Therapeutics Al Co | Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen |
| US7968085B2 (en) | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
| CN100540565C (zh) | 2005-01-14 | 2009-09-16 | 无锡宏创医药科技有限公司 | 修饰的Exendins及其应用 |
| WO2007139941A2 (en) | 2006-05-26 | 2007-12-06 | Amylin Pharmaceuticals, Inc. | Composition and methods for treatment of congestive heart failure |
| CN101125207B (zh) | 2006-11-14 | 2012-09-05 | 上海华谊生物技术有限公司 | 带有聚乙二醇基团的艾塞丁或其类似物及其制剂和用途 |
| WO2008116294A1 (en) | 2007-03-23 | 2008-10-02 | Matregen Corp. | Exendin analogs |
| WO2009123759A2 (en) | 2008-04-02 | 2009-10-08 | Moerae Matrix, Inc. | Therapeutic uses of biocompatible biogel compositions |
| ES2672526T3 (es) | 2008-06-26 | 2018-06-14 | Prolynx Llc | Profármacos y conjugados de fármaco-macromolécula que presentan velocidades de liberación de fármaco controladas |
| WO2010017215A2 (en) | 2008-08-04 | 2010-02-11 | The Regents Of The University Of California | Biodegradable microspheres and methods of use thereof |
| US9345662B2 (en) | 2008-11-19 | 2016-05-24 | Rutgers, The State University Of New Jersey | Degradable hydrogel compositions and methods |
| PT3345593T (pt) | 2009-11-13 | 2023-11-27 | Sanofi Aventis Deutschland | Composição farmacêutica compreendendo despro36exendina- 4(1-39)-lys6-nh2 e metionina |
| US8703907B2 (en) | 2010-05-05 | 2014-04-22 | Prolynx Llc | Controlled drug release from dendrimers |
| EP2566334B1 (en) * | 2010-05-05 | 2018-04-18 | Prolynx, LLC | Controlled drug release from solid supports |
| ES2584381T3 (es) * | 2010-05-05 | 2016-09-27 | Prolynx Llc | Liberación controlada de compuestos activos desde conjugados macromoleculares |
| WO2011156407A2 (en) | 2010-06-09 | 2011-12-15 | Amylin Pharmaceuticals, Inc. | Glp-1 receptor agonists to treat pancre-atitis |
| CA2848142C (en) | 2011-09-07 | 2021-05-18 | Prolynx Llc | Hydrogels with biodegradable crosslinking |
| US20140256626A1 (en) | 2011-10-18 | 2014-09-11 | Prolynx Llc | Peg conjugates of exenatide |
| MX371201B (es) * | 2013-10-04 | 2020-01-22 | Prolynx Llc | Conjugados de liberación lenta de sn-38. |
| CN106456799B (zh) * | 2014-06-03 | 2020-05-22 | 江苏佳瑞生物技术有限公司 | 肽-药物偶联物 |
| KR20180129825A (ko) | 2016-03-16 | 2018-12-05 | 프로린크스 엘엘시 | 엑세나타이드 유사체의 연장된 방출 컨쥬게이트 |
| WO2019152672A1 (en) | 2018-01-31 | 2019-08-08 | Prolynx Llc | Aseptic method and apparatus to prepare sterile formulations of drug-linked hydrogel microspheres |
| CN119970617A (zh) * | 2019-04-05 | 2025-05-13 | 普罗林科斯有限责任公司 | 改良偶联接头 |
| CA3151529A1 (en) * | 2019-08-28 | 2021-03-04 | Prolynx Llc | Conjugated inhibitors of dna damage response |
-
2020
- 2020-04-03 CN CN202411655990.2A patent/CN119970617A/zh active Pending
- 2020-04-03 WO PCT/US2020/026726 patent/WO2020206358A1/en not_active Ceased
- 2020-04-03 SG SG11202110436UA patent/SG11202110436UA/en unknown
- 2020-04-03 JP JP2021559266A patent/JP2022526985A/ja active Pending
- 2020-04-03 CA CA3134838A patent/CA3134838A1/en active Pending
- 2020-04-03 US US17/601,575 patent/US12364771B2/en active Active
- 2020-04-03 AU AU2020253560A patent/AU2020253560B2/en active Active
- 2020-04-03 MX MX2021011997A patent/MX2021011997A/es unknown
- 2020-04-03 KR KR1020217036326A patent/KR20210150496A/ko active Pending
- 2020-04-03 EP EP20783127.2A patent/EP3946460A4/en active Pending
- 2020-04-03 CN CN202080041310.1A patent/CN114286693A/zh not_active Withdrawn
- 2020-04-03 BR BR112021020023A patent/BR112021020023A2/pt unknown
-
2021
- 2021-09-30 MX MX2024014691A patent/MX2024014691A/es unknown
-
2024
- 2024-10-08 JP JP2024176403A patent/JP2025011192A/ja active Pending
-
2025
- 2025-05-20 US US19/213,933 patent/US20260007768A1/en active Pending
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